lactoferrin and Pancreatic-Diseases

Topics: Biopsy; Carcinoembryonic Antigen; Celiac Artery; Cholangiography; Cholecystokinin; Lactoferrin; Laparoscopy; Mesenteric Arteries; Pancreatic Diseases; Pancreatic Juice; Pancreatic Neoplasms; Pancreatitis; Radionuclide Imaging; Secretin; Tomography, X-Ray Computed; Ultrasonography

To determine the possible mechanism for chronic pancreatitis causing pancreatic duct stones.. A total of 172 patients with chronic pancreatitis (n=67), pancreatic duct stones (n=62), and pancreatic injury (n=43), admitted to from August 2000 to October 2008, preoperatively diagnosed by endoscopic retrograde cholangiopancreatograpby(ERCP) or computed tomography(CT), and intraoperatively confirmed by exploration and biopsy, were divided into 3 groups. Pancreatic fluid was drawn to test the concentrations of pancreatic stone protein (PSP), lactoferrin (LF) and Ca2+.. The chronic pancreatitis (the CP group) presented hard consistency, shrinkage and nodular fibrosis of the pancreas; besides the above symptoms, the pancreatic duct stones (the PS group) presented dilatation of the pancreatic ductal system with various stones; pancreatic injury (the PI group) presented broken pancreas of different grades with fluid or blood. Compared with that of the PI group, PSP concentration of both the PS group and the CP group was elevated (P<0.05), and was more apparent in the CP group. Concentrations of LF and Ca2+ were also elevated (P<0.05), which were more obvious in the PS group.. Decreased concentrations of PSP and increased concentrations of LF and Ca2+ may play very important roles in chronic pancreatitis causing pancreatic duct stones.

Topics: Adult; Aged; Calcium; Calculi; Female; Humans; Lactoferrin; Lithostathine; Male; Middle Aged; Pancreatic Diseases; Pancreatic Ducts; Pancreatic Juice; Pancreatitis, Chronic

The authors investigated in patients with renal disease the lactoferrin content in duodenal aspirate. The aspirate was obtained after previous stimulation of the pancreas with pancreozymin. Lactoferrin estimation is described in the literature as a sensitive examination of changes of exocrine pancreatic secretion. The authors provided evidence that by assessing lactoferrin it is possible to detect initial changes of reduced exocrine pancreatic capacity already in subjects who are on the waiting list of chronic intermittent haemodialyzation programmes (CHIDP); maximum increase of the lactoferrin content in the duodenal aspirate corresponds with the severity of chronic renal failure. Transplantation of the kidneys leads to normalization of the amount of lactoferrin secreted by the pancreas which is evidence of normalization of pancreatic secretion. In patients with chronic renal failure lactoferrin is a sensitive marker of developing uraemic pancreatopathy.

Topics: Humans; Intestinal Secretions; Kidney Failure, Chronic; Kidney Transplantation; Lactoferrin; Pancreatic Diseases; Renal Dialysis

Authors report on their experiences with the evaluation of lactoferrin in the duodenal juice in patients with pancreatic diseases. The duodenal juice was collected after preceeding stimulation of the pancreas by means of a cholecystokinin-secretin-Test (CCK-S-test). Authors show that the evaluation of lactoferrin in connection with the CCK-S-test can better differentiate between inflammatory and neoplastic pancreatic diseases. The estimation shows the sufficiently sensitive, simply and quickly practicable. Therefore it is recommended as a diagnostic procedure for pancreatology.

Topics: Duodenum; Humans; Intestinal Secretions; Lactoferrin; Lactoglobulins; Pancreatic Diseases

Topics: Calculi; Chronic Disease; Duodenum; Humans; Intestinal Secretions; Lactoferrin; Lactoglobulins; Pancreatic Diseases; Pancreatitis; Radioimmunoassay

Lactoferrin and albumin concentrations in pure pancreatic juice were studied by radial immunodiffusion in 81 patients. Lactoferrin concentration (% of total protein) was specifically increased in patients suffering from chronic calcifying pancreatitis (mean +/- SE: 0.169 +/- 0.024) and no overlap was observed with patients suffering from other pancreatic diseases (0.008 +/- 0.001), organic nonpancreatic diseases (0.011 +/- 0.001) and without organic disease (0.01 +/- 0.001). Lactoferrin concentration was not found to be correlated with chronic alcohol consumption or pancreatic insufficiency. Albumin concentration (% of total protein) was increased in patients suffering from chronic calcifying pancreatitis (5.55 +/- 0.49) and other pancreatic diseases (5.45 +/- 1.02). These values were significantly higher (P less than 0.001) than the corresponding values in patients with organic nonpancreatic diseases (1.66 +/- 0.16) and patients without organic diseases (1.46 +/- 0.22). Measuring lactoferrin and albumin in pancreatic juice may aid in the diagnosis of pancreatic disease and in the differentiation of chronic calcifying pancreatitis, even in the earliest stage, from other pancreatic diseases such as pancreatic carcinoma or acute pancreatitis.

Topics: Adult; Albumins; Alcohol Drinking; Chronic Disease; Female; Humans; Immunodiffusion; Lactoferrin; Lactoglobulins; Lipase; Male; Middle Aged; Pancreatic Diseases; Pancreatic Juice; Pancreatitis

Topics: Adult; Alcoholism; Animals; Calculi; Dogs; Humans; Lactoferrin; Lactoglobulins; Middle Aged; Pancreatic Diseases; Pancreatic Juice