Page last updated: 2024-10-30

lamotrigine and Ache

lamotrigine has been researched along with Ache in 45 studies

Research Excerpts

ExcerptRelevanceReference
" The 2 treatment periods began with an 8-week, double-blind titration period, during which the number of pills of study drug was increased until either total pain relief was achieved, 1 or more unmanageable adverse events were reported, or a maximum of 16 pills (400 mg of lamotrigine) were used daily."9.12A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis. ( Breuer, B; Guleyupoglu, N; Knotkova, H; Pappagallo, M; Portenoy, RK; Wallenstein, S, 2007)
"Lamotrigine, a sodium channel blocker that selectively inhibits the neuronal release of glutamate, has been shown to produce analgesia in acute and chronic pain models in rats without causing noticeable sedation."9.09Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials. ( Klamt, JG; Posner, J, 1999)
"Lamotrigine 200 mg/d reduced the median pain score to 5, compared to 7 during placebo (p = 0."9.09Lamotrigine for central poststroke pain: a randomized controlled trial. ( Andersen, G; Gottrup, H; Jensen, TS; Kristensen, BT; Vestergaard, K, 2001)
"Randomised controlled trials (RCTs) of lamotrigine in acute, and chronic pain (including cancer pain) were identified from MEDLINE, EMBASE and CENTRAL up to January 2011."8.87Lamotrigine for acute and chronic pain. ( Derry, S; Moore, RA; Wiffen, PJ, 2011)
"To assess the analgesic efficacy and adverse effects of the anticonvulsant lamotrigine for acute and chronic pain."8.84Lamotrigine for acute and chronic pain. ( Rees, J; Wiffen, PJ, 2007)
"The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain."7.74A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007)
"Intrathecal (IT) lamotrigine, a sodium channel blocker which suppresses neuronal release of glutamate, has been shown to produce a long-lasting antihyperalgesic effect in the neuropathic pain models."7.71The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain. ( Buerkle, H; Lee, TH; Lin, SH; Wang, CJ; Wu, PC; Yang, LC, 2002)
"Some opioid-resistant pain conditions can be alleviated by voltage-dependent Na(+) channel blockers such as lamotrigine."7.71Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage. ( Blackburn-Munro, G; Dickinson, T; Fleetwood-Walker, SM, 2001)
"Outcome measures were the areas of secondary hyperalgesia to brush and von Frey hair stimulation and the painfulness of noxious thermal stimulation in nonsensitized skin."6.71A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. ( Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC, 2003)
"Intensive pain is difficult to control with standard analgesics."5.35Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report. ( Aleksić-Shihabi, A; Buca, A; Jukić, I; Titlić, M; Tonkić, A, 2009)
"Pain associated with hyperalgesia of the affected area occurs in a number of conditions."5.30Lamotrigine for pain with hyperalgesia. ( Dennehy, F; Harbison, J; Keating, D, 1997)
"Our study confirmed that pamidronate, prednisone, and guideline-recommended anticonvulsants were effective for reducing pain intensity for CPSP."5.22Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis. ( Bo, Z; Gangfeng, G; Jian, W; Jian, Y; Ke, H; Maoxia, L; Xiaojing, L; Xiaolan, L; Yan, L; Yang, F; Zhao, C, 2022)
" The 2 treatment periods began with an 8-week, double-blind titration period, during which the number of pills of study drug was increased until either total pain relief was achieved, 1 or more unmanageable adverse events were reported, or a maximum of 16 pills (400 mg of lamotrigine) were used daily."5.12A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis. ( Breuer, B; Guleyupoglu, N; Knotkova, H; Pappagallo, M; Portenoy, RK; Wallenstein, S, 2007)
"The anticonvulsant lamotrigine has been reported to be efficacious and well tolerated as monotherapy in the treatment of bipolar patients as well as in treatment-refractory bipolar disorder."5.10Lamotrigine as an augmentation agent in treatment-resistant depression. ( Barbee, JG; Jamhour, NJ, 2002)
"Lamotrigine, a sodium channel blocker that selectively inhibits the neuronal release of glutamate, has been shown to produce analgesia in acute and chronic pain models in rats without causing noticeable sedation."5.09Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials. ( Klamt, JG; Posner, J, 1999)
"Lamotrigine 200 mg/d reduced the median pain score to 5, compared to 7 during placebo (p = 0."5.09Lamotrigine for central poststroke pain: a randomized controlled trial. ( Andersen, G; Gottrup, H; Jensen, TS; Kristensen, BT; Vestergaard, K, 2001)
" Overall, there was a low quality of evidence that gabapentin, pregabalin, amitriptyline, and venlafaxine were effective in reducing pain intensity in patients with cancer pain."4.95Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review. ( de Graeff, A; Dijkstra, D; Jongen, JL; Mostovaya, I; van den Beuken-van Everdingen, MH; Vissers, KC, 2017)
"Randomised controlled trials (RCTs) of lamotrigine in acute, and chronic pain (including cancer pain) were identified from MEDLINE, EMBASE and CENTRAL up to January 2011."4.87Lamotrigine for acute and chronic pain. ( Derry, S; Moore, RA; Wiffen, PJ, 2011)
"To assess the analgesic efficacy and adverse effects of the anticonvulsant lamotrigine for acute and chronic pain."4.84Lamotrigine for acute and chronic pain. ( Rees, J; Wiffen, PJ, 2007)
"The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain."3.74A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007)
"Intrathecal (IT) lamotrigine, a sodium channel blocker which suppresses neuronal release of glutamate, has been shown to produce a long-lasting antihyperalgesic effect in the neuropathic pain models."3.71The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain. ( Buerkle, H; Lee, TH; Lin, SH; Wang, CJ; Wu, PC; Yang, LC, 2002)
"Some opioid-resistant pain conditions can be alleviated by voltage-dependent Na(+) channel blockers such as lamotrigine."3.71Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage. ( Blackburn-Munro, G; Dickinson, T; Fleetwood-Walker, SM, 2001)
"The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models."3.69The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. ( Fontana, DJ; Gogas, KR; Hedley, LR; Hunter, JC; Jacobson, LO; Kassotakis, L; Thompson, J, 1997)
"Outcome measures were the areas of secondary hyperalgesia to brush and von Frey hair stimulation and the painfulness of noxious thermal stimulation in nonsensitized skin."2.71A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. ( Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC, 2003)
"Gabapentin has demonstrated efficacy, specifically in painful diabetic neuropathy and postherpetic neuralgia."2.41Use of anticonvulsants for treatment of neuropathic pain. ( Backonja, MM, 2002)
"Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use."1.91Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023)
"Lamotrigine was the most frequently initiated drug in psychiatry, in both boys and girls."1.48Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses. ( Karlsson Lind, L; von Euler, M; Wettermark, B; Wide, K, 2018)
"Intensive pain is difficult to control with standard analgesics."1.35Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report. ( Aleksić-Shihabi, A; Buca, A; Jukić, I; Titlić, M; Tonkić, A, 2009)
"Pain associated with hyperalgesia of the affected area occurs in a number of conditions."1.30Lamotrigine for pain with hyperalgesia. ( Dennehy, F; Harbison, J; Keating, D, 1997)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (22.22)18.2507
2000's27 (60.00)29.6817
2010's5 (11.11)24.3611
2020's3 (6.67)2.80

Authors

AuthorsStudies
Yang, J1
Gharagozloo, P1
Yao, J1
Ilyin, VI3
Carter, RB3
Nguyen, P3
Robledo, S2
Woodward, RM2
Hogenkamp, DJ2
Shao, B1
Victory, S1
Goehring, RR1
Sun, Q1
Hogenkamp, D1
Hodges, DD1
Islam, K1
Sha, D1
Zhang, C1
Sakellaropoulos, G1
Yogeeswari, P1
Ragavendran, JV1
Sriram, D1
Nageswari, Y1
Kavya, R1
Sreevatsan, N1
Vanitha, K1
Stables, J1
Jarvis, MF1
Honore, P1
Shieh, CC1
Chapman, M1
Joshi, S1
Zhang, XF1
Kort, M1
Carroll, W1
Marron, B1
Atkinson, R1
Thomas, J1
Liu, D1
Krambis, M1
Liu, Y1
McGaraughty, S1
Chu, K1
Roeloffs, R1
Zhong, C1
Mikusa, JP1
Hernandez, G1
Gauvin, D1
Wade, C1
Zhu, C1
Pai, M1
Scanio, M1
Shi, L1
Drizin, I1
Gregg, R1
Matulenko, M1
Hakeem, A1
Gross, M1
Johnson, M1
Marsh, K1
Wagoner, PK1
Sullivan, JP1
Faltynek, CR1
Krafte, DS1
Bo, Z1
Jian, Y1
Yan, L1
Gangfeng, G1
Xiaojing, L1
Xiaolan, L1
Zhao, C1
Ke, H1
Yang, F1
Maoxia, L1
Jian, W1
Lopez, MR1
VanCott, AC1
Amuan, ME1
Panahi, S1
Henion, A1
Pugh, MJ1
Vandevelde, A1
Benbrika, S1
Madigand, J1
Dollfus, S1
Karlsson Lind, L1
Wide, K1
Wettermark, B1
von Euler, M1
Szabo, AZ1
Bocsan, IC1
Suciu, S1
Buzoianu, AD1
van den Beuken-van Everdingen, MH1
de Graeff, A1
Jongen, JL1
Dijkstra, D1
Mostovaya, I1
Vissers, KC1
Titlic, M2
Jukic, I2
Tonkic, A2
Josipovic-Jelic, Z1
Boschi, V1
Mihalj, M1
Punda, A1
Sindrup, SH1
Buca, A1
Aleksić-Shihabi, A1
Scrivani, S1
Wallin, D1
Moulton, EA1
Cole, S1
Wasan, AD1
Lockerman, L1
Bajwa, Z1
Upadhyay, J1
Becerra, L1
Borsook, D1
Wiffen, PJ2
Derry, S1
Moore, RA1
Lee, TH1
Wang, CJ1
Wu, PC1
Buerkle, H1
Lin, SH1
Yang, LC1
Laughlin, TM1
Tram, KV1
Wilcox, GL1
Birnbaum, AK1
Barbee, JG1
Jamhour, NJ1
Backonja, MM1
Keswani, SC1
Pardo, CA1
Cherry, CL1
Hoke, A1
McArthur, JC1
Yen, HL1
Chan, W1
Petersen, KL1
Maloney, A1
Hoke, F1
Dahl, JB1
Rowbotham, MC1
Hong, HB1
Xu, RJ1
Lindia, JA1
Köhler, MG1
Martin, WJ1
Abbadie, C1
Reiss, JP1
Sam, D1
Sareen, J1
Pomonis, JD1
Whiteside, GT1
Harrison, JE1
Pearson, MS1
Mark, L1
Turchin, PI1
Gottshall, S1
Olanrewaju, S1
Benjamin, E1
Coderre, TJ1
Kumar, N1
Lefebvre, CD1
Yu, JS1
Rees, J1
Breuer, B1
Pappagallo, M1
Knotkova, H1
Guleyupoglu, N1
Wallenstein, S1
Portenoy, RK1
Bras, M1
Harbison, J1
Dennehy, F1
Keating, D1
Hunter, JC1
Gogas, KR1
Hedley, LR1
Jacobson, LO1
Kassotakis, L1
Thompson, J1
Fontana, DJ1
Canavero, S1
Bonicalzi, V1
Kukushkin, ML1
Danilova, EI1
Grafova, VN1
Smirnova, VS1
Reshetniak, VK1
Webb, J1
Kamali, F1
McCleane, G2
Cianchetti, C1
Zuddas, A1
Randazzo, AP1
Perra, L1
Marrosu, MG1
Klamt, JG1
Posner, J1
Carrieri, PB1
Bonuso, S1
Bruno, R1
Vincitorio, CM1
Caruso, G1
Devulder, J2
De Laat, M1
Leandri, M1
Lundardi, G1
Inglese, M1
Messmer-Uccelli, M1
Mancardi, GL1
Gottlieb, A1
Solaro, C1
Vestergaard, K1
Andersen, G1
Gottrup, H1
Kristensen, BT1
Jensen, TS1
Blackburn-Munro, G1
Dickinson, T1
Fleetwood-Walker, SM1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study[NCT03419949]0 participants Expanded AccessAvailable
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety[NCT05427058]36 participants (Anticipated)Interventional2022-08-01Not yet recruiting
Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI[NCT00243152]6 participants (Actual)Interventional2005-10-31Completed
Efficacy and Safety of Antidepressant Augmentation With Lamotrigine in Patients With Treatment-Resistant Depression[NCT00652171]Phase 334 participants (Actual)Interventional2004-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Blood Oxygenation Level-dependent (BOLD) Changes in Neural Pain Circuitry Following Treatment With Lamotrigine During Experimentally Induced Pain States

fMRI scans acquired Stimuli Type: Brush Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness fMRI scans acquired Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** fMRI scans acquired Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** Cortical, subcortical, and brain stem sensory regions Z-scores Increase or decrease in activation as affected by the drug (NCT00243152)
Timeframe: Week 10 during scanning session

InterventionZ-statistic (Number)
Heat Affected Thalamus (10,-14,8)Heat Affected Post-Central (-56,-12,28)Cold Affected Post-Central (68, -8, 32)Cold Affected Thalamus (-4, -8, 0)Brush Affected Post-Central (66,-16,14)Brush Affected Thalamus (-14,-22, 4)Brush Affected Spinal Trigeminal Nucles(2,-48,-68)
Lamotrigine vs Placebo-2.9294-2.7323-2.5114-3.0333.905-3.7912.9058

Subjective Ratings of Pain During Magnetic Resonance Scanning

"Quantitative Sensory Testing (QST)~Stimuli Type: Heat, Cold, Brush Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness~Ratings on a likert scale of 0-10 with 0 being defined as no pain and 10 being defined as worst possible pain" (NCT00243152)
Timeframe: week 10 (during the scan)

,
Interventionscores on a pain scale (Mean)
Heat AffectedHeat UnaffectedCold AffectedCold UnaffectedBrush AffectedBrush Unaffected
Lamotrigine3.232.12.22.81.2
Placebo5.542.51.13.9.4

Reviews

10 reviews available for lamotrigine and Ache

ArticleYear
Pharmacotherapies for Central Post-Stroke Pain: A Systematic Review and Network Meta-Analysis.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Anticonvulsants; Etanercept; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis; Pain; Pamidr

2022
Common mechanisms involved in manic switch and pain relief induced by lamotrigine: A case report and a literature review.
    L'Encephale, 2021, Volume: 47, Issue:3

    Topics: Anticonvulsants; Bipolar Disorder; Humans; Lamotrigine; Pain; Pain Management

2021
Pharmacological Treatment of Pain in Cancer Patients: The Role of Adjuvant Analgesics, a Systematic Review.
    Pain practice : the official journal of World Institute of Pain, 2017, Volume: 17, Issue:3

    Topics: Amines; Analgesics; Anticonvulsants; Antidepressive Agents; Chemotherapy, Adjuvant; Cyclohexanecarbo

2017
Lamotrigine in the treatment of pain syndromes and neuropathic pain.
    Bratislavske lekarske listy, 2008, Volume: 109, Issue:9

    Topics: Analgesics; Anticonvulsants; Humans; Lamotrigine; Neuralgia; Pain; Triazines

2008
Lamotrigine for acute and chronic pain.
    The Cochrane database of systematic reviews, 2011, Feb-16, Issue:2

    Topics: Acute Disease; Analgesics; Chronic Disease; Humans; Lamotrigine; Pain; Randomized Controlled Trials

2011
Use of anticonvulsants for treatment of neuropathic pain.
    Neurology, 2002, Sep-10, Volume: 59, Issue:5 Suppl 2

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;

2002
HIV-associated sensory neuropathies.
    AIDS (London, England), 2002, Nov-08, Volume: 16, Issue:16

    Topics: Analgesics; Anti-HIV Agents; HIV Infections; Humans; Lamotrigine; Nerve Growth Factors; Pain; Periph

2002
[Progress on painful diabetic peripheral neuropathy treated by integrative medicine].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2005, Volume: 25, Issue:4

    Topics: Amines; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Cyclohe

2005
Lamotrigine for acute and chronic pain.
    The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2

    Topics: Acute Disease; Analgesics; Anticonvulsants; Chronic Disease; Humans; Lamotrigine; Pain; Randomized C

2007
[Psychopharmacotherapy in psychiatric comorbidities among patients with chronic pain].
    L'Encephale, 2007, Volume: 33, Issue:Pt 3

    Topics: Amines; Analgesics; Anticonvulsants; Bupropion; Chronic Disease; Cyclohexanecarboxylic Acids; Dopami

2007

Trials

9 trials available for lamotrigine and Ache

ArticleYear
A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:6

    Topics: Adult; Amines; Anticonvulsants; Brain; Cold Temperature; Cross-Over Studies; Cyclohexanecarboxylic A

2010
Lamotrigine as an augmentation agent in treatment-resistant depression.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:8

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Anxiety Disorders; Bipolar Disorder; Chronic Disease

2002
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
    The journal of pain, 2003, Volume: 4, Issue:7

    Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combinatio

2003
A randomized, double-blind, placebo-controlled, two-period, crossover, pilot trial of lamotrigine in patients with central pain due to multiple sclerosis.
    Clinical therapeutics, 2007, Volume: 29, Issue:9

    Topics: Anticonvulsants; Cross-Over Studies; Double-Blind Method; Female; Humans; Lamotrigine; Male; Middle

2007
Analgesic effects of lamotrigine and phenytoin on cold-induced pain: a crossover placebo-controlled study in healthy volunteers.
    Pain, 1998, Volume: 76, Issue:3

    Topics: Adult; Anticonvulsants; Blood Pressure; Cold Temperature; Cross-Over Studies; Double-Blind Method; F

1998
Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials.
    Anaesthesia, 1999, Volume: 54, Issue:8

    Topics: Administration, Oral; Adult; Analgesics; Carbon Dioxide; Cross-Over Studies; Double-Blind Method; Ev

1999
200 mg daily of lamotrigine has no analgesic effect in neuropathic pain: a randomised, double-blind, placebo controlled trial.
    Pain, 1999, Volume: 83, Issue:1

    Topics: Adult; Analgesics; Anticonvulsants; Double-Blind Method; Drug Administration Schedule; Female; Human

1999
Lamotrigine in trigeminal neuralgia secondary to multiple sclerosis.
    Journal of neurology, 2000, Volume: 247, Issue:7

    Topics: Analgesics; Analgesics, Non-Narcotic; Carbamazepine; Female; Humans; Lamotrigine; Male; Middle Aged;

2000
Lamotrigine for central poststroke pain: a randomized controlled trial.
    Neurology, 2001, Jan-23, Volume: 56, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Double-Blind Method; Female; Humans; Lamotrigine; Male; Middle Ag

2001

Other Studies

26 other studies available for lamotrigine and Ache

ArticleYear
3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers.
    Journal of medicinal chemistry, 2004, Mar-11, Volume: 47, Issue:6

    Topics: Analgesics; Animals; Cell Line; Humans; Male; Pain; Patch-Clamp Techniques; Peripheral Nervous Syste

2004
Phenoxyphenyl pyridines as novel state-dependent, high-potency sodium channel inhibitors.
    Journal of medicinal chemistry, 2004, Aug-12, Volume: 47, Issue:17

    Topics: Analgesics; Animals; Animals, Newborn; Brain; Cell Line; Humans; In Vitro Techniques; Male; NAV1.2 V

2004
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
    Journal of medicinal chemistry, 2007, May-17, Volume: 50, Issue:10

    Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia;

2007
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, May-15, Volume: 104, Issue:20

    Topics: Action Potentials; Analgesics; Aniline Compounds; Animals; Capsaicin; Evoked Potentials; Furans; Gan

2007
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
    Military medicine, 2023, 11-03, Volume: 188, Issue:11-12

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam

2023
Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; Epilepsy

2018
Comparative animal study of the antinociceptive efficacy of lamotrigine and gabapentin for the management of pain.
    Acta physiologica Hungarica, 2015, Volume: 102, Issue:4

    Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; gamma-Aminobutyric Acid; Lamotrigine

2015
Nicotinic acetylcholine receptor agonism: progress in the management of neuropathic pain?
    Pain, 2009, Volume: 146, Issue:3

    Topics: Azetidines; Excitatory Amino Acid Antagonists; Humans; Lamotrigine; Nicotinic Agonists; Pain; Periph

2009
Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report.
    Acta clinica Croatica, 2009, Volume: 48, Issue:2

    Topics: Adult; Anticonvulsants; Cervical Vertebrae; Female; Humans; Intervertebral Disc Displacement; Lamotr

2009
The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain.
    Life sciences, 2002, May-10, Volume: 70, Issue:25

    Topics: Analgesics; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Inflammation; Inject

2002
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3

    Topics: Acetates; Acute Disease; Adrenergic alpha-Agonists; Amines; Analgesics, Non-Narcotic; Analgesics, Op

2002
An East-West approach to the management of central post-stroke pain.
    Cerebrovascular diseases (Basel, Switzerland), 2003, Volume: 16, Issue:1

    Topics: Acetates; Acupuncture; Aged; Amines; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Secon

2003
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Gan

2005
Psychosis in multiple sclerosis associated with left temporal lobe lesions on serial MRI scans.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2006, Volume: 13, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Delusions; Excitatory Amino Acid Antagonists; Female;

2006
Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3

    Topics: Animals; Carbamazepine; Humans; Hyperalgesia; Lamotrigine; Male; Motor Activity; Pain; Pyrimidines;

2006
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
    Journal of neurochemistry, 2007, Volume: 100, Issue:5

    Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease

2007
Lamotrigine for pain with hyperalgesia.
    Irish medical journal, 1997, Volume: 90, Issue:2

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Hyperalgesia; Lamotrigine; Male; Pain; Tri

1997
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.
    European journal of pharmacology, 1997, Apr-18, Volume: 324, Issue:2-3

    Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Anticonvulsants; Chronic Disease; Cyclohexanec

1997
Lamotrigine control of central pain.
    Pain, 1996, Volume: 68, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anticonvulsants; Central Nervous System Diseases; Female

1996
[Effect of lamotrigine on development of neurogenic pain syndrome in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:5

    Topics: Analgesics; Animals; Anticonvulsants; Convulsants; Lamotrigine; Neurons; Pain; Pain Measurement; Pen

1998
Lamotrigine can reduce neurogenic pain associated with multiple sclerosis.
    The Clinical journal of pain, 1998, Volume: 14, Issue:3

    Topics: Adult; Analgesics; Female; Humans; Lamotrigine; Multiple Sclerosis; Pain; Triazines

1998
Lamotrigine adjunctive therapy in painful phenomena in MS: preliminary observations.
    Neurology, 1999, Jul-22, Volume: 53, Issue:2

    Topics: Analgesics; Female; Humans; Lamotrigine; Male; Multiple Sclerosis; Pain; Triazines

1999
Efficacy of lamotrigine on sensory symptoms and pain in peripheral neuropathies.
    Journal of pain and symptom management, 1999, Volume: 18, Issue:3

    Topics: Aged; Anticonvulsants; Female; Humans; Lamotrigine; Male; Middle Aged; Pain; Peripheral Nervous Syst

1999
Lamotrigine in the treatment of chronic refractory neuropathic pain.
    Journal of pain and symptom management, 2000, Volume: 19, Issue:5

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Chronic Disease; Drug Therapy, Combination; Female; Hum

2000
Is 200mg lamotrigine daily analgesic or not?
    Pain, 2000, Volume: 86, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Humans; Lamotrigine; Pain; Triazines

2000
Non-opioid actions of lamotrigine within the rat dorsal horn after inflammation and neuropathic nerve damage.
    Neuroscience research, 2001, Volume: 39, Issue:4

    Topics: Action Potentials; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Calcium Channel Blockers; Chole

2001