lamotrigine has been researched along with Exanthema in 66 studies
Exanthema: Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lamotrigine is a novel anticonvulsant agent that has recently been introduced as a long-term treatment in bipolar disorder." | 8.82 | Lamotrigine in the treatment of bipolar disorder. ( Bhagwagar, Z; Goodwin, GM, 2005) |
| "To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine." | 8.81 | Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002) |
| "Although lamotrigine may be useful for treating patients with treatment-resistant bipolar disorder, some lamotrigine-associated adverse effects, including mild to moderate skin rash, may prevent the continuation of treatment." | 7.88 | Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder. ( Inaba, T; Kato, TA; Kunitake, Y; Mizoguchi, Y; Monji, A; Sogawa, R; Tateishi, H, 2018) |
| " We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion." | 7.83 | Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( Ozisik, L; Saka, E; Tanriover, MD, 2016) |
| "Lamotrigine (LTG) has a good efficacy and tolerability as initial monotherapy for patients with newly diagnosed epilepsy (NDE)." | 7.79 | Depression in patients with newly diagnosed epilepsy predicts lamotrigine-induced rash: a short-term observational study. ( Park, SP, 2013) |
| "This is the first reported case of lamotrigine-induced DRESS syndrome with pancreatitis as the initial visceral involvement." | 7.76 | First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis. ( Augusto, JF; Croue, A; Dib, N; Lerolle, N; Mercat, A; Peres, M; Roquin, G, 2010) |
| "To examine the safety of lamotrigine (LTG) used in general practice to treat epilepsy." | 7.69 | Safety of long-term lamotrigine in epilepsy. ( Freemantle, SN; Mackay, FJ; Mann, RD; Pearce, GL; Wilton, LV, 1997) |
| " Partly because of these properties, frequent dosing adjustments are generally unnecessary, and therapeutic monitoring is not required under most circumstances." | 6.43 | Pharmacokinetics, toxicology and safety of lamotrigine in epilepsy. ( Biton, V, 2006) |
| "Angioedema has been reported with the use of oxcarbazepine and carbamazepine." | 5.38 | Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine. ( Alkhotani, A; McLachlan, RS, 2012) |
| "We assessed rash incidence in 100 patients with DSM-IV bipolar disorder instructed, for their first 3 months taking lamotrigine, to avoid other new medicines and new foods, cosmetics, conditioners, deodorants, detergents, and fabric softeners, as well as sunburn and exposure to poison ivy/oak." | 5.11 | Dermatology precautions and slower titration yield low incidence of lamotrigine treatment-emergent rash. ( Alarcon, AM; Becker, OV; Chandler, RA; Ketter, TA; Nowakowska, C; O'Keeffe, CM; Schumacher, MR; Wang, PW, 2005) |
| "Lamotrigine is a novel anticonvulsant agent that has recently been introduced as a long-term treatment in bipolar disorder." | 4.82 | Lamotrigine in the treatment of bipolar disorder. ( Bhagwagar, Z; Goodwin, GM, 2005) |
| "To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine." | 4.81 | Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002) |
| "We prospectively enrolled 33 adult patients (age 18-85) who were diagnosed with epilepsy and started lamotrigine administration for the first time at a single tertiary hospital." | 4.02 | A new rapid titration protocol for lamotrigine that reduces the risk of skin rash. ( Chang, H; Chu, K; Jang, Y; Jun, JS; Jung, KH; Jung, KY; Kang, HR; Kim, N; Kim, TJ; Lee, SK; Lee, ST; Moon, J; Park, KI; Shin, YW, 2021) |
| "Although lamotrigine may be useful for treating patients with treatment-resistant bipolar disorder, some lamotrigine-associated adverse effects, including mild to moderate skin rash, may prevent the continuation of treatment." | 3.88 | Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder. ( Inaba, T; Kato, TA; Kunitake, Y; Mizoguchi, Y; Monji, A; Sogawa, R; Tateishi, H, 2018) |
| " We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion." | 3.83 | Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( Ozisik, L; Saka, E; Tanriover, MD, 2016) |
| "Lamotrigine (LTG) has a good efficacy and tolerability as initial monotherapy for patients with newly diagnosed epilepsy (NDE)." | 3.79 | Depression in patients with newly diagnosed epilepsy predicts lamotrigine-induced rash: a short-term observational study. ( Park, SP, 2013) |
| " All had dermatological manifestations, eosinophilia and systemic (haematological and hepatic) manifestations that could be attributed to treatment with aromatic AEDs (carbamazepine, 2 patients; lamotrigine, 3 patients; phenytoin, 3 patients)." | 3.77 | Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. ( Kochen, S; Pereira de Silva, N; Piquioni, P; Saidon, P, 2011) |
| "This is the first reported case of lamotrigine-induced DRESS syndrome with pancreatitis as the initial visceral involvement." | 3.76 | First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis. ( Augusto, JF; Croue, A; Dib, N; Lerolle, N; Mercat, A; Peres, M; Roquin, G, 2010) |
| "We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy." | 3.75 | Life-threatening organ failure after lamotrigine therapy. ( Dargan, PI; Ferguson, LP; Hood, JL; Tibby, SM, 2009) |
| " We present a 12 years old female who was a known case of idiopathic generalized tonic-clonic convulsion and presented with fever, diarrhea and generalized erythematous eruption after 2 weeks of being under treatment with maintenance doses of Lamotrigine (LTG) and Valproate (VPA)." | 3.74 | Intravenous immunoglobulin in the treatment of lamotrigine- induced toxic epidermal necrolysis. ( Inaloo, S; Serati Shirazi, Z, 2008) |
| "This report describes the laboratory and physical manifestations of lamotrigine-like toxicity in a young man with refractory epilepsy receiving lamotrigine presenting as anticonvulsant hypersensitivity syndrome (AHS) associated with an abrupt change of drug product." | 3.74 | Progressive anticonvulsant hypersensitivity syndrome associated with change of drug product. ( Sabers, A; Sabroe, TP, 2008) |
| "To examine the safety of lamotrigine (LTG) used in general practice to treat epilepsy." | 3.69 | Safety of long-term lamotrigine in epilepsy. ( Freemantle, SN; Mackay, FJ; Mann, RD; Pearce, GL; Wilton, LV, 1997) |
| "Lamotrigine was added to the current therapy regime for DSM-IV bipolar I patients on an open-label basis for 12 weeks." | 2.74 | Rash in adult patients receiving lamotrigine to treat bipolar I disorder in Korea: a multicenter, prospective, naturalistic, open-label trial. ( Ahn, YM; Bahk, WM; Chung, SK; Jon, DI; Joo, YH; Jung, SH; Kim, W; Kim, Y; Lee, YS; Min, KJ; Seo, JS; Seok, JH; Shin, YC; Won, SH; Woo, YS; Yoon, BH, 2009) |
| "Carbamazepine or phenytoin was withdrawn over the next 4 weeks; then patients entered a 12-week monotherapy period." | 2.69 | An active-control trial of lamotrigine monotherapy for partial seizures. ( Chang, GY; Gilliam, F; Messenheimer, J; Nyberg, J; Risner, ME; Rudd, GD; Sackellares, JC; Vazquez, B, 1998) |
| "Rash was the most commonly reported AE, occurring in 7." | 2.52 | Safety of lamotrigine in paediatrics: a systematic review. ( Choonara, I; Egunsola, O; Sammons, HM, 2015) |
| "The overall incidence of skin rash with LTG therapy was 9." | 2.52 | Risk of a lamotrigine-related skin rash: current meta-analysis and postmarketing cohort analysis. ( Huang, DH; Huang, XS; Jia, WQ; Lang, SY; Tian, CL; Wang, XQ; Xiong, J; Xu, WH; Yu, SY; Zhang, JT, 2015) |
| "Rash was the only adverse effect causing discontinuation (N = 7)." | 2.46 | Lamotrigine adjunctive therapy for refractory generalized tonic-clonic seizures. ( Leong, K; Marson, AG; Tjia-Leong, E, 2010) |
| "Lamotrigine has been shown to be useful in the long-term prophylaxis of depressive episodes in BD." | 2.45 | Lamotrigine-associated rash: to rechallenge or not to rechallenge? ( Bhagwagar, Z; Lorberg, B; Youssef, NA, 2009) |
| " Partly because of these properties, frequent dosing adjustments are generally unnecessary, and therapeutic monitoring is not required under most circumstances." | 2.43 | Pharmacokinetics, toxicology and safety of lamotrigine in epilepsy. ( Biton, V, 2006) |
| " Data from clinical trials clearly point to exceeding currently recommended dosage guidelines of lamotrigine and co-administration of valproic acid (valproate sodium) as risk factors for rash." | 2.40 | Safety review of adult clinical trial experience with lamotrigine. ( Giorgi, L; Messenheimer, J; Mullens, EL; Young, F, 1998) |
| "The mechanism of drug-induced skin rash is not well understood." | 1.91 | Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash. ( Bairam, A; Cao, Y; Liu, MC; Uetrecht, J, 2023) |
| "Patients with DRESS syndrome typically present with rash, swelling, fever, and systemic manifestations." | 1.72 | DRUG-INDUCED HYPERSENSITIVITY SYNDROME CAUSED BY LAMOTRIGINE, A CASE REPORT. ( Ikić Matijašević, M; Nesek Adam, V; Vrhovski, D, 2022) |
| "Lithium carbonate was associated with increased risks of rash (PT), drug interaction (PT), and tubulointerstitial diseases (SMQ)." | 1.72 | Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database. ( Nabekura, T; Uwai, Y, 2022) |
| "The diagnoses were major depressive disorder (n = 39), bipolar I disorder (n = 10), and bipolar II disorder (n = 35)." | 1.56 | A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash. ( Kagawa, S; Kondo, T; Mihara, K; Nagai, G; Nakamura, A; Nemoto, K; Suzuki, T, 2020) |
| " LEV has milder adverse events than OXC and LTG in clinical practice." | 1.56 | Comparison of long-term efficacy, tolerability, and safety of oxcarbazepine, lamotrigine, and levetiracetam in patients with newly diagnosed focal epilepsy: An observational study in the real world. ( Li, R; Li, Y; Ou, S; Pan, S; Wang, Y; Xia, L; Zhou, Q, 2020) |
| "Maculopapular exanthema and delayed-appearing urticaria were the most reported hypersensitivity reactions to AEDs." | 1.51 | Hypersensitivity reactions to antiepileptic drugs in children. ( Atanasković-Marković, M; Ćirković Veličković, T; Gavrović-Jankulović, M; Janković, J; Nikolić, D; Škorić, D; Tmušić, V, 2019) |
| "She was diagnosed with left frontal lobe epilepsy, and a lamotrigine regimen was initiated." | 1.40 | Seizure freedom after lamotrigine rash: a peculiar phenomenon in epilepsy. ( Iwasaki, M; Jin, K; Kakisaka, Y; Kato, K; Nakasato, N, 2014) |
| "Angioedema has been reported with the use of oxcarbazepine and carbamazepine." | 1.38 | Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine. ( Alkhotani, A; McLachlan, RS, 2012) |
| "The development of a skin rash is often associated with a rapid escalation of lamotrigine dose." | 1.35 | Feasibility of a slower lamotrigine titration schedule for bipolar depression: a naturalistic study. ( Chang, JS; Ha, K; Ha, TH; Joe, SH; Rim, HD; Won, S, 2009) |
| " The dosage schedule was: 5 mg every day or every second day for 14 days, increased by 5 mg every 14th day to 25 mg a day." | 1.33 | Lamotrigine-induced rash--worth a rechallenge. ( Dam, M; P-Codrea Tigaran, S; Sidenius, P, 2005) |
| "Severe rash is rare when using the currently recommended titration rate." | 1.33 | Predictors of Lamotrigine-associated rash. ( Buchsbaum, R; Hager, M; Hirsch, LJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, DB, 2006) |
| "Lamotrigine is a novel anticonvulsant initially used in epilepsy treatment." | 1.33 | The relevance of monitoring lamotrigine serum concentrations in chronic pain patients. ( Devulder, J, 2006) |
| "The lamotrigine was stopped immediately when the rash was identified and was subsequently re-introduced, using a special very-low-dose-escalation regime, starting with 0." | 1.31 | Successful re-introduction of lamotrigine after initial rash. ( Besag, FM; Ng, GY; Pool, F, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (9.09) | 18.2507 |
| 2000's | 25 (37.88) | 29.6817 |
| 2010's | 24 (36.36) | 24.3611 |
| 2020's | 11 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelnabi, M | 1 |
| Elmssary, M | 1 |
| Sekhon, J | 1 |
| Benjanuwattra, J | 1 |
| Uwai, Y | 1 |
| Nabekura, T | 1 |
| Vrhovski, D | 1 |
| Ikić Matijašević, M | 1 |
| Nesek Adam, V | 1 |
| Cao, Y | 1 |
| Bairam, A | 1 |
| Liu, MC | 1 |
| Uetrecht, J | 1 |
| Tsai, LH | 1 |
| Lin, JW | 1 |
| Suzuki, T | 1 |
| Mihara, K | 1 |
| Nagai, G | 1 |
| Kagawa, S | 1 |
| Nakamura, A | 1 |
| Nemoto, K | 1 |
| Kondo, T | 1 |
| Fujii, K | 1 |
| Okayasu, H | 1 |
| Shinozaki, T | 1 |
| Shimoda, K | 1 |
| Ozeki, Y | 1 |
| Bresnahan, R | 1 |
| Panebianco, M | 1 |
| Marson, AG | 2 |
| Li, R | 1 |
| Zhou, Q | 1 |
| Ou, S | 1 |
| Wang, Y | 1 |
| Li, Y | 1 |
| Xia, L | 1 |
| Pan, S | 1 |
| Thirumalareddy, AR | 1 |
| Konakanchi, VC | 1 |
| Boina, K | 1 |
| Suggu, S | 1 |
| Shirzadi, M | 1 |
| Saunes, M | 1 |
| Reimers, A | 1 |
| Brodtkorb, E | 1 |
| Jang, Y | 1 |
| Moon, J | 1 |
| Kim, N | 1 |
| Kim, TJ | 1 |
| Jun, JS | 1 |
| Shin, YW | 1 |
| Chang, H | 1 |
| Kang, HR | 1 |
| Lee, ST | 1 |
| Jung, KH | 1 |
| Park, KI | 1 |
| Jung, KY | 1 |
| Chu, K | 1 |
| Lee, SK | 2 |
| Kverno, K | 1 |
| Beauvois, L | 1 |
| Dudley-Brown, S | 1 |
| Iriki, H | 1 |
| Ouchi, T | 1 |
| Ito, H | 1 |
| Sawada, M | 1 |
| Mukai, M | 1 |
| Nomura, H | 1 |
| Baba, Y | 1 |
| Adachi, T | 1 |
| Funakoshi, T | 1 |
| Amagai, M | 1 |
| Takahashi, H | 1 |
| Inaba, T | 1 |
| Sogawa, R | 1 |
| Mizoguchi, Y | 1 |
| Tateishi, H | 1 |
| Kunitake, Y | 1 |
| Kato, TA | 1 |
| Monji, A | 1 |
| Hosohata, K | 1 |
| Inada, A | 1 |
| Oyama, S | 1 |
| Niinomi, I | 1 |
| Wakabayashi, T | 1 |
| Iwanaga, K | 1 |
| Atanasković-Marković, M | 1 |
| Janković, J | 1 |
| Tmušić, V | 1 |
| Gavrović-Jankulović, M | 1 |
| Ćirković Veličković, T | 1 |
| Nikolić, D | 1 |
| Škorić, D | 1 |
| Park, SP | 1 |
| Kakisaka, Y | 1 |
| Jin, K | 1 |
| Kato, K | 1 |
| Iwasaki, M | 1 |
| Nakasato, N | 1 |
| Wang, XQ | 2 |
| Xiong, J | 1 |
| Xu, WH | 1 |
| Yu, SY | 1 |
| Huang, XS | 1 |
| Zhang, JT | 1 |
| Tian, CL | 1 |
| Huang, DH | 1 |
| Jia, WQ | 1 |
| Lang, SY | 2 |
| Nathan, K | 1 |
| Agarwal, A | 1 |
| Gable, B | 1 |
| McFarland, M | 1 |
| Egunsola, O | 1 |
| Choonara, I | 1 |
| Sammons, HM | 1 |
| Provenzani, A | 1 |
| Labbozzetta, M | 1 |
| Notarbartolo, M | 1 |
| Poma, P | 1 |
| Polidori, P | 1 |
| Vizzini, G | 1 |
| D'Alessandro, N | 1 |
| Jang, HW | 1 |
| Kim, SW | 1 |
| Cho, YJ | 1 |
| Heo, K | 1 |
| Lee, BI | 1 |
| Jang, IJ | 1 |
| Lee, MG | 1 |
| Kim, WJ | 1 |
| Lee, JH | 1 |
| Ozisik, L | 1 |
| Tanriover, MD | 1 |
| Saka, E | 1 |
| Lorberg, B | 1 |
| Youssef, NA | 1 |
| Bhagwagar, Z | 2 |
| Serati Shirazi, Z | 1 |
| Inaloo, S | 1 |
| Joe, SH | 1 |
| Chang, JS | 1 |
| Won, S | 1 |
| Rim, HD | 1 |
| Ha, TH | 1 |
| Ha, K | 1 |
| Ferguson, LP | 1 |
| Dargan, PI | 1 |
| Hood, JL | 1 |
| Tibby, SM | 1 |
| Woo, YS | 1 |
| Bahk, WM | 1 |
| Jon, DI | 1 |
| Joo, YH | 1 |
| Kim, W | 1 |
| Seo, JS | 1 |
| Ahn, YM | 1 |
| Chung, SK | 1 |
| Won, SH | 1 |
| Shin, YC | 1 |
| Yoon, BH | 1 |
| Jung, SH | 1 |
| Seok, JH | 1 |
| Lee, YS | 1 |
| Kim, Y | 1 |
| Min, KJ | 1 |
| Pae, CU | 1 |
| Egger, C | 1 |
| Muehlbacher, M | 1 |
| Grohmann, R | 1 |
| Stuppaeck, C | 1 |
| Shi, XB | 1 |
| Tian, HJ | 1 |
| Wang, RF | 1 |
| Yang, F | 1 |
| Roquin, G | 1 |
| Peres, M | 1 |
| Lerolle, N | 1 |
| Dib, N | 1 |
| Mercat, A | 1 |
| Croue, A | 1 |
| Augusto, JF | 1 |
| Tjia-Leong, E | 1 |
| Leong, K | 1 |
| Pereira de Silva, N | 1 |
| Piquioni, P | 1 |
| Kochen, S | 1 |
| Saidon, P | 1 |
| Mills, JK | 1 |
| Lewis, TG | 1 |
| Mughal, K | 1 |
| Ali, I | 1 |
| Ugur, A | 1 |
| Whitehouse, WP | 1 |
| Moosbrugger, EA | 1 |
| Adams, BB | 1 |
| Yang, CY | 1 |
| Dao, RL | 1 |
| Lee, TJ | 1 |
| Lu, CW | 1 |
| Yang, CH | 1 |
| Hung, SI | 1 |
| Chung, WH | 1 |
| Alkhotani, A | 1 |
| McLachlan, RS | 1 |
| Monzón, S | 1 |
| Garcés, MM | 1 |
| Reichelt, C | 1 |
| Lezaun, A | 1 |
| Colás, C | 1 |
| Singh, J | 1 |
| Zarate, CA | 1 |
| Krystal, AD | 1 |
| Manfredi, G | 1 |
| Pacchiarotti, I | 1 |
| Kotzalidis, GD | 1 |
| Ruberto, A | 1 |
| Girardi, P | 1 |
| Tatarelli, R | 1 |
| Zidd, AG | 1 |
| Hack, JB | 1 |
| P-Codrea Tigaran, S | 1 |
| Sidenius, P | 1 |
| Dam, M | 1 |
| Rahman, M | 1 |
| Haider, N | 1 |
| Ketter, TA | 2 |
| Wang, PW | 1 |
| Chandler, RA | 1 |
| Alarcon, AM | 1 |
| Becker, OV | 1 |
| Nowakowska, C | 1 |
| O'Keeffe, CM | 1 |
| Schumacher, MR | 1 |
| Goodwin, GM | 1 |
| Hirsch, LJ | 1 |
| Weintraub, DB | 1 |
| Buchsbaum, R | 1 |
| Spencer, HT | 1 |
| Straka, T | 1 |
| Hager, M | 1 |
| Resor, SR | 1 |
| Greist, JH | 1 |
| Graham, JA | 1 |
| Roberts, JN | 1 |
| Thompson, TR | 1 |
| Nanry, KP | 1 |
| Devulder, J | 1 |
| Biton, V | 1 |
| Hussain, N | 1 |
| Gosalakkal, JA | 1 |
| Sabroe, TP | 1 |
| Sabers, A | 1 |
| Pellock, JM | 1 |
| Messenheimer, J | 2 |
| Mullens, EL | 1 |
| Giorgi, L | 1 |
| Young, F | 1 |
| Mackay, FJ | 1 |
| Wilton, LV | 1 |
| Pearce, GL | 1 |
| Freemantle, SN | 1 |
| Mann, RD | 1 |
| Tugendhaft, P | 1 |
| Simonart, T | 1 |
| Gilliam, F | 1 |
| Vazquez, B | 1 |
| Sackellares, JC | 1 |
| Chang, GY | 1 |
| Nyberg, J | 1 |
| Risner, ME | 1 |
| Rudd, GD | 1 |
| Wong, IC | 1 |
| Mawer, GE | 1 |
| Sander, JW | 1 |
| Messenheimer, JA | 1 |
| Guberman, AH | 1 |
| Simpson, DM | 1 |
| Olney, R | 1 |
| McArthur, JC | 1 |
| Khan, A | 1 |
| Godbold, J | 1 |
| Ebel-Frommer, K | 1 |
| Besag, FM | 1 |
| Ng, GY | 1 |
| Pool, F | 1 |
| Wensween, CA | 1 |
| Bouwes Bavinck, JN | 1 |
| Hurley, SC | 1 |
| Anderson, GD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protocol Establishment for the Prevention of Lamotrigine-induced Skin Rash in Epilepsy Patients: A Pilot Study[NCT03220256] | Phase 2 | 30 participants (Anticipated) | Interventional | 2016-08-02 | Recruiting | ||
| A Multi-centre, Observational Study to Evaluate the Incidence of Non-serious Rash in Korean Bipolar I Patients With Lamotrigine Therapy in Real World Setting[NCT00460226] | 238 participants (Actual) | Observational | 2007-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for lamotrigine and Exanthema
| Article | Year |
|---|---|
Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizures.
Topics: Anticonvulsants; Chemotherapy, Adjuvant; Dizziness; Drug Eruptions; Drug Resistant Epilepsy; Epileps | 2020 |
Risk of a lamotrigine-related skin rash: current meta-analysis and postmarketing cohort analysis.
Topics: Anticonvulsants; Drug Eruptions; Exanthema; Humans; Incidence; Lamotrigine; Randomized Controlled Tr | 2015 |
Safety of lamotrigine in paediatrics: a systematic review.
Topics: Abdominal Pain; Anticonvulsants; Child; Dizziness; Drug Therapy, Combination; Exanthema; Headache; H | 2015 |
Lamotrigine-associated rash: to rechallenge or not to rechallenge?
Topics: Anticonvulsants; Bipolar Disorder; Databases, Bibliographic; Dose-Response Relationship, Drug; Drug | 2009 |
Lamotrigine adjunctive therapy for refractory generalized tonic-clonic seizures.
Topics: Anticonvulsants; Chemotherapy, Adjuvant; Drug Eruptions; Epilepsy, Tonic-Clonic; Exanthema; Humans; | 2010 |
Lamotrigine in the treatment of bipolar disorder.
Topics: Bipolar Disorder; Exanthema; Humans; Lamotrigine; Triazines | 2005 |
Pharmacokinetics, toxicology and safety of lamotrigine in epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Exanthema; Humans; Intestinal Absorptio | 2006 |
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; | 1997 |
Safety review of adult clinical trial experience with lamotrigine.
Topics: Adolescent; Adult; Anticonvulsants; Calcium Channel Blockers; Drug Therapy, Combination; Exanthema; | 1998 |
Lamotrigine update and its use in mood disorders.
Topics: Acetates; Aggression; Amines; Antidepressive Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; | 2002 |
Children versus adults: pharmacokinetic and adverse-effect differences.
Topics: Adolescent; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 2002 |
5 trials available for lamotrigine and Exanthema
| Article | Year |
|---|---|
Rash in adult patients receiving lamotrigine to treat bipolar I disorder in Korea: a multicenter, prospective, naturalistic, open-label trial.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Exanthema; Female; Humans; Incidence; Korea; Lamotrigine; | 2009 |
Dermatology precautions and slower titration yield low incidence of lamotrigine treatment-emergent rash.
Topics: Adult; Ambulatory Care; Anticonvulsants; Bipolar Disorder; Cohort Studies; Drug Administration Sched | 2005 |
The effect of dermatologic precautions on the incidence of rash with addition of lamotrigine in the treatment of bipolar I disorder: a randomized trial.
Topics: Adolescent; Adult; Ambulatory Care; Antipsychotic Agents; Bipolar Disorder; Cohort Studies; Comorbid | 2006 |
An active-control trial of lamotrigine monotherapy for partial seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsies, Partial; E | 1998 |
A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy.
Topics: Adult; Analgesics; Analysis of Variance; Double-Blind Method; Drug Eruptions; Exanthema; Female; HIV | 2000 |
50 other studies available for lamotrigine and Exanthema
| Article | Year |
|---|---|
Acute onset of fever, eosinophilia, rash, acute kidney injury, and a positive Monospot test in a patient on lamotrigine: DRESS syndrome.
Topics: Acute Kidney Injury; Anticonvulsants; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Fever | 2022 |
Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database.
Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Drug | 2022 |
DRUG-INDUCED HYPERSENSITIVITY SYNDROME CAUSED BY LAMOTRIGINE, A CASE REPORT.
Topics: Anticonvulsants; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Female; Humans; Lamotrigin | 2022 |
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash.
Topics: Drug Eruptions; Exanthema; Humans; Lamotrigine; Nevirapine; Oxides; Sertraline; Sulfates; Sulfotrans | 2023 |
Use of clozapine for resolving lamotrigine-induced skin lesions caused by schizophrenia treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Exanthema; Female; Humans; Lamotrigine; Schizophrenia | 2019 |
A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash.
Topics: Antipsychotic Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Exanthem | 2020 |
Slower titration of lamotrigine reduces the risk of rash.
Topics: Age Factors; Cross-Sectional Studies; Drug Administration Schedule; Exanthema; Humans; Lamotrigine; | 2020 |
Comparison of long-term efficacy, tolerability, and safety of oxcarbazepine, lamotrigine, and levetiracetam in patients with newly diagnosed focal epilepsy: An observational study in the real world.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Dizziness; Drug A | 2020 |
Acute localised exanthematous pustulosis (ALEP) over penis secondary to lamotrigine.
Topics: Acute Generalized Exanthematous Pustulosis; Anticonvulsants; Exanthema; Humans; Lamotrigine; Male; P | 2022 |
Rash during lamotrigine treatment is not always drug hypersensitivity: A retrospective cohort study among children and adults.
Topics: Adult; Anticonvulsants; Child; Drug Hypersensitivity; Exanthema; Humans; Lamotrigine; Retrospective | 2021 |
A new rapid titration protocol for lamotrigine that reduces the risk of skin rash.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Exanthema; Humans; Lamotrigin | 2021 |
Lamotrigine rash: Benign allergy or severe adverse reaction?
Topics: Adult; Anticonvulsants; Exanthema; Female; Humans; Hypersensitivity; Lamotrigine; Severity of Illnes | 2018 |
Case of lamotrigine-induced drug adverse reaction under tocilizumab treatment with clinical and virological features of drug-induced hypersensitivity syndrome.
Topics: Adult; Antibodies, Monoclonal, Humanized; Anticonvulsants; Arthritis, Rheumatoid; Biopsy; C-Reactive | 2018 |
Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Antimanic Agents; Bipolar Disorder; Che | 2018 |
Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database.
Topics: Anticonvulsants; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Exanthema; Fem | 2019 |
Hypersensitivity reactions to antiepileptic drugs in children.
Topics: Adolescent; Allergens; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Different | 2019 |
Depression in patients with newly diagnosed epilepsy predicts lamotrigine-induced rash: a short-term observational study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Depression; Epilepsy; Exanthema; Female; Humans; Lamotrigi | 2013 |
Seizure freedom after lamotrigine rash: a peculiar phenomenon in epilepsy.
Topics: Anticonvulsants; Drug Eruptions; Epilepsy, Frontal Lobe; Exanthema; Female; Humans; Lamotrigine; Mid | 2014 |
Lamotrigine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).
Topics: Anticonvulsants; Drug Hypersensitivity Syndrome; Eosinophils; Exanthema; Female; Fever; Humans; Lamo | 2015 |
Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?
Topics: Anticonvulsants; Exanthema; Female; Genotype; Glucuronosyltransferase; Humans; Lamotrigine; Multiple | 2015 |
GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy.
Topics: Anticonvulsants; Asian People; Cohort Studies; Drug Eruptions; Epilepsy; Exanthema; Genetic Predispo | 2015 |
Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome.
Topics: Adult; Anticonvulsants; Autoimmune Diseases; Drug Hypersensitivity; Eosinophilia; Exanthema; Female; | 2016 |
Intravenous immunoglobulin in the treatment of lamotrigine- induced toxic epidermal necrolysis.
Topics: Blister; Child; Exanthema; Female; Fever; Humans; Immunoglobulins, Intravenous; Lamotrigine; Seizure | 2008 |
Feasibility of a slower lamotrigine titration schedule for bipolar depression: a naturalistic study.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Dr | 2009 |
Life-threatening organ failure after lamotrigine therapy.
Topics: Anticonvulsants; Child; Contraindications; Drug Therapy, Combination; Exanthema; Female; Fever; Huma | 2009 |
Rash and lamotrigine in bipolar patients.
Topics: Antimanic Agents; Bipolar Disorder; Exanthema; Humans; Lamotrigine; Randomized Controlled Trials as | 2010 |
Clozapine intoxication in a patient with lamotrigine-induced rash.
Topics: Analgesics; Antipsychotic Agents; Bipolar Disorder; Clozapine; Exanthema; Humans; Lamotrigine; Male; | 2010 |
Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Chi | 2010 |
First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis.
Topics: Aged; Drug Eruptions; Eosinophilia; Exanthema; Humans; Lamotrigine; Male; Pancreatitis; Syndrome; Tr | 2010 |
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Carbamazepine; Disease Susceptibility; | 2011 |
Retention rate of clobazam, topiramate and lamotrigine in children with intractable epilepsies at 1 year.
Topics: Adolescent; Benzodiazepines; Child; Child, Preschool; Clobazam; Epilepsy; Exanthema; Female; Fructos | 2011 |
Disseminated eruption of ectopic sebaceous glands following Stevens-Johnson syndrome.
Topics: Adolescent; Biopsy, Needle; Exanthema; Facial Dermatoses; Female; Follow-Up Studies; Humans; Immunoh | 2011 |
Severe cutaneous adverse reactions to antiepileptic drugs in Asians.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Exanthema; Female; Follow-Up Studies; Humans; L | 2011 |
Levetiracetam induced angioedema in a patient with previous anticonvulsant hypersensitivity reaction to phenytoin and lamotrigine.
Topics: Adult; Angioedema; Anticonvulsants; Exanthema; Female; Humans; Lamotrigine; Levetiracetam; Phenytoin | 2012 |
Positive patch test in hypersensitivity to lamotrigine.
Topics: Aged; Anticonvulsants; Exanthema; Humans; Lamotrigine; Male; Patch Tests; Triazines | 2002 |
Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Drug Synergism; Exanthema; Excitatory Amino Acid Ant | 2004 |
Successful rechallenge with slowly titrated lamotrigine after rash.
Topics: Antimanic Agents; Bipolar Disorder; Diagnostic and Statistical Manual of Mental Disorders; Dose-Resp | 2004 |
Pediatric ingestion of lamotrigine.
Topics: Anticonvulsants; Consciousness Disorders; Exanthema; Female; Humans; Infant; Lamotrigine; Liver; Tri | 2004 |
Lamotrigine-induced rash--worth a rechallenge.
Topics: Anticonvulsants; Epilepsy, Generalized; Exanthema; Humans; Lamotrigine; Retrospective Studies; Risk | 2005 |
Anticonvulsant hypersensitivity syndrome from addition of lamotrigine to divalproex.
Topics: Anticonvulsants; Bipolar Disorder; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Fema | 2005 |
Predictors of Lamotrigine-associated rash.
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Anticonvulsants; Child; Drug Administration Schedul | 2006 |
The relevance of monitoring lamotrigine serum concentrations in chronic pain patients.
Topics: Administration, Oral; Adult; Analgesics; Chronic Disease; Cytochrome P-450 Enzyme System; Dose-Respo | 2006 |
Lamotrigine rash--a potentially life-threatening complication.
Topics: Anticonvulsants; Child; Epilepsy; Exanthema; Humans; Lamotrigine; Male; Physical Examination; Triazi | 2007 |
Progressive anticonvulsant hypersensitivity syndrome associated with change of drug product.
Topics: Adult; Anticonvulsants; Arthralgia; Arthritis; Drugs, Generic; Epilepsy; Exanthema; Fever; Humans; L | 2008 |
Safety of long-term lamotrigine in epilepsy.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Anticonvulsants; Chil | 1997 |
Phenytoin-like hypersensitivity associated with lamotrigine.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Exanthema; Humans; Lamotrigine; P | 1998 |
Factors influencing the incidence of lamotrigine-related skin rash.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Therapy, Combinati | 1999 |
Rash with lamotrigine: dosing guidelines.
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Exanthema; Humans; Lamotrigine; Pra | 2000 |
Successful re-introduction of lamotrigine after initial rash.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Adminis | 2000 |
[Overlapping acute disseminated exanthematous pustulosis and toxic epidermal necrolysis].
Topics: Acute Disease; Adult; Anticonvulsants; Diagnosis, Differential; Exanthema; Female; Fever; Humans; La | 2001 |