lactoferrin has been researched along with Sarcoma* in 1 studies
1 other study(ies) available for lactoferrin and Sarcoma
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Identification of novel candidate circulating biomarkers for malignant soft tissue sarcomas: Correlation with metastatic progression.
Soft tissue sarcomas (STS) are a heterogeneous group of rare tumors for which identification and validation of biological markers may improve clinical management. The fraction of low-molecular-weight (LMW) circulating proteins and fragments of proteins is a rich source of new potential biomarkers. To identify circulating biomarkers useful for STS early diagnosis and prognosis, we analyzed 53 high-grade STS sera using hydrogel core-shell nanoparticles that selectively entrap LMW proteins by size exclusion and affinity chromatography, protect them from degradation and amplify their concentration for mass spectrometry detection. Twenty-two analytes mostly involved in inflammatory and immunological response, showed a progressive increase from benign to malignant STS with a relative difference in abundance, more than 50% when compared to healthy control. 16 of these were higher in metastatic compared to non-metastatic tumors. Cox's regression analysis revealed a statistical significant association between the abundance of lactotransferrin (LTF) and complement factor H-related 5 (CFHR5) and risk of metastasis. In particular, CFHR5 was associated with the risk of metastasis. The role of circulating proteins involved in metastatic progression will be crucial for a better understanding of STS biology and patient management. Topics: Biomarkers, Tumor; Blood Proteins; Complement System Proteins; Early Diagnosis; Humans; Lactoferrin; Nanoparticles; Neoplasm Metastasis; Prognosis; Sarcoma; Tandem Mass Spectrometry | 2016 |