lamotrigine has been researched along with Cerebral Ischemia in 22 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lamotrigine (LTG) has shown benefits in animal models of cerebral ischemia, but the mechanism involved was not fully studied." | 7.81 | Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. ( Han, H; Qian, Q; Sun, G; Yu, Y; Zhao, D, 2015) |
| "The effects of Lamotrigine (LTG) which blocks ischemia induced glutamate (Glu) release, on lipid peroxidation have been evaluated in cortical and cerebellar tissues of rat brain during focal cerebral ischemia." | 7.71 | Lipid peroxidation in rat brain during focal cerebral ischemia: prevention of malondialdehyde and lipid conjugated diene production by a novel antiepileptic, lamotrigine. ( Balkan, E; Balkan, S; Gumuslu, S; Ozben, T; Serteser, M, 2002) |
| "The dose-response effects of pretreatment with lamotrigine (a phenyltriazine derivative that inhibits neuronal glutamate release) in a porcine cerebral ischemia model during cardiopulmonary bypass were studied." | 7.70 | Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. ( Black, D; Conroy, BP; Crumrine, RC; DeWitt, DS; Jenkins, LW; Johnston, WE; Lin, CY, 1999) |
| "Lamotrigine had neuroprotective effects in a gerbil model of global cerebral ischemia." | 7.69 | Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. ( Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP, 1995) |
| "Focal cerebral ischemia was produced by the permanent occlusion of right middle cerebral artery (MCA) in urethane anesthetized rats." | 5.30 | Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats. ( Balkan, E; Balkan, S; Gümüslü, S; Oguz, N; Ozben, T; Serteser, M, 1997) |
| "Lamotrigine (LTG) has shown benefits in animal models of cerebral ischemia, but the mechanism involved was not fully studied." | 3.81 | Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. ( Han, H; Qian, Q; Sun, G; Yu, Y; Zhao, D, 2015) |
| "The effects of Lamotrigine (LTG) which blocks ischemia induced glutamate (Glu) release, on lipid peroxidation have been evaluated in cortical and cerebellar tissues of rat brain during focal cerebral ischemia." | 3.71 | Lipid peroxidation in rat brain during focal cerebral ischemia: prevention of malondialdehyde and lipid conjugated diene production by a novel antiepileptic, lamotrigine. ( Balkan, E; Balkan, S; Gumuslu, S; Ozben, T; Serteser, M, 2002) |
| "The dose-response effects of pretreatment with lamotrigine (a phenyltriazine derivative that inhibits neuronal glutamate release) in a porcine cerebral ischemia model during cardiopulmonary bypass were studied." | 3.70 | Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. ( Black, D; Conroy, BP; Crumrine, RC; DeWitt, DS; Jenkins, LW; Johnston, WE; Lin, CY, 1999) |
| "We examined whether the anti-ischemic effect of lamotrigine (LTG), which inhibits the presynapic sodium channel, could be enhanced by the calcium channel blocker-flunarizine (FNR) in cerebral ischemia." | 3.70 | Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia. ( Lee, YS; Roh, JK; Yoon, BW, 1999) |
| "Lamotrigine had neuroprotective effects in a gerbil model of global cerebral ischemia." | 3.69 | Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. ( Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP, 1995) |
| " In this experiment, we tested the efficacy of neuroprotection with lamotrigine, a novel antiepileptic drug that blocks voltage gated sodium channels and inhibits the ischemia-induced release of glutamate in the gerbil forebrain model of cerebral ischemia." | 3.69 | Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study. ( Howlett, W; Ijaz, S; Kanthan, R; Mahmood, RH; Miyashita, H; Murabit, MA; Shuaib, A; Wishart, T, 1995) |
| "Because chronic treatment with migraine prophylactic drugs suppresses SD susceptibility, we tested whether migraine prophylaxis can also suppress ischemic depolarizations and improve stroke outcome." | 1.42 | Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. ( Ayata, C; Can, A; Daneshmand, A; Eikermann-Haerter, K; Ferrari, MD; Lee, JH; Sengul, B; van den Maagdenberg, AM; Wei, Y; Yalcin, N; Yu, ES; Zheng, Y, 2015) |
| "Two 10 minute periods of global cerebral ischemia were produced by inflating a neck tourniquet." | 1.31 | The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate. ( Koinig, H; Morimoto, Y; Zornow, MH, 2001) |
| "Lamotrigine has neuroprotective effect during HCA." | 1.31 | Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest. ( Anttila, V; Biancari, F; Hirvonen, J; Jäntti, V; Juvonen, T; Kiviluoma, KT; Ohtonen, P; Pokela, M; Rimpiläinen, J; Romsi, P; Vainionpää, V, 2002) |
| "Focal cerebral ischemia was produced by the permanent occlusion of right middle cerebral artery (MCA) in urethane anesthetized rats." | 1.30 | Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats. ( Balkan, E; Balkan, S; Gümüslü, S; Oguz, N; Ozben, T; Serteser, M, 1997) |
| "Lamotrigine (LTG) is an anticonvulsant drug whose mechanism of action may involve the inhibition of glutamate release by blocking voltage-dependent sodium channels." | 1.30 | Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest. ( Bergstrand, K; Cooper, AT; Cooper, BR; Crumrine, RC; Faison, WL, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, IC | 1 |
| Kuo, PC | 1 |
| Yen, JH | 1 |
| Paraiso, HC | 1 |
| Curfman, ET | 1 |
| Hong-Goka, BC | 1 |
| Sweazey, RD | 1 |
| Chang, FL | 1 |
| Samsonia, M | 1 |
| Kandelaki, M | 1 |
| Baratashvili, N | 1 |
| Belozertsev, IuA | 1 |
| Zapol'skaia, IuA | 1 |
| Belozertsev, FIu | 1 |
| Iuntsev, SV | 1 |
| Ozkul, A | 1 |
| Sair, A | 1 |
| Akyol, A | 1 |
| Yenisey, C | 1 |
| Dost, T | 1 |
| Tataroglu, C | 1 |
| Eikermann-Haerter, K | 1 |
| Lee, JH | 1 |
| Yalcin, N | 1 |
| Yu, ES | 1 |
| Daneshmand, A | 1 |
| Wei, Y | 1 |
| Zheng, Y | 1 |
| Can, A | 1 |
| Sengul, B | 1 |
| Ferrari, MD | 1 |
| van den Maagdenberg, AM | 1 |
| Ayata, C | 1 |
| Han, H | 1 |
| Qian, Q | 1 |
| Yu, Y | 1 |
| Zhao, D | 1 |
| Sun, G | 1 |
| Serteser, M | 2 |
| Ozben, T | 2 |
| Gumuslu, S | 2 |
| Balkan, S | 3 |
| Balkan, E | 2 |
| Calabresi, P | 1 |
| Marti, M | 1 |
| Picconi, B | 1 |
| Saulle, E | 1 |
| Costa, C | 1 |
| Centonze, D | 1 |
| Pisani, F | 1 |
| Bernardi, G | 1 |
| Ataus, SA | 1 |
| Onal, MZ | 1 |
| Ozdem, SS | 1 |
| Locke, KW | 1 |
| Schulz, JB | 1 |
| Matthews, RT | 1 |
| Jenkins, BG | 1 |
| Brar, P | 1 |
| Beal, MF | 1 |
| Smith, SE | 1 |
| Meldrum, BS | 1 |
| Wiard, RP | 1 |
| Dickerson, MC | 1 |
| Beek, O | 1 |
| Norton, R | 1 |
| Cooper, BR | 2 |
| Rataud, J | 1 |
| Debarnot, F | 1 |
| Mary, V | 1 |
| Pratt, J | 1 |
| Stutzmann, JM | 1 |
| Shuaib, A | 1 |
| Mahmood, RH | 1 |
| Wishart, T | 1 |
| Kanthan, R | 1 |
| Murabit, MA | 1 |
| Ijaz, S | 1 |
| Miyashita, H | 1 |
| Howlett, W | 1 |
| Oguz, N | 1 |
| Crumrine, RC | 2 |
| Bergstrand, K | 1 |
| Cooper, AT | 1 |
| Faison, WL | 1 |
| Conroy, BP | 1 |
| Black, D | 1 |
| Lin, CY | 1 |
| Jenkins, LW | 1 |
| DeWitt, DS | 1 |
| Johnston, WE | 1 |
| Lee, YS | 1 |
| Yoon, BW | 1 |
| Roh, JK | 1 |
| Anttila, V | 2 |
| Rimpiläinen, J | 2 |
| Pokela, M | 2 |
| Kiviluoma, K | 1 |
| Mäkiranta, M | 1 |
| Jäntti, V | 2 |
| Vainionpää, V | 2 |
| Hirvonen, J | 2 |
| Juvonen, T | 2 |
| Miyamoto, TA | 1 |
| Miyamoto, KJ | 1 |
| Koinig, H | 1 |
| Morimoto, Y | 1 |
| Zornow, MH | 1 |
| Romsi, P | 1 |
| Kiviluoma, KT | 1 |
| Biancari, F | 1 |
| Ohtonen, P | 1 |
1 trial available for lamotrigine and Cerebral Ischemia
| Article | Year |
|---|---|
Lamotrigine improves cerebral outcome after hypothermic circulatory arrest: a study in a chronic porcine model.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Ischemia; Calcium Channel Blockers; Cardiopul | 2000 |
21 other studies available for lamotrigine and Cerebral Ischemia
| Article | Year |
|---|---|
A Combination of Three Repurposed Drugs Administered at Reperfusion as a Promising Therapy for Postischemic Brain Injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Drug Therapy, Combination; Female; Lamotrigine; Lovastati | 2017 |
[EVALUATION OF NEUROPROTECTIVE ACTIVITY OF COMPLEX IMPACT OF MAGNESIUM OF SULFATE, LAMOTRYGINE AND N-ACETYLCYSTEINE UNDER CONDITIONS OF COMBINED NORMOBARIC HYPOXIA WITH LIGATION OF RIGHT CAROTID ARTERY IN RATS].
Topics: Acetylcysteine; Administration, Oral; Animals; Animals, Outbred Strains; Brain Ischemia; Carotid Art | 2018 |
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C | 2012 |
Effects of lithium and lamotrigine on oxidative-nitrosative stress and spatial learning deficit after global cerebral ischemia.
Topics: Animals; Brain Ischemia; Carotid Artery, Common; Female; Lamotrigine; Ligation; Lithium Compounds; M | 2014 |
Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice.
Topics: Animals; Anticonvulsants; Brain Ischemia; Calcium Channels, N-Type; Chemoprevention; Cortical Spread | 2015 |
Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats.
Topics: Amyloid beta-Peptides; Animals; Brain Ischemia; Cognition Disorders; Hippocampus; Lamotrigine; Male; | 2015 |
Lipid peroxidation in rat brain during focal cerebral ischemia: prevention of malondialdehyde and lipid conjugated diene production by a novel antiepileptic, lamotrigine.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Lamotrigine; Lipid Peroxidation; Male; Malondialdeh | 2002 |
Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study.
Topics: Acetamides; Animals; Anticonvulsants; Brain Ischemia; Cell Hypoxia; Corpus Striatum; Dose-Response R | 2003 |
The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Brain Ischemia; Cerebral Infarction; Cytidine | 2004 |
Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap.
Topics: Animals; Benzenesulfonates; Brain Ischemia; Corpus Striatum; Dizocilpine Maleate; Dose-Response Rela | 1995 |
Cerebroprotective effect of lamotrigine after focal ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Drug Administration Schedule; Drug Evaluation, Preclin | 1995 |
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Behavior, Animal; Brain Chemistry; Brain Isch | 1995 |
Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents.
Topics: Animals; Anticonvulsants; Brain Ischemia; Carbamazepine; Cerebral Arteries; Electrophysiology; Elect | 1994 |
Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study.
Topics: Animals; Anticonvulsants; Brain Ischemia; Gerbillinae; Glutamic Acid; Hippocampus; Lamotrigine; Male | 1995 |
Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cerebellum; Cerebral Arteries; Cerebral Cortex; Cyclic GMP | 1997 |
Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Heart Arrest; Hippocampus; Lamotrigine; Neuroprotec | 1997 |
Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass.
Topics: Analgesics; Animals; Brain Ischemia; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Gluta | 1999 |
Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Drug | 1999 |
pH-stat strategy and hypothermia of 25 degrees C alone should protect the central nervous system consistently from 75 minutes of circulatory arrest.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Heart Arrest, Induced; Hypothermia, Induced; Lamo | 2001 |
The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate.
Topics: Animals; Blood Gas Analysis; Body Temperature; Brain Ischemia; Extracellular Space; Female; Glutamic | 2001 |
Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Electroencephalography; F | 2002 |