lactic acid has been researched along with Ventricular Fibrillation in 30 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesize that these abnormalities may limit cardiac resuscitation from ventricular fibrillation (VF) and investigated whether NHE-1 inhibition with the benzoylguanidine derivative cariporide could improve resuscitability, postresuscitation myocardial function, and short-term survival in isolated heart and intact rat models of VF." | 3.71 | Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide. ( Ayoub, IM; Gazmuri, RJ; Hoffner, E; Kolarova, JD, 2001) |
| "Ventricular fibrillation was induced by angioplasty-balloon occlusion of the left coronary artery." | 1.35 | Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation. ( Epstein, A; Farstad, M; Grong, K; Husby, P; Nordrehaug, JE; Pettersen, RJ; Rotevatn, S; Tuseth, V; Wentzel-Larsen, T, 2009) |
| "Trimetazidine is a widely used anti-ischemic agent, but effects of its chronic treatment on myocardial preconditioning in anesthetized animals have not been investigated." | 1.33 | Effects of chronic trimetazidine treatment on myocardial preconditioning in anesthetized rats. ( Celik, A; Demiryürek, AT; Demiryürek, S; Kara, AF; Tarakçioğlu, M, 2006) |
| "After 4 min of cardiac arrest, followed by 3 min of basic life support CPR, 17 animals were randomly assigned to receive, every 5 min, either a combination of vasopressin and epinephrine (vasopressin [IU/kg]/epinephrine [ micro g/kg]: 0." | 1.32 | Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs. ( Klima, GCDN; Krismer, AC; Lindner, KH; Mayr, VD; Pechlaner, S; Rheinberger, K; Stadlbauer, KH; Voelckel, WG; Wagner-Berger, HG; Wenzel, V, 2003) |
| "By inducing cardiopulmonary arrest (2-7 min) in 28 Wistar rats, ETCO2 and serum lactate levels were studied after and just before CPR, respectively." | 1.29 | End-tidal CO2 and plasma lactate level: a comparison of their use as parameters for evaluating successful CPR. ( Kimura, T; Naganuma, T; Okubo, N; Sato, S; Tanaka, M, 1993) |
| "Published results of dose-response effects of adrenergic drugs (epinephrine [E]) vary so much between studies because of differences in animal models and duration of ischemia before drug administration." | 1.28 | Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model. ( Ahnefeld, FW; Bowdler, IM; Lindner, KH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.67) | 18.7374 |
| 1990's | 10 (33.33) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 7 (23.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jauchem, JR | 3 |
| Azam, MA | 1 |
| Wagg, CS | 1 |
| Massé, S | 1 |
| Farid, T | 1 |
| Lai, PF | 1 |
| Kusha, M | 1 |
| Asta, J | 1 |
| Jaimes, R | 1 |
| Kuzmiak-Glancy, S | 1 |
| Kay, MW | 1 |
| Lopaschuk, GD | 1 |
| Nanthakumar, K | 1 |
| Wilder, CD | 1 |
| Masoud, R | 1 |
| Yazar, D | 1 |
| O'Brien, BA | 1 |
| Eykyn, TR | 1 |
| Curtis, MJ | 1 |
| Tuseth, V | 1 |
| Pettersen, RJ | 1 |
| Epstein, A | 1 |
| Grong, K | 1 |
| Husby, P | 1 |
| Farstad, M | 1 |
| Wentzel-Larsen, T | 1 |
| Rotevatn, S | 1 |
| Nordrehaug, JE | 1 |
| Dokken, BB | 1 |
| Hilwig, WR | 1 |
| Teachey, MK | 1 |
| Panchal, RA | 1 |
| Hubner, K | 1 |
| Allen, D | 1 |
| Rogers, DC | 1 |
| Kern, KB | 1 |
| Lie, RH | 1 |
| Stoettrup, N | 1 |
| Sloth, E | 1 |
| Hasenkam, JM | 1 |
| Kroyer, R | 1 |
| Nielsen, TT | 1 |
| Sesma, J | 1 |
| Labandeira, J | 1 |
| Sara, MJ | 1 |
| Espila, JL | 1 |
| Arteche, A | 1 |
| Saez, MJ | 1 |
| Stadlbauer, KH | 1 |
| Wagner-Berger, HG | 1 |
| Wenzel, V | 1 |
| Voelckel, WG | 1 |
| Krismer, AC | 1 |
| Klima, GCDN | 1 |
| Rheinberger, K | 1 |
| Pechlaner, S | 1 |
| Mayr, VD | 1 |
| Lindner, KH | 2 |
| Nemoto, M | 1 |
| Kara, AF | 1 |
| Demiryürek, S | 1 |
| Celik, A | 1 |
| Tarakçioğlu, M | 1 |
| Demiryürek, AT | 1 |
| Moon, SW | 1 |
| Lee, SW | 1 |
| Choi, SH | 1 |
| Hong, YS | 1 |
| Kim, SJ | 1 |
| Kim, NH | 1 |
| Salerno, TA | 2 |
| Chiong, MA | 1 |
| Vester, EG | 1 |
| Perings, C | 1 |
| Kuhls, S | 1 |
| Ochiulet-Vester, J | 1 |
| Strauer, BE | 1 |
| Lerman, BB | 1 |
| Engelstein, ED | 1 |
| Sato, S | 1 |
| Kimura, T | 2 |
| Okubo, N | 1 |
| Naganuma, T | 1 |
| Tanaka, M | 1 |
| Runsiö, M | 1 |
| Bergfeldt, L | 1 |
| Rosenqvist, M | 1 |
| Owall, A | 1 |
| Jorfeldt, L | 1 |
| Wolfhard, UF | 1 |
| Brinkmann, M | 1 |
| Splittgerber, FH | 2 |
| Knocks, M | 2 |
| Sack, S | 2 |
| Piotrowski, JA | 2 |
| Schieffer, M | 1 |
| Günnicker, M | 2 |
| Bode, F | 1 |
| Wiegand, U | 1 |
| Raasch, W | 1 |
| Richardt, G | 1 |
| Potratz, J | 1 |
| Wolfhard, U | 1 |
| Hayashi, Y | 1 |
| Tajima, K | 1 |
| Kirimoto, T | 1 |
| Miyake, H | 1 |
| Matsuura, N | 1 |
| Gazmuri, RJ | 2 |
| Ayoub, IM | 1 |
| Hoffner, E | 1 |
| Kolarova, JD | 1 |
| Ahnefeld, FW | 1 |
| Bowdler, IM | 1 |
| Bengtsson, L | 1 |
| Gunnes, S | 1 |
| Norman, B | 1 |
| Karlsson, J | 1 |
| Yamaguchi, N | 1 |
| Lamontagne, D | 1 |
| de Champlain, J | 1 |
| Nadeau, R | 1 |
| von Planta, M | 1 |
| Weil, MH | 1 |
| Rackow, EC | 1 |
| Wittnich, C | 1 |
| Peniston, C | 1 |
| Ianuzzo, D | 1 |
| Abel, JG | 1 |
| Carden, DL | 1 |
| Martin, GB | 1 |
| Nowak, RM | 1 |
| Foreback, CC | 1 |
| Tomlanovich, MC | 1 |
| Ditchey, RV | 1 |
| Horwitz, LD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest[NCT06071910] | 20 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lactic acid and Ventricular Fibrillation
| Article | Year |
|---|---|
Exposures to conducted electrical weapons (including TASER® devices): how many and for how long are acceptable?
Topics: Animals; Blood Glucose; Conducted Energy Weapon Injuries; Creatine Kinase; Delirium; Electric Stimul | 2015 |
Deaths in custody: are some due to electronic control devices (including TASER devices) or excited delirium?
Topics: Acidosis; Animals; Cause of Death; Confounding Factors, Epidemiologic; Delirium; Electroshock; Fever | 2010 |
Pathophysiologic changes due to TASER® devices versus excited delirium: potential relevance to deaths-in-custody?
Topics: Acidosis; Animals; Blood Glucose; Body Temperature; Catecholamines; Channelopathies; Conducted Energ | 2011 |
1 trial available for lactic acid and Ventricular Fibrillation
| Article | Year |
|---|---|
Myocardial lactate extraction during repeated fibrillation/defibrillation episodes in defibrillator implantation testing.
Topics: Aged; Cardiac Pacing, Artificial; Coronary Disease; Defibrillators, Implantable; Equipment Failure A | 1998 |
26 other studies available for lactic acid and Ventricular Fibrillation
| Article | Year |
|---|---|
Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.
Topics: Animals; Dichloroacetic Acid; Heart; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; | 2015 |
Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation.
Topics: Animals; Cardiac Catheters; Electrocardiography; Lactic Acid; Magnetic Resonance Spectroscopy; Male; | 2016 |
Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation.
Topics: Acute Disease; Animals; Blood Flow Velocity; Brain Ischemia; Cardiac Catheterization; Cerebrovascula | 2009 |
Glucagon-like peptide-1 (GLP-1) attenuates post-resuscitation myocardial microcirculatory dysfunction.
Topics: Animals; Blood Glucose; Cardiac Output; Cardiopulmonary Resuscitation; Coronary Circulation; Coronar | 2010 |
Post-conditioning with cyclosporine A fails to reduce the infarct size in an in vivo porcine model.
Topics: Animals; Biomarkers; Coronary Circulation; Cyclosporine; Hemodynamics; Immunosuppressive Agents; Lac | 2010 |
Effect of intra-aortic occlusion balloon in external thoracic compressions during CPR in pigs.
Topics: Animals; Blood Gas Analysis; Breath Tests; Capnography; Carbon Dioxide; Cardiac Output; Cardiopulmon | 2002 |
Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation with a combination of vasopressin and epinephrine in pigs.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Weight; Cardiopulmonary Resuscitation; Drug Combin | 2003 |
Experimental evaluation of the influence of complete artificial circulation on renal circulation and tissue metabolism -comparative study of pulsatile vs nonpulsatile circulation.
Topics: Analysis of Variance; Animals; beta 2-Microglobulin; Blood Urea Nitrogen; Creatinine; Disease Models | 2003 |
Effects of chronic trimetazidine treatment on myocardial preconditioning in anesthetized rats.
Topics: Animals; Blood Pressure; Carbachol; Cardiotonic Agents; Heart Rate; Ischemic Preconditioning, Myocar | 2006 |
Arterial minus end-tidal CO2 as a prognostic factor of hospital survival in patients resuscitated from cardiac arrest.
Topics: Algorithms; Blood Gas Analysis; Carbon Dioxide; Cardiopulmonary Resuscitation; Emergency Service, Ho | 2007 |
Ventricular fibrillation induced prior to cardioplegic arrest in hypertrophied pig hearts.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Cardiomegaly; Creatine Kinase; Glycogen; Heart | 1983 |
[Myocardial lactate extraction during programmed ventricular stimulation and its value for etiologically-related therapy of ischemic ventricular tachyarrhythmia].
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiac Pacing, Artificial; Coronary Artery Bypass; Coronary C | 1995 |
Metabolic determinants of defibrillation. Role of adenosine.
Topics: Adenosine; Animals; Catecholamines; Dogs; Electric Countershock; Lactates; Lactic Acid; Theophylline | 1995 |
End-tidal CO2 and plasma lactate level: a comparison of their use as parameters for evaluating successful CPR.
Topics: Animals; Carbon Dioxide; Cardiopulmonary Resuscitation; Heart Arrest; Lactates; Lactic Acid; Rats; R | 1993 |
Changes in human coronary sinus blood flow and myocardial metabolism induced by ventricular fibrillation and defibrillation.
Topics: Adult; Aged; Coronary Circulation; Electric Countershock; Female; Humans; Lactic Acid; Male; Middle | 1998 |
Differential effects of defibrillation on systemic and cardiac sympathetic activity.
Topics: Adult; Aged; Atrial Fibrillation; Autonomic Nervous System; Defibrillators, Implantable; Electric Co | 1998 |
Effects of defibrillator implantation testing on myocardial metabolism.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Cardiomyopathies; Coronary Disease; Defibrillators, Implant | 1999 |
Cardioprotective effects of MET-88, a gamma-butyrobetaine hydroxylase inhibitor, on cardiac dysfunction induced by ischemia/reperfusion in isolated rat hearts.
Topics: Animals; Carnitine; Enzyme Inhibitors; gamma-Butyrobetaine Dioxygenase; Heart Function Tests; Hemody | 2000 |
Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiopulmonary Resuscitation; Disease Models, Anim | 2001 |
Comparison of different doses of epinephrine on myocardial perfusion and resuscitation success during cardiopulmonary resuscitation in a pig model.
Topics: Animals; Carbon Dioxide; Cerebrovascular Circulation; Coronary Circulation; Dose-Response Relationsh | 1991 |
The effect of lidocaine on myocardial ischemia with asanguinous reperfusion. An in vitro study.
Topics: Adenine Nucleotides; Animals; Coronary Circulation; Heart Arrest, Induced; In Vitro Techniques; Lact | 1991 |
Occlusion time dependency of regional noradrenaline release and cardiac arrhythmias during reperfusion of acutely ischaemic heart in the dog in vivo.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Dogs; Heart Ventricles; Lactates; | 1990 |
Myocardial potassium uptake during experimental cardiopulmonary resuscitation.
Topics: Animals; Carbon Dioxide; Hemodynamics; Lactates; Lactic Acid; Myocardium; Potassium; Resuscitation; | 1989 |
Relative vulnerability of neonatal and adult hearts to ischemic injury.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Coronary Circulation; Glucose-6-Phosphate; | 1987 |
Lactic acidosis during closed-chest CPR in dogs.
Topics: Acidosis, Lactic; Animals; Arteries; Blood Pressure; Dogs; Electric Countershock; Lactates; Lactic A | 1987 |
Metabolic evidence of inadequate coronary blood flow during closed-chest resuscitation in dogs.
Topics: Adenosine Triphosphate; Animals; Blood Gas Analysis; Coronary Circulation; Dogs; Hemodynamics; Lacta | 1985 |