lamotrigine has been researched along with Parkinson Disease in 9 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The phenytoin treatment causes cerebellar defect and anemia." | 2.82 | The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022) |
| "The neurodegenerative disorders (Parkinson's disease, Alzheimer's dementia, Huntington's disease, cerebellar degeneration) are common medical and social problems." | 2.40 | [Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities]. ( Klivényi, P; Vécsei, L, 1997) |
| "In rodent models of Parkinson's disease such as reserpinized or 6-hydroxydopamine substantia nigra lesioned rats, blockade of glutamate receptors of the NMDA (N-methyl-D-aspartate) or the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptor subtypes and concomitant treatment with L-DOPA (L-3,4-dihydroxyphenylalanine) or direct dopamine agonists restores locomotor activity and induces rotations." | 1.29 | Lamotrigine has no antiparkinsonian activity in rat models of Parkinson's disease. ( Eblen, F; Kockgether, T; Löschmann, PA; Wachtel, H; Wüllner, U, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Panda, SP | 1 |
| Dhurandhar, Y | 1 |
| Agrawal, M | 1 |
| Marino, SE | 1 |
| Meador, KJ | 1 |
| Loring, DW | 1 |
| Okun, MS | 1 |
| Fernandez, HH | 1 |
| Fessler, AJ | 1 |
| Kustra, RP | 1 |
| Miller, JM | 1 |
| Ray, PG | 1 |
| Roy, A | 1 |
| Schoenberg, MR | 1 |
| Vahle, VJ | 1 |
| Werz, MA | 1 |
| Sabolek, M | 1 |
| Runge, U | 1 |
| Meldrum, BS | 1 |
| Zipp, F | 2 |
| Baas, H | 2 |
| Fischer, PA | 2 |
| Löschmann, PA | 1 |
| Eblen, F | 1 |
| Wüllner, U | 1 |
| Wachtel, H | 1 |
| Kockgether, T | 1 |
| Klivényi, P | 1 |
| Vécsei, L | 1 |
| Shinotoh, H | 1 |
| Vingerhoets, FJ | 1 |
| Lee, CS | 1 |
| Uitti, RJ | 1 |
| Schulzer, M | 1 |
| Calne, DB | 1 |
| Tsui, J | 1 |
| Bürklin, F | 1 |
| Stecker, K | 1 |
3 reviews available for lamotrigine and Parkinson Disease
| Article | Year |
|---|---|
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La | 2022 |
The role of glutamate in epilepsy and other CNS disorders.
Topics: Animals; Central Nervous System Diseases; Epilepsy; Glutamic Acid; Humans; Lamotrigine; Mice; N-Meth | 1994 |
[Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities].
Topics: Aged; Aging; Alzheimer Disease; Calcium Channel Blockers; Cerebellar Diseases; Dementia; Electron Tr | 1997 |
3 trials available for lamotrigine and Parkinson Disease
| Article | Year |
|---|---|
Subjective perception of cognition is related to mood and not performance.
Topics: Adult; Affect; Anticonvulsants; Cognition; Cross-Over Studies; Depression; Double-Blind Method; Epil | 2009 |
Lamotrigine trial in idiopathic parkinsonism: a double-blind, placebo-controlled, crossover study.
Topics: Adult; Anticonvulsants; Antiparkinson Agents; Carbidopa; Cross-Over Studies; Dose-Response Relations | 1997 |
Lamotrigine in Parkinson's disease--a double blind study.
Topics: Adult; Aged; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Lamotrigine; Male; Middl | 1995 |
3 other studies available for lamotrigine and Parkinson Disease
| Article | Year |
|---|---|
Lamotrigine induced dyskinesia in Parkinson's disease.
Topics: Anticonvulsants; Dopamine Agonists; Dyskinesia, Drug-Induced; Epilepsy, Temporal Lobe; Humans; Lamot | 2010 |
Lamotrigine--antiparkinsonian activity by blockade of glutamate release?
Topics: Aged; Anticonvulsants; Antiparkinson Agents; Female; Glutamates; Glutamic Acid; Humans; Lamotrigine; | 1993 |
Lamotrigine has no antiparkinsonian activity in rat models of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Apomorphine; Dose-Response Relationship, Drug; Lamotrigine; Male; Mot | 1995 |