lamotrigine and Epileptiform Neuralgia studies

Research Excerpts

Excerpt	Relevance	Reference
" In this study, we evaluated the efficacy and occurrence of side effects of lamotrigine (LTG) in comparison with carbamazepine (CBZ), in trigeminal neuralgia (TN) patients."	9.15	Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine. ( Abd Rahman, RB; Shaikh, S; Yaacob, HB, 2011)
" We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)."	7.70	Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000)
"This paper reports on the effectiveness of oral lamotrigine in 15 patients suffering from "essential" trigeminal neuralgia and in five patients suffering symptomatic trigeminal neuralgia concomitant with multiple sclerosis."	7.69	Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia. ( Albano, C; Cultrera, S; Favale, E; Fracassi, M; Leandri, M; Lunardi, G; Rubino, V, 1997)
"Lamotrigine is a chemically novel antiepileptic drug which has not been adequately assessed for its antineuralgic properties."	6.68	Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. ( Chaudhry, Z; Mullens, LE; Nurmikko, TJ; Patton, DW; Zakrzewska, JM, 1997)
" In this study, we evaluated the efficacy and occurrence of side effects of lamotrigine (LTG) in comparison with carbamazepine (CBZ), in trigeminal neuralgia (TN) patients."	5.15	Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine. ( Abd Rahman, RB; Shaikh, S; Yaacob, HB, 2011)
" Memory alteration was least common with lamotrigine and oxcarbazepine, and there was less association between fatigues with oxcarbazepine/pregabalin."	3.88	Adverse effects of anti-epileptics in trigeminal neuralgiform pain. ( Cregg, R; Lee, G; O'Keeffe, AG; Reading, J; Tentolouris-Piperas, V; Zakrzewska, JM, 2018)
" We report 11 MS patients with trigeminal neuralgia (TN): 6 intolerant to a therapeutic dosage of CBZ, showing serious adverse effects and subsequently treated with a combination of low-dose CBZ and gabapentin (GBP) (group 1); 5 treated with lamotrigine (LMT), showing adverse effects and subsequently treated with GBP (group 2)."	3.70	Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. ( Leandri, M; Mancardi, GL; Messmer Uccelli, M; Solaro, C; Uccelli, A, 2000)
"This paper reports on the effectiveness of oral lamotrigine in 15 patients suffering from "essential" trigeminal neuralgia and in five patients suffering symptomatic trigeminal neuralgia concomitant with multiple sclerosis."	3.69	Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia. ( Albano, C; Cultrera, S; Favale, E; Fracassi, M; Leandri, M; Lunardi, G; Rubino, V, 1997)
"Lamotrigine is a chemically novel antiepileptic drug which has not been adequately assessed for its antineuralgic properties."	2.68	Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. ( Chaudhry, Z; Mullens, LE; Nurmikko, TJ; Patton, DW; Zakrzewska, JM, 1997)
" When sodium channel blockers cannot reach full dosage because of side effects, an add-on treatment with lamotrigine or baclofen should be considered."	2.58	Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. ( Cruccu, G; Di Stefano, G; Truini, A, 2018)
"Trigeminal neuralgia is a unique neuropathic pain disorder with a specific therapy."	2.42	Management issues of neuropathic trigeminal pain from a medical perspective. ( Watson, CP, 2004)

Research

Studies (20)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Blood Oxygenation Level-dependent (BOLD) Changes in Neural Pain Circuitry Following Treatment With Lamotrigine During Experimentally Induced Pain States

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (30.00)	18.2507
2000's	6 (30.00)	29.6817
2010's	7 (35.00)	24.3611
2020's	1 (5.00)	2.80

Authors	Studies
Pergolizzi, JV	1
Gharibo, C	1
Magnusson, P	1
Breve, F	1
LeQuang, JA	1
Varrassi, G	1
Tentolouris-Piperas, V	1
Lee, G	1
Reading, J	1
O'Keeffe, AG	1
Zakrzewska, JM	3
Cregg, R	1
Solaro, CM	1
Ferriero, G	1
Di Stefano, G	1
Truini, A	1
Cruccu, G	1
Lambru, G	1
Matharu, MS	1
Scrivani, S	1
Wallin, D	1
Moulton, EA	1
Cole, S	1
Wasan, AD	1
Lockerman, L	1
Bajwa, Z	1
Upadhyay, J	1
Becerra, L	1
Borsook, D	1
Martin, WJ	1
Forouzanfar, T	1
Shaikh, S	1
Yaacob, HB	1
Abd Rahman, RB	1
Watson, CP	1
Jorns, TP	1
Canavero, S	3
Bonicalzi, V	3
Ferroli, P	1
Zeme, S	1
Montalenti, E	1
Benna, P	1
Lunardi, G	1
Leandri, M	3
Albano, C	1
Cultrera, S	1
Fracassi, M	1
Rubino, V	1
Favale, E	1
Chaudhry, Z	1
Nurmikko, TJ	1
Patton, DW	1
Mullens, LE	1
Carrazana, EJ	1
Schachter, SC	1
Solaro, C	2
Messmer Uccelli, M	1
Uccelli, A	1
Mancardi, GL	2
Lundardi, G	1
Inglese, M	1
Messmer-Uccelli, M	1
Gottlieb, A	1
McCleane, GJ	1
Christensen, D	1
Gautron, M	1
Guilbaud, G	1
Kayser, V	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI[NCT00243152]		6 participants (Actual)	Interventional	2005-10-31	Completed
Lamotrigine in Trigeminal Neuralgia: Efficacy and Safety in Comparison With Carbamazepine[NCT00913107]	Phase 2/Phase 3	21 participants (Actual)	Interventional	2007-09-30	Completed
Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain[NCT01447108]	Phase 4	16 participants (Actual)	Interventional	2011-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

fMRI scans acquired Stimuli Type: Brush Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness fMRI scans acquired Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** fMRI scans acquired Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** Cortical, subcortical, and brain stem sensory regions Z-scores Increase or decrease in activation as affected by the drug (NCT00243152)
Timeframe: Week 10 during scanning session

Subjective Ratings of Pain During Magnetic Resonance Scanning

Intervention	Z-statistic (Number)
	Heat Affected Thalamus (10,-14,8)	Heat Affected Post-Central (-56,-12,28)	Cold Affected Post-Central (68, -8, 32)	Cold Affected Thalamus (-4, -8, 0)	Brush Affected Post-Central (66,-16,14)	Brush Affected Thalamus (-14,-22, 4)	Brush Affected Spinal Trigeminal Nucles(2,-48,-68)
Lamotrigine vs Placebo	-2.9294	-2.7323	-2.5114	-3.033	3.905	-3.791	2.9058

"Quantitative Sensory Testing (QST)~Stimuli Type: Heat, Cold, Brush Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness~Ratings on a likert scale of 0-10 with 0 being defined as no pain and 10 being defined as worst possible pain" (NCT00243152)
Timeframe: week 10 (during the scan)

Article	Year
Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. Drugs, 2018, Volume: 78, Issue:14 Topics: Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; Drug Therapy, Combination; Gabapent	2018
SUNCT, SUNA and trigeminal neuralgia: different disorders or variants of the same disorder? Current opinion in neurology, 2014, Volume: 27, Issue:3 Topics: Anticonvulsants; Carbamazepine; Deep Brain Stimulation; Functional Neuroimaging; Humans; Hypothalamu	2014
The efficacy of anticonvulsants on orofacial pain: a systematic review. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2011, Volume: 111, Issue:5 Topics: Amines; Anticonvulsants; Burning Mouth Syndrome; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Ac	2011
Management issues of neuropathic trigeminal pain from a medical perspective. Journal of orofacial pain, 2004,Fall, Volume: 18, Issue:4 Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; C	2004
Evidence-based approach to the medical management of trigeminal neuralgia. British journal of neurosurgery, 2007, Volume: 21, Issue:3 Topics: Analgesics; Baclofen; Carbamazepine; Drug Therapy, Combination; Evidence-Based Medicine; Female; GAB	2007
Lamotrigine in the management of neuropathic pain: a review of the literature. The Clinical journal of pain, 2000, Volume: 16, Issue:4 Topics: Analgesics; Diabetic Neuropathies; Humans; Lamotrigine; Triazines; Trigeminal Neuralgia	2000

Article	Year
A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study. Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:6 Topics: Adult; Amines; Anticonvulsants; Brain; Cold Temperature; Cross-Over Studies; Cyclohexanecarboxylic A	2010
Lamotrigine for trigeminal neuralgia: efficacy and safety in comparison with carbamazepine. Journal of the Chinese Medical Association : JCMA, 2011, Volume: 74, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Analgesics; Carbamazepine; Cross-Over Studies; Female; Humans; Lamot	2011
Lamotrigine control of trigeminal neuralgia: an expanded study. Journal of neurology, 1997, Volume: 244, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Lamotrigine; Male; Middle Aged; Tri	1997
Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain, 1997, Volume: 73, Issue:2 Topics: Adult; Aged; Analgesics; Cross-Over Studies; Double-Blind Method; Female; Humans; Lamotrigine; Male;	1997
Lamotrigine in trigeminal neuralgia secondary to multiple sclerosis. Journal of neurology, 2000, Volume: 247, Issue:7 Topics: Analgesics; Analgesics, Non-Narcotic; Carbamazepine; Female; Humans; Lamotrigine; Male; Middle Aged;	2000

Article	Year
Pharmacotherapeutic management of trigeminal neuropathic pain: an update. Expert opinion on pharmacotherapy, 2022, Volume: 23, Issue:10 Topics: Anticonvulsants; Carbamazepine; Humans; Lamotrigine; Neuralgia; Trigeminal Neuralgia	2022
Adverse effects of anti-epileptics in trigeminal neuralgiform pain. Acta neurologica Scandinavica, 2018, Volume: 137, Issue:6 Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Fatigue; Female; Humans; Lamot	2018
Refactory Trigeminal Neuralgia successfully treated by combination therapy (Pregabalin plus Lamotrigine). Multiple sclerosis and related disorders, 2018, Volume: 25 Topics: Aged; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle Aged; Pr	2018
Lamotrigine control of idiopathic trigeminal neuralgia. Journal of neurology, neurosurgery, and psychiatry, 1995, Volume: 59, Issue:6 Topics: Adult; Aged; Analgesics, Non-Narcotic; Carbamazepine; Female; Follow-Up Studies; Humans; Lamotrigine	1995
Clinical effectiveness of lamotrigine and plasma levels in essential and symptomatic trigeminal neuralgia. Neurology, 1997, Volume: 48, Issue:6 Topics: Aged; Calcium Channel Blockers; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Middle Aged; P	1997
Alternative uses of lamotrigine and gabapentin in the treatment of trigeminal neuralgia. Neurology, 1998, Volume: 50, Issue:4 Topics: Acetates; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Huma	1998
Comments on Zakrzewska et al., PAIN, 73 (1997) 223-230. Pain, 1998, Volume: 76, Issue:1-2 Topics: Analgesics; Humans; Lamotrigine; Triazines; Trigeminal Neuralgia	1998
Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis. European neurology, 2000, Volume: 44, Issue:1 Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Res	2000
Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain. Pain, 2001, Volume: 93, Issue:2 Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models	2001

lamotrigine and Epileptiform Neuralgia