lactic acid has been researched along with Vasospasm, Intracranial in 12 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH)." | 7.78 | Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage. ( Bege, N; Beseoglu, K; Eicker, S; Etminan, N; Frauenknecht, K; Hänggi, D; Heiroth, HJ; Kamp, MA; Kissel, T; Macht, S; Perrin, J; Sommer, C; Steiger, HJ, 2012) |
| "To investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH)." | 3.78 | Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage. ( Bege, N; Beseoglu, K; Eicker, S; Etminan, N; Frauenknecht, K; Hänggi, D; Heiroth, HJ; Kamp, MA; Kissel, T; Macht, S; Perrin, J; Sommer, C; Steiger, HJ, 2012) |
| "Bedside intracerebral microdialysis monitoring of patients with subarachnoid hemorrhage and signs of delayed ischemia revealed dramatic changes in extracellular concentrations of glucose, lactate, and glycerol that could be directly correlated to the clinical status of the patients." | 3.70 | Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration. ( Brandt, L; Nilsson, OG; Säveland, H; Ungerstedt, U, 1999) |
| "Thirteen subarachnoid hemorrhage patients (age, 48." | 2.71 | Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study. ( Amthauer, H; Haux, D; Küchler, I; Lüdemann, L; Plotkin, M; Sarrafzadeh, AS; Unterberg, AW, 2004) |
| "Delayed cerebral ischemia (DCI), which encompasses all neurobiological events occurring in the subacute-late stage after aSAH, has a complex pathogenesis and can occur in the absence of instrumental vasospasm." | 1.91 | Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. ( Balducci, MT; Blagia, M; Bozzi, MT; Chibbaro, S; de Gennaro, L; De Robertis, M; Messina, R; Pop, R; Severac, F; Signorelli, F, 2023) |
| "OBJECTIVE Delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is one of the major contributors to poor outcome." | 1.48 | Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage. ( Enblad, P; Engquist, H; Hillered, L; Howells, T; Johnson, U; Lewén, A; Nilsson, P; Ronne-Engström, E; Rostami, E, 2018) |
| "Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3." | 1.34 | Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status. ( Ak, A; Cengiz, SL; Karaköse, S; Ustün, ME, 2007) |
| "After subarachnoid hemorrhage (SAH) cerebral metabolism is significantly impaired." | 1.34 | Cerebral energy failure after subarachnoid hemorrhage: the role of relative hyperglycolysis. ( Böker, DK; Oertel, MF; Scharbrodt, W; Schmidinger, A; Schwedler, M; Stein, M; Wachter, D, 2007) |
| "In a 36-year-old man, an anterior communicating artery aneurysm caused an SAH (Hunt and Hess Grade IV, Fisher Grade III)." | 1.32 | Transluminal balloon angioplasty improves brain tissue oxygenation and metabolism in severe vasospasm after aneurysmal subarachnoid hemorrhage: case report. ( Behr, R; Hoelper, BM; Hofmann, E; Soldner, F; Sporleder, R, 2003) |
| "Even though cerebral vasospasm after subarachnoid hemorrhage (SAH) causes cerebral ischemia or infarction, the metabolic alterations in cerebrospinal fluids (CSF) after SAH have not been studied." | 1.31 | Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs. ( Aoki, K; Badr, A; Tibbs, R; Yin, W; Zhang, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Svedung Wettervik, T | 1 |
| Hånell, A | 1 |
| Howells, T | 2 |
| Ronne-Engström, E | 2 |
| Enblad, P | 2 |
| Lewén, A | 2 |
| Messina, R | 3 |
| de Gennaro, L | 3 |
| De Robertis, M | 3 |
| Pop, R | 3 |
| Chibbaro, S | 3 |
| Severac, F | 3 |
| Blagia, M | 3 |
| Balducci, MT | 3 |
| Bozzi, MT | 3 |
| Signorelli, F | 3 |
| Rostami, E | 1 |
| Engquist, H | 1 |
| Johnson, U | 1 |
| Nilsson, P | 1 |
| Hillered, L | 1 |
| Hänggi, D | 1 |
| Perrin, J | 1 |
| Eicker, S | 1 |
| Beseoglu, K | 1 |
| Etminan, N | 1 |
| Kamp, MA | 1 |
| Heiroth, HJ | 1 |
| Bege, N | 1 |
| Macht, S | 1 |
| Frauenknecht, K | 1 |
| Sommer, C | 1 |
| Kissel, T | 1 |
| Steiger, HJ | 1 |
| Hoelper, BM | 1 |
| Hofmann, E | 1 |
| Sporleder, R | 1 |
| Soldner, F | 1 |
| Behr, R | 1 |
| Sarrafzadeh, AS | 2 |
| Haux, D | 1 |
| Lüdemann, L | 1 |
| Amthauer, H | 1 |
| Plotkin, M | 1 |
| Küchler, I | 1 |
| Unterberg, AW | 2 |
| Cengiz, SL | 1 |
| Ak, A | 1 |
| Ustün, ME | 1 |
| Karaköse, S | 1 |
| Mehta, AK | 1 |
| Yadav, KS | 1 |
| Sawant, KK | 1 |
| Oertel, MF | 1 |
| Schwedler, M | 1 |
| Stein, M | 1 |
| Wachter, D | 1 |
| Scharbrodt, W | 1 |
| Schmidinger, A | 1 |
| Böker, DK | 1 |
| Nilsson, OG | 1 |
| Brandt, L | 1 |
| Ungerstedt, U | 1 |
| Säveland, H | 1 |
| Yin, W | 1 |
| Tibbs, R | 1 |
| Aoki, K | 1 |
| Badr, A | 1 |
| Zhang, J | 1 |
| Sakowitz, OW | 1 |
| Benndorf, G | 1 |
| Lanksch, WR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for lactic acid and Vasospasm, Intracranial
| Article | Year |
|---|---|
Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study.
Topics: Adult; Aged; Biomarkers; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Ex | 2004 |
Role of bedside microdialysis in the diagnosis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Cerebral Angiography; Cerebrovascular Circulation; Critical Care; Female; Glucos | 2001 |
10 other studies available for lactic acid and Vasospasm, Intracranial
| Article | Year |
|---|---|
Association of Arterial Metabolic Content with Cerebral Blood Flow Regulation and Cerebral Energy Metabolism-A Multimodality Analysis in Aneurysmal Subarachnoid Hemorrhage.
Topics: Carbon Dioxide; Cerebrovascular Circulation; Energy Metabolism; Glucose; Humans; Lactic Acid; Oxygen | 2022 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Cerebr | 2018 |
Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage.
Topics: Angiography, Digital Subtraction; Animals; Brain; Calcium-Binding Proteins; Delayed-Action Preparati | 2012 |
Transluminal balloon angioplasty improves brain tissue oxygenation and metabolism in severe vasospasm after aneurysmal subarachnoid hemorrhage: case report.
Topics: Adult; Angioplasty, Balloon; Blood Flow Velocity; Blood Glucose; Brain; Carotid Artery, Internal; Ca | 2003 |
Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status.
Topics: Animals; Basilar Artery; Biomarkers; Cisterna Magna; Disease Models, Animal; Lactic Acid; Male; Nerv | 2007 |
Nimodipine loaded PLGA nanoparticles: formulation optimization using factorial design, characterization and in vitro evaluation.
Topics: Calcium Channel Blockers; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Delayed-Act | 2007 |
Cerebral energy failure after subarachnoid hemorrhage: the role of relative hyperglycolysis.
Topics: Adult; Blood Pressure; Brain Diseases, Metabolic; Brain Ischemia; Cerebral Arteries; Cerebrovascular | 2007 |
Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Brain Ischemia; Cerebral Cortex; Female; Glutamic Acid; Glyc | 1999 |
Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.
Topics: Animals; Basilar Artery; Caspase Inhibitors; Caspases; Cerebrospinal Fluid; Disease Models, Animal; | 2001 |