Compounds > lapatinib
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lapatinib and Cancer of Colon

lapatinib has been researched along with Cancer of Colon in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abbasi Asbagh, L; Barber, PR; Bosch-Vilaró, A; Jacobs, B; Kim, P; Kirkland, R; Liu, X; Michel, J; Ng, T; Pomella, V; Singh, S; Tejpar, S; Vojnovic, B; Weitsman, G1
Antonacopoulou, A; Floratou, K; Giannopoulou, E; Kalofonos, HP; Papavassiliou, AG1
Fazzone, W; LaBonte, MJ; Ladner, RD; Lenz, HJ; Louie, SG; Manegold, PC; Wilson, PM1
Amaravadi, R1
Almendro, V; Ametller, E; Casas, I; Fernández-Nogueira, P; García-Recio, S; Gascón, P; Mayordomo, C; Pastor-Arroyo, EM; Vinyals, L1
Dicker, DT; Dolloff, NG; El-Deiry, WS; Hart, LS; Humphreys, R; Mayes, PA1
Cheng, T; Ge, Z; Li, R; Qiao, K; Zhang, L; Zhang, X1
Brattain, MG; Conway, AN; Hauser, J; Hu, YP; Humphrey, L; Li, S; Vinci, MA; Wang, J; Willson, JK; Zborowska, E; Zhou, Y1

Other Studies

8 other study(ies) available for lapatinib and Cancer of Colon

ArticleYear
Feedback activation of HER3 attenuates response to EGFR inhibitors in colon cancer cells.
    Oncotarget, 2017, Jan-17, Volume: 8, Issue:3

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Feedback, Physiological; Humans; Lapatinib; Phosphorylation; Protein Kinase Inhibitors; Protein Multimerization; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Up-Regulation

2017
Dual targeting of EGFR and HER-2 in colon cancer cell lines.
    Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Caco-2 Cells; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Gefitinib; Humans; Lapatinib; Quinazolines; Receptor, ErbB-2; Trastuzumab

2009
The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38.
    International journal of cancer, 2009, Dec-15, Volume: 125, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Camptothecin; Cell Cycle; Cell Proliferation; Chromatography, Liquid; Colonic Neoplasms; Colony-Forming Units Assay; Drug Synergism; ErbB Receptors; Flow Cytometry; Humans; Irinotecan; Lapatinib; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Quinazolines; Receptor, ErbB-2; Stomach Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2009
Autophagy can contribute to cell death when combining targeted therapy.
    Cancer biology & therapy, 2009, Volume: 8, Issue:21

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Death; Colonic Neoplasms; HCT116 Cells; Humans; Indoles; Lapatinib; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Quinazolines

2009
Targeting of substance P induces cancer cell death and decreases the steady state of EGFR and Her2.
    Journal of cellular physiology, 2012, Volume: 227, Issue:4

    Topics: Antibodies; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Lapatinib; Ligands; Male; Neoplasms; Neurokinin-1 Receptor Antagonists; Piperidines; Prostatic Neoplasms; Quinazolines; Receptor, ErbB-2; Receptors, Neurokinin-1; Signal Transduction; Substance P; Trastuzumab

2012
Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation.
    Science translational medicine, 2011, Jun-08, Volume: 3, Issue:86

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; HCT116 Cells; HT29 Cells; Humans; Immunohistochemistry; Lapatinib; Mice; Mice, Nude; Microscopy, Fluorescence; Quinazolines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays

2011
Novel dithiocarbamic acid esters derived from 6-aminomethyl-4-anilinoquinazolines and 6-aminomethyl-4-anilino-3-cyanoquinolines as potent EGFR inhibitors.
    Archiv der Pharmazie, 2013, Volume: 346, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; ErbB Receptors; Esters; Female; HCT116 Cells; Humans; Lapatinib; Protein Kinase Inhibitors; Quinazolines; Quinolines; Structure-Activity Relationship

2013
Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.
    Cancer research, 2006, Jan-01, Volume: 66, Issue:1

    Topics: Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; ErbB Receptors; Humans; Lapatinib; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Tyrphostins; Xenograft Model Antitumor Assays

2006