lansoprazole and Laryngitis studies

Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.

Laryngitis: Inflammation of the LARYNGEAL MUCOSA, including the VOCAL CORDS. Laryngitis is characterized by irritation, edema, and reduced pliability of the mucosa leading to VOICE DISORDERS such as APHONIA and HOARSENESS.

Research Excerpts

Excerpt	Relevance	Reference
"Patients diagnosed with idiopathic chronic laryngitis were randomized to receive either lansoprazole 30 mg p."	9.09	Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. ( Buchner, A; El-Serag, HB; Gavin, M; Inadomi, JM; Lee, P; McCarthy, DM, 2001)
"Only patients with GERD had significantly (P = 0."	6.75	Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. ( Garrett, CG; Goutte, M; Hagaman, D; Jerome, WG; Slaughter, JC; Smith, BS; Vaezi, MF; Washington, MK, 2010)
"Patients diagnosed with idiopathic chronic laryngitis were randomized to receive either lansoprazole 30 mg p."	5.09	Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. ( Buchner, A; El-Serag, HB; Gavin, M; Inadomi, JM; Lee, P; McCarthy, DM, 2001)
"Only patients with GERD had significantly (P = 0."	2.75	Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. ( Garrett, CG; Goutte, M; Hagaman, D; Jerome, WG; Slaughter, JC; Smith, BS; Vaezi, MF; Washington, MK, 2010)
"Gastro-oesophageal reflux is thought to cause chronic laryngitis through laryngopharyngeal reflux."	1.34	Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy. ( Goh, KL; Gopala, K; Qua, CS; Wong, CH, 2007)

Research

Studies (3)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

GerdQ Score

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Vaezi, MF	1
Slaughter, JC	1
Smith, BS	1
Washington, MK	1
Jerome, WG	1
Garrett, CG	1
Hagaman, D	1
Goutte, M	1
Qua, CS	1
Wong, CH	1
Gopala, K	1
Goh, KL	1
El-Serag, HB	1
Lee, P	1
Buchner, A	1
Inadomi, JM	1
Gavin, M	1
McCarthy, DM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Assessing the Impacts of an Upper Esophageal Sphincter Assist Device on Laryngeal Symptoms and Salivary Pepsin: A Pilot Study[NCT02552966]		20 participants (Actual)	Interventional	2015-09-01	Completed
Post-nasal Drainage as an Extraesophageal Manifestation of Reflux[NCT00199953]	Phase 2	50 participants	Interventional	2002-06-30	Completed
A Randomized, Placebo-Controlled Assessment of Lansoprazole 30 mg Bid in the Treatment of Gastroesophageal Reflux Associated With Laryngitis[NCT00369265]	Phase 4	18 participants (Actual)	Interventional	2006-08-31	Terminated (stopped due to Pharmaceutical company purchased by another company and funding was terminated.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

GERDQ score. Scale of 0-12, higher score indicates increased symptom severity. (NCT02552966)
Timeframe: 2 weeks

NGSSIQ Score

RSI Score

Intervention	units on a scale (Mean)
UESAD	8.6

Intervention	units on a scale (Mean)
UESAD	26.8

Respiratory symptom index (RSI) score. Values between 0 and 45. Higher value is associated with increased symptom severity. (NCT02552966)
Timeframe: 2 weeks

Article	Year
Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Alimentary pharmacology & therapeutics, 2010, Volume: 32, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Infective Agents; Biopsy; Chronic Disease; Dila	2010
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001
Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. The American journal of gastroenterology, 2001, Volume: 96, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Chronic Disease; Double-Blind Method; Female; Gastroe	2001

lansoprazole and Laryngitis