lamotrigine has been researched along with Brain Ischemia in 22 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lamotrigine (LTG) has shown benefits in animal models of cerebral ischemia, but the mechanism involved was not fully studied." | 7.81 | Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. ( Han, H; Qian, Q; Sun, G; Yu, Y; Zhao, D, 2015) |
| "The effects of Lamotrigine (LTG) which blocks ischemia induced glutamate (Glu) release, on lipid peroxidation have been evaluated in cortical and cerebellar tissues of rat brain during focal cerebral ischemia." | 7.71 | Lipid peroxidation in rat brain during focal cerebral ischemia: prevention of malondialdehyde and lipid conjugated diene production by a novel antiepileptic, lamotrigine. ( Balkan, E; Balkan, S; Gumuslu, S; Ozben, T; Serteser, M, 2002) |
| "The dose-response effects of pretreatment with lamotrigine (a phenyltriazine derivative that inhibits neuronal glutamate release) in a porcine cerebral ischemia model during cardiopulmonary bypass were studied." | 7.70 | Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. ( Black, D; Conroy, BP; Crumrine, RC; DeWitt, DS; Jenkins, LW; Johnston, WE; Lin, CY, 1999) |
| "Lamotrigine had neuroprotective effects in a gerbil model of global cerebral ischemia." | 7.69 | Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. ( Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP, 1995) |
| "Focal cerebral ischemia was produced by the permanent occlusion of right middle cerebral artery (MCA) in urethane anesthetized rats." | 5.30 | Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats. ( Balkan, E; Balkan, S; Gümüslü, S; Oguz, N; Ozben, T; Serteser, M, 1997) |
| "Lamotrigine (LTG) has shown benefits in animal models of cerebral ischemia, but the mechanism involved was not fully studied." | 3.81 | Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats. ( Han, H; Qian, Q; Sun, G; Yu, Y; Zhao, D, 2015) |
| "The effects of Lamotrigine (LTG) which blocks ischemia induced glutamate (Glu) release, on lipid peroxidation have been evaluated in cortical and cerebellar tissues of rat brain during focal cerebral ischemia." | 3.71 | Lipid peroxidation in rat brain during focal cerebral ischemia: prevention of malondialdehyde and lipid conjugated diene production by a novel antiepileptic, lamotrigine. ( Balkan, E; Balkan, S; Gumuslu, S; Ozben, T; Serteser, M, 2002) |
| "The dose-response effects of pretreatment with lamotrigine (a phenyltriazine derivative that inhibits neuronal glutamate release) in a porcine cerebral ischemia model during cardiopulmonary bypass were studied." | 3.70 | Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. ( Black, D; Conroy, BP; Crumrine, RC; DeWitt, DS; Jenkins, LW; Johnston, WE; Lin, CY, 1999) |
| "We examined whether the anti-ischemic effect of lamotrigine (LTG), which inhibits the presynapic sodium channel, could be enhanced by the calcium channel blocker-flunarizine (FNR) in cerebral ischemia." | 3.70 | Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia. ( Lee, YS; Roh, JK; Yoon, BW, 1999) |
| "Lamotrigine had neuroprotective effects in a gerbil model of global cerebral ischemia." | 3.69 | Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. ( Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP, 1995) |
| " In this experiment, we tested the efficacy of neuroprotection with lamotrigine, a novel antiepileptic drug that blocks voltage gated sodium channels and inhibits the ischemia-induced release of glutamate in the gerbil forebrain model of cerebral ischemia." | 3.69 | Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study. ( Howlett, W; Ijaz, S; Kanthan, R; Mahmood, RH; Miyashita, H; Murabit, MA; Shuaib, A; Wishart, T, 1995) |
| "Because chronic treatment with migraine prophylactic drugs suppresses SD susceptibility, we tested whether migraine prophylaxis can also suppress ischemic depolarizations and improve stroke outcome." | 1.42 | Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice. ( Ayata, C; Can, A; Daneshmand, A; Eikermann-Haerter, K; Ferrari, MD; Lee, JH; Sengul, B; van den Maagdenberg, AM; Wei, Y; Yalcin, N; Yu, ES; Zheng, Y, 2015) |
| "Two 10 minute periods of global cerebral ischemia were produced by inflating a neck tourniquet." | 1.31 | The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate. ( Koinig, H; Morimoto, Y; Zornow, MH, 2001) |
| "Lamotrigine has neuroprotective effect during HCA." | 1.31 | Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest. ( Anttila, V; Biancari, F; Hirvonen, J; Jäntti, V; Juvonen, T; Kiviluoma, KT; Ohtonen, P; Pokela, M; Rimpiläinen, J; Romsi, P; Vainionpää, V, 2002) |
| "Focal cerebral ischemia was produced by the permanent occlusion of right middle cerebral artery (MCA) in urethane anesthetized rats." | 1.30 | Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats. ( Balkan, E; Balkan, S; Gümüslü, S; Oguz, N; Ozben, T; Serteser, M, 1997) |
| "Lamotrigine (LTG) is an anticonvulsant drug whose mechanism of action may involve the inhibition of glutamate release by blocking voltage-dependent sodium channels." | 1.30 | Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest. ( Bergstrand, K; Cooper, AT; Cooper, BR; Crumrine, RC; Faison, WL, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, IC | 1 |
| Kuo, PC | 1 |
| Yen, JH | 1 |
| Paraiso, HC | 1 |
| Curfman, ET | 1 |
| Hong-Goka, BC | 1 |
| Sweazey, RD | 1 |
| Chang, FL | 1 |
| Samsonia, M | 1 |
| Kandelaki, M | 1 |
| Baratashvili, N | 1 |
| Belozertsev, IuA | 1 |
| Zapol'skaia, IuA | 1 |
| Belozertsev, FIu | 1 |
| Iuntsev, SV | 1 |
| Ozkul, A | 1 |
| Sair, A | 1 |
| Akyol, A | 1 |
| Yenisey, C | 1 |
| Dost, T | 1 |
| Tataroglu, C | 1 |
| Eikermann-Haerter, K | 1 |
| Lee, JH | 1 |
| Yalcin, N | 1 |
| Yu, ES | 1 |
| Daneshmand, A | 1 |
| Wei, Y | 1 |
| Zheng, Y | 1 |
| Can, A | 1 |
| Sengul, B | 1 |
| Ferrari, MD | 1 |
| van den Maagdenberg, AM | 1 |
| Ayata, C | 1 |
| Han, H | 1 |
| Qian, Q | 1 |
| Yu, Y | 1 |
| Zhao, D | 1 |
| Sun, G | 1 |
| Serteser, M | 2 |
| Ozben, T | 2 |
| Gumuslu, S | 2 |
| Balkan, S | 3 |
| Balkan, E | 2 |
| Calabresi, P | 1 |
| Marti, M | 1 |
| Picconi, B | 1 |
| Saulle, E | 1 |
| Costa, C | 1 |
| Centonze, D | 1 |
| Pisani, F | 1 |
| Bernardi, G | 1 |
| Ataus, SA | 1 |
| Onal, MZ | 1 |
| Ozdem, SS | 1 |
| Locke, KW | 1 |
| Schulz, JB | 1 |
| Matthews, RT | 1 |
| Jenkins, BG | 1 |
| Brar, P | 1 |
| Beal, MF | 1 |
| Smith, SE | 1 |
| Meldrum, BS | 1 |
| Wiard, RP | 1 |
| Dickerson, MC | 1 |
| Beek, O | 1 |
| Norton, R | 1 |
| Cooper, BR | 2 |
| Rataud, J | 1 |
| Debarnot, F | 1 |
| Mary, V | 1 |
| Pratt, J | 1 |
| Stutzmann, JM | 1 |
| Shuaib, A | 1 |
| Mahmood, RH | 1 |
| Wishart, T | 1 |
| Kanthan, R | 1 |
| Murabit, MA | 1 |
| Ijaz, S | 1 |
| Miyashita, H | 1 |
| Howlett, W | 1 |
| Oguz, N | 1 |
| Crumrine, RC | 2 |
| Bergstrand, K | 1 |
| Cooper, AT | 1 |
| Faison, WL | 1 |
| Conroy, BP | 1 |
| Black, D | 1 |
| Lin, CY | 1 |
| Jenkins, LW | 1 |
| DeWitt, DS | 1 |
| Johnston, WE | 1 |
| Lee, YS | 1 |
| Yoon, BW | 1 |
| Roh, JK | 1 |
| Anttila, V | 2 |
| Rimpiläinen, J | 2 |
| Pokela, M | 2 |
| Kiviluoma, K | 1 |
| Mäkiranta, M | 1 |
| Jäntti, V | 2 |
| Vainionpää, V | 2 |
| Hirvonen, J | 2 |
| Juvonen, T | 2 |
| Miyamoto, TA | 1 |
| Miyamoto, KJ | 1 |
| Koinig, H | 1 |
| Morimoto, Y | 1 |
| Zornow, MH | 1 |
| Romsi, P | 1 |
| Kiviluoma, KT | 1 |
| Biancari, F | 1 |
| Ohtonen, P | 1 |
1 trial available for lamotrigine and Brain Ischemia
| Article | Year |
|---|---|
Lamotrigine improves cerebral outcome after hypothermic circulatory arrest: a study in a chronic porcine model.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Ischemia; Calcium Channel Blockers; Cardiopul | 2000 |
21 other studies available for lamotrigine and Brain Ischemia
| Article | Year |
|---|---|
A Combination of Three Repurposed Drugs Administered at Reperfusion as a Promising Therapy for Postischemic Brain Injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Drug Therapy, Combination; Female; Lamotrigine; Lovastati | 2017 |
[EVALUATION OF NEUROPROTECTIVE ACTIVITY OF COMPLEX IMPACT OF MAGNESIUM OF SULFATE, LAMOTRYGINE AND N-ACETYLCYSTEINE UNDER CONDITIONS OF COMBINED NORMOBARIC HYPOXIA WITH LIGATION OF RIGHT CAROTID ARTERY IN RATS].
Topics: Acetylcysteine; Administration, Oral; Animals; Animals, Outbred Strains; Brain Ischemia; Carotid Art | 2018 |
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C | 2012 |
Effects of lithium and lamotrigine on oxidative-nitrosative stress and spatial learning deficit after global cerebral ischemia.
Topics: Animals; Brain Ischemia; Carotid Artery, Common; Female; Lamotrigine; Ligation; Lithium Compounds; M | 2014 |
Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in mice.
Topics: Animals; Anticonvulsants; Brain Ischemia; Calcium Channels, N-Type; Chemoprevention; Cortical Spread | 2015 |
Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats.
Topics: Amyloid beta-Peptides; Animals; Brain Ischemia; Cognition Disorders; Hippocampus; Lamotrigine; Male; | 2015 |
Lipid peroxidation in rat brain during focal cerebral ischemia: prevention of malondialdehyde and lipid conjugated diene production by a novel antiepileptic, lamotrigine.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Lamotrigine; Lipid Peroxidation; Male; Malondialdeh | 2002 |
Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study.
Topics: Acetamides; Animals; Anticonvulsants; Brain Ischemia; Cell Hypoxia; Corpus Striatum; Dose-Response R | 2003 |
The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Brain Ischemia; Cerebral Infarction; Cytidine | 2004 |
Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap.
Topics: Animals; Benzenesulfonates; Brain Ischemia; Corpus Striatum; Dizocilpine Maleate; Dose-Response Rela | 1995 |
Cerebroprotective effect of lamotrigine after focal ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Drug Administration Schedule; Drug Evaluation, Preclin | 1995 |
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.
Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Behavior, Animal; Brain Chemistry; Brain Isch | 1995 |
Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents.
Topics: Animals; Anticonvulsants; Brain Ischemia; Carbamazepine; Cerebral Arteries; Electrophysiology; Elect | 1994 |
Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study.
Topics: Animals; Anticonvulsants; Brain Ischemia; Gerbillinae; Glutamic Acid; Hippocampus; Lamotrigine; Male | 1995 |
Effects of Lamotrigine on brain nitrite and cGMP levels during focal cerebral ischemia in rats.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cerebellum; Cerebral Arteries; Cerebral Cortex; Cyclic GMP | 1997 |
Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Heart Arrest; Hippocampus; Lamotrigine; Neuroprotec | 1997 |
Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass.
Topics: Analgesics; Animals; Brain Ischemia; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Gluta | 1999 |
Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Drug | 1999 |
pH-stat strategy and hypothermia of 25 degrees C alone should protect the central nervous system consistently from 75 minutes of circulatory arrest.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Heart Arrest, Induced; Hypothermia, Induced; Lamo | 2001 |
The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate.
Topics: Animals; Blood Gas Analysis; Body Temperature; Brain Ischemia; Extracellular Space; Female; Glutamic | 2001 |
Lamotrigine plus leukocyte filtration as a neuroprotective strategy in experimental hypothermic circulatory arrest.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Disease Models, Animal; Electroencephalography; F | 2002 |