Page last updated: 2024-10-30

lamotrigine and Anxiety

lamotrigine has been researched along with Anxiety in 13 studies

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"We conducted a double-blind crossover study of a low dose (15 mg, 'placebo') and an active dose (195 mg) of methylene blue in patients with bipolar disorder treated with lamotrigine."9.24Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study. ( Alda, M; Blagdon, R; Dursun, S; Garnham, J; Hajek, T; MacLellan, S; MacQueen, G; McKinnon, M; Nair, C; O'Donovan, C, 2017)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."7.78Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"We describe the case of a pregnancy healthy outcome after in utero consecutive exposure to lamotrigine and citalopram."7.74Consecutive exposure to lamotrigine and citalopram during pregnancy. ( Gentile, S; Vozzi, F, 2007)
"We assessed the effects of the anticonvulsants lamotrigine, valproate and carbamazepine in an animal model of anxiety."7.73Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels? ( Bright, JL; Harrington, NR; Mirza, NR; Stanhope, KJ; Wyatt, A, 2005)
"We conducted a double-blind crossover study of a low dose (15 mg, 'placebo') and an active dose (195 mg) of methylene blue in patients with bipolar disorder treated with lamotrigine."5.24Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study. ( Alda, M; Blagdon, R; Dursun, S; Garnham, J; Hajek, T; MacLellan, S; MacQueen, G; McKinnon, M; Nair, C; O'Donovan, C, 2017)
" In this study, the pentylenetetrazole seizure test (PTZ) was performed to assess the effectiveness of four new ASDs: lamotrigine (LTG), topiramate (TPM), felbamate (FBM), and levetiracetam (LEV) in the subsequent stages of seizures in adult fish."4.02Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish. ( Doboszewska, U; Guz, L; Pieróg, M; Poleszak, E; Serefko, A; Socała, K; Szopa, A; Wlaź, P; Wyska, E, 2021)
"We investigated the possible roles of the prelimbic medial prefrontal cortex (PL) in the regulation of anxiety-like behaviors by pharmacologically activating the terminals of neuronal inputs or postsynaptic efferent neurons with a sodium channel activator veratrine."3.80Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-Methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice. ( Inagaki, M; Ohashi, M; Oka, J; Saitoh, A; Sugiyama, A; Suzuki, S; Tsukagoshi, M; Yamada, M, 2014)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."3.78Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"We describe the case of a pregnancy healthy outcome after in utero consecutive exposure to lamotrigine and citalopram."3.74Consecutive exposure to lamotrigine and citalopram during pregnancy. ( Gentile, S; Vozzi, F, 2007)
"We assessed the effects of the anticonvulsants lamotrigine, valproate and carbamazepine in an animal model of anxiety."3.73Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels? ( Bright, JL; Harrington, NR; Mirza, NR; Stanhope, KJ; Wyatt, A, 2005)
"Lamotrigine is a new anticonvulsant with few side effects that may have mood-stabilizing and elevating effects."2.68The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness. ( Sachs, G; Sporn, J, 1997)
"Levetiracetam was independently associated with anger/aggression, nervousness/agitation, upset stomach, depression, and sleep disturbance; lamotrigine with nervousness/agitation, upset stomach, and difficulty concentrating; and valproic acid with upset stomach and shaky hands."1.43Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study. ( Fidzinski, P; Gaus, V; Holtkamp, M; Kowski, AB; Losch, F; Weissinger, F, 2016)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's6 (46.15)29.6817
2010's5 (38.46)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Pieróg, M1
Socała, K1
Doboszewska, U1
Wyska, E1
Guz, L1
Szopa, A1
Serefko, A1
Poleszak, E1
Wlaź, P1
Koneval, Z1
Knox, KM1
White, HS1
Barker-Haliski, M1
Saitoh, A1
Ohashi, M1
Suzuki, S1
Tsukagoshi, M1
Sugiyama, A1
Yamada, M2
Oka, J1
Inagaki, M1
Kowski, AB1
Weissinger, F1
Gaus, V1
Fidzinski, P1
Losch, F1
Holtkamp, M1
Alda, M1
McKinnon, M1
Blagdon, R1
Garnham, J1
MacLellan, S1
O'Donovan, C1
Hajek, T1
Nair, C1
Dursun, S1
MacQueen, G1
Foreman, MM1
Hanania, T1
Eller, M1
Moretti, M1
Meltzer-Brody, SE1
Zolnoun, D1
Steege, JF1
Rinaldi, KL1
Leserman, J1
Maschio, M1
Dinapoli, L1
Sperati, F1
Pace, A1
Fabi, A1
Vidiri, A1
Pompili, A1
Carapella, CM1
Mirza, NR1
Bright, JL1
Stanhope, KJ1
Wyatt, A1
Harrington, NR1
Kemp, S1
Feely, M1
Hay, A1
Wild, H1
Cooper, C1
Gentile, S1
Vozzi, F1
Sporn, J1
Sachs, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Double-Blind Trial of Methylene Blue for Cognitive Dysfunction in Bipolar Disorder[NCT00214877]Phase 340 participants (Anticipated)Interventional2003-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for lamotrigine and Anxiety

ArticleYear
[Trichotillomania and comorbidity--lamotrigine in a new perspective].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents; Antimanic Agents; Anxiety; Behavior, Addictive; Bipolar Di

2008

Trials

3 trials available for lamotrigine and Anxiety

ArticleYear
Methylene blue treatment for residual symptoms of bipolar disorder: randomised crossover study.
    The British journal of psychiatry : the journal of mental science, 2017, Volume: 210, Issue:1

    Topics: Adult; Anxiety; Bipolar Disorder; Cognitive Dysfunction; Cross-Over Studies; Depression; Double-Blin

2017
Open-label trial of lamotrigine focusing on efficacy in vulvodynia.
    The Journal of reproductive medicine, 2009, Volume: 54, Issue:3

    Topics: Adult; Aged; Analgesics; Anxiety; Comorbidity; Depression; Dose-Response Relationship, Drug; Female;

2009
The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:3

    Topics: Adult; Anticonvulsants; Anxiety; Bipolar Disorder; Drug Resistance; Female; Humans; Lamotrigine; Mal

1997

Other Studies

9 other studies available for lamotrigine and Anxiety

ArticleYear
Effects of new antiseizure drugs on seizure activity and anxiety-like behavior in adult zebrafish.
    Toxicology and applied pharmacology, 2021, 09-15, Volume: 427

    Topics: Age Factors; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Dose-Response Relationship, Dru

2021
Lamotrigine-resistant corneal-kindled mice: A model of pharmacoresistant partial epilepsy for moderate-throughput drug discovery.
    Epilepsia, 2018, Volume: 59, Issue:6

    Topics: Animals; Anticonvulsants; Anxiety; Body Weight; Cornea; Disease Models, Animal; Dose-Response Relati

2018
Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-Methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice.
    Journal of neuroscience research, 2014, Volume: 92, Issue:8

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anxiety; Behavior, Animal; Dizocilpine Maleate; Excit

2014
Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study.
    Epilepsy & behavior : E&B, 2016, Volume: 54

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Depression; Drug-Related Side Effects and Adve

2016
Anxiolytic effects of lamotrigine and JZP-4 in the elevated plus maze and in the four plate conflict test.
    European journal of pharmacology, 2009, Jan-14, Volume: 602, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Lamotrigine; Male; Maze Learning; Mice; Pun

2009
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
    Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr

2012
Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?
    Psychopharmacology, 2005, Volume: 180, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Calcium Channel Agonists; Calcium Channel Bl

2005
Psychological factors and use of antiepileptic drugs: pilot work using an objective measure of adherence.
    Psychology, health & medicine, 2007, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Anxiety; Culture; Depression; Drug Monitoring; Drug Therap

2007
Consecutive exposure to lamotrigine and citalopram during pregnancy.
    Archives of women's mental health, 2007, Volume: 10, Issue:6

    Topics: Antidepressive Agents, Second-Generation; Anxiety; Citalopram; Depression; Drug Administration Sched

2007