lapachol has been researched along with Benign Neoplasms in 9 studies
lapachol : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review focuses on the anti-cancer prospects of plant-derived quinones, namely, aloe-emodin, juglone, β-lapachol, plumbagin, shikonin, and thymoquinone." | 2.49 | Quinones derived from plant secondary metabolites as anti-cancer agents. ( Bao, JL; Chen, XP; Huang, MQ; Lu, JJ; Wang, YT; Wu, GS; Xu, WS, 2013) |
| "The compounds were tested on six human cancer cell lines using the MTT colorimetric assay." | 1.40 | Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives. ( Bruyère, C; Epifano, F; Fiorito, S; Genovese, S; Kiss, R; Mathieu, V, 2014) |
| "Metastasis is the major process responsible for the death in cancer patients." | 1.33 | Demonstration of the lapachol as a potential drug for reducing cancer metastasis. ( Balassiano, IT; Cabral, MC; da Gloria da Costa Carvalho, M; De Paulo, SA; Henriques Silva, N, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Eyong, KO | 1 |
| Kumar, PS | 1 |
| Kuete, V | 1 |
| Folefoc, GN | 1 |
| Nkengfack, EA | 1 |
| Baskaran, S | 1 |
| Fiorito, S | 1 |
| Epifano, F | 1 |
| Bruyère, C | 1 |
| Mathieu, V | 1 |
| Kiss, R | 1 |
| Genovese, S | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Ahmadi, ES | 1 |
| Tajbakhsh, A | 1 |
| Iranshahy, M | 1 |
| Asili, J | 1 |
| Kretschmer, N | 1 |
| Shakeri, A | 1 |
| Sahebkar, A | 1 |
| Oliveira, KM | 1 |
| Honorato, J | 1 |
| Demidoff, FC | 1 |
| Schultz, MS | 1 |
| Netto, CD | 1 |
| Cominetti, MR | 1 |
| Correa, RS | 1 |
| Batista, AA | 1 |
| Hussain, H | 1 |
| Green, IR | 1 |
| Lu, JJ | 1 |
| Bao, JL | 1 |
| Wu, GS | 1 |
| Xu, WS | 1 |
| Huang, MQ | 1 |
| Chen, XP | 1 |
| Wang, YT | 1 |
| Balassiano, IT | 1 |
| De Paulo, SA | 1 |
| Henriques Silva, N | 1 |
| Cabral, MC | 1 |
| da Gloria da Costa Carvalho, M | 1 |
| de Sandoval, NA | 1 |
| Rodríguez, CP | 1 |
| de Martínez, NR | 1 |
4 reviews available for lapachol and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity.
Topics: Anti-Infective Agents; Apoptosis; Drug Screening Assays, Antitumor; Fungi; Humans; Naphthoquinones; | 2020 |
Lapachol and lapachone analogs: a journey of two decades of patent research(1997-2016).
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Design; Humans; Naphthoquinones; | 2017 |
Quinones derived from plant secondary metabolites as anti-cancer agents.
Topics: Anthraquinones; Antineoplastic Agents, Phytogenic; Benzoquinones; Cell Line, Tumor; Cell Survival; H | 2013 |
5 other studies available for lapachol and Benign Neoplasms
| Article | Year |
|---|---|
Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.
Topics: Aldehydes; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Response Relatio | 2008 |
Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colorimetry; Growth Inhibitors; Humans; Naphtho | 2014 |
Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug.
Topics: A549 Cells; Antineoplastic Agents; Coordination Complexes; Humans; MCF-7 Cells; Naphthoquinones; Neo | 2021 |
Demonstration of the lapachol as a potential drug for reducing cancer metastasis.
Topics: Antineoplastic Agents, Phytogenic; HeLa Cells; Humans; Naphthoquinones; Neoplasm Invasiveness; Neopl | 2005 |
[Tumors caused by methylcholanthrene and lapachol. Follow-up of development with cytology].
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Methylcholanthrene; Naphthoquinones; Neopla | 1996 |