lamotrigine has been researched along with Adverse Drug Event in 33 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lamotrigine is an antiepileptic drug that can be used to control many types of seizures as a single-agent or an add-on therapy in patients over 2 years of age." | 6.82 | Lamotrigine induced priapism in children: case analysis and literature review. ( Cao, SS; Cao, XY; Ge, J; Guan, Y; Mu, F; Qiao, Y; Tang, M; Wang, JW, 2022) |
| " The treatment of choice for CAE with absence seizures only is ethosuximide." | 5.01 | A Practical Guide to Treatment of Childhood Absence Epilepsy. ( Kessler, SK; McGinnis, E, 2019) |
| " Overall, there was a low quality of evidence that gabapentin, pregabalin, amitriptyline, and venlafaxine were effective in reducing pain intensity in patients with cancer pain." | 4.95 | Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review. ( de Graeff, A; Dijkstra, D; Jongen, JL; Mostovaya, I; van den Beuken-van Everdingen, MH; Vissers, KC, 2017) |
| "Lamotrigine is recommended in bipolar maintenance when depression is prominent." | 4.89 | Lamotrigine in psychiatric disorders. ( Altshuler, LL; Gitlin, MJ; Reid, JG, 2013) |
| " Exanthema as especially clinically relevant adverse drug event was rightly chosen for carbamazepine by 18 (8%) and for lamotrigine by 12 (5%) participants." | 4.02 | Knowledge of epilepsy among German pharmacists. ( Bertsche, A; Bertsche, T; Herziger, B; Jeschke, S; Müller, RM; Neininger, MP, 2021) |
| "Pharmacogenomics (PGx) is a research area aimed at identifying genetic factors that are associated with drug responses, including drug efficacy, adverse drug reactions, and the appropriate drug dosage on a case-to-case basis." | 3.01 | Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics. ( Mushiroda, T, 2023) |
| "Lamotrigine is an antiepileptic drug that can be used to control many types of seizures as a single-agent or an add-on therapy in patients over 2 years of age." | 2.82 | Lamotrigine induced priapism in children: case analysis and literature review. ( Cao, SS; Cao, XY; Ge, J; Guan, Y; Mu, F; Qiao, Y; Tang, M; Wang, JW, 2022) |
| "(4) Good adherence is important for seizure control and is influenced by frequency of dosing, among other factors." | 2.58 | Antiepileptic drug treatment of generalized tonic-clonic seizures: An evaluation of regulatory data and five criteria for drug selection. ( Bermejo, PE; Gibbs, AA; Huberfeld, G; Kälviäinen, R; Shorvon, SD, 2018) |
| "Their efficacy in bipolar depression has not always been confirmed in more recent and methodologically more reliable studies." | 2.47 | [Lithium and anticonvulsants in bipolar depression]. ( Llorca, PM; Nourry, A; Samalin, L, 2011) |
| " Data collected included: dates of lamotrigine initiation or discontinuation, lamotrigine dosing over the time of the prescription and maximum lamotrigine dose, any cardiac-related ICD-10-CM codes or a history of a cardiology appointment, EKGs with any abnormalities or changes, any concomitantly prescribed medications with known potential to cause cardiac abnormalities, any cardiac deaths." | 1.91 | Lamotrigine use and potential for adverse cardiac effects: A retrospective evaluation in a Veteran population. ( Biehl, A; Gidal, BE; Jones, J; Kopacek, K; Kotloski, RJ; Taube, M, 2023) |
| "Lithium carbonate was associated with increased risks of rash (PT), drug interaction (PT), and tubulointerstitial diseases (SMQ)." | 1.72 | Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database. ( Nabekura, T; Uwai, Y, 2022) |
| " Nine volunteers reported adverse events, 2 experienced oropharyngeal pain, each receiving 25 mg and 50 mg." | 1.48 | Pharmacokinetics, Safety, and Tolerability of Lamotrigine Chewable/Dispersible Tablet Following Repeat-Dose Administration in Healthy Chinese Volunteers. ( Hu, J; Li, H; Li, Y; Xu, Y; Zhang, F, 2018) |
| "Allopurinol treatment, based on screening by HLA-B*58:01 genotyping, could be more cost-effective than that not based on screening." | 1.43 | HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs. ( Kim, DH; Kim, J; Kim, YJ; Lee, JH; Park, HJ; Park, JW; Park, KH, 2016) |
| "All patients ≥16years of age with epilepsy for ≥12months were routinely asked to complete the Liverpool Adverse Event Profile (LAEP) just before their appointment." | 1.43 | Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study. ( Fidzinski, P; Gaus, V; Holtkamp, M; Kowski, AB; Losch, F; Weissinger, F, 2016) |
| "Weight gain was found to be lower in the elderly for antipsychotic drugs, in particular for olanzapine." | 1.39 | Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland. ( Baumann, P; Greil, W; Grohmann, R; Häberle, A; Schuhmann, T, 2013) |
| "When lamotrigine was restarted 2 weeks later she developed similar but more severe symptoms which resolved on stopping lamotrigine." | 1.35 | Anticonvulsant hypersensitivity syndrome presenting as aseptic meningitis. ( Bazaz, R; Lily, O; Maniyar, F; Rooney, C, 2009) |
| "As pharmacokinetic drug interactions frequently cause adverse events, it is important that the relevant information is given in package inserts (PIs)." | 1.34 | Adverse events caused by drug interactions involving glucuronoconjugates of zidovudine, valproic acid and lamotrigine, and analysis of how such potential events are discussed in package inserts of Japan, UK and USA. ( Hasegawa, R; Hirata-Koizumi, M; Miyake, S; Saito, M, 2007) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 17 (51.52) | 24.3611 |
| 2020's | 12 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Parker, G | 1 |
| Jenner, A | 1 |
| Mushiroda, T | 1 |
| Uwai, Y | 1 |
| Nabekura, T | 1 |
| Ge, J | 3 |
| Cao, SS | 3 |
| Cao, XY | 3 |
| Tang, M | 3 |
| Mu, F | 3 |
| Qiao, Y | 3 |
| Guan, Y | 3 |
| Wang, JW | 3 |
| Yildiz, A | 1 |
| Siafis, S | 1 |
| Mavridis, D | 1 |
| Vieta, E | 1 |
| Leucht, S | 1 |
| Biehl, A | 1 |
| Taube, M | 1 |
| Kotloski, RJ | 1 |
| Kopacek, K | 1 |
| Jones, J | 1 |
| Gidal, BE | 1 |
| Gosselin, S | 1 |
| Ghannoum, M | 1 |
| Hoffman, RS | 1 |
| Das, S | 1 |
| Jiang, X | 1 |
| Jiang, W | 1 |
| Ting, TY | 1 |
| Polli, JE | 1 |
| Choi, SA | 1 |
| Kim, H | 1 |
| Kim, S | 1 |
| Yoo, S | 1 |
| Yi, S | 1 |
| Jeon, Y | 1 |
| Hwang, H | 1 |
| Kim, KJ | 1 |
| Usui, K | 1 |
| Yamada, K | 1 |
| Okada, K | 1 |
| Ouchi, R | 1 |
| Nibuya, M | 1 |
| Takahashi, A | 1 |
| Shito, Y | 1 |
| Watanabe, Y | 1 |
| Saeki, H | 1 |
| Suzuki, E | 1 |
| Müller, RM | 1 |
| Herziger, B | 1 |
| Jeschke, S | 1 |
| Neininger, MP | 1 |
| Bertsche, T | 1 |
| Bertsche, A | 1 |
| Eggleston, K | 1 |
| Porter, R | 1 |
| Li, Y | 1 |
| Zhang, F | 1 |
| Xu, Y | 1 |
| Hu, J | 1 |
| Li, H | 1 |
| Shorvon, SD | 1 |
| Bermejo, PE | 1 |
| Gibbs, AA | 1 |
| Huberfeld, G | 1 |
| Kälviäinen, R | 1 |
| Koristkova, B | 1 |
| Grundmann, M | 1 |
| Brozmanova, H | 1 |
| Kacirova, I | 1 |
| Hosohata, K | 1 |
| Inada, A | 1 |
| Oyama, S | 1 |
| Niinomi, I | 1 |
| Wakabayashi, T | 1 |
| Iwanaga, K | 1 |
| Kessler, SK | 1 |
| McGinnis, E | 1 |
| Alexander, T | 1 |
| Iglesia, E | 1 |
| Park, Y | 1 |
| Duncan, D | 1 |
| Peden, D | 1 |
| Sheikh, S | 1 |
| Ferris, M | 1 |
| Greil, W | 1 |
| Häberle, A | 1 |
| Schuhmann, T | 1 |
| Grohmann, R | 1 |
| Baumann, P | 1 |
| Reid, JG | 1 |
| Gitlin, MJ | 1 |
| Altshuler, LL | 1 |
| Fricke-Galindo, I | 1 |
| Martínez-Juárez, IE | 1 |
| Monroy-Jaramillo, N | 1 |
| Jung-Cook, H | 1 |
| Falfán-Valencia, R | 1 |
| Ortega-Vázquez, A | 1 |
| Alonso-Vilatela, ME | 1 |
| López-López, M | 1 |
| Park, HJ | 1 |
| Kim, YJ | 1 |
| Kim, DH | 1 |
| Kim, J | 1 |
| Park, KH | 1 |
| Park, JW | 1 |
| Lee, JH | 1 |
| Kowski, AB | 1 |
| Weissinger, F | 1 |
| Gaus, V | 1 |
| Fidzinski, P | 1 |
| Losch, F | 1 |
| Holtkamp, M | 1 |
| van den Beuken-van Everdingen, MH | 1 |
| de Graeff, A | 1 |
| Jongen, JL | 1 |
| Dijkstra, D | 1 |
| Mostovaya, I | 1 |
| Vissers, KC | 1 |
| Maniyar, F | 1 |
| Rooney, C | 1 |
| Lily, O | 1 |
| Bazaz, R | 1 |
| Hung, SI | 1 |
| Chung, WH | 1 |
| Liu, ZS | 1 |
| Chen, CH | 1 |
| Hsih, MS | 1 |
| Hui, RC | 1 |
| Chu, CY | 1 |
| Chen, YT | 1 |
| Samalin, L | 1 |
| Nourry, A | 1 |
| Llorca, PM | 1 |
| Hirata-Koizumi, M | 1 |
| Saito, M | 1 |
| Miyake, S | 1 |
| Hasegawa, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Repeat Dosing Lamotrigine in Healthy Chinese Subjects[NCT02513654] | Phase 1 | 16 participants (Actual) | Interventional | 2015-09-06 | Completed | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety[NCT05427058] | 36 participants (Anticipated) | Interventional | 2022-08-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for lamotrigine and Adverse Drug Event
| Article | Year |
|---|---|
Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics.
Topics: Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Humans; Lamotrigine | 2023 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Lamotrigine induced priapism in children: case analysis and literature review.
Topics: Adult; Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; La | 2022 |
Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis.
Topics: Adult; Bipolar Disorder; Depression; Drug-Related Side Effects and Adverse Reactions; Female; Fluoxe | 2023 |
Antiepileptic drug treatment of generalized tonic-clonic seizures: An evaluation of regulatory data and five criteria for drug selection.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug and Narcotic Control; Drug-Related Side Effect | 2018 |
A Practical Guide to Treatment of Childhood Absence Epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Electroen | 2019 |
Lamotrigine in psychiatric disorders.
Topics: Anticonvulsants; Depression; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Epidemi | 2013 |
Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review.
Topics: Amines; Analgesics; Anticonvulsants; Antidepressive Agents; Chemotherapy, Adjuvant; Cyclohexanecarbo | 2017 |
[Lithium and anticonvulsants in bipolar depression].
Topics: Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 2011 |
25 other studies available for lamotrigine and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Quality control concerns in relation to lamotrigine and their impact.
Topics: Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Drugs, Generic; Epilepsy; Humans; | 2022 |
Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database.
Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Drug | 2022 |
Lamotrigine use and potential for adverse cardiac effects: A retrospective evaluation in a Veteran population.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Hu | 2023 |
Hemodialysis for lamotrigine poisoning.
Topics: Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Lamotrigine; Renal Dialysis | 2020 |
Relationship of antiepileptic drugs to generic brittleness in patients with epilepsy.
Topics: Adult; Anticonvulsants; Cohort Studies; Drug Substitution; Drug-Related Side Effects and Adverse Rea | 2020 |
Analysis of antiseizure drug-related adverse reactions from the electronic health record using the common data model.
Topics: Anticonvulsants; Common Data Elements; Drug-Related Side Effects and Adverse Reactions; Electronic H | 2020 |
Changes in ratio of ineligible use of lamotrigine in Japan based on data from the relief system of the Pharmaceuticals and Medical Devices Agency.
Topics: Bipolar Disorder; Compensation and Redress; Drug and Narcotic Control; Drug-Related Side Effects and | 2021 |
Knowledge of epilepsy among German pharmacists.
Topics: Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; L | 2021 |
Lymphadenopathy-A rare but important side effect of lamotrigine.
Topics: Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Humans; Iatrogenic Disease; Lamotr | 2022 |
Pharmacokinetics, Safety, and Tolerability of Lamotrigine Chewable/Dispersible Tablet Following Repeat-Dose Administration in Healthy Chinese Volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Area Under Curve; Asian People; Biological | 2018 |
Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Czech Republic; Dose-Response R | 2019 |
Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database.
Topics: Anticonvulsants; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Exanthema; Fem | 2019 |
Severe DRESS syndrome managed with therapeutic plasma exchange.
Topics: Adolescent; Buprenorphine; Disease Management; Drug-Related Side Effects and Adverse Reactions; Eosi | 2013 |
Age and adverse drug reactions from psychopharmacological treatment: data from the AMSP drug surveillance programme in Switzerland.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; An | 2013 |
HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with lamotrigine-induced maculopapular exanthema in Mexican Mestizo patients.
Topics: Adolescent; Adult; Aged; Carbamazepine; Drug Eruptions; Drug-Related Side Effects and Adverse Reacti | 2014 |
HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.
Topics: Adult; Aged; Alleles; Allopurinol; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studie | 2016 |
Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Depression; Drug-Related Side Effects and Adve | 2016 |
International Consensus Group on the evidence-based pharmacologic treatment of bipolar I and II depression.
Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Central Nervous Syst | 2008 |
Anticonvulsant hypersensitivity syndrome presenting as aseptic meningitis.
Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Administration Schedule; Drug-Related Side Effects and | 2009 |
Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anticonvulsants; Asian People; Carbamazepine; C | 2010 |
Adverse events caused by drug interactions involving glucuronoconjugates of zidovudine, valproic acid and lamotrigine, and analysis of how such potential events are discussed in package inserts of Japan, UK and USA.
Topics: Area Under Curve; Communication; Disclosure; Drug Combinations; Drug Interactions; Drug Labeling; Dr | 2007 |