Page last updated: 2024-10-30

lamotrigine and Psychotic Disorders

lamotrigine has been researched along with Psychotic Disorders in 30 studies

Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Research Excerpts

ExcerptRelevanceReference
"To assess lamotrigine effectiveness in bipolar disorder (BD) patients in a clinical setting."9.13Effectiveness of lamotrigine in bipolar disorder in a clinical setting. ( Bonner, JC; Brooks, JO; Champion, LM; Culver, JL; Hoblyn, JC; Ketter, TA; Marsh, WK; Nam, JY, 2008)
"Lamotrigine has a modulating effect on glutamatergic neurotransmission relevant to pathophysiology of both schizophrenia and OCD."6.75Lamotrigine augmentation in schizophrenia and schizoaffective patients with obsessive-compulsive symptoms. ( Glick, I; Koran, LM; Poyurovsky, M, 2010)
"Lamotrigine (LTG) is a novel antiepileptic drug effective in partial and generalized seizures."5.31Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. ( Karaduman, A; Yalçin, B, 2000)
"To assess lamotrigine effectiveness in bipolar disorder (BD) patients in a clinical setting."5.13Effectiveness of lamotrigine in bipolar disorder in a clinical setting. ( Bonner, JC; Brooks, JO; Champion, LM; Culver, JL; Hoblyn, JC; Ketter, TA; Marsh, WK; Nam, JY, 2008)
" The authors wished to prospectively study the efficacy of lamotrigine as adjunctive or monotherapy in adolescents with bipolar disorder who were experiencing a depressive episode."5.12An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression. ( Chang, K; Howe, M; Saxena, K, 2006)
"A 40-year old woman with a history of acute psychotic symptoms developed agranulocytosis and neutropenia after starting therapy that included lamotrigine, mirtazapine, quetiapine, and venlafaxine."3.78Fatal agranulocytosis associated with psychotropic medication use. ( Al-Najjar, T; Ali, BA; Nazer, LH; Shankar, G, 2012)
"Lamotrigine has a modulating effect on glutamatergic neurotransmission relevant to pathophysiology of both schizophrenia and OCD."2.75Lamotrigine augmentation in schizophrenia and schizoaffective patients with obsessive-compulsive symptoms. ( Glick, I; Koran, LM; Poyurovsky, M, 2010)
"Ms F's hereditary coproporphyria was diagnosed 9 years before the current admission."2.50Lamotrigine in the treatment of psychotic depression associated with hereditary coproporphyria -- case report and a brief review of the literature. ( Gazdag, G; Kassai-Farkas, Á; Makkos, Z; Pusztai, Á; Takács, R; Ungvári, GS, 2014)
"Treatment with Lamotrigine and Amisulpiride achieved an excellent response, and she has remained symptom free for 7 months."2.48Temporal lobe epilepsy masquerading as psychosis--a case report and literature review. ( Hamelijnck, J; Needham, E, 2012)
"Psychosis is more common in people with temporal lobe epilepsy than it is in the general population."1.39Electroconvulsive therapy for psychosis in a patient with epilepsy related to hypothalamic hamartoma. ( Foucher, J; Hirsch, E; Lalanne, L; Ruppert, E; Vidailhet, P; Zimmermann, MA, 2013)
" Variables included in the analysis were age, gender, and concomitant treatment with a total of 41 drugs most often used in combination with quetiapine."1.34Quetiapine and drug interactions: evidence from a routine therapeutic drug monitoring service. ( Castberg, I; Skogvoll, E; Spigset, O, 2007)
"Lamotrigine (LTG) is a novel antiepileptic drug effective in partial and generalized seizures."1.31Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. ( Karaduman, A; Yalçin, B, 2000)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (13.33)18.2507
2000's15 (50.00)29.6817
2010's10 (33.33)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Chen, AS1
Kendall, LK1
Peretti, CS1
Chouinard, G1
Ruppert, E1
Lalanne, L1
Foucher, J1
Zimmermann, MA1
Hirsch, E1
Vidailhet, P1
Takács, R1
Makkos, Z1
Kassai-Farkas, Á1
Pusztai, Á1
Ungvári, GS1
Gazdag, G1
Szmulewicz, AG1
Valerio, MP1
Smith, JM1
Nixon, AC1
Doak, MW1
Crozier, H1
Crooks, DP1
Waring, WS1
Poyurovsky, M1
Glick, I1
Koran, LM1
Muzyk, A1
Gala, G1
Kahn, DA1
Ventriglio, A1
Vincenti, A1
Centorrino, F1
Talamo, A1
Fitzmaurice, G1
Baldessarini, RJ1
Needham, E1
Hamelijnck, J1
Turan, AB1
Seferoglu, M1
Taskapilioglu, O1
Bora, I1
Nazer, LH1
Shankar, G1
Ali, BA1
Al-Najjar, T1
Stuve, W1
Wessels, A1
Timmerman, L1
Dietrich, DE1
Gödecke-Koch, T1
Richter-Witte, C1
Emrich, HM1
Calabrese, JR1
Kasper, S1
Johnson, G1
Tajima, O1
Vieta, E1
Yatham, LN1
Young, AH1
De León, OA2
Stahl, SM1
Chan, YC1
Miller, KM1
Shaheen, N1
Votolato, NA1
Hankins, MB1
Clemens, B1
Heck, AH1
de Groot, IW1
van Harten, PN1
Reiss, JP1
Sam, D1
Sareen, J1
Chang, K1
Saxena, K1
Howe, M1
Hug, BL1
Castberg, I1
Skogvoll, E1
Spigset, O1
Ketter, TA1
Brooks, JO1
Hoblyn, JC1
Champion, LM1
Nam, JY1
Culver, JL1
Marsh, WK1
Bonner, JC1
Erfurth, A2
Walden, J1
Grunze, H2
Amann, B1
Furmaga, KM1
Bozikas, V1
Vartzopoulos, D1
Phocas, C1
Karavatos, A1
Kaprinis, G1
Yalçin, B1
Karaduman, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972]Phase 216 participants (Actual)Interventional2013-05-31Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for lamotrigine and Psychotic Disorders

ArticleYear
Lamotrigine in the treatment of psychotic depression associated with hereditary coproporphyria -- case report and a brief review of the literature.
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2014, Volume: 16, Issue:1

    Topics: Adult; Antipsychotic Agents; Coproporphyria, Hereditary; Depressive Disorder, Major; Female; Humans;

2014
Temporal lobe epilepsy masquerading as psychosis--a case report and literature review.
    Neurocase, 2012, Volume: 18, Issue:5

    Topics: Adult; Amisulpride; Anticonvulsants; Antipsychotic Agents; Diagnosis, Differential; Epilepsy, Tempor

2012
International Consensus Group on Bipolar I Depression Treatment Guidelines.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:4

    Topics: Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as

2004

Trials

4 trials available for lamotrigine and Psychotic Disorders

ArticleYear
Lamotrigine augmentation in schizophrenia and schizoaffective patients with obsessive-compulsive symptoms.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Antimanic Agents; Antipsychotic Agents; Compulsive Behavior; Drug Administration

2010
Addition of lamotrigine to clozapine in inpatients with chronic psychosis.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:10

    Topics: Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Humans; Lamotrigine; Mi

2005
An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:3

    Topics: Adolescent; Antimanic Agents; Anxiety Disorders; Attention Deficit and Disruptive Behavior Disorders

2006
Effectiveness of lamotrigine in bipolar disorder in a clinical setting.
    Journal of psychiatric research, 2008, Volume: 43, Issue:1

    Topics: Adult; Ambulatory Care; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Clinical Protocols; Coh

2008

Other Studies

23 other studies available for lamotrigine and Psychotic Disorders

ArticleYear
The Role of Lamotrigine in Postpartum Psychosis.
    The primary care companion for CNS disorders, 2022, 07-28, Volume: 24, Issue:4

    Topics: Anticonvulsants; Female; Humans; Lamotrigine; Postpartum Period; Psychotic Disorders; Puerperal Diso

2022
Aripiprazole Combined with Lamotrigine in the Treatment of a Treatment-Resistant Schizophrenic Patient with Tardive Dyskinesia and Supersensitivity Psychosis.
    Psychotherapy and psychosomatics, 2019, Volume: 88, Issue:5

    Topics: Antipsychotic Agents; Aripiprazole; Drug Resistance; Drug Therapy, Combination; Humans; Lamotrigine;

2019
Electroconvulsive therapy for psychosis in a patient with epilepsy related to hypothalamic hamartoma.
    Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:3

    Topics: Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clobazam; Delusions; Drug Resistance; Electr

2013
Obsessive-compulsive symptoms in adjunctive therapy with lamotrigine in clozapine-medicated patients.
    Schizophrenia research, 2015, Volume: 166, Issue:1-3

    Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Drug Therapy, Combination; Female;

2015
Patterns of antiepileptic drug overdose differ between men and women: admissions to the Edinburgh Poisons Unit, 2000-2007.
    QJM : monthly journal of the Association of Physicians, 2009, Volume: 102, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Overdose; Female; Humans; Lamotrigine; Male; Middle Aged

2009
Use of lamotrigine in a patient with a clozapine-related seizure.
    Journal of psychiatric practice, 2010, Volume: 16, Issue:2

    Topics: Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug

2010
Use of mood stabilizers for hospitalized psychotic and bipolar disorder patients.
    International clinical psychopharmacology, 2011, Volume: 26, Issue:2

    Topics: Anticonvulsants; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Dr

2011
Vulnerability of an epileptic case to psychosis: sodium valproate with lamotrigine, forced normalization, postictal psychosis or all?
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2012, Volume: 33, Issue:5

    Topics: Adult; Age of Onset; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epil

2012
Fatal agranulocytosis associated with psychotropic medication use.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2012, May-15, Volume: 69, Issue:10

    Topics: Adult; Agranulocytosis; Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Ag

2012
Remission of positive symptomatology of a schizophrenic psychosis after withdrawing lamotrigine: a case report.
    European psychiatry : the journal of the Association of European Psychiatrists, 2004, Volume: 19, Issue:1

    Topics: Adult; Antimanic Agents; Humans; Lamotrigine; Male; Psychotic Disorders; Remission, Spontaneous; Sch

2004
Lamotrigine in the treatment of confusion psychosis. A case report.
    Pharmacopsychiatry, 2004, Volume: 37, Issue:2

    Topics: Adult; Antidepressive Agents; Confusion; Female; Humans; Lamotrigine; Middle Aged; Psychotic Disorde

2004
Treatment of psychotic symptoms with lamotrigine in Alzheimer disease.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Female; Humans; Lamotrigine; Psychotic

2004
Anticonvulsants as mood stabilizers and adjuncts to antipsychotics: valproate, lamotrigine, carbamazepine, and oxcarbazepine and actions at voltage-gated sodium channels.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:6

    Topics: Affect; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Drug Therapy, Combin

2004
Worsening of psychotic symptoms in schizophrenia with addition of lamotrigine: a case report.
    Schizophrenia research, 2005, Oct-15, Volume: 78, Issue:2-3

    Topics: Adult; Antipsychotic Agents; Brain; Clozapine; Drug Therapy, Combination; Female; Humans; Lamotrigin

2005
Forced normalisation precipitated by lamotrigine.
    Seizure, 2005, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Behavioral Symptoms; Electroencephalography; Epilepsy; Female; H

2005
Psychosis in multiple sclerosis associated with left temporal lobe lesions on serial MRI scans.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2006, Volume: 13, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Delusions; Excitatory Amino Acid Antagonists; Female;

2006
[Somnolence of unknown origin--illness or drug problem?].
    Therapeutische Umschau. Revue therapeutique, 2006, Volume: 63, Issue:12

    Topics: Anticonvulsants; Carbamazepine; Diagnosis, Differential; Disorders of Excessive Somnolence; Drug Int

2006
Quetiapine and drug interactions: evidence from a routine therapeutic drug monitoring service.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Carbamazepine; Dibenz

2007
Lamotrigine in the treatment of schizoaffective disorder.
    Neuropsychobiology, 1998, Volume: 38, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Antimanic Agents; Drug Administration Schedule; Fem

1998
Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?
    Neuropsychobiology, 1998, Volume: 38, Issue:3

    Topics: Adult; Antimanic Agents; Female; Humans; Lamotrigine; Psychotic Disorders; Selective Serotonin Reupt

1998
Effect of lamotrigine treatment in epileptic psychosis.
    Journal of clinical psychopharmacology, 1999, Volume: 19, Issue:2

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Psychotic Disorders; Triazines

1999
Lamotrigine-induced rash after sun exposure.
    The American journal of psychiatry, 1999, Volume: 156, Issue:12

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Eruptions; Drug Therapy, Combination; Female; Haloper

1999
Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid.
    Journal of the American Academy of Dermatology, 2000, Volume: 43, Issue:5 Pt 2

    Topics: Adult; Anticonvulsants; Antimanic Agents; Drug Therapy, Combination; Female; Humans; Lamotrigine; Ps

2000