Page last updated: 2024-10-30

lamotrigine and Epilepsy, Complex Partial

lamotrigine has been researched along with Epilepsy, Complex Partial in 31 studies

Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)

Research Excerpts

ExcerptRelevanceReference
" Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake."7.78Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012)
"Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase."6.39[Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995)
"To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures."4.83A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. ( Chadwick, DW; Gamble, C; Marson, AG; Williamson, PR, 2006)
" Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake."3.78Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012)
" The second patient complained of impotence after a rash while taking phenytoin and carbamazepine."3.70Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000)
"Lamotrigine or placebo was added to the patients' existing antiepileptic drugs (AEDs)."2.68Controlled trial of lamotrigine (Lamictal) for treatment-resistant partial seizures. ( Boas, J; Dam, M; Friis, ML; Gallagher, J; Kristensen, O; Pedersen, B, 1996)
"Lamotrigine appears to be a safe and effective new AED for patients with refractory partial seizures when used as an adjunctive agent."2.39Lamotrigine: an antiepileptic agent for the treatment of partial seizures. ( Gilman, JT, 1995)
"Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase."2.39[Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995)
"The examined case displays complex partial epilepsy and comorbid mental disorder."1.37Lamotrigine treatment of a patient affected by epilepsy and anxiety disorder. ( Dadić-Hero, E; Grahovac, T; Ružić, K; Ružić-Baršić, A; Sepić-Grahovac, D, 2011)
" LTG was started with a dosage of 25 mg/day until a daily maintenance dosage of 200 mg/day was reached."1.30Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation. ( Bongiovanni, LG; Fiaschi, A; Manganotti, P; Turazzini, M; Zanette, G, 1999)
" Despite methodologic limitations in the nonrandomized treatment sequence, these findings suggest that VPA and LTG exhibit a favorable pharmacodynamic interaction in patients with refractory partial epilepsy."1.30The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. ( Di Perri, R; Oteri, G; Perucca, E; Pisani, F; Richens, A; Russo, MF, 1999)
" CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7."1.29Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy. ( Fazio, A; Perucca, E; Pisani, F; Spina, E; Tomson, T; Xiao, B, 1994)
"Lamotrigine is a very useful antiepileptic medication of a "broad spectrum' nature being effective in primary generalized epilepsy and partial seizures as add-on therapy."1.29Lamotrigine: clinical experience in 200 patients with epilepsy with follow-up to four years. ( Buchanan, N, 1996)
"Lamotrigine is a novel antiepileptic drug, chemically unrelated to the major anticonvulsants in current use."1.28Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. ( Richens, A; Timmings, PL, 1992)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (45.16)18.2507
2000's13 (41.94)29.6817
2010's4 (12.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tanaka, S1
Tanaka, T1
Kim, SE1
Park, KM1
Kim, SH1
Kwon, OY1
No, SK1
Sepić-Grahovac, D1
Grahovac, T1
Ružić-Baršić, A1
Ružić, K1
Dadić-Hero, E1
Calabrò, RS1
Italiano, D1
Militi, D1
Bramanti, P1
Hashim, N1
Bandara, D1
Tan, E1
Ilchyshyn, A1
Verrotti, A1
Latini, G1
Giannuzzi, R1
Cutarella, R1
Trotta, D1
Morgese, G1
Chiarelli, F1
Mueller, TH1
Beeber, AR1
Zacks, JM1
Michelon, P1
Vettel, JM1
Ojemann, JG1
Goforth, HW1
Rao, M1
Sucholeiki, R1
Mecarelli, O1
Pulitano, P1
Mingoia, M1
Ferretti, G1
Rossi, M1
Berloco, PB1
Muda, AO1
Gamble, C1
Williamson, PR1
Chadwick, DW1
Marson, AG1
Harden, CL1
Herzog, AG1
Nikolov, BG1
Koppel, BS1
Christos, PJ1
Fowler, K1
Labar, DR1
Hauser, WA1
Sardo, P1
Ferraro, G1
Jadresic, D1
Pisani, F2
Xiao, B1
Fazio, A1
Spina, E1
Perucca, E2
Tomson, T1
Gilman, JT1
Vogt, H1
Krämer, G1
Stolarek, I1
Blacklaw, J1
Forrest, G1
Brodie, MJ1
Schapel, GJ1
Black, AB1
Lam, EL1
Robinson, M1
Dollman, WB1
Buchanan, N1
Boas, J1
Dam, M1
Friis, ML1
Kristensen, O1
Pedersen, B1
Gallagher, J1
De Romanis, F1
Sopranzi, N1
Manganotti, P1
Bongiovanni, LG1
Zanette, G1
Turazzini, M1
Fiaschi, A1
Gatzonis, S1
Laiaki, A1
Chioni, A1
Siafakas, A1
Zournas, C1
Mantouvalos, V1
Oteri, G1
Russo, MF1
Di Perri, R1
Richens, A2
Maj, R1
Fariello, RG1
Pevarello, P1
Varasi, M1
McArthur, RA1
Salvati, P1
Husain, AM1
Carwile, ST1
Miller, PP1
Radtke, RA1
Collins, TL1
Petroff, OA1
Mattson, RH1
Sbei, M1
Campellone, JV1
Chmielewska, B1
Stelmasiak, Z1
Timmings, PL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients. Phase II, Randomized, Double-blind, Single-center Clinical Trial[NCT02652988]20 participants (Actual)Interventional2016-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for lamotrigine and Epilepsy, Complex Partial

ArticleYear
A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy.
    Neurology, 2006, May-09, Volume: 66, Issue:9

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Disease-Free Survival; Double-Blind Method; Epilepsies

2006
Lamotrigine: an antiepileptic agent for the treatment of partial seizures.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Double-Blind Method; D

1995
[Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic].
    Schweizerische medizinische Wochenschrift, 1995, Jan-28, Volume: 125, Issue:4

    Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies,

1995

Trials

6 trials available for lamotrigine and Epilepsy, Complex Partial

ArticleYear
Factors associated with poor control in partial complex epilepsy.
    Journal of child neurology, 2004, Volume: 19, Issue:4

    Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalograp

2004
Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study.
    Epilepsia, 2006, Volume: 47, Issue:9

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Ther

2006
Vigabatrin and lamotrigine in refractory epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1994, Volume: 57, Issue:8

    Topics: Anticonvulsants; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Epilepsy, Complex

1994
Combination vigabatrin and lamotrigine therapy for intractable epilepsy.
    Seizure, 1996, Volume: 5, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Drug Combinations; Epilepsy, Complex Partial; Female; gamma-Amin

1996
Controlled trial of lamotrigine (Lamictal) for treatment-resistant partial seizures.
    Acta neurologica Scandinavica, 1996, Volume: 94, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Cross-Over Studies; Double-Blind Method; Epilepsy, Complex Parti

1996
Clinical evaluation of Gabitril and Lamictal for drug-resistant epilepsy in adults.
    Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 2001, Volume: 56

    Topics: Adolescent; Adult; Anticonvulsants; Drug Resistance; Epilepsy, Complex Partial; Female; Humans; Lamo

2001

Other Studies

22 other studies available for lamotrigine and Epilepsy, Complex Partial

ArticleYear
Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2013, Volume: 15, Issue:2

    Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epilepsies, Partial; E

2013
Presence of epileptiform discharges on initial EEGs are associated with failure of retention on first antiepileptic drug in newly diagnosed cryptogenic partial epilepsy: a 2-year observational study.
    Seizure, 2010, Volume: 19, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Complex

2010
Lamotrigine treatment of a patient affected by epilepsy and anxiety disorder.
    Psychiatria Danubina, 2011, Volume: 23, Issue:1

    Topics: Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dose-Response Relationship, Drug; Electroenc

2011
Levetiracetam-associated loss of libido and anhedonia.
    Epilepsy & behavior : E&B, 2012, Volume: 24, Issue:2

    Topics: Adult; Anhedonia; Anticonvulsants; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, C

2012
Early cyclosporine treatment of incipient toxic epidermal necrolysis induced by concomitant use of lamotrigine and sodium valproate.
    Acta dermato-venereologica, 2004, Volume: 84, Issue:1

    Topics: Adult; Anticonvulsants; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Epilepsy, Comp

2004
Delirium from valproic acid with lamotrigine.
    The American journal of psychiatry, 2004, Volume: 161, Issue:6

    Topics: Anticonvulsants; Delirium; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial;

2004
Functional reorganization of spatial transformations after a parietal lesion.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Combined Modality Therapy; Drug Therapy, Combi

2004
Chronic interictal psychosis responsive to aripiprazole.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:5

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Chronic Disease; Clonazepam; Delusions;

2004
Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (Mars).
    Epilepsia, 2005, Volume: 46, Issue:10

    Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Electroencephalography; Epile

2005
Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.
    BMC neuroscience, 2007, Jul-03, Volume: 8

    Topics: Animals; Anticonvulsants; Arginine; Brain; Dentate Gyrus; Disease Models, Animal; Drug Interactions;

2007
Acute pancreatitis associated with dual vigabatrin and lamotrigine therapy.
    Seizure, 1994, Volume: 3, Issue:4

    Topics: Acute Disease; Adult; Amylases; Anticonvulsants; Epilepsy, Complex Partial; gamma-Aminobutyric Acid;

1994
Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy.
    Epilepsy research, 1994, Volume: 19, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy, Complex Partial; Female; Humans;

1994
Lamotrigine: clinical experience in 200 patients with epilepsy with follow-up to four years.
    Seizure, 1996, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Damage, Chronic; Child; Child, Preschool; Drug Thera

1996
[Lamotrigine: monotherapy in refractory epilepsy].
    La Clinica terapeutica, 1997, Volume: 148, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Drug Resistance; Epilepsy; Epilepsy, Complex Partial; Female; Hu

1997
Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation.
    Epilepsia, 1999, Volume: 40, Issue:3

    Topics: Action Potentials; Adolescent; Adult; Anticonvulsants; Cerebral Cortex; Epilepsy; Epilepsy, Complex

1999
A case of fever following antiepileptic treatment.
    Seizure, 1999, Volume: 8, Issue:3

    Topics: Adult; Anticonvulsants; Body Temperature Regulation; Carbamazepine; Drug Therapy, Combination; Epile

1999
The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction.
    Epilepsia, 1999, Volume: 40, Issue:8

    Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; Fem

1999
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
    Epilepsia, 1999, Volume: 40, Issue:11

    Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba

1999
Improved sexual function in three men taking lamotrigine for epilepsy.
    Southern medical journal, 2000, Volume: 93, Issue:3

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial;

2000
A comparison of four new antiepileptic medications.
    Seizure, 2000, Volume: 9, Issue:4

    Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose

2000
Stupor from lamotrigine toxicity.
    Epilepsia, 2001, Volume: 42, Issue:8

    Topics: Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle

2001
Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome.
    European neurology, 1992, Volume: 32, Issue:6

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combi

1992