lansoprazole has been researched along with Sensitivity and Specificity in 40 studies
Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the clinical value of an empirical trial of high-dose lansoprazole in detecting patients with gastro-oesophageal reflux disease-related non-cardiac chest pain." | 9.11 | The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain--a randomized, double-blind, placebo-controlled, crossover trial. ( Bautista, J; Briseno, M; Cui, H; Fass, R; Fullerton, H, 2004) |
| " Fifty patients with active or scarred duodenal ulcer were randomized to lansoprazole or omeprazole for 1 to 4 weeks, with clarithromycin 250 mg twice a day and tinidazole 500 mg twice a day for the first week." | 9.09 | Long-term follow-up and serologic assessment after triple therapy with omeprazole or lansoprazole of Helicobacter-associated duodenal ulcer. ( Fanti, L; Guslandi, M; Ieri, R; Mezzi, G; Passaretti, S; Testoni, PA, 2001) |
| "To determine the clinical value of an empirical trial of high-dose lansoprazole in detecting patients with gastro-oesophageal reflux disease-related non-cardiac chest pain." | 5.11 | The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain--a randomized, double-blind, placebo-controlled, crossover trial. ( Bautista, J; Briseno, M; Cui, H; Fass, R; Fullerton, H, 2004) |
| " Fifty patients with active or scarred duodenal ulcer were randomized to lansoprazole or omeprazole for 1 to 4 weeks, with clarithromycin 250 mg twice a day and tinidazole 500 mg twice a day for the first week." | 5.09 | Long-term follow-up and serologic assessment after triple therapy with omeprazole or lansoprazole of Helicobacter-associated duodenal ulcer. ( Fanti, L; Guslandi, M; Ieri, R; Mezzi, G; Passaretti, S; Testoni, PA, 2001) |
| "We examined 27 patients with hypochlorhydria or achlorhydria based on a predefined basal acid output (BAO) measurement of less than 5." | 1.39 | Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome. ( Metz, DC; Shah, P; Singh, MH; Yang, YX, 2013) |
| " The developed assay method was applied to a pharmacokinetic study in human volunteers." | 1.35 | Simultaneous estimation of four proton pump inhibitors--lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study. ( Bharathi, DV; Chatki, PK; Hotha, KK; Jagadeesh, B; Mullangi, R; Naidu, A; Thriveni, K, 2009) |
| "The other two approaches prevent more recurrences: waiting to initiate maintenance therapy until symptoms recur once requires an additional $73 for each recurrence prevented whereas maintenance PPI from the outset requires an additional $819 for each recurrence prevented." | 1.30 | Prevention of recurrences of erosive reflux esophagitis: a cost-effectiveness analysis of maintenance proton pump inhibition. ( Harris, RA; Kuppermann, M; Richter, JE, 1997) |
| "If patients experience a symptomatic recurrence on the H2RA strategies, they then receive PPI maintenance." | 1.30 | Proton pump inhibitors or histamine-2 receptor antagonists for the prevention of recurrences of erosive reflux esophagitis: a cost-effectiveness analysis. ( Harris, RA; Kuppermann, M; Richter, JE, 1997) |
| "Two different ultraviolet (UV) spectroscopic methods were developed for determination of Lansoprazole in pharmaceutical dosage forms." | 1.30 | Determination of Lansoprazole in pharmaceutical dosage forms by two different spectroscopic methods. ( Ozaltín, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (15.00) | 18.2507 |
| 2000's | 26 (65.00) | 29.6817 |
| 2010's | 7 (17.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Kajihara, Y | 1 |
| Shimoyama, T | 3 |
| Mizuki, I | 1 |
| Luo, L | 1 |
| Wen, X | 1 |
| Du, Y | 1 |
| Jiang, Z | 1 |
| Guo, X | 1 |
| Shah, P | 1 |
| Singh, MH | 1 |
| Yang, YX | 1 |
| Metz, DC | 1 |
| Hishinuma, T | 1 |
| Suzuki, K | 1 |
| Yamaguchi, H | 1 |
| Yamagishi, H | 1 |
| Koike, T | 1 |
| Ohara, S | 1 |
| Shimosegawa, T | 1 |
| Mano, N | 1 |
| Goto, J | 1 |
| Song, M | 1 |
| Gao, X | 1 |
| Hang, T | 1 |
| Wen, A | 1 |
| Wu, GL | 1 |
| Zhou, HL | 1 |
| Shentu, JZ | 1 |
| He, QJ | 1 |
| Yang, B | 1 |
| Bharathi, DV | 1 |
| Hotha, KK | 2 |
| Jagadeesh, B | 2 |
| Chatki, PK | 1 |
| Thriveni, K | 1 |
| Mullangi, R | 1 |
| Naidu, A | 1 |
| Cirilli, R | 1 |
| Ferretti, R | 1 |
| Gallinella, B | 1 |
| Turchetto, L | 1 |
| Zanitti, L | 1 |
| La Torre, F | 1 |
| Nevado, JJ | 1 |
| Peñalvo, GC | 1 |
| Sánchez, JC | 1 |
| Mochón, MC | 1 |
| Dorado, RM | 1 |
| Navarro, MV | 1 |
| Cho, YK | 1 |
| Choi, MG | 1 |
| Lim, CH | 1 |
| Nam, KW | 1 |
| Chang, JH | 1 |
| Park, JM | 1 |
| Lee, IS | 1 |
| Kim, SW | 1 |
| Choi, KY | 1 |
| Chung, IS | 1 |
| Li, F | 2 |
| Zulkoski, JP | 1 |
| Ding, J | 1 |
| Brown, W | 1 |
| Addison, T | 1 |
| Okubo, M | 1 |
| Tahara, T | 1 |
| Shibata, T | 1 |
| Nakamura, M | 1 |
| Yoshioka, D | 1 |
| Maeda, Y | 1 |
| Yonemura, J | 1 |
| Ishizuka, T | 1 |
| Arisawa, T | 1 |
| Hirata, I | 1 |
| Barreiro, JC | 1 |
| Vanzolini, KL | 1 |
| Cass, QB | 1 |
| Vijaya Bharathi, D | 1 |
| Ravindranath, LK | 1 |
| Jaya Veera, KN | 1 |
| Venkateswarulu, V | 1 |
| Oliveira, CH | 1 |
| Barrientos-Astigarraga, RE | 1 |
| Abib, E | 1 |
| Mendes, GD | 1 |
| da Silva, DR | 1 |
| de Nucci, G | 1 |
| Matsuda, M | 1 |
| Noda, Y | 1 |
| Takemori, Y | 1 |
| Radi, A | 1 |
| Juul-Hansen, P | 1 |
| Rydning, A | 1 |
| Miura, M | 1 |
| Tada, H | 1 |
| Suzuki, T | 1 |
| Bautista, J | 1 |
| Fullerton, H | 1 |
| Briseno, M | 1 |
| Cui, H | 1 |
| Fass, R | 1 |
| Yeniceli, D | 1 |
| Dogrukol-Ak, D | 1 |
| Tuncel, M | 1 |
| Asfeldt, AM | 1 |
| Løchen, ML | 1 |
| Straume, B | 1 |
| Steigen, SE | 1 |
| Florholmen, J | 1 |
| Goll, R | 1 |
| Nestegard, O | 1 |
| Paulssen, EJ | 1 |
| Uno, T | 1 |
| Yasui-Furukori, N | 1 |
| Takahata, T | 1 |
| Sugawara, K | 1 |
| Tateishi, T | 1 |
| Mana, F | 1 |
| Van Laer, W | 1 |
| Van Laere, W | 1 |
| Bossuyt, A | 1 |
| Urbain, D | 1 |
| Maguigad, J | 1 |
| Pelzer, M | 1 |
| Jiang, X | 1 |
| Ji, QC | 1 |
| Fukuda, Y | 1 |
| Fukuda, S | 1 |
| Munakata, A | 1 |
| Yoshida, Y | 1 |
| Harris, RA | 2 |
| Kuppermann, M | 2 |
| Richter, JE | 2 |
| Tanahashi, T | 1 |
| Kodama, T | 1 |
| Yamaoka, Y | 1 |
| Sawai, N | 1 |
| Tatsumi, Y | 1 |
| Kashima, K | 1 |
| Higashi, Y | 1 |
| Sasaki, Y | 1 |
| Bravo, LE | 1 |
| Realpe, JL | 1 |
| Campo, C | 1 |
| Mera, R | 1 |
| Correa, P | 1 |
| Miyabayashi, H | 1 |
| Furihata, K | 1 |
| Shimizu, T | 1 |
| Ueno, I | 1 |
| Akamatsu, T | 1 |
| Ozaltín, N | 2 |
| Miwi, H | 1 |
| Murai, T | 1 |
| Sato, K | 1 |
| Ohkura, R | 1 |
| Yamada, T | 1 |
| Nagahara, A | 1 |
| Ohtaka, K | 1 |
| Minowa, T | 1 |
| Kurosawa, A | 1 |
| Sato, N | 1 |
| Fanti, L | 1 |
| Ieri, R | 1 |
| Mezzi, G | 1 |
| Testoni, PA | 1 |
| Passaretti, S | 1 |
| Guslandi, M | 1 |
| Yardimci, C | 1 |
| Chey, WD | 1 |
| Chathadi, KV | 1 |
| Montague, J | 1 |
| Ahmed, F | 1 |
| Murthy, U | 1 |
| Katsuki, H | 1 |
| Hamada, A | 1 |
| Nakamura, C | 1 |
| Arimori, K | 1 |
| Nakano, M | 1 |
| Parente, F | 1 |
| Sainaghi, M | 1 |
| Sangaletti, O | 1 |
| Imbesi, V | 1 |
| Maconi, G | 1 |
| Anderloni, A | 1 |
| Bianchi Porro, G | 1 |
| Odaka, T | 1 |
| Yamaguchi, T | 1 |
| Koyama, H | 1 |
| Saisho, H | 1 |
| Nomura, F | 1 |
7 trials available for lansoprazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Diagnostic value of the PPI test for detection of GERD in Korean patients and factors associated with PPI responsiveness.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chi-Square Distribution; Esophageal pH Monitoring; Esophago | 2010 |
Endoscopy-negative reflux disease: what is the value of a proton-pump inhibitor test in everyday clinical practice?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Endoscopy, Gastrointestinal | 2003 |
The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain--a randomized, double-blind, placebo-controlled, crossover trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Chest Pa | 2004 |
Influence of oral Helicobacter pylori on the success of eradication therapy against gastric Helicobacter pylori.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Anti-Bacterial Agents; Clarithromy | 2000 |
Comparison of the efficacy of 400mg and 800mg of clarithromycin used with lansoprazole and amoxicillin in eradication regimens for Helicobacter pylori infection in a Japanese population.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Th | 2000 |
Long-term follow-up and serologic assessment after triple therapy with omeprazole or lansoprazole of Helicobacter-associated duodenal ulcer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Bacterial Agents; Anti-Ulcer Agents; Antibodies | 2001 |
Different effects of short-term omeprazole, lansoprazole or pantoprazole on the accuracy of the (13)C-urea breath test.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Benzimidazoles; Breath Tests; Car | 2002 |
33 other studies available for lansoprazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Evaluation of the effects of a proton pump inhibitor on Helicobacter pylori stool antigen testing.
Topics: Antigens, Bacterial; Breath Tests; Feces; Helicobacter Infections; Helicobacter pylori; Humans; Lans | 2023 |
Enantioselective analysis of lansoprazole in rat plasma by LC-MS/MS: Application to a stereoselective pharmacokinetic study.
Topics: Animals; Chromatography, Liquid; Lansoprazole; Linear Models; Male; Rats; Rats, Wistar; Reproducibil | 2018 |
Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.
Topics: Achlorhydria; Adolescent; Adult; Aged; Anti-Ulcer Agents; Esomeprazole; False Positive Reactions; Fe | 2013 |
Simple quantification of lansoprazole and rabeprazole concentrations in human serum by liquid chromatography/tandem mass spectrometry.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, Liquid; Humans; Lansoprazole; Male; Rabepra | 2008 |
Simultaneous determination of lansoprazole and its metabolites 5'-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC-MS/MS: application to a pharmacokinetic study in healthy volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Area Under Curve; Chromatography, Liquid; Drug St | 2008 |
Determination of lansoprazole in human plasma by rapid resolution liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Area Under Curve; Asian People; Calibration; Chromatography | 2008 |
Simultaneous estimation of four proton pump inhibitors--lansoprazole, omeprazole, pantoprazole and rabeprazole: development of a novel generic HPLC-UV method and its application to clinical pharmacokinetic study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, High Pressure Liquid; Drug Stability; Human | 2009 |
Development and validation of an enantioselective and chemoselective HPLC method using a Chiralpak IA column to simultaneously quantify (R)-(+)- and (S)-(-)-lansoprazole enantiomers and related impurities.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, High Pressure Liquid; Lansoprazole; Referen | 2009 |
Optimisation and validation of a new CE method for the determination of lansoprazole enantiomers in pharmaceuticals.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; beta-Cyclodextrins; Drug Stability; Electrophoresis, Capill | 2009 |
Liquid chromatography/tandem mass spectrometry sensitivity enhancement via online sample dilution and trapping: applications in microdosing and dried blood spot (DBS) bioanalysis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetonitriles; Blood Chemical Analysis; Chromatography, Hig | 2010 |
Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents | 2011 |
Direct injection of native aqueous matrices by achiral-chiral chromatography ion trap mass spectrometry for simultaneous quantification of pantoprazole and lansoprazole enantiomers fractions.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Humic Substances; Lansoprazole; Least-Squares Analysis; Pan | 2011 |
Development and validation of a highly sensitive LC-MS/MS method for quantitation of dexlansoprazole in human plasma: application to a human pharmacokinetic study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Chromatography, Liquid; Dexlansoprazole; Drug Sta | 2012 |
Lansoprazole quantification in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Chromatography, Liquid; Humans; Lansopra | 2003 |
Utility and limitations of a method for detecting Helicobacter pylori-specific antigens in the stool.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Amoxicillin; Antigens, Bact | 2003 |
Anodic voltammetric assay of lansoprazole and omeprazole on a carbon paste electrode.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Capsules; Lansoprazole; Omeprazole; Polarography; Proton Pu | 2003 |
Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, High Pressure Liquid; Humans; Kidney Transp | 2004 |
Determination of lansoprazole in pharmaceutical capsules by flow injection analysis using UV-detection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Capsules; Flow Injection Analysis; Lansoprazole; Omeprazole | 2004 |
Accuracy of a monoclonal antibody-based stool antigen test in the diagnosis of Helicobacter pylori infection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Antibodies, Monoclonal; Antigens, | 2004 |
Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography: application to measuring CYP2C19 activity.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Chromatography, High Pressure Liquid; Female; Humans | 2005 |
The early effect of proton pump inhibitor therapy on the accuracy of the 13C-urea breath test.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Breath Tests; Carbon Isotopes; Enzyme Inhibitors; Fem | 2005 |
A novel 'peak parking' strategy for ultra-performance liquid chromatography/tandem mass spectrometric detection for enhanced performance of bioanalytical assays.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Algorithms; Biological Assay; Chromatography, High Pressure | 2008 |
Validity of various diagnostic tests to evaluate cure of Helicobacter pylori infection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Bacterial Agents; Bacteriological Techniq | 1996 |
Prevention of recurrences of erosive reflux esophagitis: a cost-effectiveness analysis of maintenance proton pump inhibition.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Cost-Benefit Analysis; Esophagitis, Pept | 1997 |
Proton pump inhibitors or histamine-2 receptor antagonists for the prevention of recurrences of erosive reflux esophagitis: a cost-effectiveness analysis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Case-Control Studies; Cost-Benefit Analy | 1997 |
Analysis of the 13C-urea breath test for detection of Helicobacter pylori infection based on the kinetics of delta-13CO2 using laser spectroscopy.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Bacterial Agents; Breath Tests; Cl | 1998 |
Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Antigens, Bacterial; Bismuth; Breath Tes | 1999 |
Determination of Lansoprazole in pharmaceutical dosage forms by two different spectroscopic methods.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Calibration; Capsules; Evaluation Studie | 1999 |
Electrochemical studies and differential pulse polarographic analysis of lansoprazole in pharmaceuticals.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Calibration; Capsules; Lansoprazole; Ome | 2001 |
Intragastric acidification reduces the occurrence of false-negative urea breath test results in patients taking a proton pump inhibitor.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Breath Tests; False Negative Reactions; Female; Gastric Aci | 2001 |
High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Calibration; Chromatography, High Pressure Liquid; Humans; | 2001 |
Evaluation of the Helicobacter pylori stool antigen test for monitoring eradication therapy.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents | 2002 |