lamotrigine has been researched along with Neural Tube Defects in 3 studies
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This limitation and high risks of neural tube and other major teratogenic effects, especially of valproate, indicate the need for great caution in the use of valproate and carbamazepine to treat bipolar disorder in women of child-bearing age." | 3.88 | Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary. ( Baldessarini, RJ; Patel, N; Viguera, AC, 2018) |
| " Plasma homocysteine, folate, vitamins B12 and B6 (pyridoxal phosphate), and red cell folate levels were measured in samples while she was receiving folic acid therapy for 1 month during the second trimester of pregnancy." | 3.73 | Antiepileptic drugs: a case report in a pregnancy with a neural tube defect. ( Bongain, A; Candito, M; Guéant, JL; Naimi, M; Van Obberghen, E, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, N | 1 |
| Viguera, AC | 1 |
| Baldessarini, RJ | 1 |
| Combs-Cantrell, DT | 1 |
| Yerby, MS | 1 |
| Candito, M | 1 |
| Guéant, JL | 1 |
| Naimi, M | 1 |
| Bongain, A | 1 |
| Van Obberghen, E | 1 |
3 other studies available for lamotrigine and Neural Tube Defects
| Article | Year |
|---|---|
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Dietary Supplements; Female; Fol | 2018 |
Case reports of women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Lamo | 2003 |
Antiepileptic drugs: a case report in a pregnancy with a neural tube defect.
Topics: Adult; Anticonvulsants; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Myoclonic Epilepsy, J | 2006 |