Page last updated: 2024-10-30

lamotrigine and Sudden Unexpected Death in Epilepsy

lamotrigine has been researched along with Sudden Unexpected Death in Epilepsy in 3 studies

Sudden Unexpected Death in Epilepsy: Sudden death in a patient with EPILEPSY associated with SEIZURES and seizure-related symptoms (e.g., APNEA; HYPOXEMIA) without other identifiable accidental causes (e.g., DROWNING; WOUNDS AND INJURIES).

Research Excerpts

ExcerptRelevanceReference
"S Food and Drug Administration warnings that lamotrigine, a common sodium channel modulating anti-seizure medication (NaM-ASM), could increase the risk of sudden death in patients with structural or ischaemic cardiac disease, however, its implications for Sudden Unexpected Death in Epilepsy (SUDEP) are unclear."8.31Risk of sudden unexpected death in epilepsy (SUDEP) with lamotrigine and other sodium channel-modulating antiseizure medications. ( Auvrez, C; Barnard, S; Berkovic, SF; Chen, Z; Cook, MJ; D'Souza, W; Devinsky, O; Friedman, D; Kwan, P; Laze, J; Nightscales, R; O'Brien, TJ; Perucca, P; Sivathamboo, S; Tao, G, 2023)
"S Food and Drug Administration warnings that lamotrigine, a common sodium channel modulating anti-seizure medication (NaM-ASM), could increase the risk of sudden death in patients with structural or ischaemic cardiac disease, however, its implications for Sudden Unexpected Death in Epilepsy (SUDEP) are unclear."4.31Risk of sudden unexpected death in epilepsy (SUDEP) with lamotrigine and other sodium channel-modulating antiseizure medications. ( Auvrez, C; Barnard, S; Berkovic, SF; Chen, Z; Cook, MJ; D'Souza, W; Devinsky, O; Friedman, D; Kwan, P; Laze, J; Nightscales, R; O'Brien, TJ; Perucca, P; Sivathamboo, S; Tao, G, 2023)
"Cardiac arrhythmia has been suggested as a cause of death in some patients with SUDEP."1.72Rare sudden unexpected death in epilepsy SCN5A variants cause changes in channel function implicating cardiac arrhythmia as a cause of death. ( Bagnall, RD; Berkovic, SF; Reid, CA; Scheffer, IE; Semsarian, C; Soh, MS, 2022)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's3 (100.00)2.80

Authors

AuthorsStudies
Layer, N1
Brandes, J1
Lührs, PJ1
Wuttke, TV1
Koch, H1
Soh, MS1
Bagnall, RD1
Semsarian, C1
Scheffer, IE1
Berkovic, SF2
Reid, CA1
Nightscales, R1
Barnard, S1
Laze, J1
Chen, Z1
Tao, G1
Auvrez, C1
Sivathamboo, S1
Cook, MJ1
Kwan, P1
Friedman, D1
D'Souza, W1
Perucca, P1
Devinsky, O1
O'Brien, TJ1

Other Studies

3 other studies available for lamotrigine and Sudden Unexpected Death in Epilepsy

ArticleYear
The effect of lamotrigine and other antiepileptic drugs on respiratory rhythm generation in the pre-Bötzinger complex.
    Epilepsia, 2021, Volume: 62, Issue:11

    Topics: Animals; Anticonvulsants; Hypoxia; Lamotrigine; Mice; Sodium; Sodium Channel Blockers; Sudden Unexpe

2021
Rare sudden unexpected death in epilepsy SCN5A variants cause changes in channel function implicating cardiac arrhythmia as a cause of death.
    Epilepsia, 2022, Volume: 63, Issue:6

    Topics: Anticonvulsants; Arrhythmias, Cardiac; Cause of Death; Death, Sudden; Death, Sudden, Cardiac; Epilep

2022
Risk of sudden unexpected death in epilepsy (SUDEP) with lamotrigine and other sodium channel-modulating antiseizure medications.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Anticonvulsants; Case-Control Studies; Death, Sudden; Epilepsy; Humans; Lamotrigine; Retrospective S

2023