lanatosides and Coronary-Disease

Topics: Acute Disease; Clinical Trials as Topic; Coronary Disease; Digoxin; Drug Evaluation; Hemodynamics; Humans; Lanatosides; Mitral Valve Stenosis; Postoperative Period; Rheumatic Heart Disease; Strophanthins

The Bulgarian digitalis preparation Digilanid C for venous application has a satisc factory effect on the majority of the patients (67 per cent) with light and moderate chronic cardia insufficiency and espically in case of tachycardia in auricular fibrillation. The comparison of the results between the group of 46 patients, treated with Digilanid C and the control group of 20 patients treated with Isolanid (Richter) do not reveal essential differences in the major part of the results obtained.

Topics: Adult; Aged; Bulgaria; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Heart Rate; Hemodynamics; Humans; Hypertension; Injections, Intravenous; Lanatosides; Middle Aged; Rheumatic Heart Disease; Tachycardia

The effects of intravenous strophanthin K (0.125 and 0.25 MG) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP)P values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the lying position after both glycosides and placebo; the systemic blood pressure remained unchanged. Electromechanical systole (QS2), left ventricular ejection time (LVET) and preejection period (PEP), corrected for heart rate (QS2I, LVETI, PEPI), showed no change after placebo. The glycosides caused no change in LVETI. QS2I was significantly shortened only after lanatoside C 1.6 mg. PEPI and ICT were significantly shortened by both doses of strophanthin K and lanatoside C; the effects were dose-related. Taking into consideration the effects of cardiac glycosides on STI, use of the index ICT/QS1, the quotient of isovolumic contraction time and electro-mechanical delay, is proposed, because it showed quite sensitively the increase in myocardial contractility after digitalis. The effect of strophanthin K could be detected 10 minutes, and that of lanatoside C 30-40 minutes, after injection. The amplitude of the IP curve and the relative pulse volume showed positive and negative changes without any trend after administration of placebo or glycoside. The data suggests that the usual therapeutic doses of these cardiac glycosides do not cause significant changes in the peripheral circulation in patients with compensated coronary heart disease, but their action on STI is quite marked, showing a positive inotropic effect.

Topics: Adult; Aged; Coronary Disease; Dose-Response Relationship, Drug; Female; Heart Rate; Heart Sounds; Humans; Lanatosides; Male; Middle Aged; Myocardial Contraction; Plethysmography, Impedance; Strophanthins; Time Factors

Topics: Action Potentials; Animals; Calcium; Cardiomegaly; Coronary Disease; Electrophysiology; Female; Lanatosides; Male; Rats; Rats, Inbred Strains; Verapamil

Topics: Adult; Aged; Coronary Disease; Drugs, Chinese Herbal; Female; Heart; Heart Function Tests; Humans; Lanatosides; Male; Middle Aged

Our own experience with the production of digoxin-specific antibody preparations from the sheep and the results of the experimental and clinical use are briefly reviewed. Advantages, risks and unsolved problems of therapy with glycoside-specific antibodies are discussed.

Topics: Animals; Antibodies, Heterophile; Coronary Disease; Digitalis Glycosides; Digoxin; Heart Failure; Humans; Lanatosides; Rabbits; Sheep

Topics: Administration, Oral; Adult; Aged; Coronary Disease; Female; Heart Defects, Congenital; Heart Diseases; Humans; Hypertension; Lanatosides; Male; Middle Aged; Pulmonary Heart Disease; Rheumatic Heart Disease; Time Factors

Topics: Acute Kidney Injury; Aged; Coronary Disease; Electrocardiography; Female; Gastroenteritis; Humans; Lanatosides; Tachycardia

Topics: Adult; Aged; Blood Pressure; Coronary Circulation; Coronary Disease; Female; Heart Rate; Humans; Hypoxia; Ischemia; Lanatosides; Male; Middle Aged; Oxygen; Oxygen Consumption; Partial Pressure; Strophanthins

Topics: Adolescent; Adult; Coronary Disease; Female; Heart Ventricles; Humans; Hypertension; Iodine Radioisotopes; Lanatosides; Male; Middle Aged; Nitroglycerin; Propranolol; Pulmonary Circulation

Topics: Aged; Alcohols; Arrhythmias, Cardiac; Coronary Disease; Creatine; Drug Synergism; Drug Tolerance; Female; Hallucinations; Heart Diseases; Heart Failure; Humans; Lanatosides; Male; Middle Aged; Nausea; Nystagmus, Pathologic; Organophosphorus Compounds; Vertigo

Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Drug Tolerance; Female; Heart Failure; Humans; Lanatosides; Male; Middle Aged

Topics: Aged; Coronary Disease; Drug Combinations; Electrocardiography; Female; Heart Diseases; Humans; Lanatosides; Male; Middle Aged; Vasodilator Agents

Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Female; Heart Diseases; Heart Failure; Heart Rate; Humans; Lanatosides; Male; Middle Aged

Topics: Coronary Disease; Dibenzoxepins; Female; Heart Failure; Humans; Lanatosides; Male; Myocardial Infarction; Vasodilator Agents

Topics: Adult; Bufanolides; Cardiac Glycosides; Coronary Disease; Digitalis Glycosides; Electrocardiography; Female; Heart Ventricles; Humans; Lanatosides; Male; Middle Aged; Ouabain

Topics: Angina Pectoris; Anti-Arrhythmia Agents; Coronary Disease; Electrocardiography; Female; Humans; Lanatosides; Male; Myocardial Infarction; Nitriles; Vasodilator Agents; Verapamil

Topics: Aged; Coronary Disease; Digoxin; Female; Humans; Lanatosides; Male; Middle Aged

Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Digitalis Glycosides; Electrocardiography; Heart Rate; Humans; Lanatosides; Male; Methods; Middle Aged; Phonocardiography

Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiomyopathies; Catecholamines; Coronary Disease; Digitalis Glycosides; Diuretics; Epinephrine; Female; Glomerular Filtration Rate; Guanethidine; Heart Defects, Congenital; Heart Failure; Heart Valve Diseases; Humans; Hydrochlorothiazide; Hypertension; Lanatosides; Male; Middle Aged; Norepinephrine; Potassium; Regional Blood Flow; Sodium; Spironolactone; Trichlormethiazide

Topics: Adult; Aged; Coronary Disease; Female; Heart Failure; Humans; Lanatosides; Male; Middle Aged; Pulmonary Heart Disease

Topics: Aged; Atrial Fibrillation; Blood Flow Velocity; Body Weight; Coronary Disease; Electrocardiography; Female; Heart Diseases; Heart Failure; Humans; Hypertension; Hyperthyroidism; Intestinal Absorption; Lanatosides; Male; Middle Aged; Pulmonary Heart Disease; Pulse

Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Biomedical Research; Coronary Disease; Drug Therapy; Exercise Test; Goiter; Graves Disease; Hemodynamics; Humans; Hypertension; Lanatosides; Sympatholytics; Toxicology

Topics: Aminophylline; Angiotensins; Atrial Fibrillation; Autopsy; Blood Flow Velocity; Blood Pressure; Blood Pressure Determination; Blood Volume; Blood Volume Determination; Cardiac Catheterization; Coronary Disease; Drug Therapy; Endocarditis; Endocarditis, Subacute Bacterial; Heart Defects, Congenital; Heart Failure; Heart Function Tests; Humans; Hypertension; Lanatosides; Mitral Valve Stenosis; Norepinephrine; Pathology; Radioisotopes; Rheumatic Heart Disease; Syphilis; Syphilis, Cardiovascular

Topics: Aortic Valve Stenosis; Arrhythmias, Cardiac; Coronary Disease; Deslanoside; Humans; Hypertension; Lanatosides; Mitral Valve Insufficiency; Mitral Valve Stenosis

Topics: Atrial Fibrillation; Atrial Flutter; Cardiac Surgical Procedures; Coronary Disease; Electric Countershock; Heart Block; Hypertension; Hyperthyroidism; Lanatosides; Quinidine; Rheumatic Heart Disease; Tachycardia; Thoracic Surgery; Toxicology

Topics: Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Coronary Disease; Deslanoside; Heart Defects, Congenital; Heart Failure; Humans; Lanatosides; Myocarditis; Pulmonary Heart Disease; Tachycardia

Topics: Adolescent; Angina Pectoris; Arrhythmias, Cardiac; Atrial Fibrillation; Child; Coronary Disease; Deslanoside; Geriatrics; Heart Block; Heart Failure; Humans; Hypertension; Lanatosides; Myocardial Infarction; Pharmacology; Pulmonary Edema; Pulmonary Fibrosis; Pulmonary Heart Disease; Tachycardia; Thrombophlebitis; Toxicology; Water-Electrolyte Balance

Topics: Adenosine Triphosphate; Cardiac Glycosides; Coronary Artery Disease; Coronary Disease; Digitalis; Digitalis Glycosides; Lanatosides; Strophanthins