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lamotrigine and Drug Overdose

lamotrigine has been researched along with Drug Overdose in 34 studies

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

ExcerptRelevanceReference
"Lamotrigine is a commonly prescribed anticonvulsant medication."5.34Seizures and altered mental status after lamotrigine overdose. ( Geller, RJ; Schwartz, MD, 2007)
"Clinically significant side effects of the new anticonvulsants, such as metabolic acidosis from topiramate, autoimmune reactions from lamotrigine, hyponatremia from oxcarbazepine, or psychosis from levitiracetam can cause serious morbidity and mortality if unrecognized."4.86Emergent complications of the newer anticonvulsants. ( Dang, CV; Nelson, L; Wade, JF; Wasserberger, J, 2010)
"Lamotrigine is a broad-spectrum anticonvulsant commonly used to treat seizure and bipolar mood disorders."2.58Acute lamotrigine overdose: a systematic review of published adult and pediatric cases. ( Alyahya, B; Friesen, M; Laliberté, M; Nauche, B, 2018)
"The lamotrigine level was 78."2.52Evolving Electrocardiographic Changes in Lamotrigine Overdose: A Case Report and Literature Review. ( Casso Dominguez, A; Chavez, P; Herzog, E, 2015)
"Epilepsy affects 1."2.41New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000)
"Lamotrigine is a phenyltriazine compound that inhibits voltage-gated sodium channels, decreasing release of glutamate and aspartate, and inhibits serotonin, norepinephrine and dopamine reuptake."1.39A case series of patients with lamotrigine toxicity at one center from 2003 to 2012. ( Burkhart, KK; Donovan, JW; Haggerty, D; Moore, PW, 2013)
"Lamotrigine is a sodium channel blocking agent that is widely prescribed for treatment of seizure."1.38Lipid emulsion as rescue therapy in lamotrigine overdose. ( Castanares-Zapatero, D; Hantson, P; Huberlant, V; Morunglav, M; Wittebole, X, 2012)
"We report a case of cardiac arrest and status epilepticus following a massive LTG overdose."1.37Severe sodium channel blockade and cardiovascular collapse due to a massive lamotrigine overdose. ( Ly, BT; Minns, AB; Nogar, JN; Savaser, DJ, 2011)
"Lamotrigine is a phenyltriazine derivative used as antiepileptic drug with pharmacological profile similar to phenytoin."1.37[Massive lamotrigine poisoning--case report]. ( Bazylewicz, A; Kicka, M; Kłopotowski, T; Miśkiewicz, Ł; Picheta, S, 2011)
"The patient presented with seizures and a reduced level of consciousness."1.34Self-poisoning with lamotrigine and pregabalin. ( Braga, AJ; Chidley, K, 2007)
"Lamotrigine is a commonly prescribed anticonvulsant medication."1.34Seizures and altered mental status after lamotrigine overdose. ( Geller, RJ; Schwartz, MD, 2007)
"Lamotrigine is a novel anticonvulsant initially used in epilepsy treatment."1.33The relevance of monitoring lamotrigine serum concentrations in chronic pain patients. ( Devulder, J, 2006)
"Lamotrigine is an antiepileptic drug for the treatment of partial and generalized seizures as well as bipolar disorder."1.32Evaluation of lamotrigine toxicity reported to poison centers. ( Klein-Schwartz, W; Lofton, AL, 2004)
"Lamotrigine (Lamictal) is a new anticonvulsant drug recently approved for use in the United States."1.31Lamotrigine distribution in two postmortem cases. ( Jufer, RA; Levine, B; Smialek, JE, 2000)
"Lamotrigine is an antiepileptic agent that has been shown to be an effective adjunctive treatment for refractory partial and generalized seizures."1.31Lamotrigine overdose in an adult. ( Bateman, DN; O'Donnell, J, 2000)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.88)18.2507
2000's14 (41.18)29.6817
2010's17 (50.00)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Gosselin, S1
Ghannoum, M1
Hoffman, RS1
Alyahya, B1
Friesen, M1
Nauche, B1
Laliberté, M1
Agrawal, A1
Nogar, JN2
Koenig, S1
Moore, PW1
Donovan, JW1
Burkhart, KK1
Haggerty, D1
Eren Cevik, S1
Tasyurek, T1
Guneysel, O1
Chavez, P1
Casso Dominguez, A1
Herzog, E1
Fettiplace, MR1
Akpa, BS1
Rubinstein, I1
Weinberg, G1
Grosso, S1
Ferranti, S1
Gaggiano, C1
Grande, E1
Loi, B1
Di Bartolo, R1
Tessitore, E1
Ramlawi, M1
Tobler, O1
Sunthorn, H1
Wade, JF1
Dang, CV1
Nelson, L1
Wasserberger, J1
Nixon, AC1
Doak, MW1
Crozier, H1
Crooks, DP1
Waring, WS1
Nwogbe, B1
Ferié, J1
Smith, H1
Gunawardena, I1
Dhatariya, K1
Veerapandiyan, A1
Gallentine, WB1
Winchester, SA1
Baker, J1
Kansagra, SM1
Mikati, MA1
French, LK1
McKeown, NJ1
Hendrickson, RG1
Castanares-Zapatero, D1
Wittebole, X1
Huberlant, V1
Morunglav, M1
Hantson, P1
Waldo, SW1
Treit, K1
Goldschlager, N1
Minns, AB1
Savaser, DJ1
Ly, BT1
Kicka, M1
Kłopotowski, T1
Picheta, S1
Bazylewicz, A1
Miśkiewicz, Ł1
Fleurat, M1
Smollin, C1
Devresse, A1
Maldague, P1
Coulier, B1
Pierard, F1
Gielen, I1
Lofton, AL1
Klein-Schwartz, W1
Devulder, J1
Braga, AJ1
Chidley, K1
Daana, M1
Nevo, Y1
Tenenbaum, A1
Taustein, I1
Berger, I1
Reimers, A1
Reinholt, G1
Schwartz, MD1
Geller, RJ1
Miller, MA1
Levsky, ME1
Stopforth, J1
Briassoulis, G1
Kalabalikis, P1
Tamiolaki, M1
Hatzis, T1
Levine, B1
Jufer, RA1
Smialek, JE1
Yoon, Y1
Jagoda, A1
O'Donnell, J1
Bateman, DN1
Mycyk, MB1
Carlson, A1
Sbei, M1
Campellone, JV1

Reviews

4 reviews available for lamotrigine and Drug Overdose

ArticleYear
Acute lamotrigine overdose: a systematic review of published adult and pediatric cases.
    Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:2

    Topics: Adult; Anticonvulsants; Child; Drug Overdose; Humans; Lamotrigine; Renal Dialysis

2018
Evolving Electrocardiographic Changes in Lamotrigine Overdose: A Case Report and Literature Review.
    Cardiovascular toxicology, 2015, Volume: 15, Issue:4

    Topics: Adult; Antimanic Agents; Arrhythmias, Cardiac; Bipolar Disorder; Drug Overdose; Electrocardiography;

2015
Emergent complications of the newer anticonvulsants.
    The Journal of emergency medicine, 2010, Volume: 38, Issue:2

    Topics: Acidosis; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Overdose; Fructo

2010
New antiepileptic drugs and preparations.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4

    Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids;

2000

Other Studies

30 other studies available for lamotrigine and Drug Overdose

ArticleYear
Hemodialysis for lamotrigine poisoning.
    The American journal of emergency medicine, 2020, Volume: 38, Issue:2

    Topics: Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Lamotrigine; Renal Dialysis

2020
Management of lamotrigine overdose using hemodialysis.
    The American journal of emergency medicine, 2019, Volume: 37, Issue:8

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Overdose; Female; Humans; Lamotrigine; Renal Dialysis

2019
A case series of patients with lamotrigine toxicity at one center from 2003 to 2012.
    Clinical toxicology (Philadelphia, Pa.), 2013, Volume: 51, Issue:7

    Topics: Adrenergic Uptake Inhibitors; Adult; Arrhythmias, Cardiac; Child, Preschool; Dopamine Uptake Inhibit

2013
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Ov

2014
Confusion About Infusion: Rational Volume Limits for Intravenous Lipid Emulsion During Treatment of Oral Overdoses.
    Annals of emergency medicine, 2015, Volume: 66, Issue:2

    Topics: Bupropion; Drug Overdose; Fat Emulsions, Intravenous; Humans; Lamotrigine; Triazines

2015
Massive lamotrigine poisoning. A case report.
    Brain & development, 2017, Volume: 39, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Drug Overdose; Dyskinesia, Drug-Induced;

2017
Brugada Pattern Caused by a Flecainide Overdose.
    The Journal of emergency medicine, 2017, Volume: 52, Issue:4

    Topics: Atrial Fibrillation; Bipolar Disorder; Brugada Syndrome; Consciousness Disorders; Drug Overdose; Ele

2017
Patterns of antiepileptic drug overdose differ between men and women: admissions to the Edinburgh Poisons Unit, 2000-2007.
    QJM : monthly journal of the Association of Physicians, 2009, Volume: 102, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Overdose; Female; Humans; Lamotrigine; Male; Middle Aged

2009
Significant lamotrigine overdose associated with acute pancreatitis.
    Journal of the Royal Society of Medicine, 2009, Volume: 102, Issue:3

    Topics: Acute Disease; Antidepressive Agents; Drug Overdose; Female; Humans; Lamotrigine; Pancreatitis; Tria

2009
Oculogyric crises secondary to lamotrigine overdosage.
    Epilepsia, 2011, Volume: 52, Issue:3

    Topics: Adult; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Overdose; Dr

2011
Complete heart block and death following lamotrigine overdose.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:4

    Topics: Adult; Anticonvulsants; Drug Overdose; Fatal Outcome; Heart Block; Humans; Lamotrigine; Male; Renal

2011
Lipid emulsion as rescue therapy in lamotrigine overdose.
    The Journal of emergency medicine, 2012, Volume: 42, Issue:1

    Topics: Calcium Channel Blockers; Drug Overdose; Fat Emulsions, Intravenous; Female; Humans; Lamotrigine; Mi

2012
Possible acute myocardial infarction in a hypothermic patient.
    Archives of internal medicine, 2011, Sep-12, Volume: 171, Issue:16

    Topics: Acute Disease; Anticonvulsants; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Drug Overdose;

2011
Severe sodium channel blockade and cardiovascular collapse due to a massive lamotrigine overdose.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:9

    Topics: Calcium Channel Blockers; Drug Overdose; Female; Heart Arrest; Humans; Lamotrigine; Middle Aged; Sta

2011
[Massive lamotrigine poisoning--case report].
    Przeglad lekarski, 2011, Volume: 68, Issue:8

    Topics: Adult; Anticonvulsants; Coma; Drug Overdose; Epilepsy; Female; Humans; Lamotrigine; Respiratory Insu

2011
Case files of the University of California San Francisco Medical Toxicology Fellowship: lamotrigine toxicity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2012, Volume: 8, Issue:1

    Topics: Anticonvulsants; Drug Overdose; Excitatory Amino Acid Antagonists; Humans; Lamotrigine; Male; Middle

2012
Focal parietal necrosis of the sigmoid due to atypical neuroleptics: a case report.
    Acta gastro-enterologica Belgica, 2012, Volume: 75, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Citalopram

2012
Evaluation of lamotrigine toxicity reported to poison centers.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:11

    Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Child; Child, Preschool; Drug Overdose; Female

2004
The relevance of monitoring lamotrigine serum concentrations in chronic pain patients.
    Acta neurologica Belgica, 2006, Volume: 106, Issue:1

    Topics: Administration, Oral; Adult; Analgesics; Chronic Disease; Cytochrome P-450 Enzyme System; Dose-Respo

2006
Self-poisoning with lamotrigine and pregabalin.
    Anaesthesia, 2007, Volume: 62, Issue:5

    Topics: Adult; Anticonvulsants; Drug Overdose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Pregabali

2007
Lamotrigine overdose in a child.
    Journal of child neurology, 2007, Volume: 22, Issue:5

    Topics: Anticonvulsants; Child, Preschool; Drug Overdose; Epilepsy; Female; Humans; Lamotrigine; Triazines

2007
Acute lamotrigine overdose in an adolescent.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:5

    Topics: Adolescent; Antidepressive Agents; Depressive Disorder; Diagnosis, Differential; Drug Overdose; Emer

2007
Seizures and altered mental status after lamotrigine overdose.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:6

    Topics: Adult; Anticonvulsants; Consciousness; Drug Overdose; Humans; Lamotrigine; Seizures; Triazines

2007
Choreiform dyskinesia following isolated lamotrigine overdose.
    Journal of child neurology, 2008, Volume: 23, Issue:2

    Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Chorea; Drug Overdose; Dyskinesia, Drug-

2008
Overdose with gabapentin and lamotrigine.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1997, Volume: 87, Issue:10

    Topics: Acetates; Adolescent; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; G

1997
Lamotrigine childhood overdose.
    Pediatric neurology, 1998, Volume: 19, Issue:3

    Topics: Anticonvulsants; Child, Preschool; Drug Overdose; Epilepsy, Tonic-Clonic; Gastric Lavage; Humans; La

1998
Lamotrigine distribution in two postmortem cases.
    Journal of analytical toxicology, 2000, Volume: 24, Issue:7

    Topics: Adult; Anticonvulsants; Drug Overdose; Female; Gas Chromatography-Mass Spectrometry; Humans; Lamotri

2000
Lamotrigine overdose in an adult.
    Journal of toxicology. Clinical toxicology, 2000, Volume: 38, Issue:6

    Topics: Adult; Anticonvulsants; Drug Overdose; Female; Humans; Lamotrigine; Suicide, Attempted; Triazines

2000
Toxicologic causes of giggling.
    The Journal of emergency medicine, 2001, Volume: 21, Issue:2

    Topics: Adolescent; Anticonvulsants; Diagnosis, Differential; Drug Overdose; Female; Humans; Lamotrigine; La

2001
Stupor from lamotrigine toxicity.
    Epilepsia, 2001, Volume: 42, Issue:8

    Topics: Anticonvulsants; Coma; Drug Overdose; Epilepsy, Complex Partial; Female; Humans; Lamotrigine; Middle

2001