lamotrigine has been researched along with Drug Hypersensitivity in 33 studies
Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion." | 7.83 | Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( Ozisik, L; Saka, E; Tanriover, MD, 2016) |
| "Anticonvulsant hypersensitivity syndrome (AHS) developing to lamotrigine, a non-aromatic anticonvulsant, has rarely been reported." | 7.73 | Anticonvulsant hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro. ( Gogtay, NJ; Kanchan, S; Karande, S; Kshirsagar, NA, 2006) |
| "Lamotrigine is an antiepileptic agent used in a wide range of seizure disorders among the elderly." | 5.33 | [Drug hypersensitivity syndrome with lamotrigine two cases in elderly]. ( Bourdel-Marchasson, I; Jeandel, PY; Rainfray, M; Traissac, T, 2005) |
| "Lamotrigine is a new anticonvulsant belonging to the triazine family." | 5.30 | [Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine]. ( Barzegar, C; Bocquet, H; Bressieux, JM; Farmer, M; Jullien, M; Revuz, J; Roujeau, JC; Soto, B, 1999) |
| " More specifically, vigabatrin, which is a very useful and well tolerated new antiepileptic drug for refractory partial epilepsy, should be started at a low dosage of 0." | 4.79 | The new anticonvulsant drugs. Implications for avoidance of adverse effects. ( Krämer, G; Schmidt, D, 1994) |
| " We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion." | 3.83 | Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( Ozisik, L; Saka, E; Tanriover, MD, 2016) |
| " All had dermatological manifestations, eosinophilia and systemic (haematological and hepatic) manifestations that could be attributed to treatment with aromatic AEDs (carbamazepine, 2 patients; lamotrigine, 3 patients; phenytoin, 3 patients)." | 3.77 | Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. ( Kochen, S; Pereira de Silva, N; Piquioni, P; Saidon, P, 2011) |
| "A previous study conducted in Taiwan found a 100% association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome (SJS) in Han Chinese subjects, with an extremely high odds ratio compared with carbamazepine-tolerant subjects (odds ratio = 2,504)." | 3.74 | Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. ( Baum, L; Cheng, AS; Kwan, P; Lau, KM; Man, CB; Ng, MH; Yu, E, 2007) |
| "Anticonvulsant hypersensitivity syndrome (AHS) developing to lamotrigine, a non-aromatic anticonvulsant, has rarely been reported." | 3.73 | Anticonvulsant hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro. ( Gogtay, NJ; Kanchan, S; Karande, S; Kshirsagar, NA, 2006) |
| " the LTA by using trypan blue exclusion and to determine the utility of the assay to confirm drug hypersensitivity syndrome (DHS) to sulphonamides (SMX) and aromatic anticonvulsants." | 3.70 | A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. ( Malkiewicz, IM; Neuman, MG; Shear, NH, 2000) |
| " The adverse effect (AE) profile of this combination needs clarification." | 2.69 | Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. ( Faught, E; French, J; Harden, C; Jacobson, M; Montouris, G; Morris, G; Rosenfeld, W, 1999) |
| "Maculopapular exanthema and delayed-appearing urticaria were the most reported hypersensitivity reactions to AEDs." | 1.51 | Hypersensitivity reactions to antiepileptic drugs in children. ( Atanasković-Marković, M; Ćirković Veličković, T; Gavrović-Jankulović, M; Janković, J; Nikolić, D; Škorić, D; Tmušić, V, 2019) |
| "Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders." | 1.42 | Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report. ( Cho, HJ; Im, SG; Jang, SK; Jeon, DO; Lee, SJ; Oh, MJ; Park, YM; Yoo, SH, 2015) |
| "Lamotrigine is an antiepileptic agent used in a wide range of seizure disorders among the elderly." | 1.33 | [Drug hypersensitivity syndrome with lamotrigine two cases in elderly]. ( Bourdel-Marchasson, I; Jeandel, PY; Rainfray, M; Traissac, T, 2005) |
| "Lamotrigine was present on HLA-DR and HLA-DQ by antigen-presenting cells in the absence of drug metabolism and processing." | 1.32 | Characterization of drug-specific T cells in lamotrigine hypersensitivity. ( Chadwick, DW; Depta, JP; Dodd, CC; Farrell, J; Gibney, CA; Hopkins, JE; Naisbitt, DJ; Park, BK; Pichler, WJ; Pirmohamed, M; Wong, G, 2003) |
| "This syndrome is accompanied by fever, rash, lymphadenopathy, eosinophilia and affects parenchymal organs." | 1.32 | [Anticonvulsant hypersensitivity syndrome]. ( Papp, Z; Török, L, 2004) |
| "Lamotrigine is a new anticonvulsant belonging to the triazine family." | 1.30 | [Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine]. ( Barzegar, C; Bocquet, H; Bressieux, JM; Farmer, M; Jullien, M; Revuz, J; Roujeau, JC; Soto, B, 1999) |
| "Lamotrigine is a relatively new agent, and this report may provide useful insights on evaluating the clinical toxicology of this agent." | 1.30 | Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome. ( Hollik, DA; Mylonakis, E; Rounds, S; Vittorio, CC, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (24.24) | 18.2507 |
| 2000's | 12 (36.36) | 29.6817 |
| 2010's | 12 (36.36) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Shirzadi, M | 1 |
| Saunes, M | 1 |
| Reimers, A | 1 |
| Brodtkorb, E | 1 |
| Monroy-Arreola, A | 1 |
| Durán-Figueroa, NV | 1 |
| Méndez-Flores, S | 1 |
| Domínguez-Cherit, J | 1 |
| Watkinson, J | 1 |
| Badillo-Corona, JA | 1 |
| Whitaker, P | 1 |
| Naisbitt, DJ | 2 |
| Castrejón-Flores, JL | 1 |
| Atanasković-Marković, M | 1 |
| Janković, J | 1 |
| Tmušić, V | 1 |
| Gavrović-Jankulović, M | 1 |
| Ćirković Veličković, T | 1 |
| Nikolić, D | 1 |
| Škorić, D | 1 |
| Papadavid, E | 1 |
| Evangelia, P | 1 |
| Panayiotides, I | 1 |
| Ioannis, P | 1 |
| Makris, M | 1 |
| Michael, M | 1 |
| Giatrakou, S | 1 |
| Sophia, G | 1 |
| Dalamaga, M | 1 |
| Maria, D | 1 |
| Stavrianeas, N | 2 |
| Rigopoulos, D | 1 |
| Dimitrios, R | 1 |
| Im, SG | 1 |
| Yoo, SH | 1 |
| Park, YM | 1 |
| Lee, SJ | 1 |
| Jang, SK | 1 |
| Jeon, DO | 1 |
| Cho, HJ | 1 |
| Oh, MJ | 1 |
| Ozisik, L | 1 |
| Tanriover, MD | 1 |
| Saka, E | 1 |
| Gaeta, F | 1 |
| Alonzi, C | 1 |
| Valluzzi, RL | 1 |
| Viola, M | 1 |
| Elia, M | 1 |
| Romano, A | 1 |
| Taillia, H | 1 |
| Alla, P | 1 |
| Fournier, B | 1 |
| Bounolleau, P | 1 |
| Ouologem, M | 1 |
| Ricard, D | 1 |
| Sallansonnet-Froment, M | 1 |
| de Greslan, T | 1 |
| Renard, JL | 1 |
| Aouam, K | 1 |
| Ben Romdhane, F | 1 |
| Loussaief, C | 1 |
| Salem, R | 1 |
| Toumi, A | 1 |
| Belhadjali, H | 1 |
| Chaabane, A | 1 |
| Boughattas, NA | 1 |
| Chakroun, M | 1 |
| Dreesman, A | 1 |
| Hoorens, A | 1 |
| Hachimi-Idrissi, S | 1 |
| Pereira de Silva, N | 1 |
| Piquioni, P | 1 |
| Kochen, S | 1 |
| Saidon, P | 1 |
| Marriott, DJ | 1 |
| Periyasamy, P | 1 |
| Chow, JC | 1 |
| Huang, CW | 1 |
| Fang, CW | 1 |
| Wu, YJ | 1 |
| Tsai, JJ | 1 |
| Sato, T | 1 |
| Kuniba, H | 1 |
| Matsuo, M | 1 |
| Matsuzaka, T | 1 |
| Moriuchi, H | 1 |
| McCormack, M | 1 |
| Urban, TJ | 1 |
| Shianna, KV | 1 |
| Walley, N | 1 |
| Pandolfo, M | 1 |
| Depondt, C | 1 |
| Chaila, E | 1 |
| O'Conner, GD | 1 |
| Kasperavičiūtė, D | 1 |
| Radtke, RA | 1 |
| Heinzen, EL | 1 |
| Sisodiya, SM | 1 |
| Delanty, N | 1 |
| Cavalleri, GL | 1 |
| Comfere, NI | 1 |
| Sartori-Valinotti, JC | 1 |
| Bruce, AJ | 1 |
| Drage, LA | 1 |
| Farrell, J | 1 |
| Wong, G | 1 |
| Depta, JP | 1 |
| Dodd, CC | 1 |
| Hopkins, JE | 1 |
| Gibney, CA | 1 |
| Chadwick, DW | 1 |
| Pichler, WJ | 1 |
| Pirmohamed, M | 1 |
| Park, BK | 1 |
| Papp, Z | 1 |
| Török, L | 1 |
| Rahman, M | 1 |
| Haider, N | 1 |
| Jeandel, PY | 1 |
| Traissac, T | 1 |
| Rainfray, M | 1 |
| Bourdel-Marchasson, I | 1 |
| Chang, CC | 1 |
| Shiah, IS | 1 |
| Yeh, CB | 1 |
| Wang, TS | 1 |
| Chang, HA | 1 |
| Karande, S | 1 |
| Gogtay, NJ | 1 |
| Kanchan, S | 1 |
| Kshirsagar, NA | 1 |
| Man, CB | 1 |
| Kwan, P | 1 |
| Baum, L | 1 |
| Yu, E | 1 |
| Lau, KM | 1 |
| Cheng, AS | 1 |
| Ng, MH | 1 |
| Schmidt, D | 1 |
| Krämer, G | 1 |
| Schlienger, RG | 1 |
| Knowles, SR | 1 |
| Shear, NH | 2 |
| Hennessy, MJ | 1 |
| Koutroumanidis, M | 1 |
| Elwes, RD | 1 |
| Bocquet, H | 1 |
| Farmer, M | 1 |
| Bressieux, JM | 1 |
| Barzegar, C | 1 |
| Jullien, M | 1 |
| Soto, B | 1 |
| Roujeau, JC | 1 |
| Revuz, J | 1 |
| Mylonakis, E | 1 |
| Vittorio, CC | 1 |
| Hollik, DA | 1 |
| Rounds, S | 1 |
| Gücüyener, K | 1 |
| Türktaş, I | 1 |
| Serdaroglu, A | 1 |
| Ezgü, FS | 1 |
| Faught, E | 1 |
| Morris, G | 1 |
| Jacobson, M | 1 |
| French, J | 1 |
| Harden, C | 1 |
| Montouris, G | 1 |
| Rosenfeld, W | 1 |
| Sarris, BM | 1 |
| Wong, JG | 1 |
| Schaub, N | 1 |
| Bircher, AJ | 1 |
| Neuman, MG | 1 |
| Malkiewicz, IM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Preliminary Study of the Efficacy and Safety of Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency[NCT01379469] | Phase 2 | 20 participants (Actual) | Interventional | 2012-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lamotrigine and Drug Hypersensitivity
| Article | Year |
|---|---|
Hypersensitivity to lamotrigine and nonaromatic anticonvulsant drugs: a review.
Topics: Animals; Anticonvulsants; Drug Hypersensitivity; Humans; Lamotrigine; Skin Tests; Triazines | 2008 |
The new anticonvulsant drugs. Implications for avoidance of adverse effects.
Topics: Abnormalities, Drug-Induced; Anemia, Aplastic; Anticonvulsants; Chemical and Drug Induced Liver Inju | 1994 |
Lamotrigine-associated anticonvulsant hypersensitivity syndrome.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Hypersensitivity; Epilepsy; | 1998 |
1 trial available for lamotrigine and Drug Hypersensitivity
| Article | Year |
|---|---|
Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group.
Topics: Adolescent; Adult; Child; Dizziness; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combinatio | 1999 |
29 other studies available for lamotrigine and Drug Hypersensitivity
| Article | Year |
|---|---|
Rash during lamotrigine treatment is not always drug hypersensitivity: A retrospective cohort study among children and adults.
Topics: Adult; Anticonvulsants; Child; Drug Hypersensitivity; Exanthema; Humans; Lamotrigine; Retrospective | 2021 |
Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4
Topics: Adult; Carbamazepine; CD4-Positive T-Lymphocytes; Cytokines; Drug Hypersensitivity; Female; Humans; | 2018 |
Hypersensitivity reactions to antiepileptic drugs in children.
Topics: Adolescent; Allergens; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Different | 2019 |
Pityriasis rosea-like eruption associated with lamotrigine.
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Lamotrigine; Myocloni | 2013 |
Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report.
Topics: Adult; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Drug Hypersensitivity; Hu | 2015 |
Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome.
Topics: Adult; Anticonvulsants; Autoimmune Diseases; Drug Hypersensitivity; Eosinophilia; Exanthema; Female; | 2016 |
[Anticonvulsant hypersensitivity syndrome and lamotrigine-associated anticonvulsant hypersensitivity syndrome].
Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; | 2009 |
Hypersensitivity syndrome induced by anticonvulsants: possible cross-reactivity between carbamazepine and lamotrigine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Cross Reactions; Drug Eruptions; Drug Hypersensitivity; | 2009 |
Multiple organ dysfunction syndrome: infection or hypersensitivity reaction?
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Hypersensitivity, | 2010 |
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; Carbamazepine; Disease Susceptibility; | 2011 |
Anticonvulsant hypersensitivity syndrome secondary to lamotrigine mimicking a septic episode.
Topics: Animals; Anticonvulsants; Cattle; Drug Hypersensitivity; Female; Humans; Lamotrigine; Lupus Erythema | 2011 |
Lamotrigine-induced hypersensitivity syndrome in a Han Chinese patient with the HLA-B 5801 genotype.
Topics: Adult; Anticonvulsants; Asian People; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Female; Genot | 2013 |
[Case of drug-induced hypersensitivity syndrome due to lamotrigine: demonstration of sequential reactivation of herpesviruses].
Topics: Adolescent; Anticonvulsants; Cytomegalovirus; Drug Hypersensitivity; Female; Herpesvirus 4, Human; H | 2012 |
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
Topics: Biomarkers, Pharmacological; Carbamazepine; Drug Hypersensitivity; Genome-Wide Association Study; HL | 2012 |
Successful treatment of lamotrigine-associated drug hypersensitivity syndrome with intravenous IgG.
Topics: Adult; Anticonvulsants; Disease Progression; Drug Hypersensitivity; Female; Humans; Immunoglobulins, | 2012 |
Characterization of drug-specific T cells in lamotrigine hypersensitivity.
Topics: Adult; Anticonvulsants; Antigen Presentation; Cell Line; Cells, Cultured; Clone Cells; Cytokines; Cy | 2003 |
[Anticonvulsant hypersensitivity syndrome].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug | 2004 |
Anticonvulsant hypersensitivity syndrome from addition of lamotrigine to divalproex.
Topics: Anticonvulsants; Bipolar Disorder; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Fema | 2005 |
[Drug hypersensitivity syndrome with lamotrigine two cases in elderly].
Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Drug Hypersensitivity; Epilepsy; Female; Huma | 2005 |
Lamotrigine-associated anticonvulsant hypersensitivity syndrome in bipolar disorder.
Topics: Anticonvulsants; Bipolar Disorder; Drug Hypersensitivity; Female; Humans; Lamotrigine; Middle Aged; | 2006 |
Anticonvulsant hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.
Topics: Anticonvulsants; Child, Preschool; Drug Hypersensitivity; Epilepsy; Humans; In Vitro Techniques; Lam | 2006 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Chil | 2007 |
Neuralgic amyotrophy associated with hypersensitivity to lamotrigine.
Topics: Anticonvulsants; Brachial Plexus Neuritis; Drug Hypersensitivity; Humans; Lamotrigine; Male; Middle | 1998 |
[Lyell syndrome and Stevens-Johnson syndrome caused by lamotrigine].
Topics: Adolescent; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Hypersensitivity; Drug Th | 1999 |
Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome.
Topics: Anticonvulsants; Antimanic Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Hu | 1999 |
Suspected allergy to lamotrigine.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Epilepsy; Humans; Lamotrigine; Male; Serum Sickness; | 1999 |
Multisystem hypersensitivity reaction to lamotrigine.
Topics: Adult; Drug Hypersensitivity; Female; Humans; Lamotrigine; Triazines | 1999 |
Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Immunologic Tests; | 2000 |
A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Carbamazepine; Case-Control Studies; Cell Surviva | 2000 |