Page last updated: 2024-10-30

lamotrigine and Chemical Dependence

lamotrigine has been researched along with Chemical Dependence in 14 studies

Research Excerpts

ExcerptRelevanceReference
"To pilot the efficacy and safety data of lamotrigine adjunctive therapy to lithium and divalproex in patients with rapid-cycling bipolar disorder (RCBD) and a recent substance use disorder (SUD)."9.14Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study. ( Calabrese, JR; Chan, PK; Conroy, C; Fang, Y; Findling, RL; Ganocy, SJ; Gao, K; Kemp, DE; Serrano, MB; Wang, Z, 2010)
"Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment."5.30A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997)
"To pilot the efficacy and safety data of lamotrigine adjunctive therapy to lithium and divalproex in patients with rapid-cycling bipolar disorder (RCBD) and a recent substance use disorder (SUD)."5.14Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study. ( Calabrese, JR; Chan, PK; Conroy, C; Fang, Y; Findling, RL; Ganocy, SJ; Gao, K; Kemp, DE; Serrano, MB; Wang, Z, 2010)
"Data were analyzed from two completed studies: an open-label trial of lamotrigine in patients with bipolar disorder (BPD) and cocaine-related disorder, and a placebo-controlled trial of quetiapine in patients with BPD and alcohol-related disorders."3.75Attrition factors in clinical trials of comorbid bipolar and substance-related disorders. ( Brown, ES; Nomamiukor, N, 2009)
"Lamotrigine (LTG) was less successful in those with a parental history of mood disorders or in BP-I compared to BP-II disorder."1.43Clinical correlates of sustained response to individual drugs used in naturalistic treatment of patients with bipolar disorder. ( Altshuler, LL; Frye, MA; Grunze, H; Keck, PE; Kupka, R; Leverich, GS; McElroy, SL; Nolen, WA; Post, RM; Rowe, M; Suppes, T, 2016)
"Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment."1.30A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's6 (42.86)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Crawford, MJ1
Sanatinia, R1
Barrett, B1
Cunningham, G1
Dale, O1
Ganguli, P1
Lawrence-Smith, G1
Leeson, VC1
Lemonsky, F1
Lykomitrou-Matthews, G1
Montgomery, A1
Morriss, R1
Munjiza, J1
Paton, C1
Skorodzien, I1
Singh, V1
Tan, W1
Tyrer, P1
Reilly, JG1
Coles, AS1
Sasiadek, J1
George, TP1
Marrero-Gonzalez, PC1
Ruano, OL1
Catalano, G1
Catalano, MC1
Post, RM1
Leverich, GS1
Kupka, R1
Keck, PE1
McElroy, SL1
Altshuler, LL1
Frye, MA1
Rowe, M1
Grunze, H1
Suppes, T2
Nolen, WA1
Nomamiukor, N1
Brown, ES1
Gao, K2
Kemp, DE2
Ganocy, SJ2
Muzina, DJ1
Xia, G1
Findling, RL2
Calabrese, JR3
Parikh, SV1
LeBlanc, SR1
Ovanessian, MM1
Pavlovic, ZM1
Wang, Z1
Chan, PK1
Serrano, MB1
Conroy, C1
Fang, Y1
Yatham, LN1
Kennedy, SH1
O'Donovan, C1
Parikh, S1
MacQueen, G1
McIntyre, R1
Sharma, V1
Silverstone, P1
Alda, M1
Baruch, P1
Beaulieu, S1
Daigneault, A1
Milev, R1
Young, LT1
Ravindran, A1
Schaffer, A1
Connolly, M1
Gorman, CP1
Shen, YC1
Bhaumik, S1
Branford, D1
Duggirala, C1
Ismail, IA1
Ballasiotes, AA1
Skaer, TL1
Shelton, MD1
Bowden, CL1
Rapport, DJ1
Shirley, ER1
Kimmel, SE1
Caban, SJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Double-dummy, Controlled Trial of Lithium Versus Paroxetine in Subjects With Major Depression Who Have a Family History of Bipolar Disorder or Completed Suicide - a Pilot Study[NCT00400088]Phase 32 participants (Actual)Interventional2007-06-30Terminated (stopped due to Recruitment difficulties)
Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression: Double-Blind, Placebo-Controlled Study to Establish Efficacy and Safety[NCT00590265]50 participants (Anticipated)Interventional2008-01-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for lamotrigine and Chemical Dependence

ArticleYear
Pharmacotherapies for co-occurring substance use and bipolar disorders: A systematic review.
    Bipolar disorders, 2019, Volume: 21, Issue:7

    Topics: Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Comorbidity; Humans; Lamo

2019
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
    Bipolar disorders, 2005, Volume: 7 Suppl 3

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz

2005
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
    Bipolar disorders, 2005, Volume: 7 Suppl 3

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz

2005
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
    Bipolar disorders, 2005, Volume: 7 Suppl 3

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz

2005
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
    Bipolar disorders, 2005, Volume: 7 Suppl 3

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz

2005
Bipolar rapid cycling: focus on depression as its hallmark.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 14

    Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Bipolar Disorder; Comorbidity; Controlled Clinica

2001

Trials

2 trials available for lamotrigine and Chemical Dependence

ArticleYear
Lamotrigine for people with borderline personality disorder: a RCT.
    Health technology assessment (Winchester, England), 2018, Volume: 22, Issue:17

    Topics: Adult; Antipsychotic Agents; Borderline Personality Disorder; Cost-Benefit Analysis; Depression; Dou

2018
Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study.
    Psychopharmacology bulletin, 2010, Volume: 43, Issue:4

    Topics: Adult; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Chi-Square Distribution; Depression

2010

Other Studies

9 other studies available for lamotrigine and Chemical Dependence

ArticleYear
Dystonia associated with lamotrigine therapy: a case report and review of the literature.
    Current drug safety, 2014, Volume: 9, Issue:1

    Topics: Antidepressive Agents; Basal Ganglia Diseases; Dystonia; Humans; Lamotrigine; Male; Middle Aged; Moo

2014
Clinical correlates of sustained response to individual drugs used in naturalistic treatment of patients with bipolar disorder.
    Comprehensive psychiatry, 2016, Volume: 66

    Topics: Adult; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disor

2016
Attrition factors in clinical trials of comorbid bipolar and substance-related disorders.
    Journal of affective disorders, 2009, Volume: 112, Issue:1-3

    Topics: Adult; Alcohol-Related Disorders; Amphetamine-Related Disorders; Anticonvulsants; Antipsychotic Agen

2009
Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder.
    Bipolar disorders, 2008, Volume: 10, Issue:8

    Topics: Adult; Affect; Anticonvulsants; Antidepressive Agents, Second-Generation; Antimanic Agents; Bipolar

2008
Advancing bipolar disorder: key lessons from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2010, Volume: 55, Issue:3

    Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Anxiety Disorders;

2010
Long-term treatment and relapse prevention of alcohol and benzodiazepine dependence with lamotrigine.
    The Journal of neuropsychiatry and clinical neurosciences, 2010,Spring, Volume: 22, Issue:2

    Topics: Alcoholism; Anticonvulsants; Benzodiazepines; Central Nervous System Agents; Female; Fructose; Human

2010
Treatment of inhalant dependence with lamotrigine.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Apr-13, Volume: 31, Issue:3

    Topics: Adult; Anticonvulsants; Humans; Illicit Drugs; Lamotrigine; Male; Substance-Related Disorders; Triaz

2007
A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities.
    Seizure, 1997, Volume: 6, Issue:2

    Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Comorbidity; Cyclohexanecarboxylic Acids; Dose-Respo

1997
Use of lamotrigine in a patient with bipolar disorder and psychiatric comorbidity.
    Clinical therapeutics, 2000, Volume: 22, Issue:9

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Diagnosis, Dual (Psychiatry); Humans

2000