lansoprazole has been researched along with Testicular Neoplasms in 2 studies
Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lansoprazole treatment produced effects on the liver consistent with an enhanced metabolic capacity, including significant increases in relative liver weights, total microsomal CYP content, individual CYP protein levels, and enhanced CYP-dependent testosterone metabolism in vitro." | 1.32 | Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis. ( Coulson, M; Gibson, GG; Graham, M; Hammond, T; Plant, N, 2003) |
| "Lansoprazole is a substituted benzimidazole which inhibits gastric acid secretion by inhibiting the hydrogen-potassium ATPase (proton pump) in the parietal cell." | 1.29 | Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole. ( Ando, T; Fort, FL; Hamashima, T; Hodgen, GD; Kitazaki, T; Mahony, MC; Miyajima, H; Sato, S; Suzuki, T; Yamamoto, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coulson, M | 1 |
| Gibson, GG | 1 |
| Plant, N | 1 |
| Hammond, T | 1 |
| Graham, M | 1 |
| Fort, FL | 1 |
| Miyajima, H | 1 |
| Ando, T | 1 |
| Suzuki, T | 1 |
| Yamamoto, M | 1 |
| Hamashima, T | 1 |
| Sato, S | 1 |
| Kitazaki, T | 1 |
| Mahony, MC | 1 |
| Hodgen, GD | 1 |
2 other studies available for lansoprazole and Testicular Neoplasms
| Article | Year |
|---|---|
Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Animals; Chromatography, High Pressur | 2003 |
Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Carcinogens; Chorionic Gonadotropin; Dose-Response | 1995 |