lamotrigine and Ache
lamotrigine has been researched along with Ache in 45 studies
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The 2 treatment periods began with an 8-week, double-blind titration period, during which the number of pills of study drug was increased until either total pain relief was achieved, 1 or more unmanageable adverse events were reported, or a maximum of 16 pills (400 mg of lamotrigine) were used daily." | 9.12 | A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis. ( Breuer, B; Guleyupoglu, N; Knotkova, H; Pappagallo, M; Portenoy, RK; Wallenstein, S, 2007) |
| "Lamotrigine, a sodium channel blocker that selectively inhibits the neuronal release of glutamate, has been shown to produce analgesia in acute and chronic pain models in rats without causing noticeable sedation." | 9.09 | Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials. ( Klamt, JG; Posner, J, 1999) |
| "Lamotrigine 200 mg/d reduced the median pain score to 5, compared to 7 during placebo (p = 0." | 9.09 | Lamotrigine for central poststroke pain: a randomized controlled trial. ( Andersen, G; Gottrup, H; Jensen, TS; Kristensen, BT; Vestergaard, K, 2001) |
| "Randomised controlled trials (RCTs) of lamotrigine in acute, and chronic pain (including cancer pain) were identified from MEDLINE, EMBASE and CENTRAL up to January 2011." | 8.87 | Lamotrigine for acute and chronic pain. ( Derry, S; Moore, RA; Wiffen, PJ, 2011) |
| "To assess the analgesic efficacy and adverse effects of the anticonvulsant lamotrigine for acute and chronic pain." | 8.84 | Lamotrigine for acute and chronic pain. ( Rees, J; Wiffen, PJ, 2007) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Intrathecal (IT) lamotrigine, a sodium channel blocker which suppresses neuronal release of glutamate, has been shown to produce a long-lasting antihyperalgesic effect in the neuropathic pain models." | 7.71 | The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain. ( Buerkle, H; Lee, TH; Lin, SH; Wang, CJ; Wu, PC; Yang, LC, 2002) |
| "Some opioid-resistant pain conditions can be alleviated by voltage-dependent Na(+) channel blockers such as lamotrigine." | 7.71 | Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage. ( Blackburn-Munro, G; Dickinson, T; Fleetwood-Walker, SM, 2001) |
| "Outcome measures were the areas of secondary hyperalgesia to brush and von Frey hair stimulation and the painfulness of noxious thermal stimulation in nonsensitized skin." | 6.71 | A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. ( Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC, 2003) |
| "Intensive pain is difficult to control with standard analgesics." | 5.35 | Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report. ( Aleksić-Shihabi, A; Buca, A; Jukić, I; Titlić, M; Tonkić, A, 2009) |
| "Pain associated with hyperalgesia of the affected area occurs in a number of conditions." | 5.30 | Lamotrigine for pain with hyperalgesia. ( Dennehy, F; Harbison, J; Keating, D, 1997) |
| "Our study confirmed that pamidronate, prednisone, and guideline-recommended anticonvulsants were effective for reducing pain intensity for CPSP." | 5.22 | Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis. ( Bo, Z; Gangfeng, G; Jian, W; Jian, Y; Ke, H; Maoxia, L; Xiaojing, L; Xiaolan, L; Yan, L; Yang, F; Zhao, C, 2022) |
| " The 2 treatment periods began with an 8-week, double-blind titration period, during which the number of pills of study drug was increased until either total pain relief was achieved, 1 or more unmanageable adverse events were reported, or a maximum of 16 pills (400 mg of lamotrigine) were used daily." | 5.12 | A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis. ( Breuer, B; Guleyupoglu, N; Knotkova, H; Pappagallo, M; Portenoy, RK; Wallenstein, S, 2007) |
| "The anticonvulsant lamotrigine has been reported to be efficacious and well tolerated as monotherapy in the treatment of bipolar patients as well as in treatment-refractory bipolar disorder." | 5.10 | Lamotrigine as an augmentation agent in treatment-resistant depression. ( Barbee, JG; Jamhour, NJ, 2002) |
| "Lamotrigine, a sodium channel blocker that selectively inhibits the neuronal release of glutamate, has been shown to produce analgesia in acute and chronic pain models in rats without causing noticeable sedation." | 5.09 | Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials. ( Klamt, JG; Posner, J, 1999) |
| "Lamotrigine 200 mg/d reduced the median pain score to 5, compared to 7 during placebo (p = 0." | 5.09 | Lamotrigine for central poststroke pain: a randomized controlled trial. ( Andersen, G; Gottrup, H; Jensen, TS; Kristensen, BT; Vestergaard, K, 2001) |
| " Overall, there was a low quality of evidence that gabapentin, pregabalin, amitriptyline, and venlafaxine were effective in reducing pain intensity in patients with cancer pain." | 4.95 | Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review. ( de Graeff, A; Dijkstra, D; Jongen, JL; Mostovaya, I; van den Beuken-van Everdingen, MH; Vissers, KC, 2017) |
| "Randomised controlled trials (RCTs) of lamotrigine in acute, and chronic pain (including cancer pain) were identified from MEDLINE, EMBASE and CENTRAL up to January 2011." | 4.87 | Lamotrigine for acute and chronic pain. ( Derry, S; Moore, RA; Wiffen, PJ, 2011) |
| "To assess the analgesic efficacy and adverse effects of the anticonvulsant lamotrigine for acute and chronic pain." | 4.84 | Lamotrigine for acute and chronic pain. ( Rees, J; Wiffen, PJ, 2007) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Intrathecal (IT) lamotrigine, a sodium channel blocker which suppresses neuronal release of glutamate, has been shown to produce a long-lasting antihyperalgesic effect in the neuropathic pain models." | 3.71 | The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain. ( Buerkle, H; Lee, TH; Lin, SH; Wang, CJ; Wu, PC; Yang, LC, 2002) |
| "Some opioid-resistant pain conditions can be alleviated by voltage-dependent Na(+) channel blockers such as lamotrigine." | 3.71 | Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage. ( Blackburn-Munro, G; Dickinson, T; Fleetwood-Walker, SM, 2001) |
| "The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models." | 3.69 | The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. ( Fontana, DJ; Gogas, KR; Hedley, LR; Hunter, JC; Jacobson, LO; Kassotakis, L; Thompson, J, 1997) |
| "Outcome measures were the areas of secondary hyperalgesia to brush and von Frey hair stimulation and the painfulness of noxious thermal stimulation in nonsensitized skin." | 2.71 | A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. ( Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC, 2003) |
| "Gabapentin has demonstrated efficacy, specifically in painful diabetic neuropathy and postherpetic neuralgia." | 2.41 | Use of anticonvulsants for treatment of neuropathic pain. ( Backonja, MM, 2002) |
| "Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use." | 1.91 | Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023) |
| "Lamotrigine was the most frequently initiated drug in psychiatry, in both boys and girls." | 1.48 | Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses. ( Karlsson Lind, L; von Euler, M; Wettermark, B; Wide, K, 2018) |
| "Intensive pain is difficult to control with standard analgesics." | 1.35 | Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report. ( Aleksić-Shihabi, A; Buca, A; Jukić, I; Titlić, M; Tonkić, A, 2009) |
| "Pain associated with hyperalgesia of the affected area occurs in a number of conditions." | 1.30 | Lamotrigine for pain with hyperalgesia. ( Dennehy, F; Harbison, J; Keating, D, 1997) |
Research
Studies (45)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (22.22) | 18.2507 |
| 2000's | 27 (60.00) | 29.6817 |
| 2010's | 5 (11.11) | 24.3611 |
| 2020's | 3 (6.67) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Gharagozloo, P | 1 |
| Yao, J | 1 |
| Ilyin, VI | 3 |
| Carter, RB | 3 |
| Nguyen, P | 3 |
| Robledo, S | 2 |
| Woodward, RM | 2 |
| Hogenkamp, DJ | 2 |
| Shao, B | 1 |
| Victory, S | 1 |
| Goehring, RR | 1 |
| Sun, Q | 1 |
| Hogenkamp, D | 1 |
| Hodges, DD | 1 |
| Islam, K | 1 |
| Sha, D | 1 |
| Zhang, C | 1 |
| Sakellaropoulos, G | 1 |
| Yogeeswari, P | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Jarvis, MF | 1 |
| Honore, P | 1 |
| Shieh, CC | 1 |
| Chapman, M | 1 |
| Joshi, S | 1 |
| Zhang, XF | 1 |
| Kort, M | 1 |
| Carroll, W | 1 |
| Marron, B | 1 |
| Atkinson, R | 1 |
| Thomas, J | 1 |
| Liu, D | 1 |
| Krambis, M | 1 |
| Liu, Y | 1 |
| McGaraughty, S | 1 |
| Chu, K | 1 |
| Roeloffs, R | 1 |
| Zhong, C | 1 |
| Mikusa, JP | 1 |
| Hernandez, G | 1 |
| Gauvin, D | 1 |
| Wade, C | 1 |
| Zhu, C | 1 |
| Pai, M | 1 |
| Scanio, M | 1 |
| Shi, L | 1 |
| Drizin, I | 1 |
| Gregg, R | 1 |
| Matulenko, M | 1 |
| Hakeem, A | 1 |
| Gross, M | 1 |
| Johnson, M | 1 |
| Marsh, K | 1 |
| Wagoner, PK | 1 |
| Sullivan, JP | 1 |
| Faltynek, CR | 1 |
| Krafte, DS | 1 |
| Bo, Z | 1 |
| Jian, Y | 1 |
| Yan, L | 1 |
| Gangfeng, G | 1 |
| Xiaojing, L | 1 |
| Xiaolan, L | 1 |
| Zhao, C | 1 |
| Ke, H | 1 |
| Yang, F | 1 |
| Maoxia, L | 1 |
| Jian, W | 1 |
| Lopez, MR | 1 |
| VanCott, AC | 1 |
| Amuan, ME | 1 |
| Panahi, S | 1 |
| Henion, A | 1 |
| Pugh, MJ | 1 |
| Vandevelde, A | 1 |
| Benbrika, S | 1 |
| Madigand, J | 1 |
| Dollfus, S | 1 |
| Karlsson Lind, L | 1 |
| Wide, K | 1 |
| Wettermark, B | 1 |
| von Euler, M | 1 |
| Szabo, AZ | 1 |
| Bocsan, IC | 1 |
| Suciu, S | 1 |
| Buzoianu, AD | 1 |
| van den Beuken-van Everdingen, MH | 1 |
| de Graeff, A | 1 |
| Jongen, JL | 1 |
| Dijkstra, D | 1 |
| Mostovaya, I | 1 |
| Vissers, KC | 1 |
| Titlic, M | 2 |
| Jukic, I | 2 |
| Tonkic, A | 2 |
| Josipovic-Jelic, Z | 1 |
| Boschi, V | 1 |
| Mihalj, M | 1 |
| Punda, A | 1 |
| Sindrup, SH | 1 |
| Buca, A | 1 |
| Aleksić-Shihabi, A | 1 |
| Scrivani, S | 1 |
| Wallin, D | 1 |
| Moulton, EA | 1 |
| Cole, S | 1 |
| Wasan, AD | 1 |
| Lockerman, L | 1 |
| Bajwa, Z | 1 |
| Upadhyay, J | 1 |
| Becerra, L | 1 |
| Borsook, D | 1 |
| Wiffen, PJ | 2 |
| Derry, S | 1 |
| Moore, RA | 1 |
| Lee, TH | 1 |
| Wang, CJ | 1 |
| Wu, PC | 1 |
| Buerkle, H | 1 |
| Lin, SH | 1 |
| Yang, LC | 1 |
| Laughlin, TM | 1 |
| Tram, KV | 1 |
| Wilcox, GL | 1 |
| Birnbaum, AK | 1 |
| Barbee, JG | 1 |
| Jamhour, NJ | 1 |
| Backonja, MM | 1 |
| Keswani, SC | 1 |
| Pardo, CA | 1 |
| Cherry, CL | 1 |
| Hoke, A | 1 |
| McArthur, JC | 1 |
| Yen, HL | 1 |
| Chan, W | 1 |
| Petersen, KL | 1 |
| Maloney, A | 1 |
| Hoke, F | 1 |
| Dahl, JB | 1 |
| Rowbotham, MC | 1 |
| Hong, HB | 1 |
| Xu, RJ | 1 |
| Lindia, JA | 1 |
| Köhler, MG | 1 |
| Martin, WJ | 1 |
| Abbadie, C | 1 |
| Reiss, JP | 1 |
| Sam, D | 1 |
| Sareen, J | 1 |
| Pomonis, JD | 1 |
| Whiteside, GT | 1 |
| Harrison, JE | 1 |
| Pearson, MS | 1 |
| Mark, L | 1 |
| Turchin, PI | 1 |
| Gottshall, S | 1 |
| Olanrewaju, S | 1 |
| Benjamin, E | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Rees, J | 1 |
| Breuer, B | 1 |
| Pappagallo, M | 1 |
| Knotkova, H | 1 |
| Guleyupoglu, N | 1 |
| Wallenstein, S | 1 |
| Portenoy, RK | 1 |
| Bras, M | 1 |
| Harbison, J | 1 |
| Dennehy, F | 1 |
| Keating, D | 1 |
| Hunter, JC | 1 |
| Gogas, KR | 1 |
| Hedley, LR | 1 |
| Jacobson, LO | 1 |
| Kassotakis, L | 1 |
| Thompson, J | 1 |
| Fontana, DJ | 1 |
| Canavero, S | 1 |
| Bonicalzi, V | 1 |
| Kukushkin, ML | 1 |
| Danilova, EI | 1 |
| Grafova, VN | 1 |
| Smirnova, VS | 1 |
| Reshetniak, VK | 1 |
| Webb, J | 1 |
| Kamali, F | 1 |
| McCleane, G | 2 |
| Cianchetti, C | 1 |
| Zuddas, A | 1 |
| Randazzo, AP | 1 |
| Perra, L | 1 |
| Marrosu, MG | 1 |
| Klamt, JG | 1 |
| Posner, J | 1 |
| Carrieri, PB | 1 |
| Bonuso, S | 1 |
| Bruno, R | 1 |
| Vincitorio, CM | 1 |
| Caruso, G | 1 |
| Devulder, J | 2 |
| De Laat, M | 1 |
| Leandri, M | 1 |
| Lundardi, G | 1 |
| Inglese, M | 1 |
| Messmer-Uccelli, M | 1 |
| Mancardi, GL | 1 |
| Gottlieb, A | 1 |
| Solaro, C | 1 |
| Vestergaard, K | 1 |
| Andersen, G | 1 |
| Gottrup, H | 1 |
| Kristensen, BT | 1 |
| Jensen, TS | 1 |
| Blackburn-Munro, G | 1 |
| Dickinson, T | 1 |
| Fleetwood-Walker, SM | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study[NCT03419949] | 0 participants | Expanded Access | Available | ||||
| Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety[NCT05427058] | 36 participants (Anticipated) | Interventional | 2022-08-01 | Not yet recruiting | |||
| Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI[NCT00243152] | 6 participants (Actual) | Interventional | 2005-10-31 | Completed | |||
| Efficacy and Safety of Antidepressant Augmentation With Lamotrigine in Patients With Treatment-Resistant Depression[NCT00652171] | Phase 3 | 34 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Blood Oxygenation Level-dependent (BOLD) Changes in Neural Pain Circuitry Following Treatment With Lamotrigine During Experimentally Induced Pain States
fMRI scans acquired Stimuli Type: Brush Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness fMRI scans acquired Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** fMRI scans acquired Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** Cortical, subcortical, and brain stem sensory regions Z-scores Increase or decrease in activation as affected by the drug (NCT00243152)
Timeframe: Week 10 during scanning session
| Intervention | Z-statistic (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Heat Affected Thalamus (10,-14,8) | Heat Affected Post-Central (-56,-12,28) | Cold Affected Post-Central (68, -8, 32) | Cold Affected Thalamus (-4, -8, 0) | Brush Affected Post-Central (66,-16,14) | Brush Affected Thalamus (-14,-22, 4) | Brush Affected Spinal Trigeminal Nucles(2,-48,-68) | |
| Lamotrigine vs Placebo | -2.9294 | -2.7323 | -2.5114 | -3.033 | 3.905 | -3.791 | 2.9058 |
Subjective Ratings of Pain During Magnetic Resonance Scanning
"Quantitative Sensory Testing (QST)~Stimuli Type: Heat, Cold, Brush Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness~Ratings on a likert scale of 0-10 with 0 being defined as no pain and 10 being defined as worst possible pain" (NCT00243152)
Timeframe: week 10 (during the scan)
| Intervention | scores on a pain scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Heat Affected | Heat Unaffected | Cold Affected | Cold Unaffected | Brush Affected | Brush Unaffected | |
| Lamotrigine | 3.2 | 3 | 2.1 | 2.2 | 2.8 | 1.2 |
| Placebo | 5.5 | 4 | 2.5 | 1.1 | 3.9 | .4 |
Reviews
10 reviews available for lamotrigine and Ache
| Article | Year |
|---|---|
Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis.
Topics: Anticonvulsants; Etanercept; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis; Pain; Pamidr | 2022 |
Common mechanisms involved in manic switch and pain relief induced by lamotrigine: A case report and a literature review.
Topics: Anticonvulsants; Bipolar Disorder; Humans; Lamotrigine; Pain; Pain Management | 2021 |
Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review.
Topics: Amines; Analgesics; Anticonvulsants; Antidepressive Agents; Chemotherapy, Adjuvant; Cyclohexanecarbo | 2017 |
Lamotrigine in the treatment of pain syndromes and neuropathic pain.
Topics: Analgesics; Anticonvulsants; Humans; Lamotrigine; Neuralgia; Pain; Triazines | 2008 |
Lamotrigine for acute and chronic pain.
Topics: Acute Disease; Analgesics; Chronic Disease; Humans; Lamotrigine; Pain; Randomized Controlled Trials | 2011 |
Use of anticonvulsants for treatment of neuropathic pain.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; | 2002 |
HIV-associated sensory neuropathies.
Topics: Analgesics; Anti-HIV Agents; HIV Infections; Humans; Lamotrigine; Nerve Growth Factors; Pain; Periph | 2002 |
[Progress on painful diabetic peripheral neuropathy treated by integrative medicine].
Topics: Amines; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Cyclohe | 2005 |
Lamotrigine for acute and chronic pain.
Topics: Acute Disease; Analgesics; Anticonvulsants; Chronic Disease; Humans; Lamotrigine; Pain; Randomized C | 2007 |
[Psychopharmacotherapy in psychiatric comorbidities among patients with chronic pain].
Topics: Amines; Analgesics; Anticonvulsants; Bupropion; Chronic Disease; Cyclohexanecarboxylic Acids; Dopami | 2007 |
Trials
9 trials available for lamotrigine and Ache
| Article | Year |
|---|---|
A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study.
Topics: Adult; Amines; Anticonvulsants; Brain; Cold Temperature; Cross-Over Studies; Cyclohexanecarboxylic A | 2010 |
Lamotrigine as an augmentation agent in treatment-resistant depression.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Anxiety Disorders; Bipolar Disorder; Chronic Disease | 2002 |
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combinatio | 2003 |
A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis.
Topics: Anticonvulsants; Cross-Over Studies; Double-Blind Method; Female; Humans; Lamotrigine; Male; Middle | 2007 |
Analgesic effects of lamotrigine and phenytoin on cold-induced pain: a crossover placebo-controlled study in healthy volunteers.
Topics: Adult; Anticonvulsants; Blood Pressure; Cold Temperature; Cross-Over Studies; Double-Blind Method; F | 1998 |
Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials.
Topics: Administration, Oral; Adult; Analgesics; Carbon Dioxide; Cross-Over Studies; Double-Blind Method; Ev | 1999 |
200 mg daily of lamotrigine has no analgesic effect in neuropathic pain: a randomised, double-blind, placebo controlled trial.
Topics: Adult; Analgesics; Anticonvulsants; Double-Blind Method; Drug Administration Schedule; Female; Human | 1999 |
Lamotrigine in trigeminal neuralgia secondary to multiple sclerosis.
Topics: Analgesics; Analgesics, Non-Narcotic; Carbamazepine; Female; Humans; Lamotrigine; Male; Middle Aged; | 2000 |
Lamotrigine for central poststroke pain: a randomized controlled trial.
Topics: Adult; Aged; Analysis of Variance; Double-Blind Method; Female; Humans; Lamotrigine; Male; Middle Ag | 2001 |
Other Studies
26 other studies available for lamotrigine and Ache
| Article | Year |
|---|---|
3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers.
Topics: Analgesics; Animals; Cell Line; Humans; Male; Pain; Patch-Clamp Techniques; Peripheral Nervous Syste | 2004 |
Phenoxyphenyl pyridines as novel state-dependent, high-potency sodium channel inhibitors.
Topics: Analgesics; Animals; Animals, Newborn; Brain; Cell Line; Humans; In Vitro Techniques; Male; NAV1.2 V | 2004 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Topics: Action Potentials; Analgesics; Aniline Compounds; Animals; Capsaicin; Evoked Potentials; Furans; Gan | 2007 |
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam | 2023 |
Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; Epilepsy | 2018 |
Comparative animal study of the antinociceptive efficacy of lamotrigine and gabapentin for the management of pain.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; gamma-Aminobutyric Acid; Lamotrigine | 2015 |
Nicotinic acetylcholine receptor agonism: progress in the management of neuropathic pain?
Topics: Azetidines; Excitatory Amino Acid Antagonists; Humans; Lamotrigine; Nicotinic Agonists; Pain; Periph | 2009 |
Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report.
Topics: Adult; Anticonvulsants; Cervical Vertebrae; Female; Humans; Intervertebral Disc Displacement; Lamotr | 2009 |
The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain.
Topics: Analgesics; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Inflammation; Inject | 2002 |
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.
Topics: Acetates; Acute Disease; Adrenergic alpha-Agonists; Amines; Analgesics, Non-Narcotic; Analgesics, Op | 2002 |
An East-West approach to the management of central post-stroke pain.
Topics: Acetates; Acupuncture; Aged; Amines; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Secon | 2003 |
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Gan | 2005 |
Psychosis in multiple sclerosis associated with left temporal lobe lesions on serial MRI scans.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Delusions; Excitatory Amino Acid Antagonists; Female; | 2006 |
Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.
Topics: Animals; Carbamazepine; Humans; Hyperalgesia; Lamotrigine; Male; Motor Activity; Pain; Pyrimidines; | 2006 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Lamotrigine for pain with hyperalgesia.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Hyperalgesia; Lamotrigine; Male; Pain; Tri | 1997 |
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Anticonvulsants; Chronic Disease; Cyclohexanec | 1997 |
Lamotrigine control of central pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anticonvulsants; Central Nervous System Diseases; Female | 1996 |
[Effect of lamotrigine on development of neurogenic pain syndrome in rats].
Topics: Analgesics; Animals; Anticonvulsants; Convulsants; Lamotrigine; Neurons; Pain; Pain Measurement; Pen | 1998 |
Lamotrigine can reduce neurogenic pain associated with multiple sclerosis.
Topics: Adult; Analgesics; Female; Humans; Lamotrigine; Multiple Sclerosis; Pain; Triazines | 1998 |
Lamotrigine adjunctive therapy in painful phenomena in MS: preliminary observations.
Topics: Analgesics; Female; Humans; Lamotrigine; Male; Multiple Sclerosis; Pain; Triazines | 1999 |
Efficacy of lamotrigine on sensory symptoms and pain in peripheral neuropathies.
Topics: Aged; Anticonvulsants; Female; Humans; Lamotrigine; Male; Middle Aged; Pain; Peripheral Nervous Syst | 1999 |
Lamotrigine in the treatment of chronic refractory neuropathic pain.
Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Drug Therapy, Combination; Female; Hum | 2000 |
Is 200mg lamotrigine daily analgesic or not?
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Humans; Lamotrigine; Pain; Triazines | 2000 |
Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage.
Topics: Action Potentials; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Calcium Channel Blockers; Chole | 2001 |