Page last updated: 2024-10-30

lansoprazole and Zollinger-Ellison Syndrome

lansoprazole has been researched along with Zollinger-Ellison Syndrome in 32 studies

Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.

Zollinger-Ellison Syndrome: A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

Research Excerpts

ExcerptRelevanceReference
"Sixty-seven patients (49 with Zollinger-Ellison syndrome [ZES], 18 without), with basal acid output (BAO) >15 mmol/h or >5 mmol/h if post-antrectomy (n = 9, all ZES), were treated with individually optimized doses of lansoprazole (7."9.11Clinical outcome using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study. ( Hirschowitz, BI; Mohnen, J; Simmons, J, 2005)
"In these patients with the Zollinger-Ellison syndrome, pantoprazole was well tolerated and equally effective to the other proton pump inhibitors in terms of antisecretory potency."9.10Effect of pantoprazole versus other proton pump inhibitors on 24-hour intragastric pH and basal acid output in Zollinger-Ellison syndrome. ( Mignon, M; Ramdani, A; Samoyeau, R, 2002)
"We report long-term, up to 4 years, prospective treatment using lansoprazole in nine male patients with duodenal ulcers and a BAO of more than 15 mmol/h whose results are compared with those in 10 male Zollinger-Ellison syndrome patients with intact stomachs reported in detail in an accompanying paper."9.08Long-term treatment with lansoprazole of patients with duodenal ulcer and basal acid output of more than 15 mmol/h. ( Hirschowitz, BI; Mohnen, J; Shaw, S, 1996)
"Lansoprazole was given for 3-48 months (median 28 months) to 26 Zollinger-Ellison syndrome patients with peptic ulcer manifestations in all and oesophagitis in 13."9.08Long-term treatment with lansoprazole for patients with Zollinger-Ellison syndrome. ( Hirschowitz, BI; Mohnen, J; Shaw, S, 1996)
"The aim of this prospective study was to confirm the efficacy and safety of lansoprazole in patients with Zollinger-Ellison syndrome (ZES)."9.08[Effectiveness and safety of lansoprazole in the treatment of Zollinger-Ellison syndrome. First six months of treatment]. ( Cadiot, G; Coste, T; Escourrou, J; Forestier, S; Mignon, M; Pospaï, D; Ruszniewski, P, 1998)
"Lansoprazole, a new substituted benzimidazole H+,K(+)-ATPase inhibitor, profoundly inhibits gastric acid secretion and has potential use in the management of diseases such as Zollinger-Ellison syndrome (ZES)."9.07Prospective study of efficacy and safety of lansoprazole in Zollinger-Ellison syndrome. ( Feigenbaum, K; Gardner, JD; Jensen, RT; Koviack, PD; Maton, PN; Metz, DC; Pisegna, JR; Ringham, GL, 1993)
"The long-term safety and efficacy of lansoprazole were studied in 21 patients with Zollinger-Ellison syndrome."9.07Prospective study of the long-term efficacy and safety of lansoprazole in patients with the Zollinger-Ellison syndrome. ( Feigenbaum, KM; Jensen, RT; Koviack, PD; Metz, DC, 1993)
"Patients enrolled in a long-term trial of lansoprazole for Zollinger-Ellison syndrome and other acid hypersecretory states had interval histories taken every six months regarding hospitalizations or other intercurrent medical conditions."7.74Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole. ( Hirschowitz, BI; Martin, T; Mohnen, J; Phadnis, M; Wilcox, CM; Worthington, J, 2008)
" pylori infection on gastritis, enterochromaffin-like cell density and hyperplasia, mucosal atrophy and serum gastrin in patients with gastric hypersecretion (basal acid output gt; 15 mmol/h) with either hypergastrinemia (Zollinger-Ellison syndrome) or normal gastrin (non-Zollinger-Ellison syndrome) before and during long-term treatment with lansoprazole."7.71Helicobacter pylori effects on gastritis, gastrin and enterochromaffin-like cells in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome acid hypersecretors treated long-term with lansoprazole. ( Haber, MM; Hirschowitz, BI, 2001)
"Over a 20-year period, patients with Zollinger-Ellison syndrome were enrolled in a prospective trial evaluating the efficacy of lansoprazole."5.15Zollinger-Ellison syndrome: presentation, response to therapy, and outcome. ( Arcury, JT; Hirschowitz, BI; Mohnen, J; Seay, T; Wilcox, CM, 2011)
"Sixty-seven patients (49 with Zollinger-Ellison syndrome [ZES], 18 without), with basal acid output (BAO) >15 mmol/h or >5 mmol/h if post-antrectomy (n = 9, all ZES), were treated with individually optimized doses of lansoprazole (7."5.11Clinical outcome using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study. ( Hirschowitz, BI; Mohnen, J; Simmons, J, 2005)
"In these patients with the Zollinger-Ellison syndrome, pantoprazole was well tolerated and equally effective to the other proton pump inhibitors in terms of antisecretory potency."5.10Effect of pantoprazole versus other proton pump inhibitors on 24-hour intragastric pH and basal acid output in Zollinger-Ellison syndrome. ( Mignon, M; Ramdani, A; Samoyeau, R, 2002)
"We report long-term, up to 4 years, prospective treatment using lansoprazole in nine male patients with duodenal ulcers and a BAO of more than 15 mmol/h whose results are compared with those in 10 male Zollinger-Ellison syndrome patients with intact stomachs reported in detail in an accompanying paper."5.08Long-term treatment with lansoprazole of patients with duodenal ulcer and basal acid output of more than 15 mmol/h. ( Hirschowitz, BI; Mohnen, J; Shaw, S, 1996)
"Lansoprazole was given for 3-48 months (median 28 months) to 26 Zollinger-Ellison syndrome patients with peptic ulcer manifestations in all and oesophagitis in 13."5.08Long-term treatment with lansoprazole for patients with Zollinger-Ellison syndrome. ( Hirschowitz, BI; Mohnen, J; Shaw, S, 1996)
"The aim of this prospective study was to confirm the efficacy and safety of lansoprazole in patients with Zollinger-Ellison syndrome (ZES)."5.08[Effectiveness and safety of lansoprazole in the treatment of Zollinger-Ellison syndrome. First six months of treatment]. ( Cadiot, G; Coste, T; Escourrou, J; Forestier, S; Mignon, M; Pospaï, D; Ruszniewski, P, 1998)
"This paper aimed at evaluating the comparative efficacy of lansoprazole and omeprazole in reducing gastric acid secretion in patients suffering from Zollinger-Ellison syndrome."5.07[Comparative efficacy of lansoprazole and omeprazole on the intragastric pH measured over a period of 24 hours and on the basal]. ( Cadiot, G; Forestier, S; Joubert-Collin, M; Mignon, M; Paul, G; Ramdani, A; Ruszniewski, P; Vallot, T, 1994)
"Lansoprazole, a new substituted benzimidazole H+,K(+)-ATPase inhibitor, profoundly inhibits gastric acid secretion and has potential use in the management of diseases such as Zollinger-Ellison syndrome (ZES)."5.07Prospective study of efficacy and safety of lansoprazole in Zollinger-Ellison syndrome. ( Feigenbaum, K; Gardner, JD; Jensen, RT; Koviack, PD; Maton, PN; Metz, DC; Pisegna, JR; Ringham, GL, 1993)
"The long-term safety and efficacy of lansoprazole were studied in 21 patients with Zollinger-Ellison syndrome."5.07Prospective study of the long-term efficacy and safety of lansoprazole in patients with the Zollinger-Ellison syndrome. ( Feigenbaum, KM; Jensen, RT; Koviack, PD; Metz, DC, 1993)
"Aim of this overview was to evaluate the main clinical trials with lansoprazole published from 1997 to 1999 in English-language journals, regarding gastroesophageal reflux disease, peptic ulcer, NSAID-induced ulcer, and ZES."4.80[Lansoprazole: an analysis of the clinical trials in the 3 years of 1997-1999]. ( Capurso, L; Dobrilla, G, 2000)
"To summarize the published data on lansoprazole, a proton pump inhibitor approved by the Food and Drug Administration for use in the treatment of duodenal ulcer, erosive esophagitis, and pathologic hypersecretory conditions (e."4.79Lansoprazole: a proton pump inhibitor. ( Garnett, WR, 1996)
"Lansoprazole is an effective acid pump inhibitor acting at the final enzymatic step of the acid secretory pathway of the parietal cell, decreasing gastric acid secretion regardless of the primary stimulus."3.77Lansoprazole. A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy in acid-related disorders. ( Barradell, LB; Faulds, D; McTavish, D, 1992)
"Patients enrolled in a long-term trial of lansoprazole for Zollinger-Ellison syndrome and other acid hypersecretory states had interval histories taken every six months regarding hospitalizations or other intercurrent medical conditions."3.74Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole. ( Hirschowitz, BI; Martin, T; Mohnen, J; Phadnis, M; Wilcox, CM; Worthington, J, 2008)
" pylori infection on gastritis, enterochromaffin-like cell density and hyperplasia, mucosal atrophy and serum gastrin in patients with gastric hypersecretion (basal acid output gt; 15 mmol/h) with either hypergastrinemia (Zollinger-Ellison syndrome) or normal gastrin (non-Zollinger-Ellison syndrome) before and during long-term treatment with lansoprazole."3.71Helicobacter pylori effects on gastritis, gastrin and enterochromaffin-like cells in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome acid hypersecretors treated long-term with lansoprazole. ( Haber, MM; Hirschowitz, BI, 2001)
"To determine the efficacy of lansoprazole control of acid and pepsin secretion over the long term in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome hypersecretors."3.71Long-term lansoprazole control of gastric acid and pepsin secretion in ZE and non-ZE hypersecretors: a prospective 10-year study. ( Hirschowitz, BI; Mohnen, J; Simmons, J, 2001)
"Relapse is infrequent and generally mild with acid secreting status closely monitored."2.75Costs and risks in the management of patients with gastric acid hypersecretion. ( Fineberg, N; Hirschowitz, BI; Mohnen, J; Wilcox, CM; Worthington, J, 2010)
"Lansoprazole is a proton pump inhibitor that reduces gastric acid secretion in a dose-dependent manner via inhibition of H+/K+-adenosine triphosphatase in gastric parietal cells."2.41An overview of the pharmacology, efficacy, safety and cost-effectiveness of lansoprazole. ( Bown, RL, 2002)
" Our group first performed a dose-response analysis of the efficacy of lansoprazole in reducing basal acid output (BAO) in four patients with severe Zollinger-Ellison syndrome (mean BAO 52 +/- 9 [SD] mmol H+/h) who had previously been treated with a mean omeprazole dosage of 75 mg/day."2.38Treatment of patients with Zollinger-Ellison syndrome. ( Forestier, S; Mignon, M; Pospai, D; Vallot, T; Vatier, J, 1993)
"We examined 27 patients with hypochlorhydria or achlorhydria based on a predefined basal acid output (BAO) measurement of less than 5."1.39Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome. ( Metz, DC; Shah, P; Singh, MH; Yang, YX, 2013)
"We present a potential lansoprazole dosing regimen that should result in improved H."1.37CYP2C19-guided design of a proton pump inhibitor dose regimen to avoid the need for pharmacogenetic individualization in H. pylori eradication. ( Foster, DJ; Ward, MB, 2011)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (50.00)18.2507
2000's11 (34.38)29.6817
2010's5 (15.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shah, P1
Singh, MH1
Yang, YX1
Metz, DC3
Wilcox, CM4
Martin, T1
Phadnis, M1
Mohnen, J10
Worthington, J4
Hirschowitz, BI12
Fineberg, N1
Seay, T2
Arcury, J1
Ward, MB1
Foster, DJ1
Arcury, JT1
Simmons, J3
Mayer, A1
Sheiner, E1
Holcberg, G1
Haber, M1
Dítĕ, P1
Prásek, J1
Jensen, RT3
Fraker, DL1
Paul, G1
Ramdani, A2
Mignon, M5
Vallot, T2
Forestier, S4
Cadiot, G2
Ruszniewski, P3
Joubert-Collin, M2
Arnold, R1
Hochlaf, S1
Vatier, J2
Seifert, E1
Pospai, D2
Pisegna, JR1
Ringham, GL1
Feigenbaum, K1
Koviack, PD2
Maton, PN1
Gardner, JD1
Feigenbaum, KM1
Shaw, S2
Garnett, WR1
Franko, TG1
Richter, JE1
Coste, T1
Escourrou, J1
Dobrilla, G1
Capurso, L1
Haber, MM1
Bown, RL1
Samoyeau, R1
Barradell, LB1
Faulds, D1
McTavish, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Long-Term Study of the Efficacy and Safety of Lansoprazole in the Treatment of Zollinger-Ellison and Other Acid Hypersecretors[NCT00204373]Phase 472 participants (Actual)Interventional2003-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Long-term Medical(Non-surgical)Control of Gastric Acid Production Assessed From Time of Study Enrollment, up to 240 Months Post Enrollment.

number of participants with control of gastric acid production (NCT00204373)
Timeframe: up to 240 months from study enrollment

Interventionparticipants (Number)
Single Group72

The Median Survival From the Time of Diagnosis.

The median survival from the time of diagnosis (NCT00204373)
Timeframe: survival or up to 240 months

Interventionyears (Median)
Single Group6.6

Reviews

8 reviews available for lansoprazole and Zollinger-Ellison Syndrome

ArticleYear
[Proton pump blockers and their significance in gastroenterology].
    Vnitrni lekarstvi, 1995, Volume: 41, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Esophagitis, Peptic; Gas

1995
[Lansoprazole--profile of a new proton pump inhibitor].
    Leber, Magen, Darm, 1994, Volume: 24, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Drug A

1994
Treatment of patients with Zollinger-Ellison syndrome.
    Clinical therapeutics, 1993, Volume: 15 Suppl B

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Clinical Trials as Topic; F

1993
Lansoprazole: a proton pump inhibitor.
    The Annals of pharmacotherapy, 1996, Volume: 30, Issue:12

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Drug Interactions; Esophagitis; Humans;

1996
Proton-pump inhibitors for gastric acid-related disease.
    Cleveland Clinic journal of medicine, 1998, Volume: 65, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Esophagitis; Gastric Acid; Helicobacter

1998
[Lansoprazole: an analysis of the clinical trials in the 3 years of 1997-1999].
    Recenti progressi in medicina, 2000, Volume: 91, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;

2000
An overview of the pharmacology, efficacy, safety and cost-effectiveness of lansoprazole.
    International journal of clinical practice, 2002, Volume: 56, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Digestive System Diseases; Duodenal Ulcer; Dyspepsia; Enzym

2002
Lansoprazole. A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy in acid-related disorders.
    Drugs, 1992, Volume: 44, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Biological Availability; Duodenal Ulcer;

1992

Trials

12 trials available for lansoprazole and Zollinger-Ellison Syndrome

ArticleYear
Costs and risks in the management of patients with gastric acid hypersecretion.
    Journal of clinical gastroenterology, 2010, Volume: 44, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Costs and Cost Analysis; Endoscop

2010
Presentation, response to lansoprazole therapy, and outcome of Zollinger-Ellison syndrome-like gastric acid hypersecretors.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Biopsy; Drug Administration Sched

2011
Zollinger-Ellison syndrome: presentation, response to therapy, and outcome.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2011, Volume: 43, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Drug Adm

2011
Clinical outcome using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Duodenal Ulcer; Esophagitis

2005
[Comparative efficacy of lansoprazole and omeprazole on the intragastric pH measured over a period of 24 hours and on the basal].
    Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:8-9

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Female; Gastric Acid; Gastr

1994
Prospective study of efficacy and safety of lansoprazole in Zollinger-Ellison syndrome.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Adult; Aged; Anti-Ulcer Agents;

1993
Prospective study of the long-term efficacy and safety of lansoprazole in patients with the Zollinger-Ellison syndrome.
    Alimentary pharmacology & therapeutics, 1993, Volume: 7 Suppl 1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Alanine Transaminase; Anti-Ulcer Agents; Aspar

1993
Long-term treatment with lansoprazole of patients with duodenal ulcer and basal acid output of more than 15 mmol/h.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Duodenal Ulcer; Enzyme Inhibitors

1996
Long-term treatment with lansoprazole for patients with Zollinger-Ellison syndrome.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Enzyme I

1996
[Effectiveness and safety of lansoprazole in the treatment of Zollinger-Ellison syndrome. First six months of treatment].
    Gastroenterologie clinique et biologique, 1998, Volume: 22, Issue:10

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Dose-Response Relationship, Drug; Enzyme Inhib

1998
Effect of pantoprazole versus other proton pump inhibitors on 24-hour intragastric pH and basal acid output in Zollinger-Ellison syndrome.
    Gastroenterologie clinique et biologique, 2002, Volume: 26, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Female; Gastric Acid; Ga

2002
Lansoprazole. A review of its pharmacodynamic and pharmacokinetic properties and its therapeutic efficacy in acid-related disorders.
    Drugs, 1992, Volume: 44, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Biological Availability; Duodenal Ulcer;

1992

Other Studies

13 other studies available for lansoprazole and Zollinger-Ellison Syndrome

ArticleYear
Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.
    Pancreas, 2013, Volume: 42, Issue:6

    Topics: Achlorhydria; Adolescent; Adult; Aged; Anti-Ulcer Agents; Esomeprazole; False Positive Reactions; Fe

2013
Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole.
    BMC gastroenterology, 2008, May-28, Volume: 8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anti

2008
CYP2C19-guided design of a proton pump inhibitor dose regimen to avoid the need for pharmacogenetic individualization in H. pylori eradication.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome

2011
Zollinger Ellison syndrome, treated with lansoprazole, during pregnancy.
    Archives of gynecology and obstetrics, 2007, Volume: 276, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Female; Gastrinoma; Gastrins; Hum

2007
Chromogranin A in patients with acid hypersecretion and/or hypergastrinaemia.
    Alimentary pharmacology & therapeutics, 2007, Sep-15, Volume: 26, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Chromogranin A; Confounding Factors, Epi

2007
Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors.
    Alimentary pharmacology & therapeutics, 2008, Jun-01, Volume: 27, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Female; Gastric Acid; Gastric Acidity Determination; Humans

2008
Zollinger-Ellison syndrome. Advances in treatment of gastric hypersecretion and the gastrinoma.
    JAMA, 1994, May-11, Volume: 271, Issue:18

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Blood Chemical Analysis; Combined Modali

1994
Second proton-pump inhibitor marketed.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, Aug-01, Volume: 52, Issue:15

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Duodenal Ulcer; Esophagitis; Humans; Lan

1995
[What are the indications for proton pump inhibitors? R. Arnold, Marburg, elaborates on the clinical aspects of the controversy regarding lansoprazole. Interview by Gerrit Lichtenberg].
    Fortschritte der Medizin, 1994, Jan-20, Volume: 112, Issue:1-2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Carcinogenicity Tests; Carcinoi

1994
[Dose-response effect of lansoprazole in patients with Zollinger-Ellison syndrome].
    Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Aged; Anti-Ulcer Agents; Depression,

1994
Helicobacter pylori effects on gastritis, gastrin and enterochromaffin-like cells in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome acid hypersecretors treated long-term with lansoprazole.
    Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Enterochromaffin-like Cells; Enzyme Inhibitors; Fema

2001
Long-term lansoprazole control of gastric acid and pepsin secretion in ZE and non-ZE hypersecretors: a prospective 10-year study.
    Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Dose-Response Relationship, Drug; Drug Administratio

2001
Minor effects of Helicobacter pylori on gastric secretion and dose of lansoprazole during long-term treatment in ZE and non-ZE acid hypersecretors.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Dose-Response Relationship, Drug;

2002