lanatosides and Hypertension

To investigate whether the impaired reflex response to cardiopulmonary baroreceptor unloading in hypertensive patients with left ventricular hypertrophy can be promptly improved by a pharmacological challenge. For this purpose we studied the effects of acute digitalis administration on cardiopulmonary baroreflex, evaluated by forearm noradrenaline spillover.. Eleven hypertensives with left ventricular hypertrophy and 10 age- and sex-matched normotensives underwent the application of -5 and -10 mmHg lower-body negative pressure (LBNP) before and after the administration of digitalis. Forearm noradrenaline spillover, measured using a tracer technique, was used to estimate the reflex sympathetic response.. Under control conditions LBNP evoked a similar fall in right atrial pressure in the two study groups. In the normotensives there was a significant increase in forearm noradrenaline spillover. In the hypertensives no significant changes in forearm noradrenaline spillover were found. Intravenous administration of 0.02 mg/kg lanatoside C was associated with an increase in systolic blood pressure and a reduction in forearm noradrenaline spillover in both groups. In the normotensives the percentage change in forearm noradrenaline spillover induced by LBNP increased significantly in response to digitalis administration. However, digitalis restored the response of forearm noradrenaline spillover to LBNP in the hypertensives, so that no significant difference in this response was detected between the two study groups. Digitalis did not modify the effects of LBNP on cardiac pressures in either group.. The present results demonstrate that administration of lanatoside C restores the response of forearm noradrenaline spillover to cardiopulmonary baroreceptor unloading in hypertensive patients with left ventricular hypertrophy. This indicates that the impairment of cardiopulmonary baroreflexes in these patients can be reversed by acute pharmacological treatment. Therefore, impairment of this reflex response seems to be related to functional rather than to structural abnormalities of the hypertrophied ventricle.

Topics: Digitalis Glycosides; Female; Forearm; Hemodynamics; Humans; Hypertension; Hypertrophy, Left Ventricular; Lanatosides; Male; Middle Aged; Norepinephrine; Pressoreceptors; Reflex; Sympathetic Nervous System

The Bulgarian digitalis preparation Digilanid C for venous application has a satisc factory effect on the majority of the patients (67 per cent) with light and moderate chronic cardia insufficiency and espically in case of tachycardia in auricular fibrillation. The comparison of the results between the group of 46 patients, treated with Digilanid C and the control group of 20 patients treated with Isolanid (Richter) do not reveal essential differences in the major part of the results obtained.

Topics: Adult; Aged; Bulgaria; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Heart Rate; Hemodynamics; Humans; Hypertension; Injections, Intravenous; Lanatosides; Middle Aged; Rheumatic Heart Disease; Tachycardia

Topics: Administration, Oral; Blood Pressure; Cardiac Glycosides; Cardiac Volume; Chromium Isotopes; Digitalis Glycosides; Digoxin; Female; Heart; Heart Failure; Heart Function Tests; Heart Rate; Hemodynamics; Humans; Hypertension; Lanatosides; Male; Middle Aged; Strophanthins; Time Factors

Several studies in animals and in man have suggested that the inhibitory influence of baroreceptors on heart rate and peripheral circulation is enhanced by digitalis. Because the atrio-ventricular node represents a key site for the clinical action of digitalis we studied how baroreceptor control of atrio-ventricular conduction is modified by digitalis at therapeutical doses. In eight subjects heart rate was kept constant by atrial pacing to assess neural influences on atrio-ventricular conduction rate without the modifications caused by simultaneous changes in cardiac cycle length. Arterial baroreceptors were stimulated by increasing or reducing blood pressure (intra-arterial recording), via an iv bolus of phenylephrine or nitroglycerine. The baroreflex sensitivity was assessed in ms . mmHg-1 as the slope of the linear regressions relating the rise or fall in systolic blood pressure to the lengthening or shortening in St- (atrial stimulus artifact) Q interval (ECG recording). The study was performed before and 45 min after iv administration of digitalis (0.8 mg of Lanatoside C). Baroreflex sensitivity during baroreceptor stimulation was 2.9 +/- 1.1 ms . mmHg-1 (mean +/- SE) before digitalis, whereas after digitalis a significantly and markedly greater value of 5.6 +/- 1.5 ms . mmHg-1 was found. Baroreflex sensitivity during baroreceptor deactivation was 0.9 +/- 0.1 ms . mmHg-1 before digitalis, and was not significantly affected by the drug. Thus in man the baroreceptor control of atrio-ventricular conduction is strikingly potentiated by digitalis although this potentiation is only evident in the upper portion of the stimulus-response curve of the reflex.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adult; Atrioventricular Node; Blood Pressure; Female; Heart Conduction System; Humans; Hypertension; Lanatosides; Male; Nitroglycerin; Phenylephrine; Pressoreceptors; Reflex; Sinoatrial Node

Topics: Administration, Oral; Adult; Aged; Coronary Disease; Female; Heart Defects, Congenital; Heart Diseases; Humans; Hypertension; Lanatosides; Male; Middle Aged; Pulmonary Heart Disease; Rheumatic Heart Disease; Time Factors

There was no significant difference in the tissue calcium content between spontaneously hypertensive rat (SHR) and normotensive rat aortae. 45Ca uptake was significantly greater, whereas 45Ca influx was significantly less in SHR than in control aortae. There was no difference in 45Ca efflux in SHR and control tissues. 45Ca influx in both SHR and control tissues was increased by potassium, not increased by norepinephrine and inhibited by Co++, Mn++ and La+++ (all 0.5 mM). Both SHR and control aortae were equally inhibited by Mn++ and Co++ (0.1 mM). There was no difference in the 45Ca uptake by microsome fraction from both SHR and control tissue. These data indicate some differences in the translocation of Ca++ at the cellular level in SHR and control aortae.

Topics: Animals; Aorta; Binding Sites; Calcium; Cobalt; Female; Hypertension; Lanatosides; Magnesium; Male; Microsomes; Muscle, Smooth; Norepinephrine; Potassium; Rats

Topics: Adolescent; Adult; Coronary Disease; Female; Heart Ventricles; Humans; Hypertension; Iodine Radioisotopes; Lanatosides; Male; Middle Aged; Nitroglycerin; Propranolol; Pulmonary Circulation

Topics: Adult; Digoxin; Electrocardiography; Heart Atria; Humans; Hypertension; Lanatosides; Middle Aged; Vectorcardiography

Topics: Adolescent; Adult; Electrocardiography; Female; Heart Diseases; Heart Ventricles; Hemodynamics; Humans; Hypertension; Hypertension, Renal; Lanatosides; Male; Middle Aged; Phonocardiography

Topics: Digoxin; Guanethidine; Heart; Humans; Hypertension; Lanatosides

Topics: Cardiac Glycosides; Digitoxin; Digoxin; Heart Failure; Humans; Hypertension; Lanatosides; Male; Middle Aged; Postoperative Care; Preoperative Care; Strophanthins; Sympathectomy

Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiomyopathies; Catecholamines; Coronary Disease; Digitalis Glycosides; Diuretics; Epinephrine; Female; Glomerular Filtration Rate; Guanethidine; Heart Defects, Congenital; Heart Failure; Heart Valve Diseases; Humans; Hydrochlorothiazide; Hypertension; Lanatosides; Male; Middle Aged; Norepinephrine; Potassium; Regional Blood Flow; Sodium; Spironolactone; Trichlormethiazide

Topics: Aged; Atrial Fibrillation; Blood Flow Velocity; Body Weight; Coronary Disease; Electrocardiography; Female; Heart Diseases; Heart Failure; Humans; Hypertension; Hyperthyroidism; Intestinal Absorption; Lanatosides; Male; Middle Aged; Pulmonary Heart Disease; Pulse

Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Biomedical Research; Coronary Disease; Drug Therapy; Exercise Test; Goiter; Graves Disease; Hemodynamics; Humans; Hypertension; Lanatosides; Sympatholytics; Toxicology

Topics: Aminophylline; Angiotensins; Atrial Fibrillation; Autopsy; Blood Flow Velocity; Blood Pressure; Blood Pressure Determination; Blood Volume; Blood Volume Determination; Cardiac Catheterization; Coronary Disease; Drug Therapy; Endocarditis; Endocarditis, Subacute Bacterial; Heart Defects, Congenital; Heart Failure; Heart Function Tests; Humans; Hypertension; Lanatosides; Mitral Valve Stenosis; Norepinephrine; Pathology; Radioisotopes; Rheumatic Heart Disease; Syphilis; Syphilis, Cardiovascular

Topics: Aortic Valve Stenosis; Arrhythmias, Cardiac; Coronary Disease; Deslanoside; Humans; Hypertension; Lanatosides; Mitral Valve Insufficiency; Mitral Valve Stenosis

Topics: Atrial Fibrillation; Atrial Flutter; Cardiac Surgical Procedures; Coronary Disease; Electric Countershock; Heart Block; Hypertension; Hyperthyroidism; Lanatosides; Quinidine; Rheumatic Heart Disease; Tachycardia; Thoracic Surgery; Toxicology

Topics: Cardiac Catheterization; Humans; Hypertension; Hypertension, Pulmonary; Lanatosides; Mitral Valve Insufficiency; Mitral Valve Stenosis; Pharmacology; Pneumonectomy; Pulmonary Circulation; Pulmonary Emphysema

Topics: Adolescent; Angina Pectoris; Arrhythmias, Cardiac; Atrial Fibrillation; Child; Coronary Disease; Deslanoside; Geriatrics; Heart Block; Heart Failure; Humans; Hypertension; Lanatosides; Myocardial Infarction; Pharmacology; Pulmonary Edema; Pulmonary Fibrosis; Pulmonary Heart Disease; Tachycardia; Thrombophlebitis; Toxicology; Water-Electrolyte Balance

Topics: Digitalis; Digitalis Glycosides; Guinea Pigs; Hypertension; Lanatosides