lamotrigine has been researched along with Behavior Disorders in 34 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 8.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "Using a retrospective chart review, we identified six patients with epilepsy who reported transient emergent psychological symptoms during stable, chronic lamotrigine monotherapy." | 7.75 | End-of-dose emergent psychopathology in ambulatory patients with epilepsy on stable-dose lamotrigine monotherapy: a case series of six patients. ( Frey, LC; Shrestha, A; Spitz, MC; Strom, LA, 2009) |
| "Lamotrigine (LTG) is a valuable addition to the medical management of epilepsy with wide spectrum of efficacy and good outcomes for quality of life." | 7.70 | Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine. ( Beran, RG; Gibson, RJ, 1998) |
| "To describe significant positive or negative psychotropic effects of lamotrigine (LTG) observed in epilepsy patients with mental retardation (MR)." | 7.70 | Positive and negative psychotropic effects of lamotrigine in patients with epilepsy and mental retardation. ( Devinsky, O; Dhoon, A; Ettinger, AB; Kanner, A; Saracco, J; Weisbrot, DM, 1998) |
| "Lamotrigine is a broad-spectrum antiepileptic drug, initially approved in 1994 for the adjunctive treatment of partial seizures in adults and for the generalized seizures of Lennox-Gastaut syndrome in pediatric (>2 years old) and adult populations." | 6.43 | Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. ( Arif, H; Hirsch, LJ; Malik, S, 2006) |
| " All 9 patients became hyperactive and agitated over a broad range of lamotrigine dosing (0." | 5.36 | Reversible lamotrigine-induced neurobehavioral disturbances in children with epilepsy. ( Cardenas, JF; Ng, YT; Rho, JM, 2010) |
| " The following keywords were searched: lamotrigine, psychiatric, mood disorders, depression, personality disorders, anxiety, schizophrenia, side effects, and rash." | 4.89 | Lamotrigine in psychiatric disorders. ( Altshuler, LL; Gitlin, MJ; Reid, JG, 2013) |
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 4.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| " More specifically, vigabatrin, which is a very useful and well tolerated new antiepileptic drug for refractory partial epilepsy, should be started at a low dosage of 0." | 4.79 | The new anticonvulsant drugs. Implications for avoidance of adverse effects. ( Krämer, G; Schmidt, D, 1994) |
| "Using a retrospective chart review, we identified six patients with epilepsy who reported transient emergent psychological symptoms during stable, chronic lamotrigine monotherapy." | 3.75 | End-of-dose emergent psychopathology in ambulatory patients with epilepsy on stable-dose lamotrigine monotherapy: a case series of six patients. ( Frey, LC; Shrestha, A; Spitz, MC; Strom, LA, 2009) |
| "We report the case of a 16-year-old male with Mucopolysaccharidosis III type A (Sanfilippo syndrome) who was commenced on risperidone for behaviour management." | 3.75 | Extrapyramidal symptoms and medication use in Mucopolysaccharidosis type III. ( Sillence, D; Tchan, MC, 2009) |
| "Lamotrigine (LTG) is a valuable addition to the medical management of epilepsy with wide spectrum of efficacy and good outcomes for quality of life." | 3.70 | Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine. ( Beran, RG; Gibson, RJ, 1998) |
| "To describe significant positive or negative psychotropic effects of lamotrigine (LTG) observed in epilepsy patients with mental retardation (MR)." | 3.70 | Positive and negative psychotropic effects of lamotrigine in patients with epilepsy and mental retardation. ( Devinsky, O; Dhoon, A; Ettinger, AB; Kanner, A; Saracco, J; Weisbrot, DM, 1998) |
| "The results of this study suggest that the administration of lamotrigine to patients with severe Alzheimer's disease with BPSD may be effective and may make it possible to avoid increasing the dosage of antipsychotic medications prescribed to elderly patients." | 2.80 | Clinical efficacy of lamotrigine and changes in the dosages of concomitantly used psychotropic drugs in Alzheimer's disease with behavioural and psychological symptoms of dementia: a preliminary open-label trial. ( Gen, K; Suzuki, H, 2015) |
| "Lamotrigine is a broad-spectrum antiepileptic drug, initially approved in 1994 for the adjunctive treatment of partial seizures in adults and for the generalized seizures of Lennox-Gastaut syndrome in pediatric (>2 years old) and adult populations." | 2.43 | Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. ( Arif, H; Hirsch, LJ; Malik, S, 2006) |
| " Future studies of formal pharmacokinetic modeling of AEDs during pregnancy and the postpartum period could provide an important step toward achieving effective drug dosing to maintain therapeutic objectives for the mother but, at the same time, to minimize fetal drug exposure." | 2.42 | Antiepileptic drug pharmacokinetics during pregnancy and lactation. ( Pennell, PB, 2003) |
| "Lamotrigine is a new antiepileptic drug that may possess unique cognitive and behavioral characteristics." | 2.40 | Behavioral and cognitive effects of lamotrigine. ( Baker, GA; Meador, KJ, 1997) |
| " In the meantime, a review of the established pharmacokinetic and pharmacodynamic activities of these agents is the first step in defining their optimal uses and limitations in the psychiatric setting." | 2.40 | Pharmacokinetics of new anticonvulsants in psychiatry. ( Morris, HH, 1998) |
| "The diagnoses were major depressive disorder (n = 39), bipolar I disorder (n = 10), and bipolar II disorder (n = 35)." | 1.56 | A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash. ( Kagawa, S; Kondo, T; Mihara, K; Nagai, G; Nakamura, A; Nemoto, K; Suzuki, T, 2020) |
| "Topiramate was more likely prescribed for those with comorbid headache or migraine (incident: 335 of 1251 [26." | 1.51 | Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. ( Faught, E; Fishman, J; Kalilani, L; Kim, H; Thurman, DJ, 2019) |
| "Lamotrigine was the most frequently initiated drug in psychiatry, in both boys and girls." | 1.48 | Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses. ( Karlsson Lind, L; von Euler, M; Wettermark, B; Wide, K, 2018) |
| " All 9 patients became hyperactive and agitated over a broad range of lamotrigine dosing (0." | 1.36 | Reversible lamotrigine-induced neurobehavioral disturbances in children with epilepsy. ( Cardenas, JF; Ng, YT; Rho, JM, 2010) |
| " Concerning pharmacokinetic drug interactions, we conclude that lamotrigine can be safely combined with most psychotropic drugs." | 1.33 | Drug interactions between lamotrigine and psychoactive drugs: evidence from a therapeutic drug monitoring service. ( Reimers, A; Skogvoll, E; Spigset, O; Sund, JK, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 19 (55.88) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Fernström, J | 1 |
| Ohlsson, L | 1 |
| Asp, M | 1 |
| Lavant, E | 1 |
| Holck, A | 1 |
| Grudet, C | 1 |
| Westrin, Å | 1 |
| Lindqvist, D | 1 |
| Suzuki, T | 1 |
| Mihara, K | 1 |
| Nagai, G | 1 |
| Kagawa, S | 1 |
| Nakamura, A | 1 |
| Nemoto, K | 1 |
| Kondo, T | 1 |
| Karlsson Lind, L | 1 |
| Wide, K | 1 |
| Wettermark, B | 1 |
| von Euler, M | 1 |
| Kim, H | 1 |
| Faught, E | 1 |
| Thurman, DJ | 1 |
| Fishman, J | 1 |
| Kalilani, L | 1 |
| Reid, JG | 1 |
| Gitlin, MJ | 1 |
| Altshuler, LL | 1 |
| Suzuki, H | 1 |
| Gen, K | 1 |
| Kubagawa, T | 1 |
| Furusho, J | 1 |
| Isozaki, Y | 1 |
| Chowdhury, A | 1 |
| Brodie, MJ | 1 |
| Reimers, A | 2 |
| Kalinin, VV | 1 |
| Cardenas, JF | 1 |
| Rho, JM | 1 |
| Ng, YT | 1 |
| Frey, LC | 1 |
| Strom, LA | 1 |
| Shrestha, A | 1 |
| Spitz, MC | 1 |
| Tchan, MC | 1 |
| Sillence, D | 1 |
| Liguori, C | 1 |
| Albanese, M | 1 |
| Sancesario, G | 1 |
| Stefani, A | 1 |
| Marciani, MG | 1 |
| Pierantozzi, M | 1 |
| Pennell, PB | 1 |
| Hirsch, LJ | 2 |
| Weintraub, D | 1 |
| Du, Y | 1 |
| Buchsbaum, R | 1 |
| Spencer, HT | 1 |
| Hager, M | 1 |
| Straka, T | 1 |
| Bazil, CW | 1 |
| Adams, DJ | 1 |
| Resor, SR | 1 |
| Morrell, MJ | 1 |
| Aulakh, JS | 1 |
| Hawkins, JW | 1 |
| Athwal, HS | 1 |
| Sheikh, JI | 1 |
| Yesavage, J | 1 |
| Tinklenberg, JR | 1 |
| Bryois, C | 1 |
| Nanzer, N | 1 |
| Eliez, S | 1 |
| Etter, M | 1 |
| Aubry, JM | 1 |
| Bertschy, G | 1 |
| Skogvoll, E | 1 |
| Sund, JK | 1 |
| Spigset, O | 1 |
| Surve, TY | 1 |
| Mittal, G | 1 |
| Khadse, SS | 1 |
| Khanna, SA | 1 |
| Ketter, TA | 1 |
| Greist, JH | 1 |
| Graham, JA | 1 |
| Roberts, JN | 1 |
| Thompson, TR | 1 |
| Nanry, KP | 1 |
| Malik, S | 1 |
| Arif, H | 1 |
| Howland, RH | 1 |
| Plattner, B | 1 |
| Pahs, G | 1 |
| Kindler, J | 1 |
| Williams, RP | 1 |
| Hall, RE | 1 |
| Mayer, H | 1 |
| Steiner, H | 1 |
| Feucht, M | 1 |
| Selek, S | 1 |
| Savas, HA | 1 |
| Greiner, C | 1 |
| Wittmann, M | 1 |
| Haen, E | 1 |
| Bras, M | 1 |
| Schmidt, D | 1 |
| Krämer, G | 1 |
| Meador, KJ | 1 |
| Baker, GA | 1 |
| Beran, RG | 1 |
| Gibson, RJ | 1 |
| Ettinger, AB | 1 |
| Weisbrot, DM | 1 |
| Saracco, J | 1 |
| Dhoon, A | 1 |
| Kanner, A | 1 |
| Devinsky, O | 1 |
| Anand, A | 1 |
| Charney, DS | 1 |
| Oren, DA | 1 |
| Berman, RM | 1 |
| Hu, XS | 1 |
| Cappiello, A | 1 |
| Krystal, JH | 1 |
| Alao, AO | 1 |
| Dewan, MJ | 1 |
| Morris, HH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Maternal Pharmacokinetic and Placental Transfer of Levetiracetam[NCT04117425] | 50 participants (Anticipated) | Interventional | 2022-04-20 | Recruiting | |||
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| An Investigation of the Antidepressant Efficacy and Safety of an AMPAkine (Org 24448) in Major Depressive Disorder, A Double-Blind, Placebo-Controlled, Randomized Study[NCT00113022] | Phase 2 | 9 participants (Actual) | Interventional | 2005-05-31 | Terminated (stopped due to Terminated due to concerns about adverse events in separate study.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The MADRS is a measure of depression severity examined on a weekly basis. The minimum score on the 10 item scale is 0 indicating no depression. The maximum score is 60 indicating a very severe depression. Scores of 18 and above are generally considered to suggest significant levels of depression. (NCT00113022)
Timeframe: 8 weeks
| Intervention | Scores on a scale (Least Squares Mean) |
|---|---|
| Org 24448 | 26.425 |
| Placebo | 24.205 |
11 reviews available for lamotrigine and Behavior Disorders
| Article | Year |
|---|---|
Lamotrigine in psychiatric disorders.
Topics: Anticonvulsants; Depression; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Epidemi | 2013 |
[Mental disorders in epilepsy and their correction with lamotrigine].
Topics: Anticonvulsants; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Lamotrigine; Mental Disorders; | 2008 |
Antiepileptic drug pharmacokinetics during pregnancy and lactation.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Fetal Hypoxia | 2003 |
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Drug Interactions; Drug Therapy, | 2004 |
[Psychiatry].
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Attention Deficit Disorder with Hyperacti | 2005 |
Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders.
Topics: Anticonvulsants; Antimanic Agents; Dose-Response Relationship, Drug; Epilepsy; Humans; Lamotrigine; | 2006 |
Glutamate-modulating drugs & the treatment of mental disorders.
Topics: Acamprosate; Amantadine; Cycloserine; Glutamic Acid; Humans; Ketamine; Lamotrigine; Memantine; Menta | 2007 |
[Psychopharmacotherapy in psychiatric comorbidities among patients with chronic pain].
Topics: Amines; Analgesics; Anticonvulsants; Bupropion; Chronic Disease; Cyclohexanecarboxylic Acids; Dopami | 2007 |
The new anticonvulsant drugs. Implications for avoidance of adverse effects.
Topics: Abnormalities, Drug-Induced; Anemia, Aplastic; Anticonvulsants; Chemical and Drug Induced Liver Inju | 1994 |
Behavioral and cognitive effects of lamotrigine.
Topics: Adult; Anticonvulsants; Child; Cognition Disorders; Epilepsy; Female; Humans; Intellectual Disabilit | 1997 |
Pharmacokinetics of new anticonvulsants in psychiatry.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Felbamate; Fructo | 1998 |
3 trials available for lamotrigine and Behavior Disorders
| Article | Year |
|---|---|
Clinical efficacy of lamotrigine and changes in the dosages of concomitantly used psychotropic drugs in Alzheimer's disease with behavioural and psychological symptoms of dementia: a preliminary open-label trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 2015 |
The effect of dermatologic precautions on the incidence of rash with addition of lamotrigine in the treatment of bipolar I disorder: a randomized trial.
Topics: Adolescent; Adult; Ambulatory Care; Antipsychotic Agents; Bipolar Disorder; Cohort Studies; Comorbid | 2006 |
Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists.
Topics: Adult; Affect; Brief Psychiatric Rating Scale; Cognition Disorders; Double-Blind Method; Excitatory | 2000 |
20 other studies available for lamotrigine and Behavior Disorders
| Article | Year |
|---|---|
Plasma circulating cell-free mitochondrial DNA in depressive disorders.
Topics: Biomarkers; Cell-Free Nucleic Acids; DNA, Mitochondrial; Humans; Lamotrigine; Lithium; Mental Disord | 2021 |
A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash.
Topics: Antipsychotic Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Exanthem | 2020 |
Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; Epilepsy | 2018 |
Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dissociative Disorders; Epilepsi | 2019 |
[Study of lamotrigine efficacy on behavior disorders affecting patients with severe mental retardation].
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Intellectual Disability; Lamotr | 2015 |
Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Drug Resistant Epilepsy; Female; Follow-Up S | 2016 |
Trends and changes in the clinical use of lamotrigine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Databases, Fac | 2009 |
Reversible lamotrigine-induced neurobehavioral disturbances in children with epilepsy.
Topics: Akathisia, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; | 2010 |
End-of-dose emergent psychopathology in ambulatory patients with epilepsy on stable-dose lamotrigine monotherapy: a case series of six patients.
Topics: Adult; Affective Symptoms; Agoraphobia; Anticonvulsants; Bipolar Disorder; Depression; Epilepsy; Fem | 2009 |
Extrapyramidal symptoms and medication use in Mucopolysaccharidosis type III.
Topics: Adolescent; Adult; Anticonvulsants; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; C | 2009 |
May a suspicious psychiatric disorder hide sporadic hemiplegic migraine? Genetic test as prompting factor for diagnosis.
Topics: Adolescent; Brain; Calcium Channel Blockers; Calcium Channels; Electroencephalography; Female; Human | 2013 |
Tolerability and effectiveness of lamotrigine in complex elderly patients.
Topics: Aged; Aged, 80 and over; Aging; Antimanic Agents; Female; Humans; Lamotrigine; Male; Mental Disorder | 2005 |
Drug interactions between lamotrigine and psychoactive drugs: evidence from a therapeutic drug monitoring service.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Drug Interactions; Drug Mo | 2005 |
Epilepsy with myoclonic absences.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tonic-Clonic; F | 2006 |
Juvenile myoclonic epilepsy: a benign disorder? Personality traits and psychiatric symptoms.
Topics: Adolescent; Adult; Anticonvulsants; Child; Ethosuximide; Female; Fructose; Humans; Lamotrigine; Leve | 2007 |
Psychosis, delirium, or manic switch due to lamotrigine?
Topics: Anticonvulsants; Bipolar Disorder; Delirium; Humans; Lamotrigine; Mental Disorders; Triazines | 2007 |
Lamotrigine serum concentrations under valproate comedication: "contraindication" or "safe combination"? A case report.
Topics: Adult; Anticonvulsants; Antimanic Agents; Chromatography, High Pressure Liquid; Contraindications; D | 2007 |
Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine.
Topics: Adolescent; Adult; Aggression; Anticonvulsants; Comorbidity; Drug Administration Schedule; Epilepsy; | 1998 |
Positive and negative psychotropic effects of lamotrigine in patients with epilepsy and mental retardation.
Topics: Adolescent; Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; | 1998 |
Evaluating the tolerability of the newer mood stabilizers.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Central Nervous System Diseases; Cyclohexanecar | 2001 |