lactic acid has been researched along with Ventricular Dysfunction, Left in 36 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart." | 9.14 | Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. ( Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB, 2010) |
| "The effect of L-propionylcarnitine on patients with left ventricular dysfunction (EF < 45%) NYHA class II, symptomatic despite therapy with digitalis and diuretics was evaluated in a phase II parallel, double-blind, randomized, placebo-controlled study." | 9.07 | Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. ( Brunelli, C; Canale, C; Caponnetto, S; Masperone, MA; Terracchini, V; Valentini, G, 1994) |
| "The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF)." | 7.71 | Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. ( Blackburn, B; Chandler, MP; Morita, H; Roth, BA; Sabbah, HN; Stanley, WC; Suzuki, G; Wolff, A, 2002) |
| "We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction." | 7.70 | N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. ( Arai, M; Chen, XH; Fujiwara, H; Fujiwara, T; Hashimoto, K; Minatoguchi, S; Nishida, Y; Takemura, G; Uno, Y; Wang, N, 2000) |
| "Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart." | 5.14 | Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. ( Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB, 2010) |
| "The effect of L-propionylcarnitine on patients with left ventricular dysfunction (EF < 45%) NYHA class II, symptomatic despite therapy with digitalis and diuretics was evaluated in a phase II parallel, double-blind, randomized, placebo-controlled study." | 5.07 | Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. ( Brunelli, C; Canale, C; Caponnetto, S; Masperone, MA; Terracchini, V; Valentini, G, 1994) |
| "The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF)." | 3.71 | Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. ( Blackburn, B; Chandler, MP; Morita, H; Roth, BA; Sabbah, HN; Stanley, WC; Suzuki, G; Wolff, A, 2002) |
| "We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction." | 3.70 | N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. ( Arai, M; Chen, XH; Fujiwara, H; Fujiwara, T; Hashimoto, K; Minatoguchi, S; Nishida, Y; Takemura, G; Uno, Y; Wang, N, 2000) |
| "Treatment with clonidine markedly suppressed norepinephrine levels during exercise (matched peak exercise workload: control, 2137 +/- 187 versus clonidine, 1430 +/- 161 pg/mL), increased leg blood flow (control, 1." | 2.68 | Effect of sympathoinhibition on exercise performance in patients with heart failure. ( Chomsky, DB; Lang, CC; Rayos, GH; Wilson, JR; Wood, AJ, 1997) |
| "Cardiac fibrosis was significantly reduced by ONO-1301-PLGA (p<0." | 1.35 | Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters. ( Akaike, M; Hirata, Y; Igarashi, T; Sakai, Y; Sata, M; Soeki, T, 2009) |
| "In adenosine-treated patients, the extent of all of these abnormalities during the first inflation was less than in untreated patients and did not change with subsequent inflations." | 1.32 | Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humans. ( Bolli, R; Leesar, MA; Stoddard, MF; Tang, XL; Xuan, YT, 2003) |
| "Coronary flow reserve in the same brain death model was assessed by changes in coronary flow and resistance induced by administering a vasodilator directly into the coronary artery in another eight dogs." | 1.32 | Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart. ( Imasaka, K; Kajihara, N; Masuda, M; Morita, S; Nishimura, Y; Oishi, Y; Yasui, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (25.00) | 18.2507 |
| 2000's | 13 (36.11) | 29.6817 |
| 2010's | 10 (27.78) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Hiraki, N | 1 |
| Tanaka, TD | 1 |
| Yoshimura, M | 1 |
| Bensman, RS | 1 |
| Berrens, Z | 1 |
| Mkaliainga, T | 1 |
| Banda, B | 1 |
| Puri, K | 1 |
| Sanyahumbi, A | 1 |
| Byczkowski, T | 1 |
| Eckerle, M | 1 |
| Nakamura, M | 1 |
| Imamura, T | 1 |
| Moon, JI | 1 |
| Shin, J | 1 |
| Hwang, JH | 1 |
| Kim, WY | 1 |
| Kim, SH | 1 |
| Lescano de Souza Junior, A | 1 |
| Mancini Filho, J | 1 |
| Pavan Torres, R | 1 |
| Irigoyen, MC | 1 |
| Curi, R | 1 |
| Marcondi, NO | 1 |
| Rocco, IS | 1 |
| Bolzan, DW | 1 |
| Pauletti, HO | 1 |
| Begot, I | 1 |
| Anjos, NR | 1 |
| Moreira, RSL | 1 |
| Nasrala, ML | 1 |
| Arena, R | 1 |
| Gomes, WJ | 1 |
| Guizilini, S | 1 |
| Cosmo, S | 1 |
| Francisco, JC | 1 |
| Cunha, RC | 1 |
| Macedo, RM | 1 |
| Faria-Neto, JR | 1 |
| Simeoni, R | 1 |
| Carvalho, KA | 1 |
| Olandoski, M | 1 |
| Miyague, NI | 1 |
| Amaral, VF | 1 |
| Guarita-Souza, LC | 1 |
| Thiele, H | 1 |
| Azam, MA | 1 |
| Wagg, CS | 1 |
| Massé, S | 1 |
| Farid, T | 1 |
| Lai, PF | 1 |
| Kusha, M | 1 |
| Asta, J | 1 |
| Jaimes, R | 1 |
| Kuzmiak-Glancy, S | 1 |
| Kay, MW | 1 |
| Lopaschuk, GD | 1 |
| Nanthakumar, K | 1 |
| Turer, AT | 1 |
| Stevens, RD | 1 |
| Bain, JR | 1 |
| Muehlbauer, MJ | 1 |
| van der Westhuizen, J | 1 |
| Mathew, JP | 1 |
| Schwinn, DA | 1 |
| Glower, DD | 1 |
| Newgard, CB | 1 |
| Podgoreanu, MV | 1 |
| Hirata, Y | 1 |
| Soeki, T | 1 |
| Akaike, M | 1 |
| Sakai, Y | 1 |
| Igarashi, T | 1 |
| Sata, M | 1 |
| Casserly, B | 1 |
| Pietras, L | 1 |
| Schuyler, J | 1 |
| Wang, R | 1 |
| Hill, NS | 1 |
| Klinger, JR | 1 |
| Jensen, SA | 1 |
| Hasbak, P | 1 |
| Mortensen, J | 1 |
| Sørensen, JB | 1 |
| Alders, DJ | 1 |
| Groeneveld, AB | 1 |
| Binsl, TW | 1 |
| de Kanter, FJ | 1 |
| van Beek, JH | 1 |
| Nakajima, J | 1 |
| Bessho, M | 1 |
| Adachi, T | 1 |
| Yamagishi, T | 1 |
| Tokuno, S | 1 |
| Horinouchi, H | 1 |
| Ohsuzu, F | 1 |
| Junno, J | 1 |
| Bruun, E | 1 |
| Gutierrez, JH | 1 |
| Erkinaro, T | 1 |
| Haapsamo, M | 1 |
| Acharya, G | 1 |
| Räsänen, J | 1 |
| Chandler, MP | 1 |
| Stanley, WC | 1 |
| Morita, H | 1 |
| Suzuki, G | 1 |
| Roth, BA | 1 |
| Blackburn, B | 1 |
| Wolff, A | 1 |
| Sabbah, HN | 1 |
| Meyer, K | 2 |
| Steiner, R | 1 |
| Lastayo, P | 1 |
| Lippuner, K | 1 |
| Allemann, Y | 1 |
| Eberli, F | 1 |
| Schmid, J | 1 |
| Saner, H | 1 |
| Hoppeler, H | 1 |
| Leesar, MA | 1 |
| Stoddard, MF | 1 |
| Xuan, YT | 1 |
| Tang, XL | 1 |
| Bolli, R | 1 |
| Oishi, Y | 1 |
| Nishimura, Y | 1 |
| Imasaka, K | 1 |
| Kajihara, N | 1 |
| Morita, S | 1 |
| Masuda, M | 1 |
| Yasui, H | 1 |
| Nakajima-Takenaka, C | 1 |
| Sakata, S | 1 |
| Kato, S | 1 |
| Ohga, Y | 1 |
| Murata, KY | 1 |
| Taniguchi, S | 1 |
| Takaki, M | 1 |
| Quaglietta, D | 1 |
| Belanger, MP | 1 |
| Wittnich, C | 1 |
| Sidi, A | 1 |
| Muehlschlegel, JD | 1 |
| Kirby, DS | 1 |
| Lobato, EB | 1 |
| Samek, L | 1 |
| Pinchas, A | 1 |
| Baier, M | 1 |
| Betz, P | 1 |
| Roskamm, H | 1 |
| Caponnetto, S | 1 |
| Canale, C | 1 |
| Masperone, MA | 1 |
| Terracchini, V | 1 |
| Valentini, G | 1 |
| Brunelli, C | 1 |
| Lang, CC | 1 |
| Rayos, GH | 1 |
| Chomsky, DB | 1 |
| Wood, AJ | 1 |
| Wilson, JR | 1 |
| Dziekan, G | 1 |
| Myers, J | 1 |
| Goebbels, U | 1 |
| Muller, P | 1 |
| Reinhart, W | 1 |
| Ratti, R | 1 |
| Hafeli, W | 1 |
| Dubach, P | 1 |
| Recchia, FA | 1 |
| McConnell, PI | 1 |
| Bernstein, RD | 1 |
| Vogel, TR | 1 |
| Xu, X | 1 |
| Hintze, TH | 1 |
| Bartels, GL | 2 |
| van den Heuvel, FM | 1 |
| van Veldhuisen, DJ | 2 |
| van der Ent, M | 2 |
| Remme, WJ | 2 |
| Wolfhard, U | 1 |
| Knocks, M | 1 |
| Splittgerber, FH | 1 |
| Sack, S | 1 |
| Piotrowski, JA | 1 |
| Günnicker, M | 1 |
| Kanellopoulos, GK | 1 |
| Svindland, A | 1 |
| Ilebekk, A | 1 |
| Goverud, I | 1 |
| Kvernebo, K | 1 |
| van den Heuvel, AF | 1 |
| Fukuda, H | 1 |
| Luo, CS | 1 |
| Gu, X | 1 |
| Guo, L | 1 |
| Digerness, SB | 1 |
| Li, J | 1 |
| Pike, MM | 1 |
| Nikolaidis, LA | 1 |
| Hentosz, T | 1 |
| Doverspike, A | 1 |
| Huerbin, R | 1 |
| Stolarski, C | 1 |
| Shen, YT | 1 |
| Shannon, RP | 1 |
| Nishida, Y | 1 |
| Minatoguchi, S | 1 |
| Arai, M | 1 |
| Takemura, G | 1 |
| Uno, Y | 1 |
| Hashimoto, K | 1 |
| Wang, N | 1 |
| Chen, XH | 1 |
| Fujiwara, T | 1 |
| Fujiwara, H | 1 |
| Graham, MR | 1 |
| Warrian, RK | 1 |
| Girling, LG | 1 |
| Doiron, L | 1 |
| Lefevre, GR | 1 |
| Cheang, M | 1 |
| Mutch, WA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Non Invasive Mechanical Ventilation on Tissue Perfusion in Patients After Cardiac Surgery[NCT02767687] | 80 participants (Actual) | Interventional | 2013-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and Ventricular Dysfunction, Left
| Article | Year |
|---|---|
Practical Management of ECPELLA.
Topics: Acidosis; Assisted Circulation; Combined Modality Therapy; Extracorporeal Membrane Oxygenation; Femo | 2020 |
[Treatment of cardiogenic shock: what is proven?].
Topics: Combined Modality Therapy; Early Medical Intervention; Evidence-Based Medicine; Hospital Mortality; | 2013 |
6 trials available for lactic acid and Ventricular Dysfunction, Left
| Article | Year |
|---|---|
Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2010 |
Eccentric exercise in coronary patients: central hemodynamic and metabolic responses.
Topics: Adult; Aged; Coronary Artery Disease; Exercise Therapy; Female; Heart Rate; Hemodynamics; Humans; La | 2003 |
Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction.
Topics: Adult; Aged; Cardiotonic Agents; Carnitine; Double-Blind Method; Echocardiography, Doppler; Exercise | 1994 |
Effect of sympathoinhibition on exercise performance in patients with heart failure.
Topics: Cardiomyopathy, Dilated; Chronic Disease; Clonidine; Coronary Disease; Exercise; Exercise Test; Hemo | 1997 |
Effects of exercise training on limb blood flow in patients with reduced ventricular function.
Topics: Adult; Blood Flow Velocity; Cardiac Output; Exercise Therapy; Follow-Up Studies; Forearm; Humans; La | 1998 |
Acute anti-ischemic effects of perindoprilat in men with coronary artery disease and their relation with left ventricular function.
Topics: Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Ca | 1999 |
28 other studies available for lactic acid and Ventricular Dysfunction, Left
| Article | Year |
|---|---|
A Man With Left Ventricular Hypertrophy.
Topics: Adult; Atrophy; Cardiomyopathies; Cerebellar Diseases; Cognitive Dysfunction; Echocardiography; Gluc | 2022 |
Prevalence of Cardiac Dysfunction in Malawian Children With Severe Febrile Illness.
Topics: Child; Echocardiography; Heart Diseases; Humans; Lactic Acid; Prevalence; Ventricular Dysfunction, L | 2022 |
Impact of left ventricular function on tissue perfusion and renal outcomes in patients with sepsis.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Female; Glomerular Filtration Rate; Humans; Lactic Aci | 2021 |
Pretreatment with fish oil attenuates heart ischaemia consequences in rats.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dietary Supplements; Disease Models, Animal; | 2017 |
Noninvasive Ventilation After Coronary Artery Bypass Grafting in Subjects With Left-Ventricular Dysfunction.
Topics: Adult; Aged; Blood Gas Analysis; Coronary Artery Bypass; Female; Humans; Lactic Acid; Male; Middle A | 2018 |
Effect of exercise associated with stem cell transplantation on ventricular function in rats after acute myocardial infarction.
Topics: Analysis of Variance; Animals; Bone Marrow Transplantation; Collagen; Disease Models, Animal; Lactic | 2012 |
Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.
Topics: Animals; Dichloroacetic Acid; Heart; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; | 2015 |
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.
Topics: Aged; Anaerobic Threshold; Cardiac Output; Cardiopulmonary Bypass; Carnitine; Coronary Artery Diseas | 2009 |
Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.
Topics: Animals; Cardiomyopathy, Dilated; Cricetinae; Delayed-Action Preparations; Disease Models, Animal; D | 2009 |
Cardiac atria are the primary source of ANP release in hypoxia-adapted rats.
Topics: Animals; Atrial Natriuretic Factor; Body Weight; Calcium; Glucose; Heart Atria; Hydrogen-Ion Concent | 2010 |
Endotoxemia decreases matching of regional blood flow and O2 delivery to O2 uptake in the porcine left ventricle.
Topics: Animals; Cardiac Output; Coronary Circulation; Coronary Vessels; Endotoxemia; Endotoxins; Hypotensio | 2011 |
Hemoglobin vesicle improves recovery of cardiac function after ischemia-reperfusion by attenuating oxidative stress in isolated rat hearts.
Topics: Animals; Blood Substitutes; Catalase; Coronary Circulation; Glutathione; Glutathione Disulfide; Glut | 2011 |
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia.
Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin | 2013 |
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.
Topics: Acetanilides; Animals; Cardiotonic Agents; Chronic Disease; Coronary Circulation; Disease Models, An | 2002 |
Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humans.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Echocardiography; Electrocardiography; Female; Heart; Hum | 2003 |
Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart.
Topics: Animals; Brain Death; Coronary Circulation; Disease Models, Animal; Dogs; Hemodynamics; Lactic Acid; | 2003 |
Detrimental effects after dobutamine infusion on rat left ventricular function: mechanical work and energetics.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Blotting, Western; Calcium; Carrier Proteins; Cro | 2005 |
Ventricle-specific metabolic differences in the newborn piglet myocardium in vivo and during arrested global ischemia.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adaptation, Physiological; Adenosine Triphosphate; Animals; Animal | 2008 |
Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and myocardial stunning in pigs.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Coronary S | 2008 |
Relationship between ventilatory threshold and onset of ischaemia in ECG during stress testing.
Topics: Aged; Coronary Disease; Electrocardiography; Exercise Test; Humans; Isosorbide Dinitrate; Lactates; | 1995 |
Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog.
Topics: Animals; Blood Pressure; Carbon Dioxide; Consciousness; Diastole; Dogs; Fatty Acids, Nonesterified; | 1998 |
Effects of defibrillator implantation testing on myocardial metabolism.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Cardiomyopathies; Coronary Disease; Defibrillators, Implant | 1999 |
Transventricular non-transmural laser treatment of hypoperfused porcine myocardium acutely reduces left ventricular contractile function.
Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Gas Analysis; Coronary Circulation; Coronary Dise | 1999 |
Differential anti-ischaemic effects of muscarinic receptor blockade in patients with obstructive coronary artery disease; impaired vs normal left ventricular function.
Topics: Atropine; Biomarkers; Blood Flow Velocity; Cardiac Catheterization; Catecholamines; Coronary Angiogr | 1999 |
The effect of K(atp)channel activation on myocardial cationic and energetic status during ischemia and reperfusion: role in cardioprotection.
Topics: Adenosine Triphosphate; Animals; Cations; Energy Metabolism; Lactic Acid; Male; Myocardial Ischemia; | 2001 |
Mechanisms whereby rapid RV pacing causes LV dysfunction: perfusion-contraction matching and NO.
Topics: Animals; Cell Respiration; Consciousness; Coronary Circulation; Dogs; Enzyme Inhibitors; Female; Gly | 2001 |
N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction.
Topics: 1-Deoxynojirimycin; Adenosine Triphosphate; Animals; Blood Flow Velocity; Disease Models, Animal; En | 2000 |
Fractal or biologically variable delivery of cardioplegic solution prevents diastolic dysfunction after cardiopulmonary bypass.
Topics: Animals; Blood Pressure; Cardiac Output; Cardioplegic Solutions; Cardiopulmonary Bypass; Diastole; F | 2002 |