lactoferrin and Chediak-Higashi-Syndrome

The initiation of both the normal and pathologic responses of human neutrophils to surface stimulation and the ensuing biochemical and physiologic events are elucidated. This knowledge has contributed to an understanding of the controlling mechanisms that may account for impaired phagocytic function in several clinical disorders associated with recurrent bacterial infections.

Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Bactericidal Activity; Calcium; Cell Adhesion; Chediak-Higashi Syndrome; Chemotaxis, Leukocyte; Child; Cyclic AMP; Cytoplasmic Granules; Granulomatous Disease, Chronic; Guinea Pigs; Humans; Ion Channels; Lactoferrin; Male; Membrane Potentials; Neutrophils; Opsonin Proteins; Oxygen Consumption; Phagocyte Bactericidal Dysfunction; Phagocytosis; Rabbits

Topics: Abscess; Adult; Cell Adhesion; Cell Aggregation; Cell Membrane; Chediak-Higashi Syndrome; Chemotaxis, Leukocyte; Granulocytes; Humans; Lactoferrin; Lactoglobulins; Male; Microscopy, Electron; Phagocyte Bactericidal Dysfunction; Recurrence; Skin Diseases