lamotrigine has been researched along with Weight Gain in 17 studies
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four-hundred and thirty-four patients with partial seizures were randomized to pregabalin, lamotrigine, or placebo as adjunctive therapy for 17 weeks of double-blind treatment." | 9.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "Unlike many pharmacotherapies for mood disorders, lamotrigine has not been shown to be associated with weight gain." | 9.12 | A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. ( Merideth, CH, 2006) |
| "We evaluated the serum leptin and insulin as predictors of weight gain in children receiving long-term treatment with valproate (VPA), carbamazepine (CBZ), lamotrigine (LTG)." | 7.75 | States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. ( Fida, NM; Hamed, EA; Hamed, SA, 2009) |
| "This open-label, cross-sectional study compared (1) endocrine and lipid measures during the early follicular phase of the menstrual cycle; (2) prevalence of menstrual disorders (from patient diaries recorded over three cycles); and (3) body weight of women with epilepsy on lamotrigine monotherapy (n=119) with those on valproate monotherapy (n=103) for <5 years." | 7.72 | Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. ( Ayala, R; Dam, M; Gomez, G; Isojärvi, J; Messenheimer, J; Morrell, MJ; O'Neill, F; Taylor, AE; Tennis, P, 2003) |
| " Valproic acid appears to be use cautionally in obese females with epilepsy." | 5.24 | Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study. ( Sadhotra, A; Sidhu, HS; Srinivas, R, 2017) |
| "Four-hundred and thirty-four patients with partial seizures were randomized to pregabalin, lamotrigine, or placebo as adjunctive therapy for 17 weeks of double-blind treatment." | 5.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "Unlike many pharmacotherapies for mood disorders, lamotrigine has not been shown to be associated with weight gain." | 5.12 | A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults. ( Merideth, CH, 2006) |
| "A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies." | 5.12 | Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder. ( Bowden, CL; Calabrese, JR; Ketter, TA; Sachs, GS; Thompson, TR; White, RL, 2006) |
| "The 2 older FDA-approved treatments for bipolar depression, olanzapine-fluoxetine combination (OFC) and quetiapine (QTP) monotherapy, were efficacious (response NNT=4 for OFC, NNT=6 for QTP), but similarly likely to yield harms (OFC weight gain NNH=6; QTP sedation/somnolence NNH=5)." | 4.90 | Balancing benefits and harms of treatments for acute bipolar depression. ( Calabrese, JR; Citrome, L; Dell'Osso, B; Frye, MA; Ketter, TA; Miller, S, 2014) |
| " Weight gain and pharmacokinetic interaction with lamotrigine are perhaps the most consistent problems in use." | 4.82 | Valproate. ( Bowden, CL, 2003) |
| "We evaluated the serum leptin and insulin as predictors of weight gain in children receiving long-term treatment with valproate (VPA), carbamazepine (CBZ), lamotrigine (LTG)." | 3.75 | States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. ( Fida, NM; Hamed, EA; Hamed, SA, 2009) |
| "This open-label, cross-sectional study compared (1) endocrine and lipid measures during the early follicular phase of the menstrual cycle; (2) prevalence of menstrual disorders (from patient diaries recorded over three cycles); and (3) body weight of women with epilepsy on lamotrigine monotherapy (n=119) with those on valproate monotherapy (n=103) for <5 years." | 3.72 | Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. ( Ayala, R; Dam, M; Gomez, G; Isojärvi, J; Messenheimer, J; Morrell, MJ; O'Neill, F; Taylor, AE; Tennis, P, 2003) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures." | 2.45 | The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? ( Abou-Khalil, B; Montouris, G, 2009) |
| "Weight gain was found to be lower in the elderly for antipsychotic drugs, in particular for olanzapine." | 1.39 | Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland. ( Baumann, P; Greil, W; Grohmann, R; Häberle, A; Schuhmann, T, 2013) |
| "Absence status was aggravated with carbamazepine and generalised tonic-clonic seizures were not controlled with ethosuximide." | 1.36 | Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status. ( Genton, P; Velizarova, R, 2010) |
| "Juvenile myoclonic epilepsy is a common, under-recognised form of epilepsy which is best treated with sodium valproate." | 1.29 | Juvenile myoclonic epilepsy: diagnosis, management and outcome. ( Buchanan, N; Sharpe, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Buraniqi, E | 1 |
| Dabaja, H | 1 |
| Wirrell, EC | 1 |
| Sidhu, HS | 1 |
| Srinivas, R | 1 |
| Sadhotra, A | 1 |
| Greil, W | 1 |
| Häberle, A | 1 |
| Schuhmann, T | 1 |
| Grohmann, R | 1 |
| Baumann, P | 1 |
| Ketter, TA | 2 |
| Miller, S | 1 |
| Dell'Osso, B | 1 |
| Calabrese, JR | 2 |
| Frye, MA | 1 |
| Citrome, L | 1 |
| Hamed, SA | 1 |
| Fida, NM | 1 |
| Hamed, EA | 1 |
| Montouris, G | 1 |
| Abou-Khalil, B | 1 |
| Baulac, M | 1 |
| Leon, T | 1 |
| O'Brien, TJ | 1 |
| Whalen, E | 1 |
| Barrett, J | 1 |
| Velizarova, R | 1 |
| Genton, P | 1 |
| Graovac, M | 1 |
| Ružić, K | 1 |
| Rebić, J | 1 |
| Dadić-Hero, E | 1 |
| Kaštelan, A | 1 |
| Frančišković, T | 1 |
| Biton, V | 1 |
| Levisohn, P | 1 |
| Hoyler, S | 1 |
| Vuong, A | 1 |
| Hammer, AE | 1 |
| Bowden, CL | 2 |
| Morrell, MJ | 1 |
| Isojärvi, J | 1 |
| Taylor, AE | 1 |
| Dam, M | 1 |
| Ayala, R | 1 |
| Gomez, G | 1 |
| O'Neill, F | 1 |
| Tennis, P | 1 |
| Messenheimer, J | 1 |
| Reiss, JP | 1 |
| Sam, D | 1 |
| Sareen, J | 1 |
| Merideth, CH | 1 |
| Sachs, GS | 1 |
| White, RL | 1 |
| Thompson, TR | 1 |
| Manent, JB | 1 |
| Jorquera, I | 1 |
| Franco, V | 1 |
| Ben-Ari, Y | 1 |
| Perucca, E | 1 |
| Represa, A | 1 |
| Sharpe, C | 1 |
| Buchanan, N | 1 |
4 reviews available for lamotrigine and Weight Gain
| Article | Year |
|---|---|
Impact of Antiseizure Medications on Appetite and Weight in Children.
Topics: Anticonvulsants; Appetite; Child; Epilepsy; Humans; Lamotrigine; Weight Gain | 2022 |
Balancing benefits and harms of treatments for acute bipolar depression.
Topics: Acute Disease; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Diben | 2014 |
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Gener | 2009 |
Valproate.
Topics: Antimanic Agents; Bipolar Disorder; Drug Interactions; Humans; Lamotrigine; Lithium Compounds; Progn | 2003 |
5 trials available for lamotrigine and Weight Gain
| Article | Year |
|---|---|
Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study.
Topics: Adiponectin; Adolescent; Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Cholesterol; Choles | 2017 |
A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dizziness; Double-Blind Method; Epilepsies, Partial; Fem | 2010 |
Lamotrigine versus valproate monotherapy-associated weight change in adolescents with epilepsy: results from a post hoc analysis of a randomized, double-blind clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Body Mass Index; Child; Double-Blind Metho | 2003 |
A single-center, double-blind, placebo-controlled evaluation of lamotrigine in the treatment of obesity in adults.
Topics: Adult; Anticonvulsants; Body Mass Index; Double-Blind Method; Drug Administration Schedule; Female; | 2006 |
Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Body Weight; Comorbidity; Double-Blind Method; Humans; Lam | 2006 |
8 other studies available for lamotrigine and Weight Gain
| Article | Year |
|---|---|
Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; An | 2013 |
States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain.
Topics: Adolescent; Age Factors; Anticonvulsants; Body Mass Index; Carbamazepine; Case-Control Studies; Chil | 2009 |
Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Diagnosis, Differential; Dose-Response Relationship, D | 2010 |
Weight gain induced with olanzapine in adolescent.
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Body Mass Index; Cooperative Beh | 2011 |
Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy.
Topics: Adult; Analysis of Variance; Androgens; Confidence Intervals; Cross-Sectional Studies; Epilepsy; Fem | 2003 |
Psychosis in multiple sclerosis associated with left temporal lobe lesions on serial MRI scans.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Delusions; Excitatory Amino Acid Antagonists; Female; | 2006 |
Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats.
Topics: Animals; Anticonvulsants; Brain; Cell Count; Cell Movement; Dose-Response Relationship, Drug; Female | 2008 |
Juvenile myoclonic epilepsy: diagnosis, management and outcome.
Topics: Adolescent; Adult; Alcohol Drinking; Anticonvulsants; Carbamazepine; Epilepsies, Myoclonic; Female; | 1995 |