lamotrigine has been researched along with Drug Refractory Epilepsy in 30 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gabapentin as monotherapy probably controlled seizures no better and no worse than comparator AEDs (lamotrigine, carbamazepine, oxcarbazepine, and topiramate)." | 9.41 | Gabapentin monotherapy for epilepsy: A review. ( Abakumova, T; Hoyle, CHV; Ziganshina, LE, 2023) |
| "Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures." | 7.91 | Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. ( Nieoczym, D; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2019) |
| "Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period of life." | 5.48 | Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats. ( Keramati, K; Mahdavi, A; Moezifar, M; Narenji Sani, R; Saberi, N, 2018) |
| "Gabapentin as monotherapy probably controlled seizures no better and no worse than comparator AEDs (lamotrigine, carbamazepine, oxcarbazepine, and topiramate)." | 5.41 | Gabapentin monotherapy for epilepsy: A review. ( Abakumova, T; Hoyle, CHV; Ziganshina, LE, 2023) |
| "To determine the effects of lamotrigine on (1) seizures, (2) adverse-effect profile, and (3) cognition and quality of life, compared to placebo, when used as an add-on treatment for people with drug-resistant focal epilepsy." | 5.05 | Lamotrigine add-on therapy for drug-resistant focal epilepsy. ( Bresnahan, R; Marson, AG; Panebianco, M; Ramaratnam, S, 2020) |
| " The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy." | 4.98 | Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018) |
| "We identified a significant decrease in the serum concentrations of clobazam, desmethylclobazam, and lamotrigine following a 12-week ketogenic diet intervention in children with drug resistant epilepsy." | 4.31 | Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet. ( Gervin, K; Iversen, PO; Kverneland, M; Landmark, CJ; Pedersen, S; Rudi, K; Selmer, KK, 2023) |
| "Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures." | 3.91 | Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. ( Nieoczym, D; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2019) |
| "28), indicating a dose-response relationship." | 2.61 | Pregabalin add-on for drug-resistant focal epilepsy. ( Bresnahan, R; Hemming, K; Marson, AG; Panebianco, M, 2019) |
| "Epilepsy is a very common neurological disease with high morbidity and mortality." | 1.91 | [Epilepsy and inequality: demographic description and analysis of the difficulty in accessing advanced resources in a population in a small health area]. ( Cánovas-Iniesta, M; Navarro-Lozano, M; Palazón-Cabanes, B; Pérez-Navarro, VM, 2023) |
| "Abdominal epilepsy is a rare seizure disorder characterized by episodic gastrointestinal symptoms with electroencephalogram abnormalities." | 1.51 | Abdominal Epilepsy Treated With Vagal Nerve Stimulation: A Case Report. ( Kochanski, RB; Kraimer, KL; Lynn, F; Sani, S; Smith, M, 2019) |
| "Pregnancy is a state where drug pharmacokinetic changes are more pronounced and more rapid than any other period of life." | 1.48 | Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats. ( Keramati, K; Mahdavi, A; Moezifar, M; Narenji Sani, R; Saberi, N, 2018) |
| "Juvenile myoclonic epilepsy is often regarded as a benign epileptic syndrome, but in this setting, half of the individuals with JME have refractory epilepsy with only about a quarter of those seizure-free in the previous year." | 1.48 | Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center. ( Cação, G; Mannan, S; Parra, J; Sander, JW; Sisodiya, SM, 2018) |
| "Oxcarbazepine was used in 82 patients, topiramate in 120 patients, lamotrigine in 73 patients, levetiracetam in 135 patients, pregabalin in 47 patients, tiagabine in 43 patients, gabapentin in 18 patients, lacosamide in 12 patients, and retigabine in 6 patients." | 1.48 | Comparative effectiveness of add-on therapy with newer-generation antiepileptic drugs in Bulgarian patients with refractory epilepsy. ( Viteva, E; Zahariev, Z, 2018) |
| "Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE])." | 1.46 | Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy. ( Aroni, S; Marrosu, F; Melis, M; Milioli, G; Muntoni, AL; Parrino, L; Pillolla, G; Pistis, M; Puligheddu, M; Sagheddu, C; Terzano, GM, 2017) |
| " We sought to determine whether there were regions in the dosage range of commonly used AEDs that were associated with superior efficacy in patients with refractory epilepsy." | 1.46 | Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy. ( Castagna, CE; Miller, AB; Poolos, NP; Story, TJ; Williams, S, 2017) |
| "Lamotrigine and valproate were rated most successful with good or partial response rates in 88-100% of the patients." | 1.43 | LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs. ( Beaud, N; Borggraefe, I; Budde, J; Debus, O; Ensslen, M; Geis, T; Gilbert, M; Haeussler, M; Hahn, A; Hehr, U; Heiming, R; Herbst, SM; Kurlemann, G; Morgner, R; Morris-Rosendahl, DJ; Muelleder, K; Philippi, H; Proepper, CR; Ross, S; Schuierer, G; Strobl-Wildemann, G; von Gersdorff, G; Vosschulte, P, 2016) |
| "Our patient presented with intractable epilepsy at 2 months of age." | 1.43 | Early-life epileptic encephalopathy secondary to SZT2 pathogenic recessive variants. ( Angle, B; Millichap, JJ; Venkatesan, C, 2016) |
| "Lamotrigine treatment during KD is associated with a decreased efficacy of the KD." | 1.42 | Concomitant lamotrigine use is associated with decreased efficacy of the ketogenic diet in childhood refractory epilepsy. ( Catsman-Berrevoets, CE; Desadien, R; Neuteboom, RF; van der Louw, EJ; van der Sijs, H; Vehmeijer, FO, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (70.00) | 24.3611 |
| 2020's | 9 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, X | 1 |
| Wang, Y | 1 |
| Jing, M | 1 |
| Hua, Y | 1 |
| Wang, J | 1 |
| Pedersen, S | 1 |
| Kverneland, M | 1 |
| Rudi, K | 1 |
| Gervin, K | 1 |
| Landmark, CJ | 1 |
| Iversen, PO | 1 |
| Selmer, KK | 1 |
| Ziganshina, LE | 1 |
| Abakumova, T | 1 |
| Hoyle, CHV | 1 |
| Benoist, C | 1 |
| Boccaletti, S | 1 |
| Leach, JP | 1 |
| Cattaneo, A | 1 |
| Chaplin, A | 1 |
| Antunes, L | 1 |
| Heiman, F | 1 |
| Sander, JW | 3 |
| Pérez-Navarro, VM | 1 |
| Cánovas-Iniesta, M | 1 |
| Palazón-Cabanes, B | 1 |
| Navarro-Lozano, M | 1 |
| Panebianco, M | 3 |
| Bresnahan, R | 3 |
| Ramaratnam, S | 1 |
| Marson, AG | 3 |
| Koneval, Z | 2 |
| Knox, KM | 2 |
| Memon, A | 1 |
| Zierath, DK | 1 |
| White, HS | 2 |
| Barker-Haliski, M | 2 |
| Quon, RJ | 1 |
| Meisenhelter, S | 1 |
| Adamovich-Zeitlin, RH | 1 |
| Song, Y | 1 |
| Steimel, SA | 1 |
| Camp, EJ | 1 |
| Testorf, ME | 1 |
| MacKenzie, TA | 1 |
| Gross, RE | 1 |
| Lega, BC | 1 |
| Sperling, MR | 1 |
| Kahana, MJ | 1 |
| Jobst, BC | 1 |
| Puligheddu, M | 1 |
| Melis, M | 1 |
| Pillolla, G | 1 |
| Milioli, G | 1 |
| Parrino, L | 1 |
| Terzano, GM | 1 |
| Aroni, S | 1 |
| Sagheddu, C | 1 |
| Marrosu, F | 1 |
| Pistis, M | 1 |
| Muntoni, AL | 1 |
| Narenji Sani, R | 1 |
| Keramati, K | 1 |
| Saberi, N | 1 |
| Moezifar, M | 1 |
| Mahdavi, A | 1 |
| Rosati, A | 1 |
| Ilvento, L | 1 |
| Lucenteforte, E | 1 |
| Pugi, A | 1 |
| Crescioli, G | 1 |
| McGreevy, KS | 1 |
| Virgili, G | 1 |
| Mugelli, A | 1 |
| De Masi, S | 1 |
| Guerrini, R | 1 |
| Cação, G | 1 |
| Parra, J | 1 |
| Mannan, S | 1 |
| Sisodiya, SM | 1 |
| Xiao, F | 1 |
| Caciagli, L | 1 |
| Wandschneider, B | 1 |
| Sidhu, M | 1 |
| Winston, G | 1 |
| Burdett, J | 1 |
| Trimmel, K | 1 |
| Hill, A | 1 |
| Vollmar, C | 1 |
| Vos, SB | 1 |
| Ourselin, S | 1 |
| Thompson, PJ | 1 |
| Zhou, D | 1 |
| Duncan, JS | 1 |
| Koepp, MJ | 1 |
| Viteva, E | 1 |
| Zahariev, Z | 1 |
| Kraimer, KL | 1 |
| Kochanski, RB | 1 |
| Lynn, F | 1 |
| Smith, M | 1 |
| Sani, S | 1 |
| Hancock, CL | 1 |
| Gálvez, A | 1 |
| Markovic, I | 1 |
| Pejanovic-Skobic, N | 1 |
| Bozina, N | 1 |
| Susak Sporis, I | 1 |
| Sporis, D | 1 |
| Basic, S | 1 |
| Hemming, K | 1 |
| Lee, BI | 1 |
| Park, KM | 1 |
| Kim, SE | 1 |
| Heo, K | 1 |
| Socała, K | 1 |
| Wyska, E | 1 |
| Szafarz, M | 1 |
| Nieoczym, D | 1 |
| Wlaź, P | 1 |
| Hinc-Kasprzyk, J | 1 |
| Polak-Krzemińska, A | 1 |
| Głowacka, M | 1 |
| Ożóg-Zabolska, I | 1 |
| Herbst, SM | 1 |
| Proepper, CR | 1 |
| Geis, T | 1 |
| Borggraefe, I | 1 |
| Hahn, A | 1 |
| Debus, O | 1 |
| Haeussler, M | 1 |
| von Gersdorff, G | 1 |
| Kurlemann, G | 1 |
| Ensslen, M | 1 |
| Beaud, N | 1 |
| Budde, J | 1 |
| Gilbert, M | 1 |
| Heiming, R | 1 |
| Morgner, R | 1 |
| Philippi, H | 1 |
| Ross, S | 1 |
| Strobl-Wildemann, G | 1 |
| Muelleder, K | 1 |
| Vosschulte, P | 1 |
| Morris-Rosendahl, DJ | 1 |
| Schuierer, G | 1 |
| Hehr, U | 1 |
| Kato, T | 1 |
| Nakata, M | 1 |
| Ide, M | 1 |
| Saito, K | 1 |
| Yoshida, T | 1 |
| Awaya, T | 1 |
| Heike, T | 1 |
| van der Louw, EJ | 1 |
| Desadien, R | 1 |
| Vehmeijer, FO | 1 |
| van der Sijs, H | 1 |
| Catsman-Berrevoets, CE | 1 |
| Neuteboom, RF | 1 |
| Chowdhury, A | 1 |
| Brodie, MJ | 1 |
| Venkatesan, C | 1 |
| Angle, B | 1 |
| Millichap, JJ | 1 |
| Tombini, M | 1 |
| Pellegrino, G | 1 |
| Assenza, G | 1 |
| Di Lazzaro, V | 1 |
| Poolos, NP | 1 |
| Castagna, CE | 1 |
| Williams, S | 1 |
| Miller, AB | 1 |
| Story, TJ | 1 |
6 reviews available for lamotrigine and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Gabapentin monotherapy for epilepsy: A review.
Topics: Anticonvulsants; Carbamazepine; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Gabapentin; | 2023 |
Lamotrigine add-on therapy for drug-resistant focal epilepsy.
Topics: Adult; Anticonvulsants; Ataxia; Child; Cognition; Cross-Over Studies; Diplopia; Dizziness; Drug Resi | 2020 |
Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizures.
Topics: Anticonvulsants; Chemotherapy, Adjuvant; Dizziness; Drug Eruptions; Drug Resistant Epilepsy; Epileps | 2020 |
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch | 2018 |
Pregabalin add-on for drug-resistant focal epilepsy.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies, Partial; Gabapentin | 2019 |
Clinical opinion: Earlier employment of polytherapy in sequential pharmacotherapy of epilepsy.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; | 2019 |
2 trials available for lamotrigine and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Effects of carbamazepine and lamotrigine on functional magnetic resonance imaging cognitive networks.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain; Carbamazepine; Cognition; Dose-Response Relationshi | 2018 |
The lack of influence of IVS5-91 G>A polymorphism of the SCN1A gene on efficacy of lamotrigine in patients with focal epilepsy.
Topics: Adult; Anticonvulsants; Drug Resistance; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Genot | 2019 |
22 other studies available for lamotrigine and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Dramatic response to lamotrigine in two patients with refractory epilepsy due to calcium channel mutations
Topics: Anticonvulsants; Calcium Channels; Drug Resistant Epilepsy; Humans; Lamotrigine; Mutation; Triazines | 2022 |
Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet.
Topics: Anticonvulsants; Child; Clobazam; Diet, Ketogenic; Drug Resistant Epilepsy; Epilepsy; Humans; Infant | 2023 |
Characterising people with focal drug-resistant epilepsy: A retrospective cohort study.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Epilepsies, Partial; Epilepsy; Female; Humans; Lamotrigine | 2023 |
[Epilepsy and inequality: demographic description and analysis of the difficulty in accessing advanced resources in a population in a small health area].
Topics: Adult; Anticonvulsants; Cross-Sectional Studies; Demography; Drug Resistant Epilepsy; Epilepsy; Huma | 2023 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy.
Topics: Adult; Anticonvulsants; Attention; Carbamazepine; Drug Resistant Epilepsy; Electrocorticography; Fem | 2021 |
Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.
Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Disease Models, Animal; D | 2017 |
Effect of zonisamide on refractory epilepsy during pregnancy in lamotrigine resistant kindled rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Drug Resistance; Drug Resistant Epilepsy; Female; | 2018 |
Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Resistant Epilepsy; Electroencephalography; Female; | 2018 |
Lamotrigine-resistant corneal-kindled mice: A model of pharmacoresistant partial epilepsy for moderate-throughput drug discovery.
Topics: Animals; Anticonvulsants; Anxiety; Body Weight; Cornea; Disease Models, Animal; Dose-Response Relati | 2018 |
Comparative effectiveness of add-on therapy with newer-generation antiepileptic drugs in Bulgarian patients with refractory epilepsy.
Topics: Adult; Anticonvulsants; Bulgaria; Drug Resistant Epilepsy; Drug Therapy, Combination; Female; Gabape | 2018 |
Abdominal Epilepsy Treated With Vagal Nerve Stimulation: A Case Report.
Topics: Adolescent; Anticonvulsants; Drug Resistant Epilepsy; Epilepsies, Partial; Humans; Lamotrigine; Male | 2019 |
Lamotrigine-associated hemophagocytic lymphohistiocytosis.
Topics: Biopsy; Bone Marrow; Dexamethasone; Drug Resistant Epilepsy; Etoposide; Ferritins; Humans; Interleuk | 2019 |
Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Chromatography, High Pressure Liquid; Disease Models, | 2019 |
The use of plasmapheresis in a 4-year-old boy with toxic epidermal necrosis.
Topics: Anticonvulsants; Child, Preschool; Disease Progression; Drug Resistant Epilepsy; Humans; Lamotrigine | 2015 |
LIS1-associated classic lissencephaly: A retrospective, multicenter survey of the epileptogenic phenotype and response to antiepileptic drugs.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Anticonvulsants; Brain; Child; Ch | 2016 |
[Efficacy and tolerability of topiramate, lamotrigine, and levetiracetam in children with refractory epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Drug Resistant Epilepsy; Female; Fructose; Humans; Lamotrigine; | 2015 |
Concomitant lamotrigine use is associated with decreased efficacy of the ketogenic diet in childhood refractory epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Dr | 2015 |
Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Drug Resistant Epilepsy; Female; Follow-Up S | 2016 |
Early-life epileptic encephalopathy secondary to SZT2 pathogenic recessive variants.
Topics: Anticonvulsants; Brain; Child, Preschool; Drug Resistant Epilepsy; Electroencephalography; Humans; I | 2016 |
De novo multifocal myoclonus induced by lamotrigine in a temporal lobe epilepsy case.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Epilepsy, Tempora | 2017 |
Association between antiepileptic drug dose and long-term response in patients with refractory epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedul | 2017 |