lamotrigine has been researched along with Disease Models, Animal in 124 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mood stabilizers lithium, valproate and lamotrigine are traditionally used to treat bipolar disorder." | 8.87 | Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models. ( Chuang, DM; Fessler, EB; Wang, ZF, 2011) |
| "Data from four clinical studies support the efficacy of adjunctive lamotrigine in the treatment of schizophrenia." | 8.82 | The potential role of lamotrigine in schizophrenia. ( Goff, DC; Large, CH; Webster, EL, 2005) |
| "Thirty-two rats, eight rats per group, were randomly assigned to the sham group in which only laparotomy was performed, and to the ischemia, methylprednisolone and lamotrigine groups, where the infrarenal aorta was clamped for thirty minutes to induce spinal cord ischemia-reperfusion injury." | 8.02 | Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury. ( Fesli, R; Gokce, A; Gokce, EC; Gürer, B; Kahveci, FO; Kahveci, R; Kısa, Ü; Sargon, MF; Sarı, MF, 2021) |
| "Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures." | 7.91 | Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. ( Nieoczym, D; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2019) |
| "Findings indicate that alterations in dopamine neurotransmission, glutamate metabolism, and GABA signaling may contribute to some of the behavioral deficits observed following PCP-SI, and that lamotrigine may have some utility as an adjunctive therapy to improve certain cognitive deficits symptoms in schizophrenia." | 7.83 | Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia. ( Alexander, SP; Fone, KC; Gaskin, PL; Toledo-Rodriguez, M, 2016) |
| "The aim of the study was to determine anticonvulsant activity of lamotrigine (LTG) after acute and chronic treatment in four different protocols against maximal electroshock-induced seizures in mice." | 7.81 | Effects of Chronic Lamotrigine Administration on Maximal Electroshock- Induced Seizures in Mice. ( Banach, M; Borowicz, KK, 2015) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 7.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| "Continuously administered intrathecal lamotrigine blocked the development of mechanical allodynia induced by SNL with suppression of microglial and astrocytic activation." | 7.79 | Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation. ( Choi, YS; Jun, IG; Kim, SH; Park, JY, 2013) |
| " We evaluated the neuroprotective effects of lamotrigine, a Nav blocker, in the acute and chronic rat ocular hypertension models." | 7.79 | Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension. ( Bähr, M; Hein, K; Könnecke, B; Levkovitch-Verbin, H; Ofri, R; Sandalon, S; Sättler, MB; Simons, M, 2013) |
| " Lamotrigine (LTG) is an effective clinical treatment for epilepsy associated with absence seizures." | 7.78 | Lamotrigine ameliorates seizures and psychiatric comorbidity in a rat model of spontaneous absence epilepsy. ( Chen, SD; Huang, HY; Lee, HW; Shaw, FZ, 2012) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Chronic lamotrigine, which is effective in the depressive phase or rapid cycling bipolar disorder does not alter brain arachidonic acid turnover in the unanesthetized rat." | 7.74 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "We assessed the effects of the anticonvulsants lamotrigine, valproate and carbamazepine in an animal model of anxiety." | 7.73 | Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels? ( Bright, JL; Harrington, NR; Mirza, NR; Stanhope, KJ; Wyatt, A, 2005) |
| " The aim of the present study was to evaluate lamotrigine (LTG), an antiepileptic that inhibits presynaptic sodium and voltage-sensitive calcium channels, as a potential stroke resuscitation agent in the rat." | 7.71 | Anticonvulsant lamotrigine administered on reperfusion fails to improve experimental stroke outcomes. ( DeVries, AC; Hurn, PD; Klaus, JA; Shaivitz, AB; Traystman, RJ, 2001) |
| "The effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole) on the severity of dystonia were examined in mutant hamsters (dtsz), an animal model of idiopathic dystonia in which dystonic attacks can be age dependently induced by mild stress." | 7.69 | Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus? ( Gernert, M; Löscher, W; Richter, A, 1997) |
| "Lamotrigine had neuroprotective effects in a gerbil model of global cerebral ischemia." | 7.69 | Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. ( Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP, 1995) |
| "Recent findings of antidystonic effects of NMDA and non-NMDA receptor antagonists in an inbred line of Syrian hamsters with primary generalized dystonia prompted us to investigate the effects of lamotrigine, an inhibitor of veratrine-induced glutamate release, on the severity of dystonia in mutant hamsters." | 7.69 | The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia. ( Löscher, W; Löschmann, PA; Richter, A, 1994) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| " Therefore, in the present study, the neuroprotective effects and mechanisms of vit-D alone or in combination with lamotrigine have been evaluated in the lithium-pilocarpine model of SE in rats." | 5.46 | Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats. ( Abdel-Wahab, AF; Afify, MA; Al Ghamdi, SS; Bamagous, GA; ElSawy, NA; Ibrahim, IAA; Mahfoz, AM; Shahzad, N, 2017) |
| "In other animals with ocular hypertension, the optic nerves were examined by immunohistochemistry for the expression of the inducible form of nitric oxide synthase (iNOS) at 7 and 28 days." | 5.38 | Lamotrigine monotherapy does not provide protection against the loss of optic nerve axons in a rat model of ocular hypertension. ( Berry, D; Bull, ND; Hyatt, AJ; Marina, N; Martin, KR; Sajic, M; Smith, KJ, 2012) |
| "Lamotrigine (LTG) is an antiepileptic drug, a glutamate release inhibitor, with action at the neuronal voltage-gated sodium channel." | 5.35 | NA+, K+-ATPase activity in the brain of the rats with kainic acid-induced seizures: influence of lamotrigine. ( Ljubicić, D; Pelcić, JM; Simonić, A; Vitezić, D; Vitezić, M; Zupan, G, 2008) |
| "Lamotrigine (LTG) is an anticonvulsant that is currently in use for the treatment of various seizure disorders and that shows promise in the treatment of affective illness." | 5.31 | Lamotrigine treatment during amygdala-kindled seizure development fails to inhibit seizures and diminishes subsequent anticonvulsant efficacy. ( Krupp, E; Li, XL; Post, RM; Postma, T; Weiss, SR, 2000) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 5.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "The mood stabilizers lithium, valproate and lamotrigine are traditionally used to treat bipolar disorder." | 4.87 | Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models. ( Chuang, DM; Fessler, EB; Wang, ZF, 2011) |
| "Data from four clinical studies support the efficacy of adjunctive lamotrigine in the treatment of schizophrenia." | 4.82 | The potential role of lamotrigine in schizophrenia. ( Goff, DC; Large, CH; Webster, EL, 2005) |
| "Lamotrigine (LTG) is a novel antiepileptic drug (AED) with a spectrum of activity in animal models of epilepsy similar to that of phenytoin and carbamazepine." | 4.79 | Lamotrigine. ( Messenheimer, JA, 1995) |
| "Thirty-two rats, eight rats per group, were randomly assigned to the sham group in which only laparotomy was performed, and to the ischemia, methylprednisolone and lamotrigine groups, where the infrarenal aorta was clamped for thirty minutes to induce spinal cord ischemia-reperfusion injury." | 4.02 | Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury. ( Fesli, R; Gokce, A; Gokce, EC; Gürer, B; Kahveci, FO; Kahveci, R; Kısa, Ü; Sargon, MF; Sarı, MF, 2021) |
| "Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures." | 3.91 | Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies. ( Nieoczym, D; Socała, K; Szafarz, M; Wlaź, P; Wyska, E, 2019) |
| "Findings indicate that alterations in dopamine neurotransmission, glutamate metabolism, and GABA signaling may contribute to some of the behavioral deficits observed following PCP-SI, and that lamotrigine may have some utility as an adjunctive therapy to improve certain cognitive deficits symptoms in schizophrenia." | 3.83 | Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia. ( Alexander, SP; Fone, KC; Gaskin, PL; Toledo-Rodriguez, M, 2016) |
| "The aim of this study was to determine the effects of 2-methyl-6-(phenylethynyl)pyridine (MPEP - a selective antagonist for the glutamate metabotropic receptor subtype mGluR5) on the protective action of some novel antiepileptic drugs (lamotrigine, oxcarbazepine, pregabalin and topiramate) against maximal electroshock-induced seizures in mice." | 3.83 | Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Florek-Luszczki, M; Kondrat-Wrobel, MW; Luszczki, JJ; Zolkowska, D, 2016) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| "The aim of the study was to determine anticonvulsant activity of lamotrigine (LTG) after acute and chronic treatment in four different protocols against maximal electroshock-induced seizures in mice." | 3.81 | Effects of Chronic Lamotrigine Administration on Maximal Electroshock- Induced Seizures in Mice. ( Banach, M; Borowicz, KK, 2015) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 3.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| " We evaluated the neuroprotective effects of lamotrigine, a Nav blocker, in the acute and chronic rat ocular hypertension models." | 3.79 | Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension. ( Bähr, M; Hein, K; Könnecke, B; Levkovitch-Verbin, H; Ofri, R; Sandalon, S; Sättler, MB; Simons, M, 2013) |
| "Single intraperitoneal (ip) administration of CYT in a subthreshold dose of 2 mg/kg antagonized the protective activity of ip phenytoin and lamotrigine against MES-induced seizures in mice." | 3.79 | Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice. ( Bednarski, J; Mosiewicz, J; Mróz, T; Ognik, J; Styk, A; Tutka, P; Łuszczki, J, 2013) |
| "Continuously administered intrathecal lamotrigine blocked the development of mechanical allodynia induced by SNL with suppression of microglial and astrocytic activation." | 3.79 | Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation. ( Choi, YS; Jun, IG; Kim, SH; Park, JY, 2013) |
| "Lamotrigine is an anticonvulsant and has an antiglutamatergic action, which may contribute to its antidepressant effects, since glutamate has been linked to depression." | 3.78 | Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats. ( Abelaira, HM; Cipriano, AL; Quevedo, J; Réus, GZ; Ribeiro, KF; Scaini, G; Streck, EL; Zappellini, G, 2012) |
| " Lamotrigine (LTG) is an effective clinical treatment for epilepsy associated with absence seizures." | 3.78 | Lamotrigine ameliorates seizures and psychiatric comorbidity in a rat model of spontaneous absence epilepsy. ( Chen, SD; Huang, HY; Lee, HW; Shaw, FZ, 2012) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Chronic lamotrigine, which is effective in the depressive phase or rapid cycling bipolar disorder does not alter brain arachidonic acid turnover in the unanesthetized rat." | 3.74 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Lamotrigine has been found to be efficacious in the acute management of bipolar depression and long-term management of bipolar disorder, especially in delaying depressive recurrence, either as monotherapy or as adjunctive therapy." | 3.74 | Antidepressant-like effect of lamotrigine is reversed by veratrine: a possible role of sodium channels in bipolar depression. ( Bourin, M; Hascoet, M; Prica, C, 2008) |
| " In the mouse pentylenetetrazole induced seizures model, JZP-4 was approximately twice as potent as lamotrigine in prolonging the time to clonus." | 3.74 | In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. ( Eller, M; Foreman, MM; Hanania, T; Stables, JP; Stratton, SC; White, HS; Wilcox, KS, 2008) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| "We assessed the effects of the anticonvulsants lamotrigine, valproate and carbamazepine in an animal model of anxiety." | 3.73 | Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels? ( Bright, JL; Harrington, NR; Mirza, NR; Stanhope, KJ; Wyatt, A, 2005) |
| " The aim of the present study was to evaluate lamotrigine (LTG), an antiepileptic that inhibits presynaptic sodium and voltage-sensitive calcium channels, as a potential stroke resuscitation agent in the rat." | 3.71 | Anticonvulsant lamotrigine administered on reperfusion fails to improve experimental stroke outcomes. ( DeVries, AC; Hurn, PD; Klaus, JA; Shaivitz, AB; Traystman, RJ, 2001) |
| "Recent findings of antidystonic effects of NMDA and non-NMDA receptor antagonists in an inbred line of Syrian hamsters with primary generalized dystonia prompted us to investigate the effects of lamotrigine, an inhibitor of veratrine-induced glutamate release, on the severity of dystonia in mutant hamsters." | 3.69 | The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia. ( Löscher, W; Löschmann, PA; Richter, A, 1994) |
| "Lamotrigine had neuroprotective effects in a gerbil model of global cerebral ischemia." | 3.69 | Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. ( Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP, 1995) |
| "The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models." | 3.69 | The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. ( Fontana, DJ; Gogas, KR; Hedley, LR; Hunter, JC; Jacobson, LO; Kassotakis, L; Thompson, J, 1997) |
| "The effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole) on the severity of dystonia were examined in mutant hamsters (dtsz), an animal model of idiopathic dystonia in which dystonic attacks can be age dependently induced by mild stress." | 3.69 | Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus? ( Gernert, M; Löscher, W; Richter, A, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Epilepsy affects fetal brain development during gestation in pregnant rats, therefore anti-epileptic therapy should be continued during pregnancy." | 2.53 | Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats. ( Doğan, Z; Kamışlı, Ö; Soysal, H, 2016) |
| "A major challenge in the treatment of bipolar depression is the tendency for antidepressant medications, particularly tricyclic antidepressants, to precipitate episodes of mania, or to increase cycle frequency or symptom intensity." | 2.44 | The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders. ( Bourin, M; Prica, C, 2007) |
| "We investigated the impact of repeated seizures on hippocampal memory and amyloid-β (Aβ) load in pre-symptomatic Tg2576 mice, a transgenic model of AD." | 1.91 | Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer's disease mouse model. ( Curia, G; Giorgi, C; Malerba, F; Marchetti, C; Merenda, E; Middei, S; Paolantoni, C; Pignataro, A; Pimpinella, D; Porcheddu, GF; Rizzello, E; Saviana, M; Titta, G, 2023) |
| "Temporal lobe epilepsy is a common, chronic disorder with spontaneous seizures that is often refractory to drug therapy." | 1.91 | Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats. ( Diespirov, GP; Griflyuk, AV; Kalita, AD; Postnikova, TY; Sinyak, DS; Zaitsev, AV; Zubareva, OE, 2023) |
| "Epileptic spikes and seizures seem present early in the disease process of Alzheimer's disease (AD)." | 1.72 | Higher susceptibility to 6 Hz corneal kindling and lower responsiveness to antiseizure drugs in mouse models of Alzheimer's disease. ( Aourz, N; Barker-Haliski, M; Bjerke, M; De Bundel, D; Engelborghs, S; Nagels, G; Smolders, I; Vande Vyver, M, 2022) |
| "Lamotrigine was intravenously administered in doses of 0." | 1.62 | Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs. ( Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kambayashi, R; Kawai, S; Matsumoto, A; Nunoi, Y; Sugiyama, A; Takei, Y, 2021) |
| "Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are the most severe cutaneous drug hypersensitivity reactions, which are unpredictable adverse drug reactions." | 1.56 | Therapeutic Effects of Mesenchymal Stem Cells on a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Model. ( Cho, YS; Kim, HJ; Kim, JH; Kim, TB; Kwon, HS; Kwon, OY; Moon, HB; Oh, IY; Park, SY; Seo, B; Song, WJ, 2020) |
| "Then, spontaneous recurrent seizures (SRS), neuronal loss and astrogliosis were assessed." | 1.51 | The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy. ( Chen, Y; Sun, M; van Luijtelaar, G; Wang, J; Wang, Q, 2019) |
| "Lamotrigine (LTG) has been widely prescribed as an antipsychotic drug, although it causes idiosyncratic drug-induced liver injury in humans." | 1.51 | Strain and interindividual differences in lamotrigine-induced liver injury in mice. ( Akai, S; Oda, S; Yokoi, T, 2019) |
| "Epilepsy is a serious neurological disease affecting about 1% of people worldwide (65 million)." | 1.48 | Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model. ( Kondrat-Wróbel, MW; Łuszczki, JJ, 2018) |
| "Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE])." | 1.46 | Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy. ( Aroni, S; Marrosu, F; Melis, M; Milioli, G; Muntoni, AL; Parrino, L; Pillolla, G; Pistis, M; Puligheddu, M; Sagheddu, C; Terzano, GM, 2017) |
| " Therefore, in the present study, the neuroprotective effects and mechanisms of vit-D alone or in combination with lamotrigine have been evaluated in the lithium-pilocarpine model of SE in rats." | 1.46 | Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats. ( Abdel-Wahab, AF; Afify, MA; Al Ghamdi, SS; Bamagous, GA; ElSawy, NA; Ibrahim, IAA; Mahfoz, AM; Shahzad, N, 2017) |
| "Lamotrigine (LTG) is a popular modern antiepileptic drug (AED); however, its mechanism of action has yet to be fully understood, as it is known to modulate many members of several ion channel families." | 1.39 | Cav 2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo. ( Alpdogan, S; Dibué, M; Hescheler, J; Kamp, MA; Neiss, WF; Schneider, T; Tevoufouet, EE, 2013) |
| "The treatment with lamotrigine increased the superoxide dismutase (SOD) and catalase activity (CAT) activities in the amygdala of stressed rats." | 1.39 | Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model. ( Abelaira, HM; Dal-Pizzol, F; Mina, F; Quevedo, J; Réus, GZ; Ribeiro, KF; Romano-Silva, MA; Rosa, DV; Santana, CV; Steckert, AV, 2013) |
| "In other animals with ocular hypertension, the optic nerves were examined by immunohistochemistry for the expression of the inducible form of nitric oxide synthase (iNOS) at 7 and 28 days." | 1.38 | Lamotrigine monotherapy does not provide protection against the loss of optic nerve axons in a rat model of ocular hypertension. ( Berry, D; Bull, ND; Hyatt, AJ; Marina, N; Martin, KR; Sajic, M; Smith, KJ, 2012) |
| " The results showed that chronic administration of 30 mg/kg lamotrigine (14 days) normalized the down-regulated frontal and hippocampal VEGF protein expression as well as the behavioral deficits induced by chronic unpredictable stress." | 1.38 | VEGF regulates antidepressant effects of lamotrigine. ( Li, N; Li, T; Sun, R, 2012) |
| "Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system." | 1.37 | Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. ( Arjun, M; Menon, N; Semwal, A; Sriram, D; Yogeeswari, P, 2011) |
| " To conclude, long term administration of topiramate impairs cognitive functions during experimental epilepsy while lamotrigine and oxcarbazepine are safer." | 1.37 | Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice. ( Agarwal, NB; Agarwal, NK; Mediratta, PK; Sharma, KK, 2011) |
| "The aim of this study was to characterize the anticonvulsant effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ--an endogenous parkinsonism-preventing substance) in combination with four second-generation antiepileptic drugs (AEDs: lamotrigine [LTG], oxcarbazepine [OXC], pregabalin [PGB], and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis. ( Antkiewicz-Michaluk, L; Czuczwar, SJ; Luszczki, JJ; Raszewski, G, 2010) |
| ", lamotrigine [LTG], oxcarbazepine [OXC] and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Czuczwar, SJ; Filip, D; Luszczki, JJ, 2010) |
| "Lamotrigine is an anti-epileptic drug that blocks the voltage-gated sodium channels of the presynaptic neuron and inhibits the release of glutamate." | 1.35 | Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. ( Dagklis, T; Kaiki-Astara, A; Kallaras, K; Kouvelas, D; Papazisis, G; Pourzitaki, C; Tzachanis, D, 2008) |
| "Pretreatment with lamotrigine significantly attenuated AMPH/CDP-induced effects, but also reduced motility when tested in the presence of CDP-alone." | 1.35 | Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. ( Nielsen, AN; Redrobe, JP, 2009) |
| "Lamotrigine is an antiepileptic drug that inhibits presynaptic voltage-gated sodium channels and reduces the presynaptic release of glutamate in pathological states." | 1.35 | Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury. ( Dursun, A; Ofluoglu, E; Ozogul, C; Oztanir, N; Pasaoglu, A; Pasaoglu, H; Tufan, K; Uzum, N, 2008) |
| "Lamotrigine (LTG) is an antiepileptic drug, a glutamate release inhibitor, with action at the neuronal voltage-gated sodium channel." | 1.35 | NA+, K+-ATPase activity in the brain of the rats with kainic acid-induced seizures: influence of lamotrigine. ( Ljubicić, D; Pelcić, JM; Simonić, A; Vitezić, D; Vitezić, M; Zupan, G, 2008) |
| " The isobolographic analysis for parallel and nonparallel dose-response effects was used in the mouse maximal electroshock seizure (MES) model for evaluation of pharmacodynamic interaction." | 1.35 | Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ; Raszewski, G; Wu, JZ, 2009) |
| "Lamotrigine is a clinically used drug, which inhibits Na(+) channel activity that in turn reduces glutamate release." | 1.34 | The effects of lamotrigine on alcohol seeking and relapse. ( Heidbreder, CA; Spanagel, R; Vengeliene, V, 2007) |
| " However, these combinations were associated with significant pharmacokinetic interactions, in that LCZ increased brain TPM (94%), OXC (21%), FBM (46%), and LTG (8%) concentrations." | 1.33 | Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "Lamotrigine in treatment-resistant schizophrenia; a randomized placebo-controlled cross over trial." | 1.33 | Effects of clozapine plus lamotrigine on phencyclidine-induced hyperactivity. ( Dursun, SM; Robertson, H; Williams, HJ; Zamzow, CR, 2006) |
| " This study was designed to assess the antiepileptic activity of aspirin and to investigate the potentiation of its activity in combination with a subconvulsive dose of lamotrigine." | 1.32 | Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice. ( Anuradha, K; Pandhi, P; Tandon, M, 2003) |
| "The pharmacodynamic interaction between the antiepileptic drugs (AEDs) tiagabine (TGB) and lamotrigine (LTG) was characterized on basis of the anticonvulsant effect in the cortical stimulation model in the rat." | 1.32 | Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat. ( Danhof, M; Jonker, DM; Voskuyl, RA, 2004) |
| "Lamotrigine has neuroprotective effect during HCA." | 1.31 | Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest. ( Anttila, V; Biancari, F; Hirvonen, J; Jäntti, V; Juvonen, T; Kiviluoma, KT; Ohtonen, P; Pokela, M; Rimpiläinen, J; Romsi, P; Vainionpää, V, 2002) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 1.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "Lamotrigine (LTG) is an anticonvulsant that is currently in use for the treatment of various seizure disorders and that shows promise in the treatment of affective illness." | 1.31 | Lamotrigine treatment during amygdala-kindled seizure development fails to inhibit seizures and diminishes subsequent anticonvulsant efficacy. ( Krupp, E; Li, XL; Post, RM; Postma, T; Weiss, SR, 2000) |
| "Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate." | 1.30 | Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats. ( Klamt, JG, 1998) |
| "Lamotrigine was the only drug which antagonized tonic convulsions in the MES test (ED50 = 36 mumol/kg)." | 1.30 | Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. ( Dalby, NO; Nielsen, EB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (12.10) | 18.2507 |
| 2000's | 45 (36.29) | 29.6817 |
| 2010's | 51 (41.13) | 24.3611 |
| 2020's | 13 (10.48) | 2.80 |
| Authors | Studies |
|---|---|
| Yogeeswari, P | 3 |
| Ragavendran, JV | 2 |
| Sriram, D | 3 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 2 |
| Kotapati, S | 1 |
| Menon, N | 1 |
| Semwal, A | 1 |
| Arjun, M | 1 |
| Browne, L | 1 |
| Lidster, K | 1 |
| Al-Izki, S | 1 |
| Clutterbuck, L | 1 |
| Posada, C | 1 |
| Chan, AW | 1 |
| Riddall, D | 1 |
| Garthwaite, J | 1 |
| Baker, D | 1 |
| Selwood, DL | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Kumar, S | 1 |
| Ivanov, S | 1 |
| Lagunin, A | 1 |
| Goel, RK | 1 |
| Vande Vyver, M | 1 |
| Barker-Haliski, M | 3 |
| Aourz, N | 1 |
| Nagels, G | 1 |
| Bjerke, M | 1 |
| Engelborghs, S | 1 |
| De Bundel, D | 1 |
| Smolders, I | 1 |
| Zhuo, C | 1 |
| Zhou, C | 1 |
| Tian, H | 1 |
| Li, Q | 2 |
| Chen, J | 2 |
| Yang, L | 1 |
| Zhang, Q | 1 |
| Li, R | 1 |
| Ma, X | 1 |
| Cai, Z | 1 |
| Chen, G | 1 |
| Xu, Y | 1 |
| Song, X | 1 |
| Rizzello, E | 1 |
| Pimpinella, D | 1 |
| Pignataro, A | 1 |
| Titta, G | 1 |
| Merenda, E | 1 |
| Saviana, M | 1 |
| Porcheddu, GF | 1 |
| Paolantoni, C | 1 |
| Malerba, F | 1 |
| Giorgi, C | 1 |
| Curia, G | 1 |
| Middei, S | 1 |
| Marchetti, C | 1 |
| Zubareva, OE | 1 |
| Sinyak, DS | 1 |
| Kalita, AD | 1 |
| Griflyuk, AV | 1 |
| Diespirov, GP | 1 |
| Postnikova, TY | 1 |
| Zaitsev, AV | 1 |
| Park, SY | 1 |
| Oh, IY | 1 |
| Kim, JH | 1 |
| Kim, HJ | 1 |
| Seo, B | 1 |
| Kwon, OY | 1 |
| Song, WJ | 1 |
| Kwon, HS | 1 |
| Cho, YS | 1 |
| Moon, HB | 1 |
| Kim, TB | 1 |
| Koneval, Z | 2 |
| Knox, KM | 2 |
| Memon, A | 1 |
| Zierath, DK | 1 |
| White, HS | 5 |
| Goto, A | 1 |
| Hagiwara-Nagasawa, M | 1 |
| Kambayashi, R | 1 |
| Nunoi, Y | 1 |
| Izumi-Nakaseko, H | 1 |
| Kawai, S | 1 |
| Takei, Y | 1 |
| Matsumoto, A | 1 |
| Sugiyama, A | 1 |
| Łukawski, K | 1 |
| Czuczwar, SJ | 7 |
| Filiz, AK | 1 |
| Gumus, E | 1 |
| Karabulut, S | 1 |
| Tastemur, Y | 1 |
| Taskiran, AS | 1 |
| Załuska-Ogryzek, K | 1 |
| Marzęda, P | 1 |
| Wróblewska-Łuczka, P | 2 |
| Florek-Łuszczki, M | 2 |
| Plewa, Z | 1 |
| Bojar, H | 1 |
| Zolkowska, D | 2 |
| Łuszczki, JJ | 4 |
| Kahveci, FO | 1 |
| Kahveci, R | 1 |
| Gokce, EC | 1 |
| Gokce, A | 1 |
| Kısa, Ü | 1 |
| Sargon, MF | 1 |
| Fesli, R | 1 |
| Sarı, MF | 1 |
| Gürer, B | 1 |
| Sawicka, KM | 2 |
| Załuska, K | 1 |
| Wawryniuk, A | 2 |
| Załuska-Patel, K | 1 |
| Szczyrek, M | 1 |
| Drop, B | 1 |
| Daniluk, J | 2 |
| Szpringer, M | 1 |
| Żółkowska, D | 1 |
| Mahfoz, AM | 1 |
| Abdel-Wahab, AF | 2 |
| Afify, MA | 2 |
| Shahzad, N | 2 |
| Ibrahim, IAA | 1 |
| ElSawy, NA | 1 |
| Bamagous, GA | 2 |
| Al Ghamdi, SS | 2 |
| Puligheddu, M | 1 |
| Melis, M | 1 |
| Pillolla, G | 1 |
| Milioli, G | 1 |
| Parrino, L | 1 |
| Terzano, GM | 1 |
| Aroni, S | 1 |
| Sagheddu, C | 1 |
| Marrosu, F | 1 |
| Pistis, M | 1 |
| Muntoni, AL | 1 |
| Mahfouz, AM | 1 |
| Kondrat-Wróbel, MW | 2 |
| Samsonia, M | 1 |
| Kandelaki, M | 1 |
| Baratashvili, N | 1 |
| Abu-Rish, EY | 1 |
| Dahabiyeh, LA | 1 |
| Bustanji, Y | 1 |
| Mohamed, YS | 1 |
| Browning, MJ | 1 |
| Akai, S | 1 |
| Oda, S | 1 |
| Yokoi, T | 1 |
| Wang, J | 2 |
| Chen, Y | 1 |
| Wang, Q | 1 |
| van Luijtelaar, G | 1 |
| Sun, M | 1 |
| Chmielewski, J | 1 |
| Karwan, S | 1 |
| Socała, K | 1 |
| Wyska, E | 1 |
| Szafarz, M | 1 |
| Nieoczym, D | 1 |
| Wlaź, P | 1 |
| Abelaira, HM | 2 |
| Réus, GZ | 2 |
| Ribeiro, KF | 2 |
| Steckert, AV | 1 |
| Mina, F | 1 |
| Rosa, DV | 1 |
| Santana, CV | 1 |
| Romano-Silva, MA | 1 |
| Dal-Pizzol, F | 1 |
| Quevedo, J | 2 |
| Tutka, P | 1 |
| Mróz, T | 1 |
| Bednarski, J | 1 |
| Styk, A | 1 |
| Ognik, J | 1 |
| Mosiewicz, J | 1 |
| Łuszczki, J | 1 |
| Srivastava, AK | 1 |
| Alex, AB | 1 |
| Wilcox, KS | 2 |
| Dibué, M | 1 |
| Kamp, MA | 1 |
| Alpdogan, S | 1 |
| Tevoufouet, EE | 1 |
| Neiss, WF | 1 |
| Hescheler, J | 1 |
| Schneider, T | 1 |
| Russo, E | 1 |
| Chimirri, S | 1 |
| Aiello, R | 1 |
| De Fazio, S | 1 |
| Leo, A | 1 |
| Rispoli, V | 1 |
| Marra, R | 1 |
| Labate, A | 1 |
| De Fazio, P | 1 |
| Citraro, R | 1 |
| De Sarro, G | 1 |
| Sandalon, S | 1 |
| Könnecke, B | 1 |
| Levkovitch-Verbin, H | 1 |
| Simons, M | 1 |
| Hein, K | 1 |
| Sättler, MB | 1 |
| Bähr, M | 1 |
| Ofri, R | 1 |
| Lee, SH | 1 |
| Kang, JW | 1 |
| Lin, T | 1 |
| Lee, JE | 1 |
| Jin, DI | 1 |
| Singh, E | 1 |
| Pillai, KK | 1 |
| Mehndiratta, M | 1 |
| Zhang, MY | 2 |
| Zheng, CY | 1 |
| Zou, MM | 1 |
| Zhu, JW | 1 |
| Zhang, Y | 2 |
| Liu, CF | 1 |
| Li, QF | 1 |
| Xiao, ZC | 1 |
| Li, S | 1 |
| Ma, QH | 2 |
| Xu, RX | 2 |
| Zalewska-Kaszubska, J | 1 |
| Bajer, B | 1 |
| Gorska, D | 1 |
| Andrzejczak, D | 1 |
| Dyr, W | 1 |
| Bieńkowski, P | 1 |
| Banach, M | 1 |
| Borowicz, KK | 1 |
| Wu, H | 1 |
| Lu, MH | 1 |
| Wang, W | 1 |
| Zhu, QQ | 1 |
| Xia, YY | 1 |
| Yang, Y | 2 |
| Chen, LH | 1 |
| Omrani, A | 1 |
| van der Vaart, T | 1 |
| Mientjes, E | 1 |
| van Woerden, GM | 1 |
| Hojjati, MR | 1 |
| Li, KW | 1 |
| Gutmann, DH | 1 |
| Levelt, CN | 1 |
| Smit, AB | 1 |
| Silva, AJ | 1 |
| Kushner, SA | 1 |
| Elgersma, Y | 1 |
| Gavzan, H | 1 |
| Sayyah, M | 1 |
| Sardari, S | 1 |
| Babapour, V | 1 |
| Florek-Luszczki, M | 1 |
| Luszczki, JJ | 7 |
| Soysal, H | 1 |
| Doğan, Z | 1 |
| Kamışlı, Ö | 1 |
| Barrera-Bailón, B | 1 |
| Oliveira, JAC | 1 |
| López, DE | 1 |
| Muñoz, LJ | 1 |
| Garcia-Cairasco, N | 1 |
| Sancho, C | 1 |
| Gaskin, PL | 1 |
| Toledo-Rodriguez, M | 1 |
| Alexander, SP | 1 |
| Fone, KC | 1 |
| Gosselin, S | 1 |
| Hoegberg, LC | 1 |
| Hoffman, RS | 1 |
| Graudins, A | 1 |
| Stork, CM | 1 |
| Thomas, SH | 1 |
| Stellpflug, SJ | 1 |
| Hayes, BD | 1 |
| Levine, M | 1 |
| Morris, M | 1 |
| Nesbitt-Miller, A | 1 |
| Turgeon, AF | 1 |
| Bailey, B | 1 |
| Calello, DP | 1 |
| Chuang, R | 1 |
| Bania, TC | 1 |
| Mégarbane, B | 1 |
| Bhalla, A | 1 |
| Lavergne, V | 1 |
| Wang, K | 1 |
| Fernandez-Escobar, A | 1 |
| Han, S | 1 |
| Zhu, P | 1 |
| Wang, JH | 1 |
| Sun, Y | 2 |
| Park, SH | 1 |
| Seo, YH | 1 |
| Moon, BH | 1 |
| Choi, SH | 2 |
| Kang, S | 1 |
| Lee, KJ | 1 |
| Lee, MS | 1 |
| Chun, BG | 1 |
| Shin, KH | 1 |
| Fan, Y | 1 |
| Deng, P | 1 |
| Wang, YC | 1 |
| Lu, HC | 1 |
| Xu, ZC | 1 |
| Schulz, PE | 1 |
| Wu, JZ | 1 |
| Raszewski, G | 2 |
| Vitezić, D | 1 |
| Pelcić, JM | 1 |
| Zupan, G | 1 |
| Vitezić, M | 1 |
| Ljubicić, D | 1 |
| Simonić, A | 1 |
| Tufan, K | 1 |
| Oztanir, N | 1 |
| Ofluoglu, E | 1 |
| Ozogul, C | 1 |
| Uzum, N | 1 |
| Dursun, A | 1 |
| Pasaoglu, H | 1 |
| Pasaoglu, A | 1 |
| Redrobe, JP | 1 |
| Nielsen, AN | 1 |
| Bernášková, K | 1 |
| Mareš, P | 1 |
| Large, CH | 2 |
| Kalinichev, M | 1 |
| Lucas, A | 1 |
| Carignani, C | 1 |
| Bradford, A | 1 |
| Garbati, N | 1 |
| Sartori, I | 1 |
| Austin, NE | 1 |
| Ruffo, A | 1 |
| Jones, DN | 1 |
| Alvaro, G | 1 |
| Read, KD | 1 |
| Quan, QY | 1 |
| Yang, F | 1 |
| Wang, Y | 2 |
| Wang, JC | 1 |
| Zhao, G | 1 |
| Jiang, W | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Li, N | 2 |
| He, X | 1 |
| Qi, X | 1 |
| He, S | 1 |
| Nakato, Y | 1 |
| Abekawa, T | 1 |
| Ito, K | 1 |
| Inoue, T | 1 |
| Koyama, T | 1 |
| Filip, D | 1 |
| Agarwal, NB | 1 |
| Agarwal, NK | 1 |
| Mediratta, PK | 1 |
| Sharma, KK | 1 |
| Forcelli, PA | 1 |
| Gale, K | 1 |
| Kondratyev, A | 1 |
| Yoshino, A | 1 |
| Sun, R | 1 |
| Li, T | 1 |
| Wang, ZF | 1 |
| Fessler, EB | 1 |
| Chuang, DM | 1 |
| Zappellini, G | 1 |
| Cipriano, AL | 1 |
| Scaini, G | 1 |
| Streck, EL | 1 |
| Loutochin, O | 1 |
| Al Afraa, T | 1 |
| Campeau, L | 1 |
| Mahfouz, W | 1 |
| Elzayat, E | 1 |
| Corcos, J | 1 |
| Marina, N | 1 |
| Sajic, M | 1 |
| Bull, ND | 1 |
| Hyatt, AJ | 1 |
| Berry, D | 2 |
| Smith, KJ | 2 |
| Martin, KR | 1 |
| Huang, HY | 1 |
| Lee, HW | 1 |
| Chen, SD | 1 |
| Shaw, FZ | 1 |
| Choi, YS | 1 |
| Jun, IG | 1 |
| Kim, SH | 1 |
| Park, JY | 1 |
| Smyth, MD | 1 |
| Barbaro, NM | 1 |
| Baraban, SC | 1 |
| Erichsen, HK | 1 |
| Hao, JX | 1 |
| Xu, XJ | 1 |
| Blackburn-Munro, G | 1 |
| Tandon, M | 1 |
| Anuradha, K | 1 |
| Pandhi, P | 1 |
| Brody, SA | 1 |
| Conquet, F | 1 |
| Geyer, MA | 1 |
| Ataus, SA | 1 |
| Onal, MZ | 1 |
| Ozdem, SS | 1 |
| Locke, KW | 1 |
| Balkan, S | 1 |
| Jonker, DM | 1 |
| Voskuyl, RA | 1 |
| Danhof, M | 1 |
| Arban, R | 1 |
| Maraia, G | 1 |
| Brackenborough, K | 1 |
| Winyard, L | 1 |
| Wilson, A | 1 |
| Gerrard, P | 1 |
| Large, C | 1 |
| Mirza, NR | 1 |
| Bright, JL | 1 |
| Stanhope, KJ | 1 |
| Wyatt, A | 1 |
| Harrington, NR | 1 |
| Ratnaraj, N | 1 |
| Patsalos, PN | 1 |
| Webster, EL | 1 |
| Goff, DC | 1 |
| Lindia, JA | 1 |
| Köhler, MG | 1 |
| Martin, WJ | 2 |
| Abbadie, C | 2 |
| Garry, EM | 1 |
| Delaney, A | 1 |
| Anderson, HA | 1 |
| Sirinathsinghji, EC | 1 |
| Clapp, RH | 1 |
| Kinchington, PR | 1 |
| Krah, DL | 1 |
| Fleetwood-Walker, SM | 1 |
| Williams, HJ | 1 |
| Zamzow, CR | 1 |
| Robertson, H | 1 |
| Dursun, SM | 1 |
| Wang-Tilz, Y | 1 |
| Tilz, C | 1 |
| Wang, B | 1 |
| Tilz, GP | 1 |
| Stefan, H | 1 |
| Bechtold, DA | 1 |
| Miller, SJ | 1 |
| Dawson, AC | 1 |
| Kapoor, R | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Bourin, M | 2 |
| Prica, C | 2 |
| Lee, HJ | 1 |
| Rao, JS | 1 |
| Chang, L | 1 |
| Rapoport, SI | 1 |
| Bazinet, RP | 1 |
| Sardo, P | 1 |
| Ferraro, G | 1 |
| Papazisis, G | 1 |
| Kallaras, K | 1 |
| Kaiki-Astara, A | 1 |
| Pourzitaki, C | 1 |
| Tzachanis, D | 1 |
| Dagklis, T | 1 |
| Kouvelas, D | 1 |
| Vengeliene, V | 1 |
| Heidbreder, CA | 1 |
| Spanagel, R | 1 |
| Dencker, D | 1 |
| Dias, R | 1 |
| Pedersen, ML | 1 |
| Husum, H | 1 |
| Lee, CY | 1 |
| Fu, WM | 1 |
| Chen, CC | 1 |
| Su, MJ | 1 |
| Liou, HH | 1 |
| Danysz, W | 1 |
| Seçkin, H | 1 |
| Yigitkanli, K | 1 |
| Besalti, O | 1 |
| Kosemehmetoglu, K | 1 |
| Ozturk, E | 1 |
| Simsek, S | 1 |
| Belen, D | 1 |
| Bavbek, M | 1 |
| Foreman, MM | 1 |
| Hanania, T | 1 |
| Stratton, SC | 1 |
| Stables, JP | 1 |
| Eller, M | 1 |
| Hascoet, M | 1 |
| Richter, A | 2 |
| Löschmann, PA | 1 |
| Löscher, W | 2 |
| Wiard, RP | 1 |
| Dickerson, MC | 1 |
| Beek, O | 1 |
| Norton, R | 1 |
| Cooper, BR | 2 |
| Smith, SE | 1 |
| al-Zubaidy, ZA | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Jones-Humble, SA | 1 |
| Morgan, PF | 1 |
| Nakamura-Craig, M | 1 |
| Follenfant, RL | 1 |
| Messenheimer, JA | 1 |
| Obrenovitch, TP | 1 |
| Hosford, DA | 1 |
| Hunter, JC | 1 |
| Gogas, KR | 1 |
| Hedley, LR | 1 |
| Jacobson, LO | 1 |
| Kassotakis, L | 1 |
| Thompson, J | 1 |
| Fontana, DJ | 1 |
| Dalby, NO | 1 |
| Nielsen, EB | 1 |
| Gernert, M | 1 |
| Klamt, JG | 1 |
| Shuaib, A | 1 |
| Maj, R | 1 |
| Fariello, RG | 1 |
| Pevarello, P | 1 |
| Varasi, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| Krupp, E | 2 |
| Heynen, T | 1 |
| Li, XL | 2 |
| Post, RM | 2 |
| Weiss, SR | 2 |
| Anttila, V | 2 |
| Rimpiläinen, J | 2 |
| Pokela, M | 2 |
| Kiviluoma, K | 1 |
| Mäkiranta, M | 1 |
| Jäntti, V | 2 |
| Vainionpää, V | 2 |
| Hirvonen, J | 2 |
| Juvonen, T | 2 |
| Postma, T | 1 |
| Traystman, RJ | 1 |
| Klaus, JA | 1 |
| DeVries, AC | 1 |
| Shaivitz, AB | 1 |
| Hurn, PD | 1 |
| Christensen, D | 1 |
| Gautron, M | 1 |
| Guilbaud, G | 1 |
| Kayser, V | 1 |
| Otoom, SA | 1 |
| Nusier, MK | 1 |
| Romsi, P | 1 |
| Kiviluoma, KT | 1 |
| Biancari, F | 1 |
| Ohtonen, P | 1 |
| Zona, C | 1 |
| Tancredi, V | 1 |
| Longone, P | 1 |
| D'Arcangelo, G | 1 |
| D'Antuono, M | 1 |
| Manfredi, M | 1 |
| Avoli, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study[NCT03419949] | 0 participants | Expanded Access | Available | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for lamotrigine and Disease Models, Animal
| Article | Year |
|---|---|
Effects of phenytoin and lamotrigine treatment on serum BDNF levels in offsprings of epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Electroencephal | 2016 |
Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning
Topics: Administration, Intravenous; Anesthetics; Animals; Calcium Channel Blockers; Cocaine; Diphenhydramin | 2016 |
[Rational combinations of antiepileptic drugs for refractory epilepsy].
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Cl | 2011 |
Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models.
Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Disease Models, Animal; Humans; Lamotrigine; Lithiu | 2011 |
The potential role of lamotrigine in schizophrenia.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain; Disease Models, Animal; Drug Synergism; Drug | 2005 |
The role of mood stabilisers in the treatment of the depressive facet of bipolar disorders.
Topics: Affective Symptoms; Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Depressive Disorder; | 2007 |
Lamotrigine.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Sche | 1995 |
Sodium and potassium channel modulators: their role in neuroprotection.
Topics: Animals; Benzeneacetamides; Cell Survival; Disease Models, Animal; Lamotrigine; Neurons; Neuroprotec | 1997 |
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fru | 1999 |
1 trial available for lamotrigine and Disease Models, Animal
| Article | Year |
|---|---|
Lamotrigine improves cerebral outcome after hypothermic circulatory arrest: a study in a chronic porcine model.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Ischemia; Calcium Channel Blockers; Cardiopul | 2000 |
114 other studies available for lamotrigine and Disease Models, Animal
| Article | Year |
|---|---|
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2008 |
Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Discovery; Female; Furans; Humans; Hydrazones; Hyp | 2011 |
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.
Topics: Animals; Disease Models, Animal; Female; Humans; Imidazoles; Lymph Nodes; Male; Mice; Mice, Inbred C | 2014 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Bioinformatics guided rotenone adjuvant kindling in mice as a new animal model of drug-resistant epilepsy.
Topics: Animals; Anticonvulsants; Computational Biology; Disease Models, Animal; Epilepsy; Lamotrigine; Mice | 2022 |
Higher susceptibility to 6 Hz corneal kindling and lower responsiveness to antiseizure drugs in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; | 2022 |
Lithium produces bi-directionally regulation of mood disturbance, acts synergistically with anti-depressive/-manic agents, and did not deteriorate the cognitive impairment in murine model of bipolar disorder.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Cognitive Dysfu | 2022 |
Lamotrigine rescues neuronal alterations and prevents seizure-induced memory decline in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticonvulsants; Disease Models, Animal; Hippocam | 2023 |
Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interleukin | 2023 |
Therapeutic Effects of Mesenchymal Stem Cells on a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Model.
Topics: Animals; Disease Models, Animal; Humans; Injections, Intravenous; Lamotrigine; Leukocytes, Mononucle | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Cardiovascular Diseases; Disease Models, Anim | 2021 |
Developing precision treatments for epilepsy using patient and animal models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lamotrigine; Phenytoin | 2021 |
Protective effects of lamotrigine and vitamin B12 on pentylenetetrazole-induced epileptogenesis in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Hippocampus; Kindling, Neurologic; Lamotrigine; Ma | 2021 |
Interactions among Lacosamide and Second-Generation Antiepileptic Drugs in the Tonic-Clonic Seizure Model in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, C | 2021 |
Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Lamotrigine; Neuroprotective Agents; Rats; Reperfu | 2021 |
Ivabradine attenuates the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice.
Topics: Acetamides; Animals; Anticonvulsants; Benzazepines; Brain; Cardiovascular Agents; Disease Models, An | 2017 |
Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Drug Therapy, Combination; Lamotrigi | 2017 |
Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.
Topics: Adult; Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Disease Models, Animal; D | 2017 |
Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats.
Topics: Animals; Anticonvulsants; Antioxidants; Cholecalciferol; Chronic Disease; Cognition; Disease Models, | 2017 |
Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epileps | 2018 |
Lamotrigine-resistant corneal-kindled mice: A model of pharmacoresistant partial epilepsy for moderate-throughput drug discovery.
Topics: Animals; Anticonvulsants; Anxiety; Body Weight; Cornea; Disease Models, Animal; Dose-Response Relati | 2018 |
[EVALUATION OF NEUROPROTECTIVE ACTIVITY OF COMPLEX IMPACT OF MAGNESIUM OF SULFATE, LAMOTRYGINE AND N-ACETYLCYSTEINE UNDER CONDITIONS OF COMBINED NORMOBARIC HYPOXIA WITH LIGATION OF RIGHT CAROTID ARTERY IN RATS].
Topics: Acetylcysteine; Administration, Oral; Animals; Animals, Outbred Strains; Brain Ischemia; Carotid Art | 2018 |
Effect of lamotrigine on in vivo and in vitro cytokine secretion in murine model of inflammation.
Topics: Animals; Anticonvulsants; Concanavalin A; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosor | 2018 |
Strain and interindividual differences in lamotrigine-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Lamotrigine; Mice; | 2019 |
The effects of lamotrigine and ethosuximide on seizure frequency, neuronal loss, and astrogliosis in a model of temporal-lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2019 |
Dronedarone (a multichannel blocker) enhances the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Dronedarone; Drug Synergis | 2019 |
Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.
Topics: Animals; Anticonvulsants; Brain; Cannabidiol; Chromatography, High Pressure Liquid; Disease Models, | 2019 |
Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model.
Topics: Amygdala; Analysis of Variance; Animals; Calcium Channel Blockers; Catalase; Chronic Disease; Diseas | 2013 |
Cytisine inhibits the anticonvulsant activity of phenytoin and lamotrigine in mice.
Topics: Alkaloids; Animals; Anticonvulsants; Azocines; Disease Models, Animal; Dose-Response Relationship, D | 2013 |
Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Biophysics; Carbamazepine; Disease Models, Animal; Dose | 2013 |
Cav 2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo.
Topics: Acetamides; Animals; Anticonvulsants; Calcium Channels, R-Type; Cation Transport Proteins; Disease M | 2013 |
Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures.
Topics: Animals; Anticonvulsants; Comorbidity; Disease Models, Animal; Epilepsy; Exploratory Behavior; Food | 2013 |
Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension.
Topics: Acute Disease; Administration, Topical; Animals; Axons; Chronic Disease; Disease Models, Animal; Ele | 2013 |
Teratogenic potential of antiepileptic drugs in the zebrafish model.
Topics: Acetamides; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Ethosuximide; Female; F | 2013 |
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance; | 2014 |
Lamotrigine attenuates deficits in synaptic plasticity and accumulation of amyloid plaques in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophi | 2014 |
Voluntary alcohol consumption and plasma beta-endorphin levels in alcohol preferring rats chronically treated with lamotrigine.
Topics: Alcohol Drinking; Analysis of Variance; Animals; beta-Endorphin; Calcium Channel Blockers; Disease M | 2015 |
Effects of Chronic Lamotrigine Administration on Maximal Electroshock- Induced Seizures in Mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Blood Chemical Analysis; Brain; Chromatography, High P | 2015 |
Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy.
Topics: Adenine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; An | 2015 |
HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal).
Topics: Animals; Anticonvulsants; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Epil | 2017 |
Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; GABAergic | 2016 |
Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer's-Like Mouse Model.
Topics: Alzheimer Disease; Animals; Brain; Cognition Disorders; Cytokines; Disease Models, Animal; Gene Expr | 2016 |
Lamotrigine prevents MK801-induced alterations in early growth response factor-1 mRNA levels and immunoreactivity in the rat brain.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, D | 2008 |
Transient cerebral ischemia increases CA1 pyramidal neuron excitability.
Topics: Animals; Cardiovascular Agents; Cell Death; Disease Models, Animal; Dose-Response Relationship, Radi | 2008 |
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Carbamates; Carbamazepine; Di | 2009 |
NA+, K+-ATPase activity in the brain of the rats with kainic acid-induced seizures: influence of lamotrigine.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe | 2008 |
Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Female; Glutamic Acid; Glutathione Peroxi | 2008 |
Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Antimanic Agents; Benzamides; Bipolar Disorder; Carbamates; C | 2009 |
Similar effects of lamotrigine and phenytoin against cortical epileptic foci in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Dose-Response Relations | 2010 |
The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.
Topics: Animals; Anticonvulsants; Biophysics; Cell Line, Transformed; Dialysis; Disease Models, Animal; Dose | 2009 |
Effects of lamotrigine and topiramate on hippocampal neurogenesis in experimental temporal-lobe epilepsy.
Topics: Adult Stem Cells; Animals; Anticonvulsants; Cell Proliferation; Cell Survival; Chronic Disease; Dend | 2010 |
Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Dopamine Antago | 2010 |
The mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor | 2010 |
Lamotrigine blocks the initiation and expression of repeated high-dose methamphetamine-induced prepulse inhibition deficit in rats.
Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Disease Models, Animal; Lamotrigine; Ma | 2010 |
Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; | 2010 |
Effect of lamotrigine, oxcarbazepine and topiramate on cognitive functions and oxidative stress in PTZ-kindled mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Catalase; Cognition Disorders; Disease Models, Animal; Drug | 2011 |
Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Lamotrigine; Male; Phenyt | 2011 |
VEGF regulates antidepressant effects of lamotrigine.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Disease Models, Animal; Down-Regulation; Enzym | 2012 |
Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats.
Topics: Amygdala; Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor | 2012 |
Effect of the anticonvulsant medications pregabalin and lamotrigine on urodynamic parameters in an animal model of neurogenic detrusor overactivity.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Am | 2012 |
Lamotrigine monotherapy does not provide protection against the loss of optic nerve axons in a rat model of ocular hypertension.
Topics: Animals; Axons; Calcium Channel Blockers; Cell Count; Chromatography, High Pressure Liquid; Disease | 2012 |
Lamotrigine ameliorates seizures and psychiatric comorbidity in a rat model of spontaneous absence epilepsy.
Topics: Animals; Anticonvulsants; Anxiety Disorders; Comorbidity; Depressive Disorder; Disease Models, Anima | 2012 |
Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation.
Topics: Animals; Astrocytes; Disease Models, Animal; Hyperalgesia; Infusions, Spinal; Lamotrigine; Ligation; | 2013 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response | 2003 |
Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice.
Topics: Animals; Anticonvulsants; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Co | 2003 |
Disruption of prepulse inhibition in mice lacking mGluR1.
Topics: Acoustic Stimulation; Animals; Antimanic Agents; Brain; Disease Models, Animal; Dopamine Antagonists | 2003 |
The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Brain Ischemia; Cerebral Infarction; Cytidine | 2004 |
Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dose-Response R | 2004 |
Preclinical profile of combinations of some second-generation antiepileptic drugs: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2004 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Calcium Channel Agonists; Calcium Channel Bl | 2005 |
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Interactions | 2005 |
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Gan | 2005 |
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2005 |
Effects of clozapine plus lamotrigine on phencyclidine-induced hyperactivity.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Clozap | 2006 |
Influence of lamotrigine and topiramate on MDR1 expression in difficult-to-treat temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Carbamazep | 2006 |
Axonal protection achieved in a model of multiple sclerosis using lamotrigine.
Topics: Action Potentials; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Lamotrigine; M | 2006 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder.
Topics: Acyl Coenzyme A; Animals; Antimanic Agents; Arachidonic Acid; Bipolar Disorder; Brain; Disease Model | 2007 |
Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.
Topics: Animals; Anticonvulsants; Arginine; Brain; Dentate Gyrus; Disease Models, Animal; Drug Interactions; | 2007 |
Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy.
Topics: Amino Acids; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Fe | 2008 |
The effects of lamotrigine on alcohol seeking and relapse.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Behavior, Animal; Calcium Channel Blockers; Central | 2007 |
Effect of the new antiepileptic drug retigabine in a rodent model of mania.
Topics: Amphetamine; Animals; Anticonvulsants; Behavior, Animal; Bipolar Disorder; Carbamates; Chlordiazepox | 2008 |
Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dentate Gyrus; D | 2008 |
Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2008 |
Lamotrigine attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits.
Topics: Animals; Basilar Artery; Calcium Channels; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2008 |
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Behavior, Animal; Calcium Channel | 2008 |
Antidepressant-like effect of lamotrigine is reversed by veratrine: a possible role of sodium channels in bipolar depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Bipolar Disorder; Disease Mo | 2008 |
The novel antiepileptic drug, lamotrigine, exerts prodystonic effects in a mutant hamster model of generalized dystonia.
Topics: Administration, Oral; Aging; Animals; Anticonvulsants; Cricetinae; Disease Models, Animal; Dose-Resp | 1994 |
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Behavior, Animal; Brain Chemistry; Brain Isch | 1995 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 black mice in the MPTP animal model of Parkinson's disease.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; | 1994 |
Effect of lamotrigine in the acute and chronic hyperalgesia induced by PGE2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes.
Topics: Acute Disease; Analgesics; Animals; Anticonvulsants; Chronic Disease; Diabetes Mellitus, Experimenta | 1995 |
Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dru | 1997 |
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Anticonvulsants; Chronic Disease; Cyclohexanec | 1997 |
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 1997 |
Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus?
Topics: Animals; Antiparkinson Agents; Calcium Channel Blockers; Cricetinae; Disease Models, Animal; Dystoni | 1997 |
Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats.
Topics: Analgesics; Animals; Diabetic Neuropathies; Dinoprostone; Disease Models, Animal; Dose-Response Rela | 1998 |
Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method.
Topics: Animals; Anticonvulsants; Calibration; Cerebral Arteries; Cerebral Cortex; Coloring Agents; Disease | 1998 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 2000 |
Lamotrigine treatment during amygdala-kindled seizure development fails to inhibit seizures and diminishes subsequent anticonvulsant efficacy.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2000 |
Anticonvulsant lamotrigine administered on reperfusion fails to improve experimental stroke outcomes.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2001 |
Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2001 |
Effect of lamotrigine on a novel model of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Disease Models, Animal; Lamotrigine; Male; Membr | 2001 |
Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Electroencephalography; F | 2002 |
Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; In Vitro Techniques; La | 2002 |