Compounds > lapatinib
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lapatinib and Experimental Mammary Neoplasms

lapatinib has been researched along with Experimental Mammary Neoplasms in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's15 (75.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Gan, N; Li, H; Peng, X; Sun, Q; Suo, Z; Zhang, S; Zhao, G; Zhao, L1
Benonisson, H; Breukel, C; Brouwers, C; Camps, M; Claassens, J; Fransen, MF; Linssen, MM; Ossendorp, F; Sow, HS; van Hall, T; Verbeek, JS1
Bick, G; Cai, C; Charif, M; Guan, JL; Hao, M; Leonard, M; Lower, EE; Luo, Z; Wang, J; Yang, Y; Yeo, S; Zhang, X1
Bode, A; Grubbs, CJ; Juliana, MM; Lubet, RA; Moeinpour, F; Steele, VE1
Balko, JM; Cook, RS; Elion, DL; Gonzales-Ericsson, PI; Hicks, DJ; James, JL; Koblish, HK; Nixon, MJ; Rahman, B; Sanchez, V; Scherle, PA; Werfel, TA1
Cho, HJ; Lee, SY1
Dai, C; He, S; Hu, H; Lou, Q; Wang, L; Wu, J; You, X; Zhang, J; Zhao, M1
Arteaga, CL; Balko, JM; Cheng, H; Cook, RS; Kuba, MG; Owens, P; Perou, CM; Pfefferle, AD; Rexer, BN; Sánchez, V; Young, CD; Zhao, JJ1
Krop, IE; Lin, NU; Liu, P; Roberts, TM; Spangle, JM; Von, T; Wang, Q; Winer, EP; Zhao, JJ1
Coarfa, C; Edwards, DP; Hilsenbeck, SG; Holdman, XB; Huang, S; Mo, Q; Pond, A; Rajapakshe, K; Rosen, JM; Welte, T; Zhang, X1
Chen, X; Ding, L; Jin, L; Liang, GK; Wu, HH; Yao, ZT; Zhang, JQ1
Bégin, LR; Bourque, G; Caron, M; Deblois, G; Giguère, V; Gravel, SP; Labbé, DP; Muller, WJ; Park, M; Savage, P; Smith, HW; St-Pierre, J; Tam, IS; Tremblay, ML1
Amici, A; Andreani, C; Bartolacci, C; Belletti, B; Elexpuru Zabaleta, M; Galeazzi, R; Gambini, V; Garulli, C; Hysi, A; Iezzi, M; Kalogris, C; Marchini, C; Orlando, F; Pietrella, L; Provinciali, M; Tilio, M; Wang, J1
Brown, PH; Gilmer, TM; Hill, JL; Hilsenbeck, SG; Kim, HT; Li, Y; Osborne, CK; Sexton, KR; Shen, Q; Strecker, TE; Wang, C; Zhang, Y1
Arteaga, CL; Boimel, PJ; Coniglio, SJ; Hynes, NE; Kedrin, D; Segall, JE; Wyckoff, J1
Ballestrero, A; Cea, M; Garuti, A; Moran, E; Nencioni, A; Passalacqua, M; Patrone, F; Pistoia, V; Raffaghello, L; Soncini, D; Zoppoli, G1
Angelini, PD; Arribas, J; Aura, C; Baselga, J; Cameron, D; Chandarlapaty, S; Ellis, C; Gagnon, R; Geyer, C; Gomez, H; Guzman, M; Jimenez, J; Koehler, M; Parra, JL; Prudkin, L; Rosen, N; Sánchez, G; Scaltriti, M1
Durbin, JE; Koromilas, AE; Muller, WJ; Raven, JF; Tremblay, ML; Wang, S; Williams, V1
Deng, X; Erfani, SF; Hemler, ME; Hoff, J; Jin, H; Kaetzel, DM; Li, Q; Novak, M; Rabinovitz, I; Sharma, C; Sonnenberg, A; Stipp, CS; Yang, H; Yang, XH; Yi, Y; Zhou, P1
Aronson, AB; Bose, R; Ding, L; Ellis, MJ; Goel, N; Kavuri, SM; Koboldt, DC; Li, S; Ma, CX; Mardis, ER; Monsey, J; Searleman, AC; Shen, D; Shen, W1

Other Studies

20 other study(ies) available for lapatinib and Experimental Mammary Neoplasms

ArticleYear
A pH-sensitive T7 peptide-decorated liposome system for HER2 inhibitor extracellular delivery: an application for the efficient suppression of HER2+ breast cancer.
    Journal of materials chemistry. B, 2021, 11-03, Volume: 9, Issue:42

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Collagen Type IV; Drug Screening Assays, Antitumor; Female; Humans; Lapatinib; Liposomes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Optical Imaging; Peptide Fragments; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2

2021
Immunogenicity of rat-neu
    Scientific reports, 2020, 03-03, Volume: 10, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Female; Flow Cytometry; Lapatinib; Leukocyte Common Antigens; Male; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Quinolines; Rats; Receptor, ErbB-2; Signal Transduction; T-Lymphocytes; Trastuzumab

2020
Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.
    Cell reports, 2021, 03-09, Volume: 34, Issue:10

    Topics: Animals; Antineoplastic Agents; Cell Movement; COP9 Signalosome Complex; Epithelial-Mesenchymal Transition; Female; Genetic Vectors; Lapatinib; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mediator Complex Subunit 1; Mice; Mice, Nude; Neoplasm Metastasis; Neoplastic Stem Cells; Peptide Hydrolases; Phenotype; Receptor, ErbB-2; RNA Interference; RNA, Small Interfering; Transcriptional Activation

2021
Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models.
    Oncology reports, 2018, Volume: 40, Issue:3

    Topics: Animals; Disease Models, Animal; Drug Administration Schedule; ErbB Receptors; Female; Gefitinib; Heterocyclic Compounds, 3-Ring; Lapatinib; Male; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Triazoles

2018
Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1.
    Cancer research, 2019, 01-01, Volume: 79, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; c-Mer Tyrosine Kinase; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Lapatinib; Lung Neoplasms; Macrophages; Mammary Neoplasms, Experimental; Mice; Necrosis; Phagocytosis; Receptor, ErbB-2; T-Lymphocytes, Regulatory; Tumor Microenvironment

2019
Mitochondria Targeting and Destabilizing Hyaluronic Acid Derivative-Based Nanoparticles for the Delivery of Lapatinib to Triple-Negative Breast Cancer.
    Biomacromolecules, 2019, 02-11, Volume: 20, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Female; Humans; Hyaluronic Acid; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mitochondria; Nanoparticles; Triple Negative Breast Neoplasms

2019
Cysteine-based redox-responsive nanoparticles for small-molecule agent delivery.
    Biomaterials science, 2019, Oct-01, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Cysteine; Drug Delivery Systems; Drug Liberation; Erythrocytes; Female; Hydrogen-Ion Concentration; Lapatinib; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; Nanoparticles; Oxidation-Reduction; Rats, Sprague-Dawley; Tissue Distribution

2019
Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
    Cancer research, 2013, Jul-01, Volume: 73, Issue:13

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Female; Gene Expression; Humans; Hyperplasia; Lapatinib; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Mice, Transgenic; Mutation, Missense; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Transcriptome; Tumor Burden

2013
PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.
    Oncogene, 2016, 07-07, Volume: 35, Issue:27

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Female; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice, Knockout; Molecular Targeted Therapy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Receptor, ErbB-2; Signal Transduction; Thiazoles; Tumor Burden; Xenograft Model Antitumor Assays

2016
Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer.
    Breast cancer research : BCR, 2015, Nov-18, Volume: 17

    Topics: Animals; Breast Neoplasms; Collagen; ErbB Receptors; Female; Lapatinib; Mammary Neoplasms, Experimental; Mice; Neoplasm Recurrence, Local; Phenylurea Compounds; Pyrimidines; Quinazolines; Receptor, Fibroblast Growth Factor, Type 1; Signal Transduction; Stromal Cells; Tenascin; Up-Regulation; Wnt1 Protein

2015
[Combination of lapatinib with chlorogenic acid inhibits breast cancer metastasis by suppressing macrophage M2 polarization].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2015, Volume: 44, Issue:5

    Topics: Animals; Chlorogenic Acid; Female; Lapatinib; Lung Neoplasms; Macrophages; Mammary Neoplasms, Experimental; Mice; Neoplasm Metastasis; Quinazolines

2015
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.
    Nature communications, 2016, 07-12, Volume: 7

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; MCF-7 Cells; Mice; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Retroviridae Infections; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Virus Infections

2016
Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib.
    Cancer letters, 2016, 10-10, Volume: 381, Issue:1

    Topics: Alternative Splicing; Animals; Benzodioxoles; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Genetic Predisposition to Disease; Humans; Inhibitory Concentration 50; Lapatinib; Mammary Neoplasms, Experimental; Mice, Transgenic; Phenotype; Protein Isoforms; Protein Kinase Inhibitors; Quinazolines; Quinazolinones; Receptor, ErbB-2; Signal Transduction; Time Factors

2016
Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice.
    Journal of the National Cancer Institute, 2009, Jan-21, Volume: 101, Issue:2

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cyclin D1; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Precancerous Conditions; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; RNA, Messenger; Signal Transduction

2009
ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jun-01, Volume: 15, Issue:11

    Topics: Animals; Benzothiazoles; Cell Line, Tumor; Cell Movement; ErbB Receptors; Female; Gefitinib; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tyrphostins; Xenograft Model Antitumor Assays

2009
Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.
    PloS one, 2010, Feb-02, Volume: 5, Issue:2

    Topics: Adaptation, Physiological; Animals; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Female; Gene Expression Regulation, Neoplastic; GRB7 Adaptor Protein; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Transplantation, Heterologous; Up-Regulation

2010
Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, May-01, Volume: 16, Issue:9

    Topics: 3T3 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; ErbB Receptors; Female; Fluorouracil; Humans; Immunoblotting; In Situ Hybridization, Fluorescence; Lapatinib; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Kinase Inhibitors; Quinazolines; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Survival Analysis; Treatment Outcome; Xenograft Model Antitumor Assays

2010
Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation.
    Cell cycle (Georgetown, Tex.), 2011, Mar-01, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; Disease Progression; Female; Gefitinib; Humans; Lapatinib; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; STAT1 Transcription Factor; Transplantation, Heterologous

2011
Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.
    Neoplasia (New York, N.Y.), 2012, Volume: 14, Issue:8

    Topics: Animals; Butadienes; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Female; Focal Adhesion Kinase 1; Humans; Integrin alpha6beta4; Lapatinib; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tetraspanin 24; Transendothelial and Transepithelial Migration

2012
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
    Cancer discovery, 2013, Volume: 3, Issue:2

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Drug Resistance, Neoplasm; Female; Gene Amplification; Gene Expression; Humans; Lapatinib; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Nude; Models, Molecular; Molecular Sequence Data; Mutation; NIH 3T3 Cells; Protein Structure, Tertiary; Quinazolines; Quinolines; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Transplantation, Heterologous

2013