lamotrigine has been researched along with Substance Withdrawal Syndrome in 22 studies
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the tolerability and pharmacokinetics of oral loading with lamotrigine (LTG) among epilepsy patients after temporary drug discontinuation in an epilepsy monitoring unit." | 9.10 | Tolerability and pharmacokinetics of oral loading with lamotrigine in epilepsy monitoring units. ( Del Mar Carreño, M; Hovinga, CA; Lardizabal, DV; Morris, HH, 2003) |
| "This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery." | 7.75 | Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. ( Bidlack, JM; Morris, HH, 2009) |
| "The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG)." | 6.73 | Lamotrigine in bipolar disorder: efficacy during pregnancy. ( Baldessarini, RJ; Calamaras, MR; Juric, S; Knight, B; Newport, DJ; Pennell, PB; Stowe, ZN; Viguera, AC, 2008) |
| "The duration and frequency of seizure activities and electrographic seizure onset of 41 patients totally withdrawing from CBZ monotherapy (n = 20), LTG monotherapy (n = 10) and CBZ + LTG combined therapy (n = 11) were intensively studied by therapeutic intensive seizure analysis (TISA) method." | 6.71 | Changes of seizures activity during rapid withdrawal of lamotrigine. ( Koebnick, C; Pauli, E; Stefan, H; Tilz, C; Wang, B; Wang-Tilz, Y, 2005) |
| "Lamotrigine treatment was associated with significant improvements in mood, drug craving, and drug use." | 5.33 | Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. ( Beard, L; Brown, ES; Dhanani, N; Orsulak, P; Perantie, DC; Rush, AJ, 2006) |
| "To investigate the tolerability and pharmacokinetics of oral loading with lamotrigine (LTG) among epilepsy patients after temporary drug discontinuation in an epilepsy monitoring unit." | 5.10 | Tolerability and pharmacokinetics of oral loading with lamotrigine in epilepsy monitoring units. ( Del Mar Carreño, M; Hovinga, CA; Lardizabal, DV; Morris, HH, 2003) |
| "This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery." | 3.75 | Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. ( Bidlack, JM; Morris, HH, 2009) |
| "The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG)." | 2.73 | Lamotrigine in bipolar disorder: efficacy during pregnancy. ( Baldessarini, RJ; Calamaras, MR; Juric, S; Knight, B; Newport, DJ; Pennell, PB; Stowe, ZN; Viguera, AC, 2008) |
| "The duration and frequency of seizure activities and electrographic seizure onset of 41 patients totally withdrawing from CBZ monotherapy (n = 20), LTG monotherapy (n = 10) and CBZ + LTG combined therapy (n = 11) were intensively studied by therapeutic intensive seizure analysis (TISA) method." | 2.71 | Changes of seizures activity during rapid withdrawal of lamotrigine. ( Koebnick, C; Pauli, E; Stefan, H; Tilz, C; Wang, B; Wang-Tilz, Y, 2005) |
| "Lamotrigine was well-tolerated in subjects, although one did develop an allergic rash." | 2.69 | The effect of lamotrigine on naloxone-precipitated opiate withdrawal. ( Kosten, TR; Pearsall, HR; Rosen, MI, 1998) |
| "Lamotrigine was started at 25 mg/d, reached a maximum of 100 mg/d after 2 months and was retained at this dose for 1 more month." | 1.37 | Lamotrigine withdrawal may worsen RBD symptoms. ( Bonakis, A; Economou, NT; Ferini-Strambi, L; Ghika, A; Kyrozis, A; Vassilopoulos, D, 2011) |
| " The objective of the study was to determine whether plasma blood levels during chronic administration at therapeutic doses would accurately predict changes in corticomotor excitability." | 1.33 | Cortical excitability during prolonged antiepileptic drug treatment and drug withdrawal. ( Bagic, A; Cohen, LG; Lee, HW; Seo, HJ; Theodore, WH, 2005) |
| "Lamotrigine treatment was associated with significant improvements in mood, drug craving, and drug use." | 1.33 | Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. ( Beard, L; Brown, ES; Dhanani, N; Orsulak, P; Perantie, DC; Rush, AJ, 2006) |
| "Pretreatment with lamotrigine (5-100 mg/kg, s." | 1.29 | Inhibition of morphine withdrawal by lamotrigine: involvement of nitric oxide. ( Cuéllar, B; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 15 (68.18) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lau, C | 1 |
| Watson, H | 1 |
| Cheong, J | 1 |
| Bidlack, JM | 1 |
| Morris, HH | 2 |
| Habibi-Asl, B | 1 |
| Hassanzadeh, K | 1 |
| Vafai, H | 1 |
| Mohammadi, S | 1 |
| Azar, NJ | 1 |
| Lagrange, AH | 1 |
| Wang, L | 1 |
| Song, Y | 1 |
| Abou-Khalil, BW | 1 |
| Economou, NT | 1 |
| Bonakis, A | 1 |
| Ghika, A | 1 |
| Ferini-Strambi, L | 1 |
| Vassilopoulos, D | 1 |
| Kyrozis, A | 1 |
| Trinka, E | 1 |
| Dilitz, E | 1 |
| Unterberger, I | 1 |
| Luef, G | 1 |
| Deisenhammer, F | 1 |
| Niedermüller, U | 1 |
| Thaler, C | 1 |
| Bauer, G | 1 |
| Lardizabal, DV | 1 |
| Hovinga, CA | 1 |
| Del Mar Carreño, M | 1 |
| Stuve, W | 1 |
| Wessels, A | 1 |
| Timmerman, L | 1 |
| Cramer, JA | 1 |
| Hammer, AE | 1 |
| Kustra, RP | 1 |
| Subuh Surja, AA | 1 |
| Brotzge, KE | 1 |
| El-Mallakh, RS | 1 |
| Wang-Tilz, Y | 1 |
| Tilz, C | 1 |
| Wang, B | 1 |
| Pauli, E | 1 |
| Koebnick, C | 1 |
| Stefan, H | 1 |
| Mohanraj, R | 1 |
| Brodie, MJ | 1 |
| Lee, HW | 1 |
| Seo, HJ | 1 |
| Cohen, LG | 1 |
| Bagic, A | 1 |
| Theodore, WH | 1 |
| Brown, ES | 1 |
| Perantie, DC | 1 |
| Dhanani, N | 1 |
| Beard, L | 1 |
| Orsulak, P | 1 |
| Rush, AJ | 1 |
| Krupitsky, EM | 1 |
| Rudenko, AA | 1 |
| Burakov, AM | 1 |
| Slavina, TY | 1 |
| Grinenko, AA | 1 |
| Pittman, B | 1 |
| Gueorguieva, R | 1 |
| Petrakis, IL | 1 |
| Zvartau, EE | 1 |
| Krystal, JH | 1 |
| Newport, DJ | 1 |
| Stowe, ZN | 1 |
| Viguera, AC | 1 |
| Calamaras, MR | 1 |
| Juric, S | 1 |
| Knight, B | 1 |
| Pennell, PB | 1 |
| Baldessarini, RJ | 1 |
| Lizasoain, I | 1 |
| Leza, JC | 1 |
| Cuéllar, B | 1 |
| Moro, MA | 1 |
| Lorenzo, P | 1 |
| Nicolodi, M | 1 |
| Del Bianco, PL | 1 |
| Sicuteri, F | 1 |
| Rosen, MI | 1 |
| Pearsall, HR | 1 |
| Kosten, TR | 1 |
| Gelisse, P | 1 |
| Kissani, N | 1 |
| Crespel, A | 1 |
| Jafari, H | 1 |
| Baldy-Moulinier, M | 1 |
| Covington, EC | 1 |
| Anderson, GD | 1 |
| Gidal, BE | 1 |
| Messenheimer, JA | 1 |
| Gilliam, FG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| Neurobiology of Opioid Dependence: 1[NCT00000192] | Phase 2 | 0 participants (Actual) | Interventional | 1993-01-31 | Withdrawn | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lamotrigine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Anticonvulsants for neuropathic pain and detoxification.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Acids; Gabapenti | 1998 |
8 trials available for lamotrigine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Tolerability and pharmacokinetics of oral loading with lamotrigine in epilepsy monitoring units.
Topics: Administration, Oral; Adult; Anticonvulsants; Biological Availability; Dose-Response Relationship, D | 2003 |
Quality of life improvement with conversion to lamotrigine monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography | 2004 |
Changes of seizures activity during rapid withdrawal of lamotrigine.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, C | 2005 |
Pharmacological outcomes in newly diagnosed epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, C | 2005 |
Antiglutamatergic strategies for ethanol detoxification: comparison with placebo and diazepam.
Topics: Adult; Alcoholism; Arousal; Autonomic Nervous System; Depression; Diazepam; Excitatory Amino Acid An | 2007 |
Lamotrigine in bipolar disorder: efficacy during pregnancy.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Fe | 2008 |
The effect of lamotrigine on naloxone-precipitated opiate withdrawal.
Topics: Adult; Analgesics; Double-Blind Method; Female; Heroin Dependence; Humans; Infusions, Intravenous; L | 1998 |
Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoin.
Topics: Adolescent; Adult; Aged; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 2002 |
13 other studies available for lamotrigine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Poor neonatal adaptation following in-utero exposure to quetiapine and lamotrigine.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Hypothyroidism; Infant, Newborn; Infa | 2015 |
Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism.
Topics: Anticonvulsants; Data Collection; Female; Humans; Lamotrigine; Levetiracetam; Middle Aged; Phenobarb | 2009 |
Development of morphine induced tolerance and withdrawal symptoms is attenuated by lamotrigine and magnesium sulfate in mice.
Topics: Analgesics; Animals; Calcium Channels; Dose-Response Relationship, Drug; Drug Tolerance; Lamotrigine | 2009 |
Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Resistance; Drug Tolerance | 2010 |
Lamotrigine withdrawal may worsen RBD symptoms.
Topics: Aged; Anticonvulsants; Humans; Lamotrigine; Male; REM Sleep Behavior Disorder; Substance Withdrawal | 2011 |
Non convulsive status epilepticus after replacement of valproate with lamotrigine.
Topics: Adult; Aged; Anticoagulants; Benzodiazepines; Electroencephalography; Epilepsy, Generalized; Female; | 2002 |
Remission of positive symptomatology of a schizophrenic psychosis after withdrawing lamotrigine: a case report.
Topics: Adult; Antimanic Agents; Humans; Lamotrigine; Male; Psychotic Disorders; Remission, Spontaneous; Sch | 2004 |
Serious rash with lamotrigine after carbamazepine discontinuation: a case report.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme System; Drug Eruptions; Humans; Lamotrigine; | 2005 |
Cortical excitability during prolonged antiepileptic drug treatment and drug withdrawal.
Topics: Adult; Anticonvulsants; Carbamazepine; Electric Stimulation; Evoked Potentials, Motor; Humans; Lamot | 2005 |
Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study.
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Cocaine; | 2006 |
Inhibition of morphine withdrawal by lamotrigine: involvement of nitric oxide.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ex | 1996 |
Modulation of excitatory amino acids pathway: a possible therapeutic approach to chronic daily headache associated with analgesic drugs abuse.
Topics: Acetates; Adult; Amines; Chronic Disease; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagon | 1997 |
Is there a lamotrigine withdrawal syndrome?
Topics: Adult; Anticonvulsants; Epilepsy; Humans; Lamotrigine; Male; Preoperative Care; Substance Withdrawal | 2002 |