lamotrigine has been researched along with Epilepsy, Complex Partial in 31 studies
Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake." | 7.78 | Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012) |
| "Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase." | 6.39 | [Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995) |
| "To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures." | 4.83 | A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. ( Chadwick, DW; Gamble, C; Marson, AG; Williamson, PR, 2006) |
| " Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake." | 3.78 | Levetiracetam-associated loss of libido and anhedonia. ( Bramanti, P; Calabrò, RS; Italiano, D; Militi, D, 2012) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "Lamotrigine or placebo was added to the patients' existing antiepileptic drugs (AEDs)." | 2.68 | Controlled trial of lamotrigine (Lamictal) for treatment-resistant partial seizures. ( Boas, J; Dam, M; Friis, ML; Gallagher, J; Kristensen, O; Pedersen, B, 1996) |
| "Lamotrigine appears to be a safe and effective new AED for patients with refractory partial seizures when used as an adjunctive agent." | 2.39 | Lamotrigine: an antiepileptic agent for the treatment of partial seizures. ( Gilman, JT, 1995) |
| "Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase." | 2.39 | [Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995) |
| "The examined case displays complex partial epilepsy and comorbid mental disorder." | 1.37 | Lamotrigine treatment of a patient affected by epilepsy and anxiety disorder. ( Dadić-Hero, E; Grahovac, T; Ružić, K; Ružić-Baršić, A; Sepić-Grahovac, D, 2011) |
| " LTG was started with a dosage of 25 mg/day until a daily maintenance dosage of 200 mg/day was reached." | 1.30 | Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation. ( Bongiovanni, LG; Fiaschi, A; Manganotti, P; Turazzini, M; Zanette, G, 1999) |
| " Despite methodologic limitations in the nonrandomized treatment sequence, these findings suggest that VPA and LTG exhibit a favorable pharmacodynamic interaction in patients with refractory partial epilepsy." | 1.30 | The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. ( Di Perri, R; Oteri, G; Perucca, E; Pisani, F; Richens, A; Russo, MF, 1999) |
| " CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7." | 1.29 | Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy. ( Fazio, A; Perucca, E; Pisani, F; Spina, E; Tomson, T; Xiao, B, 1994) |
| "Lamotrigine is a very useful antiepileptic medication of a "broad spectrum' nature being effective in primary generalized epilepsy and partial seizures as add-on therapy." | 1.29 | Lamotrigine: clinical experience in 200 patients with epilepsy with follow-up to four years. ( Buchanan, N, 1996) |
| "Lamotrigine is a novel antiepileptic drug, chemically unrelated to the major anticonvulsants in current use." | 1.28 | Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome. ( Richens, A; Timmings, PL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (45.16) | 18.2507 |
| 2000's | 13 (41.94) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, S | 1 |
| Tanaka, T | 1 |
| Kim, SE | 1 |
| Park, KM | 1 |
| Kim, SH | 1 |
| Kwon, OY | 1 |
| No, SK | 1 |
| Sepić-Grahovac, D | 1 |
| Grahovac, T | 1 |
| Ružić-Baršić, A | 1 |
| Ružić, K | 1 |
| Dadić-Hero, E | 1 |
| Calabrò, RS | 1 |
| Italiano, D | 1 |
| Militi, D | 1 |
| Bramanti, P | 1 |
| Hashim, N | 1 |
| Bandara, D | 1 |
| Tan, E | 1 |
| Ilchyshyn, A | 1 |
| Verrotti, A | 1 |
| Latini, G | 1 |
| Giannuzzi, R | 1 |
| Cutarella, R | 1 |
| Trotta, D | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Mueller, TH | 1 |
| Beeber, AR | 1 |
| Zacks, JM | 1 |
| Michelon, P | 1 |
| Vettel, JM | 1 |
| Ojemann, JG | 1 |
| Goforth, HW | 1 |
| Rao, M | 1 |
| Sucholeiki, R | 1 |
| Mecarelli, O | 1 |
| Pulitano, P | 1 |
| Mingoia, M | 1 |
| Ferretti, G | 1 |
| Rossi, M | 1 |
| Berloco, PB | 1 |
| Muda, AO | 1 |
| Gamble, C | 1 |
| Williamson, PR | 1 |
| Chadwick, DW | 1 |
| Marson, AG | 1 |
| Harden, CL | 1 |
| Herzog, AG | 1 |
| Nikolov, BG | 1 |
| Koppel, BS | 1 |
| Christos, PJ | 1 |
| Fowler, K | 1 |
| Labar, DR | 1 |
| Hauser, WA | 1 |
| Sardo, P | 1 |
| Ferraro, G | 1 |
| Jadresic, D | 1 |
| Pisani, F | 2 |
| Xiao, B | 1 |
| Fazio, A | 1 |
| Spina, E | 1 |
| Perucca, E | 2 |
| Tomson, T | 1 |
| Gilman, JT | 1 |
| Vogt, H | 1 |
| Krämer, G | 1 |
| Stolarek, I | 1 |
| Blacklaw, J | 1 |
| Forrest, G | 1 |
| Brodie, MJ | 1 |
| Schapel, GJ | 1 |
| Black, AB | 1 |
| Lam, EL | 1 |
| Robinson, M | 1 |
| Dollman, WB | 1 |
| Buchanan, N | 1 |
| Boas, J | 1 |
| Dam, M | 1 |
| Friis, ML | 1 |
| Kristensen, O | 1 |
| Pedersen, B | 1 |
| Gallagher, J | 1 |
| De Romanis, F | 1 |
| Sopranzi, N | 1 |
| Manganotti, P | 1 |
| Bongiovanni, LG | 1 |
| Zanette, G | 1 |
| Turazzini, M | 1 |
| Fiaschi, A | 1 |
| Gatzonis, S | 1 |
| Laiaki, A | 1 |
| Chioni, A | 1 |
| Siafakas, A | 1 |
| Zournas, C | 1 |
| Mantouvalos, V | 1 |
| Oteri, G | 1 |
| Russo, MF | 1 |
| Di Perri, R | 1 |
| Richens, A | 2 |
| Maj, R | 1 |
| Fariello, RG | 1 |
| Pevarello, P | 1 |
| Varasi, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| Husain, AM | 1 |
| Carwile, ST | 1 |
| Miller, PP | 1 |
| Radtke, RA | 1 |
| Collins, TL | 1 |
| Petroff, OA | 1 |
| Mattson, RH | 1 |
| Sbei, M | 1 |
| Campellone, JV | 1 |
| Chmielewska, B | 1 |
| Stelmasiak, Z | 1 |
| Timmings, PL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients. Phase II, Randomized, Double-blind, Single-center Clinical Trial[NCT02652988] | 20 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lamotrigine and Epilepsy, Complex Partial
| Article | Year |
|---|---|
A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Disease-Free Survival; Double-Blind Method; Epilepsies | 2006 |
Lamotrigine: an antiepileptic agent for the treatment of partial seizures.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Double-Blind Method; D | 1995 |
[Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic].
Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, | 1995 |
6 trials available for lamotrigine and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Factors associated with poor control in partial complex epilepsy.
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalograp | 2004 |
Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Ther | 2006 |
Vigabatrin and lamotrigine in refractory epilepsy.
Topics: Anticonvulsants; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Epilepsy, Complex | 1994 |
Combination vigabatrin and lamotrigine therapy for intractable epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Drug Combinations; Epilepsy, Complex Partial; Female; gamma-Amin | 1996 |
Controlled trial of lamotrigine (Lamictal) for treatment-resistant partial seizures.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Over Studies; Double-Blind Method; Epilepsy, Complex Parti | 1996 |
Clinical evaluation of Gabitril and Lamictal for drug-resistant epilepsy in adults.
Topics: Adolescent; Adult; Anticonvulsants; Drug Resistance; Epilepsy, Complex Partial; Female; Humans; Lamo | 2001 |
22 other studies available for lamotrigine and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Clobazam; Drug Therapy, Combination; Epilepsies, Partial; E | 2013 |
Presence of epileptiform discharges on initial EEGs are associated with failure of retention on first antiepileptic drug in newly diagnosed cryptogenic partial epilepsy: a 2-year observational study.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Complex | 2010 |
Lamotrigine treatment of a patient affected by epilepsy and anxiety disorder.
Topics: Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dose-Response Relationship, Drug; Electroenc | 2011 |
Levetiracetam-associated loss of libido and anhedonia.
Topics: Adult; Anhedonia; Anticonvulsants; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, C | 2012 |
Early cyclosporine treatment of incipient toxic epidermal necrolysis induced by concomitant use of lamotrigine and sodium valproate.
Topics: Adult; Anticonvulsants; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Epilepsy, Comp | 2004 |
Delirium from valproic acid with lamotrigine.
Topics: Anticonvulsants; Delirium; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; | 2004 |
Functional reorganization of spatial transformations after a parietal lesion.
Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Combined Modality Therapy; Drug Therapy, Combi | 2004 |
Chronic interictal psychosis responsive to aripiprazole.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Chronic Disease; Clonazepam; Delusions; | 2004 |
Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (Mars).
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Electroencephalography; Epile | 2005 |
Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.
Topics: Animals; Anticonvulsants; Arginine; Brain; Dentate Gyrus; Disease Models, Animal; Drug Interactions; | 2007 |
Acute pancreatitis associated with dual vigabatrin and lamotrigine therapy.
Topics: Acute Disease; Adult; Amylases; Anticonvulsants; Epilepsy, Complex Partial; gamma-Aminobutyric Acid; | 1994 |
Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy, Complex Partial; Female; Humans; | 1994 |
Lamotrigine: clinical experience in 200 patients with epilepsy with follow-up to four years.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Damage, Chronic; Child; Child, Preschool; Drug Thera | 1996 |
[Lamotrigine: monotherapy in refractory epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Drug Resistance; Epilepsy; Epilepsy, Complex Partial; Female; Hu | 1997 |
Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation.
Topics: Action Potentials; Adolescent; Adult; Anticonvulsants; Cerebral Cortex; Epilepsy; Epilepsy, Complex | 1999 |
A case of fever following antiepileptic treatment.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Carbamazepine; Drug Therapy, Combination; Epile | 1999 |
The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction.
Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy, Complex Partial; Fem | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
A comparison of four new antiepileptic medications.
Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose | 2000 |
Stupor from lamotrigine toxicity.
Topics: Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle | 2001 |
Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combi | 1992 |