lamotrigine has been researched along with MELAS Syndrome in 2 studies
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 16-year-old woman with MELAS developed fever and myoclonic epilepsy which improved with conventional anti-epileptic drugs." | 5.39 | [A case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) with treatment-resistant status epilepticus that was effectively treated with lamotrigine]. ( Hayashi, S; Kai, T; Maruyama, Y; Masuda, S; Nagado, T; Tokunaga, H, 2013) |
| "A 16-year-old woman with MELAS developed fever and myoclonic epilepsy which improved with conventional anti-epileptic drugs." | 1.39 | [A case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) with treatment-resistant status epilepticus that was effectively treated with lamotrigine]. ( Hayashi, S; Kai, T; Maruyama, Y; Masuda, S; Nagado, T; Tokunaga, H, 2013) |
| "A 41-year-old Caucasian female with MELAS syndrome, presenting with short stature, microcytic anaemia, increased blood-sedimentation rate, myopathy, hyper-gammaglobulinaemia, an iron-metabolism defect, migraine-like headaches, and stroke-like episodes, developed complex partial and generalised seizures at age 32 years." | 1.36 | Regression of stroke-like lesions in MELAS-syndrome after seizure control. ( Barton, P; Finsterer, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kai, T | 1 |
| Masuda, S | 1 |
| Tokunaga, H | 1 |
| Hayashi, S | 1 |
| Nagado, T | 1 |
| Maruyama, Y | 1 |
| Finsterer, J | 1 |
| Barton, P | 1 |
2 other studies available for lamotrigine and MELAS Syndrome
| Article | Year |
|---|---|
[A case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) with treatment-resistant status epilepticus that was effectively treated with lamotrigine].
Topics: Adolescent; Anticonvulsants; Drug Resistance; Female; Humans; Lamotrigine; MELAS Syndrome; Status Ep | 2013 |
Regression of stroke-like lesions in MELAS-syndrome after seizure control.
Topics: Adult; Anticonvulsants; Cerebral Cortex; Diagnosis, Differential; Electroencephalography; Female; Hu | 2010 |