lamotrigine has been researched along with Trigeminal Neuralgia in 20 studies
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we evaluated the efficacy and occurrence of side effects of lamotrigine (LTG) in comparison with carbamazepine (CBZ), in trigeminal neuralgia (TN) patients." | 9.15 | Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine. ( Abd Rahman, RB; Shaikh, S; Yaacob, HB, 2011) |
| " We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)." | 7.70 | Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000) |
| "This paper reports on the effectiveness of oral lamotrigine in 15 patients suffering from "essential" trigeminal neuralgia and in five patients suffering symptomatic trigeminal neuralgia concomitant with multiple sclerosis." | 7.69 | Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia. ( Albano, C; Cultrera, S; Favale, E; Fracassi, M; Leandri, M; Lunardi, G; Rubino, V, 1997) |
| "Lamotrigine is a chemically novel antiepileptic drug which has not been adequately assessed for its antineuralgic properties." | 6.68 | Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. ( Chaudhry, Z; Mullens, LE; Nurmikko, TJ; Patton, DW; Zakrzewska, JM, 1997) |
| " In this study, we evaluated the efficacy and occurrence of side effects of lamotrigine (LTG) in comparison with carbamazepine (CBZ), in trigeminal neuralgia (TN) patients." | 5.15 | Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine. ( Abd Rahman, RB; Shaikh, S; Yaacob, HB, 2011) |
| " Memory alteration was least common with lamotrigine and oxcarbazepine, and there was less association between fatigues with oxcarbazepine/pregabalin." | 3.88 | Adverse effects of anti-epileptics in trigeminal neuralgiform pain. ( Cregg, R; Lee, G; O'Keeffe, AG; Reading, J; Tentolouris-Piperas, V; Zakrzewska, JM, 2018) |
| " We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)." | 3.70 | Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000) |
| "This paper reports on the effectiveness of oral lamotrigine in 15 patients suffering from "essential" trigeminal neuralgia and in five patients suffering symptomatic trigeminal neuralgia concomitant with multiple sclerosis." | 3.69 | Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia. ( Albano, C; Cultrera, S; Favale, E; Fracassi, M; Leandri, M; Lunardi, G; Rubino, V, 1997) |
| "Lamotrigine is a chemically novel antiepileptic drug which has not been adequately assessed for its antineuralgic properties." | 2.68 | Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. ( Chaudhry, Z; Mullens, LE; Nurmikko, TJ; Patton, DW; Zakrzewska, JM, 1997) |
| " When sodium channel blockers cannot reach full dosage because of side effects, an add-on treatment with lamotrigine or baclofen should be considered." | 2.58 | Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. ( Cruccu, G; Di Stefano, G; Truini, A, 2018) |
| "Trigeminal neuralgia is a unique neuropathic pain disorder with a specific therapy." | 2.42 | Management issues of neuropathic trigeminal pain from a medical perspective. ( Watson, CP, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pergolizzi, JV | 1 |
| Gharibo, C | 1 |
| Magnusson, P | 1 |
| Breve, F | 1 |
| LeQuang, JA | 1 |
| Varrassi, G | 1 |
| Tentolouris-Piperas, V | 1 |
| Lee, G | 1 |
| Reading, J | 1 |
| O'Keeffe, AG | 1 |
| Zakrzewska, JM | 3 |
| Cregg, R | 1 |
| Solaro, CM | 1 |
| Ferriero, G | 1 |
| Di Stefano, G | 1 |
| Truini, A | 1 |
| Cruccu, G | 1 |
| Lambru, G | 1 |
| Matharu, MS | 1 |
| Scrivani, S | 1 |
| Wallin, D | 1 |
| Moulton, EA | 1 |
| Cole, S | 1 |
| Wasan, AD | 1 |
| Lockerman, L | 1 |
| Bajwa, Z | 1 |
| Upadhyay, J | 1 |
| Becerra, L | 1 |
| Borsook, D | 1 |
| Martin, WJ | 1 |
| Forouzanfar, T | 1 |
| Shaikh, S | 1 |
| Yaacob, HB | 1 |
| Abd Rahman, RB | 1 |
| Watson, CP | 1 |
| Jorns, TP | 1 |
| Canavero, S | 3 |
| Bonicalzi, V | 3 |
| Ferroli, P | 1 |
| Zeme, S | 1 |
| Montalenti, E | 1 |
| Benna, P | 1 |
| Lunardi, G | 1 |
| Leandri, M | 3 |
| Albano, C | 1 |
| Cultrera, S | 1 |
| Fracassi, M | 1 |
| Rubino, V | 1 |
| Favale, E | 1 |
| Chaudhry, Z | 1 |
| Nurmikko, TJ | 1 |
| Patton, DW | 1 |
| Mullens, LE | 1 |
| Carrazana, EJ | 1 |
| Schachter, SC | 1 |
| Solaro, C | 2 |
| Messmer Uccelli, M | 1 |
| Uccelli, A | 1 |
| Mancardi, GL | 2 |
| Lundardi, G | 1 |
| Inglese, M | 1 |
| Messmer-Uccelli, M | 1 |
| Gottlieb, A | 1 |
| McCleane, GJ | 1 |
| Christensen, D | 1 |
| Gautron, M | 1 |
| Guilbaud, G | 1 |
| Kayser, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI[NCT00243152] | 6 participants (Actual) | Interventional | 2005-10-31 | Completed | |||
| Lamotrigine in Trigeminal Neuralgia: Efficacy and Safety in Comparison With Carbamazepine[NCT00913107] | Phase 2/Phase 3 | 21 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain[NCT01447108] | Phase 4 | 16 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
fMRI scans acquired Stimuli Type: Brush Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness fMRI scans acquired Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** fMRI scans acquired Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** Cortical, subcortical, and brain stem sensory regions Z-scores Increase or decrease in activation as affected by the drug (NCT00243152)
Timeframe: Week 10 during scanning session
| Intervention | Z-statistic (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Heat Affected Thalamus (10,-14,8) | Heat Affected Post-Central (-56,-12,28) | Cold Affected Post-Central (68, -8, 32) | Cold Affected Thalamus (-4, -8, 0) | Brush Affected Post-Central (66,-16,14) | Brush Affected Thalamus (-14,-22, 4) | Brush Affected Spinal Trigeminal Nucles(2,-48,-68) | |
| Lamotrigine vs Placebo | -2.9294 | -2.7323 | -2.5114 | -3.033 | 3.905 | -3.791 | 2.9058 |
"Quantitative Sensory Testing (QST)~Stimuli Type: Heat, Cold, Brush Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness~Ratings on a likert scale of 0-10 with 0 being defined as no pain and 10 being defined as worst possible pain" (NCT00243152)
Timeframe: week 10 (during the scan)
| Intervention | scores on a pain scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Heat Affected | Heat Unaffected | Cold Affected | Cold Unaffected | Brush Affected | Brush Unaffected | |
| Lamotrigine | 3.2 | 3 | 2.1 | 2.2 | 2.8 | 1.2 |
| Placebo | 5.5 | 4 | 2.5 | 1.1 | 3.9 | .4 |
6 reviews available for lamotrigine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia.
Topics: Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; Drug Therapy, Combination; Gabapent | 2018 |
SUNCT, SUNA and trigeminal neuralgia: different disorders or variants of the same disorder?
Topics: Anticonvulsants; Carbamazepine; Deep Brain Stimulation; Functional Neuroimaging; Humans; Hypothalamu | 2014 |
The efficacy of anticonvulsants on orofacial pain: a systematic review.
Topics: Amines; Anticonvulsants; Burning Mouth Syndrome; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Ac | 2011 |
Management issues of neuropathic trigeminal pain from a medical perspective.
Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; C | 2004 |
Evidence-based approach to the medical management of trigeminal neuralgia.
Topics: Analgesics; Baclofen; Carbamazepine; Drug Therapy, Combination; Evidence-Based Medicine; Female; GAB | 2007 |
Lamotrigine in the management of neuropathic pain: a review of the literature.
Topics: Analgesics; Diabetic Neuropathies; Humans; Lamotrigine; Triazines; Trigeminal Neuralgia | 2000 |
5 trials available for lamotrigine and Trigeminal Neuralgia
| Article | Year |
|---|---|
A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study.
Topics: Adult; Amines; Anticonvulsants; Brain; Cold Temperature; Cross-Over Studies; Cyclohexanecarboxylic A | 2010 |
Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Carbamazepine; Cross-Over Studies; Female; Humans; Lamot | 2011 |
Lamotrigine control of trigeminal neuralgia: an expanded study.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Lamotrigine; Male; Middle Aged; Tri | 1997 |
Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial.
Topics: Adult; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Female; Humans; Lamotrigine; Male; | 1997 |
Lamotrigine in trigeminal neuralgia secondary to multiple sclerosis.
Topics: Analgesics; Analgesics, Non-Narcotic; Carbamazepine; Female; Humans; Lamotrigine; Male; Middle Aged; | 2000 |
9 other studies available for lamotrigine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Pharmacotherapeutic management of trigeminal neuropathic pain: an update.
Topics: Anticonvulsants; Carbamazepine; Humans; Lamotrigine; Neuralgia; Trigeminal Neuralgia | 2022 |
Adverse effects of anti-epileptics in trigeminal neuralgiform pain.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Fatigue; Female; Humans; Lamot | 2018 |
Refactory Trigeminal Neuralgia successfully treated by combination therapy (Pregabalin plus Lamotrigine).
Topics: Aged; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle Aged; Pr | 2018 |
Lamotrigine control of idiopathic trigeminal neuralgia.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Carbamazepine; Female; Follow-Up Studies; Humans; Lamotrigine | 1995 |
Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia.
Topics: Aged; Calcium Channel Blockers; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Middle Aged; P | 1997 |
Alternative uses of lamotrigine and gabapentin in the treatment of trigeminal neuralgia.
Topics: Acetates; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Huma | 1998 |
Comments on Zakrzewska et al., PAIN, 73 (1997) 223-230.
Topics: Analgesics; Humans; Lamotrigine; Triazines; Trigeminal Neuralgia | 1998 |
Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Res | 2000 |
Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2001 |