lactoferrin and Constriction--Pathologic

To evaluate the accuracy and best cut-off value of fecal calprotectin (FC) and fecal lactoferrin (FL) to predict disease recurrence in asymptomatic patients presenting with anastomotic strictures.. This was a longitudinal single tertiary center study based on prospectively collected data (recorded in a clinical database created for this purpose) performed between March 2010 and November 2014. Crohn's disease (CD) patients with anastomotic stricture who submitted to postoperative endoscopic evaluation were included. Stools were collected on the day before bowel cleaning for FC and FL. Endoscopic balloon dilation (EBD) was performed if the patient presented an anastomotic stricture not traversed by the colonoscope, regardless of patients' symptoms. Successful dilation was defined as passage of the colonoscope through the dilated stricture into the neotermimal ileum. Postoperative recurrence was defined as a modified Rutgeerts score of ≥ i2b.. Fecal markers are good predictors of CD endoscopic recurrence in patients with asymptomatic anastomotic stricture. FC and FL may guide the need for EBD in this context.

Topics: Adult; Anastomosis, Surgical; Biomarkers; Catheterization; Colectomy; Colon; Colonoscopes; Colonoscopy; Constriction, Pathologic; Crohn Disease; Dilatation; Feces; Female; Humans; Ileum; Lactoferrin; Leukocyte L1 Antigen Complex; Longitudinal Studies; Male; Middle Aged; Postoperative Period; Prospective Studies; Recurrence