lanatosides and Arrhythmias--Cardiac

Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digitalis Glycosides; Drug Evaluation; Electric Countershock; Female; Humans; Lanatosides; Pregnancy; Pregnancy Complications, Cardiovascular

Topics: Adenosine Triphosphatases; Arrhythmias, Cardiac; Digitalis Glycosides; Digitoxin; Digoxin; Heart; Heart Failure; Heart Rate; Humans; Kidney Diseases; Kinetics; Lanatosides; Lidocaine; Myocardium; Pacemaker, Artificial; Phenytoin; Potassium; Procainamide; Propranolol; Quinidine; Thyroid Diseases

Topics: Arrhythmias, Cardiac; Biopharmaceutics; Digitalis Glycosides; Digitoxin; Digoxin; Half-Life; Heart; Humans; Lanatosides; Ouabain; Structure-Activity Relationship; Vascular Resistance

Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Digitalis Glycosides; Electrocardiography; Female; Humans; Lanatosides; Male; Middle Aged; Pacemaker, Artificial; Potassium

The material has been collected in the course of two years and covers 48 cases with paroxysms of supraventricular paroxysmal tachycardia (28), auricular fibrillation (4) ventricular tachycardia (2), group and polytopic ventricular extrasystoles (14), organic cardiac diseases (30) and 18--inorganic heart diseases. Paroxysms were interrupted by isolamid, tachmalin lidocain via slow intravenous infusion with constant ECG, auscultation and hemodynamic control, monitor follow up. The paroxysms successfully coped were 43. It proved possible to interrupt the rhythm disorders under the conditions of non-integrated polyclinic provided the functional consulting room is well equipped. The problem of early and effective treatment of rhythm disorders even under polyclinical conditions is solved, thus avoiding the unnecessary hospitalization of some of those patients and delay in the effective treatment of the other part of the patients. The early diagnosis and proper therapeutic behaviour of the physician towards the patient from the very first moment of contact to the transportation and hospitalization of the patient is of vital importance. The interruption of rhythm disorders must very cautiously be performed--the ventricular tachycardia and polytopic extrasystoles in particular, that considered only an introductory treatment.

Topics: Adult; Ajmaline; Ambulatory Care; Arrhythmias, Cardiac; Cardiac Glycosides; Electrocardiography; Female; Humans; Infusions, Parenteral; Lanatosides; Lidocaine; Male; Middle Aged

Topics: Aconitine; Animals; Arrhythmias, Cardiac; Chlordiazepoxide; Dogs; Injections, Intravenous; Injections, Intraventricular; Lanatosides

The material has been collected for two years and covers 48 case with paroxysm of supraventricular paroxysmal tachycardia (28), auricular fibrillation (4), ventricular tachycardia (2), group and polytopic ventricular extrasystoles (14), with organic heart diseases (30) and with non-organic heart diseases (18). The paroxysms were coped with isolanid , tachmalin and lidocain , sow intravenous infusion under constant ECG, auscultatory and hemodynamic control and monitors. The number of the successfully coped paroxysms is 43. It proved to be possible to interrupt the rhythm disturbances under the conditions of non-integrated polyclinic in case of properly equipped functional consulting room. In this way the problem of early and effective treatment of rhythm disturbances under polyclinical conditions is solved, hence--avoiding both the unnecessary hospitalization of part of those patients and the delay in the initiation of effective treatment of the other part of them. The early diagnosis and adequate therapeutic behaviour of the physician towards the patient at their first contact till the moment of their transportation and hospitalization proved to be of particular significance. The out-patient department interruption of rhythm disorders should very cautiously be performed, particularly in case of ventricular tachycardia and polytopic extrasystoles, that being only their initial treatment.

Topics: Adult; Ajmaline; Ambulatory Care; Arrhythmias, Cardiac; Cardiac Glycosides; Electrocardiography; Female; Humans; Infusions, Parenteral; Lanatosides; Lidocaine; Male; Middle Aged; Monitoring, Physiologic

Topics: Adolescent; Adult; Age Factors; Aged; Arrhythmias, Cardiac; Child; Child, Preschool; Digitalis Glycosides; Digoxin; Heart Block; Humans; Infant; Infant, Newborn; Lanatosides; Medigoxin; Middle Aged

Functional ablation of the cerebral cortex by cortical spreading depression (CSD) significantly increased the dose of desacetyl lanatoside C required to induce A-V block and ventricular fibrillation. To examine the role of the posterior hypothalamus in the increased resistance of decorticated rats to arrhythmia induced by toxic doses of desacetyl lanatoside C, four groups of animals were injected with this drug: group 1 rats had a craniotomy; group 2 rats had a craniotomy and functional decortication; group 3 rats had a craniotomy and a hypothalamic lesion; and group 4 rats had a craniotomy, hypothalamic lesion and functional decortication. The dose of drug required to induce A-V block and ventricular fibrillation was significantly less in group 1, than in groups 2,3 and 4, and there was no statistically significant difference between these last three groups. These results are consistent with the hypothesis that the increased resistance to arrhythmia induced by desacetyl lanatoside C in decorticated rats is mediated by the posterior hypothalamus.

Topics: Animals; Arrhythmias, Cardiac; Brain; Cerebral Cortex; Deslanoside; Heart Rate; Hypothalamus; Hypothalamus, Posterior; Lanatosides; Male; Neurons; Rats; Rats, Inbred Strains

Topics: Animals; Arrhythmias, Cardiac; Brain; Cerebral Cortex; Cortical Spreading Depression; Deslanoside; Hypothalamus; Lanatosides; Rats

Topics: Animals; Arrhythmias, Cardiac; Guinea Pigs; Kinetics; Lanatosides; Male; Metipranolol; Propanolamines; Rabbits; Radiation Injuries, Experimental

Topics: Arrhythmias, Cardiac; Digitalis Glycosides; Heart Failure; Humans; Lanatosides; Magnesium; Magnesium Deficiency; Magnesium Sulfate; Potassium

Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electrocardiography; Female; Heart Rate; Lanatosides; Male; Propiophenones

Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Female; Heart Rate; Lanatosides; Male; Nifedipine; Pyridines

Topics: Animals; Arrhythmias, Cardiac; Brain; Cats; Deslanoside; Lanatosides; Serotonin

The present study was performed to determine whether increases in the tissue content of serotonin creatinine SO4 in the periphery would influence the arrhythmogenic effect of deslanoside. This was accomplished by infusing serotonin into anesthetized cats exposed to a subarrhythmic dose of deslanoside, determining doses of deslanoside required to produce ventricular tachycardia and ventricular fibrillation, and determining ventricular pacemaker rate (obtained during vagal-induced sinus node suppression). It was found that animals receiving serotonin creatinine SO4 plus deslanoside exhibited a greater increase in ventricular rate during sinus node suppression than with 5-HT infusion alone. No corresponding increase in ventricular pacemaker rate during sinus node suppression was observed with creatinine SO4 plus deslanoside. In addition, the dose of deslanoside to produce ventricular fibrillation in these animals was significantly correlated with the increase in ventricular pacemaker rate seen during th 5-HT infusion in the presence of deslanoside. Studies were also performed to determine whether the arrhythmogenic interaction of serotonin with deslanoside was associated with alterations in either cardiac tissue, blood or plasma levels of serotonin and 5-hydroxyindoleacetic acid. The data revealed a significant correlation between serotonin content in the left ventricle and the dose of deslanoside required to produce ventricular fibrillation. These results suggest that exogenous serotonin interacts with deslanoside to enhance the arrhythmogenic action of deslanoside.

Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Creatinine; Deslanoside; Drug Interactions; Female; Heart Rate; Hydroxyindoleacetic Acid; Lanatosides; Male; Myocardium; Serotonin

Topics: Animals; Apomorphine; Arrhythmias, Cardiac; Blood Pressure; Brain; Cardiovascular System; Cats; Decerebrate State; Deslanoside; Haloperidol; Heart; Heart Conduction System; Heart Rate; Lanatosides; Piribedil; Propantheline; Receptors, Dopamine

6 patients with severe digitalis intoxication were studied while hospitalised in a coronary care unit. 2 and 4 patients had ingested high doses of lanatosid C and digoxin, respectively. In three cases ventricular arrhythmias, in one of these and two further cases SA blocking and an additional A-V-block in one case were observed. Maximum blood levels of digoxin between 3.4 and 20 ng/ml were determined several hours after the ingestion. The maximal blood levels were achieved in one patient only 52 h after ingesting lanatosid C and in one patient taking digoxin after 12.5 h. Potassium concentrations in plasma were elevated in 4 patients. Antiarrhythmic and electrolyte therapy is discussed and the usefulness of a stomach lavage for diminishing the quantity of absorbed lanatosid C is shown in one patient who had a maximal blood level of 3.4 ng/ml after taking 23.7 mg of lanatosid C. Cumulative urinary excretion of this patient was 0.68 mg within 5.5 days. This result confirms the minimal enteral absorption under the therapy chosen.

Topics: Adult; Aged; Arrhythmias, Cardiac; Digitalis Glycosides; Digoxin; Female; Heart Block; Humans; Intestinal Absorption; Kinetics; Lanatosides; Male; Middle Aged; Poisoning

Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Brain Stem; Cats; Deslanoside; Fenclonine; Heart Rate; Hypothalamus; Lanatosides; Methysergide; Serotonin; Tryptamines

Topics: Adult; Arrhythmias, Cardiac; Atrial Fibrillation; Electrocardiography; Heart Conduction System; Humans; Lanatosides; Male

Topics: Animals; Arrhythmias, Cardiac; Calcium; Cardiac Output; Chlorides; Digitalis Glycosides; Dogs; Drug Evaluation; Electrocardiography; Female; Heart Ventricles; Injections, Intramuscular; Injections, Intravenous; Lanatosides; Magnesium; Male; Potassium; Tachycardia

Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Digitalis Glycosides; Digoxin; Drug Synergism; Drug Therapy, Combination; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Lanatosides; Propranolol; Quinidine; Refractory Period, Electrophysiological; Tachycardia

Topics: Aconitum; Animals; Arrhythmias, Cardiac; Carotid Arteries; Dogs; Electric Stimulation; Electrodes, Implanted; Hypothalamus; Lanatosides; Tetrodotoxin; Time Factors; Vagotomy; Vagus Nerve; Ventricular Fibrillation

Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart Conduction System; Lanatosides; Propranolol

Topics: Arrhythmias, Cardiac; Desensitization, Immunologic; Digitalis Glycosides; Drug Eruptions; Drug Hypersensitivity; Erythema; Humans; Injections, Intravenous; Lanatosides; Male; Middle Aged; Pruritus; Skin Manifestations

Topics: Arrhythmias, Cardiac; Digitalis Glycosides; Digoxin; Electrocardiography; Heart Failure; Heart Rate; Humans; Injections, Intravenous; Lanatosides; Time Factors

Topics: Ajmaline; Apgar Score; Arrhythmias, Cardiac; Cesarean Section; Digoxin; Electrocardiography; Extraction, Obstetrical; Female; Fetus; Heart Block; Humans; Infant; Infant, Newborn; Lanatosides; Pregnancy; Prenatal Diagnosis; Tachycardia; Tachycardia, Paroxysmal; Ventricular Fibrillation; Verapamil; Wolff-Parkinson-White Syndrome

Topics: Aged; Alcohols; Arrhythmias, Cardiac; Coronary Disease; Creatine; Drug Synergism; Drug Tolerance; Female; Hallucinations; Heart Diseases; Heart Failure; Humans; Lanatosides; Male; Middle Aged; Nausea; Nystagmus, Pathologic; Organophosphorus Compounds; Vertigo

Topics: Administration, Oral; Arrhythmias, Cardiac; Body Weight; Computers; Digitalis Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Humans; Injections; Kidney; Kinetics; Lanatosides; Myocardium

Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Drug Tolerance; Female; Heart Failure; Humans; Lanatosides; Male; Middle Aged

Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Cardiovascular Diseases; Female; Humans; Lanatosides; Male; Middle Aged; Postoperative Complications

Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Female; Heart Diseases; Heart Failure; Heart Rate; Humans; Lanatosides; Male; Middle Aged

Topics: Adult; Aged; Arrhythmias, Cardiac; Body Weight; Diuresis; Female; Heart Failure; Heart Rate; Humans; Lanatosides; Male; Middle Aged

Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digitalis Glycosides; Electrocardiography; Guinea Pigs; Heart Arrest; Indoles; Lanatosides; Propranolol; Sympatholytics

Topics: Administration, Oral; Arrhythmias, Cardiac; Cardiac Glycosides; Diet Therapy; Digitoxin; Digoxin; Diuresis; Drug Tolerance; Edetic Acid; Electrocardiography; Gastrointestinal Diseases; Heart Failure; Heart Rate; Humans; Injections, Intravenous; Lanatosides; Nervous System Diseases; Phytotherapy; Plants, Medicinal; Poisoning; Potassium; Rest; Strophanthins

Topics: Acute Disease; Arrhythmias, Cardiac; Atropine; Digitalis Glycosides; Electric Countershock; Humans; Injections, Intravenous; Intensive Care Units; Lanatosides; Lidocaine; Middle Aged; Myocardial Infarction; Pulmonary Edema; Shock, Cardiogenic

Topics: Ajmaline; Arrhythmias, Cardiac; Digoxin; Electric Countershock; Female; Glucagon; Heart Failure; Humans; Lanatosides; Middle Aged; Mitral Valve Insufficiency; Phenytoin; Phytotherapy; Plants, Medicinal; Pulmonary Edema; Quinidine; Rauwolfia; Water-Electrolyte Balance

Topics: Arrhythmias, Cardiac; Biliary Tract; Digitalis Glycosides; Digitoxin; Digoxin; Gastrointestinal Diseases; Heart Diseases; Humans; Intestinal Absorption; Kidney; Lanatosides; Liver; Lung; Muscles; Myocardium; Nervous System Diseases; Strophanthins; Vision Disorders

Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digitalis Glycosides; Digitoxin; Female; Humans; Lanatosides; Male; Middle Aged; Pyridines; Strophanthins

Topics: Animals; Arrhythmias, Cardiac; Atropine; Electrocardiography; Head; Heart; Injections, Intravenous; Lanatosides; Rabbits; Radiation Effects

Topics: Arrhythmias, Cardiac; Blood Pressure; Glucagon; Heart Failure; Heart Rate; Hemodynamics; Humans; Lanatosides; Myocardial Infarction; Resorcinols

Topics: Animals; Arrhythmias, Cardiac; Cardiac Glycosides; Cats; Digitoxin; Female; Heart; Heart Failure; Lanatosides; Male; Strophanthins

Topics: Adrenergic beta-Antagonists; Anilides; Animals; Arrhythmias, Cardiac; Dogs; Drug Synergism; Female; Lanatosides; Mortality; Ouabain; Sympatholytics

Topics: Aconitum; Animals; Arrhythmias, Cardiac; Cardiac Glycosides; Electrocardiography; Female; Heart Conduction System; Lanatosides; Male; Methods; Rabbits; Vagus Nerve

Topics: Arrhythmias, Cardiac; Cardiovascular System; Electrocardiography; Heart Ventricles; Injections, Intramuscular; Injections, Intravenous; Lanatosides; Oxytocin; Pentylenetetrazole; Picrotoxin

Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Heart Atria; Heart Block; Heart Conduction System; Lanatosides; Myocardium; Vagotomy; Vagus Nerve

Topics: Animals; Arrhythmias, Cardiac; Cats; Digitalis Glycosides; Digitoxin; Digoxin; Female; Lanatosides; Male; Ouabain; Reserpine; Vagus Nerve; Ventricular Fibrillation

Topics: Adult; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Digitalis Glycosides; Female; Heart Diseases; Humans; Lanatosides; Male; Middle Aged

Topics: Adolescent; Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Child; Child, Preschool; Digoxin; Heart Defects, Congenital; Heart Diseases; Heart Septal Defects, Atrial; Humans; Lanatosides; Middle Aged; Postoperative Complications; Preoperative Care; Retrospective Studies; Tachycardia

Topics: Animals; Arrhythmias, Cardiac; Digitalis Glycosides; Dogs; Electric Countershock; Lanatosides; Mathematics; Methods; Quinidine; Time Factors; Ventricular Fibrillation

Topics: Adult; Anesthesia, Inhalation; Arrhythmias, Cardiac; Bronchial Fistula; Electrocardiography; Female; Halothane; Humans; Hypokalemia; Lanatosides; Propranolol

Topics: Adult; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Female; Heart Diseases; Humans; Lanatosides; Male; Middle Aged

Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Atrial Fibrillation; Biomedical Research; Coronary Disease; Drug Therapy; Exercise Test; Goiter; Graves Disease; Hemodynamics; Humans; Hypertension; Lanatosides; Sympatholytics; Toxicology

Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Central Nervous System; Deslanoside; Dogs; Electrocardiography; Ganglia; Ganglia, Autonomic; Hexamethonium; Hexamethonium Compounds; Lanatosides; Pentylenetetrazole; Pharmacology; Physiology; Picrotoxin; Research; Tetraethylammonium; Tetraethylammonium Compounds; Toxicology

Topics: Aged; Arrhythmias, Cardiac; Female; Heart Diseases; Humans; Lanatosides; Male; Middle Aged

Topics: Arrhythmias, Cardiac; Cardiac Glycosides; Digitalis Glycosides; Heart Defects, Congenital; Heart Failure; Heart Valve Diseases; Humans; Lanatosides; Mitral Valve Insufficiency; Mitral Valve Stenosis; Strophanthins; Tricuspid Valve Stenosis

Topics: Arrhythmias, Cardiac; Atropine; Digitalis Glycosides; Drug Therapy; Humans; Isoproterenol; Lanatosides; Phenytoin; Procaine; Quinidine

Topics: Aortic Valve Stenosis; Arrhythmias, Cardiac; Coronary Disease; Deslanoside; Humans; Hypertension; Lanatosides; Mitral Valve Insufficiency; Mitral Valve Stenosis

Topics: Animals; Arrhythmias, Cardiac; Dogs; Electrocardiography; Heart Block; Humans; Isoproterenol; Lanatosides; Pacemaker, Artificial; Pharmacology; Procainamide; Research; Ventricular Fibrillation

Topics: Arrhythmias, Cardiac; Cardiac Complexes, Premature; Drug Therapy; Electrocardiography; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Lanatosides; Rauwolfia

Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Deslanoside; Dogs; Lanatosides; Pentylenetetrazole; Picrotoxin

Topics: Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Coronary Disease; Deslanoside; Heart Defects, Congenital; Heart Failure; Humans; Lanatosides; Myocarditis; Pulmonary Heart Disease; Tachycardia

Topics: Arrhythmias, Cardiac; Child; Digitalis Glycosides; Electrocardiography; Glomerulonephritis; Heart Block; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Lanatosides; Myocarditis; Pericarditis; Pericarditis, Constrictive; Pneumonia; Rheumatic Heart Disease; Strophanthins; Toxicology

Topics: Adolescent; Angina Pectoris; Arrhythmias, Cardiac; Atrial Fibrillation; Child; Coronary Disease; Deslanoside; Geriatrics; Heart Block; Heart Failure; Humans; Hypertension; Lanatosides; Myocardial Infarction; Pharmacology; Pulmonary Edema; Pulmonary Fibrosis; Pulmonary Heart Disease; Tachycardia; Thrombophlebitis; Toxicology; Water-Electrolyte Balance

Topics: Arrhythmias, Cardiac; Digitalis; Digitalis Glycosides; Heart Failure; Lanatosides

Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Digitalis; Digitalis Glycosides; Heart Conduction System; Lanatosides; Tachycardia

Topics: Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Digitalis; Heart Conduction System; Heart Failure; Humans; Lanatosides

Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Brugada Syndrome; Cardiac Conduction System Disease; Digitalis; Digitalis Glycosides; Heart Conduction System; Humans; Lanatosides

Topics: Arrhythmias, Cardiac; Digitalis; Digitalis Glycosides; Humans; Lanatosides; Tachycardia, Supraventricular

Topics: Arrhythmias, Cardiac; Humans; Lanatosides