lactic acid has been researched along with Uterine Cervical Neoplasms in 37 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this work was to prepare paclitaxel-loaded PLGA nanoparticles and determine cytotoxicity of released paclitaxel for two hypoxic human tumor cell lines: breast carcinoma (MCF-7) and carcinoma cervicis (HeLa)." | 3.75 | Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells. ( Bai, L; Dou, K; Guo, G; Jin, C; Song, W; Wu, H, 2009) |
| "Before heating, locally advanced cervical cancers are mostly hypoxic, acidic, exhibit substrate and energy deprivation and show lactate accumulation, which is spatially and temporally heterogeneous." | 2.48 | Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia. ( Kelleher, DK; Vaupel, PW, 2012) |
| "Tanshinone IIA (Tan IIA) is a diterpenoid naphthoquinone found in traditional Chinese medicine, Danshen (Salvia sp." | 1.51 | Tanshinone IIA inhibits glucose metabolism leading to apoptosis in cervical cancer. ( Chen, X; Kong, X; Liu, Z; Sun, X; Zhang, R; Zhang, W; Zhu, W, 2019) |
| "Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate." | 1.51 | Lactate secreted by cervical cancer cells modulates macrophage phenotype. ( Alvarez, KLF; Baracat, EC; Boccardo, E; Carvalho, JP; Lepique, AP; Lorenzi, NP; Margarido, PFR; Rossetti, RAM; Stone, SC; Tacla, M; Yokochi, K, 2019) |
| "Highly glycolytic cervical cancers largely resist treatment by cisplatin and coadministered pelvic irradiation as the present standard of care." | 1.48 | Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism. ( Elhammali, AE; Floberg, JM; Huang, X; McCormick, ML; Patti, GJ; Rashmi, R; Schwarz, JK; Spitz, DR, 2018) |
| "The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively." | 1.43 | STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. ( Dias, S; Domingues, G; Felix, A; Ferreira, J; Goncalves, LG; Lam, EW; Maximo, V; Serpa, J; Silva, F; Silva, LS, 2016) |
| "Curcumin (CUR) is a well-known natural compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic, and chemo-resistance associated genes/proteins." | 1.43 | Curcumin Nanoformulation for Cervical Cancer Treatment. ( Chauhan, N; Chauhan, SC; Gara, RK; Jaggi, M; Khan, S; Kumari, S; Maher, DM; Sikander, M; Yallapu, MM; Zafar, N; Zaman, MS, 2016) |
| "tissue penetration in hypo-vascularized cervical cancer lesions." | 1.43 | Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer. ( Curtis, LT; Frieboes, HB; Sims, LB; Steinbach-Rankins, JM, 2016) |
| "Three cervical cancer cell lines were examined: HeLa, Ca Ski and C33A." | 1.42 | L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation. ( Ciszewski, WM; Kania, KD; Wagner, W, 2015) |
| "Cervical cancer is a human papilloma virus (HPV)-related cancer, but most HPV infections are transient or intermittent and resolve spontaneously." | 1.39 | Normal and tumour cervical cells respond differently to vaginal lactobacilli, independent of pH and lactate. ( Akrami, SM; Mirsalehian, A; Modarressi, MH; Motevaseli, E; Mousavi, AS; Shirzad, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.70) | 18.7374 |
| 1990's | 2 (5.41) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 23 (62.16) | 24.3611 |
| 2020's | 7 (18.92) | 2.80 |
| Authors | Studies |
|---|---|
| de Magalhães, CCB | 1 |
| Linhares, IM | 1 |
| Masullo, LF | 1 |
| Eleutério, RMN | 1 |
| Witkin, SS | 1 |
| Eleutério, J | 1 |
| Wagner, W | 3 |
| Sobierajska, K | 1 |
| Kania, KD | 3 |
| Paradowska, E | 1 |
| Ciszewski, WM | 3 |
| Han, X | 1 |
| Du, S | 1 |
| Chen, X | 3 |
| Min, X | 1 |
| Dong, Z | 1 |
| Wang, Y | 1 |
| Zhu, C | 1 |
| Wei, F | 1 |
| Gao, S | 1 |
| Cai, Q | 1 |
| Wei, X | 1 |
| Sun, K | 1 |
| Li, S | 1 |
| Lin, C | 1 |
| Wei, Z | 1 |
| Hao, Y | 1 |
| Liu, Y | 1 |
| Zhong, S | 1 |
| You, Y | 1 |
| Ao, K | 1 |
| Chong, T | 1 |
| Luo, X | 1 |
| Yin, M | 1 |
| Ye, M | 1 |
| He, H | 1 |
| Lu, A | 1 |
| Chen, J | 1 |
| Li, X | 1 |
| Zhang, J | 3 |
| Guo, X | 1 |
| Colbert, LE | 1 |
| El Alam, MB | 1 |
| Wang, R | 1 |
| Karpinets, T | 1 |
| Lo, D | 1 |
| Lynn, EJ | 1 |
| Harris, TA | 1 |
| Elnaggar, JH | 1 |
| Yoshida-Court, K | 1 |
| Tomasic, K | 1 |
| Bronk, JK | 1 |
| Sammouri, J | 1 |
| Yanamandra, AV | 1 |
| Olvera, AV | 1 |
| Carlin, LG | 1 |
| Sims, T | 1 |
| Delgado Medrano, AY | 1 |
| Napravnik, TC | 1 |
| O'Hara, M | 1 |
| Lin, D | 1 |
| Abana, CO | 1 |
| Li, HX | 1 |
| Eifel, PJ | 1 |
| Jhingran, A | 1 |
| Joyner, M | 1 |
| Lin, L | 1 |
| Ramondetta, LM | 1 |
| Futreal, AM | 1 |
| Schmeler, KM | 1 |
| Mathew, G | 1 |
| Dorta-Estremera, S | 1 |
| Wu, X | 1 |
| Ajami, NJ | 1 |
| Wong, M | 1 |
| Taniguchi, C | 1 |
| Petrosino, JF | 1 |
| Sastry, KJ | 1 |
| Okhuysen, PC | 1 |
| Martinez, SA | 1 |
| Tan, L | 1 |
| Mahmud, I | 1 |
| Lorenzi, PL | 1 |
| Wargo, JA | 1 |
| Klopp, AH | 1 |
| Liu, Z | 1 |
| Zhu, W | 1 |
| Kong, X | 1 |
| Sun, X | 1 |
| Zhang, W | 1 |
| Zhang, R | 1 |
| Jiang, X | 1 |
| Yuan, J | 1 |
| Dou, Y | 1 |
| Zeng, D | 1 |
| Xiao, S | 1 |
| Blauz, A | 1 |
| Rashmi, R | 1 |
| Huang, X | 1 |
| Floberg, JM | 1 |
| Elhammali, AE | 1 |
| McCormick, ML | 1 |
| Patti, GJ | 1 |
| Spitz, DR | 1 |
| Schwarz, JK | 1 |
| Wang, CH | 1 |
| Shyu, RY | 1 |
| Wu, CC | 1 |
| Chen, ML | 1 |
| Lee, MC | 1 |
| Lin, YY | 1 |
| Wang, LK | 1 |
| Jiang, SY | 1 |
| Tsai, FM | 1 |
| Li, C | 1 |
| Jia, L | 1 |
| Yu, Y | 1 |
| Jin, L | 1 |
| Stone, SC | 1 |
| Rossetti, RAM | 1 |
| Alvarez, KLF | 1 |
| Carvalho, JP | 1 |
| Margarido, PFR | 1 |
| Baracat, EC | 1 |
| Tacla, M | 1 |
| Boccardo, E | 1 |
| Yokochi, K | 1 |
| Lorenzi, NP | 1 |
| Lepique, AP | 1 |
| Motevaseli, E | 1 |
| Shirzad, M | 1 |
| Akrami, SM | 1 |
| Mousavi, AS | 1 |
| Mirsalehian, A | 1 |
| Modarressi, MH | 1 |
| Zeng, X | 1 |
| Tao, W | 2 |
| Mei, L | 2 |
| Huang, L | 1 |
| Tan, C | 1 |
| Feng, SS | 1 |
| Punfa, W | 2 |
| Suzuki, S | 1 |
| Pitchakarn, P | 2 |
| Yodkeeree, S | 2 |
| Naiki, T | 1 |
| Takahashi, S | 1 |
| Limtrakul, P | 2 |
| Payne, GS | 1 |
| deSouza, NM | 1 |
| Messiou, C | 1 |
| Leach, MO | 1 |
| Silva, LS | 1 |
| Goncalves, LG | 1 |
| Silva, F | 1 |
| Domingues, G | 1 |
| Maximo, V | 1 |
| Ferreira, J | 1 |
| Lam, EW | 1 |
| Dias, S | 1 |
| Felix, A | 1 |
| Serpa, J | 1 |
| Zaman, MS | 1 |
| Chauhan, N | 1 |
| Yallapu, MM | 1 |
| Gara, RK | 1 |
| Maher, DM | 1 |
| Kumari, S | 1 |
| Sikander, M | 1 |
| Khan, S | 1 |
| Zafar, N | 1 |
| Jaggi, M | 1 |
| Chauhan, SC | 1 |
| Sims, LB | 1 |
| Curtis, LT | 1 |
| Frieboes, HB | 1 |
| Steinbach-Rankins, JM | 1 |
| Xu, G | 1 |
| Yu, X | 1 |
| Sheng, Y | 1 |
| Liu, G | 1 |
| Neveu, MA | 1 |
| De Preter, G | 1 |
| Joudiou, N | 1 |
| Bol, A | 1 |
| Brender, JR | 1 |
| Saito, K | 1 |
| Kishimoto, S | 1 |
| Grégoire, V | 1 |
| Jordan, BF | 1 |
| Krishna, MC | 1 |
| Feron, O | 1 |
| Gallez, B | 1 |
| Hamoudeh, M | 1 |
| Diab, R | 1 |
| Fessi, H | 1 |
| Dumontet, C | 1 |
| Cuchet, D | 1 |
| Jin, C | 1 |
| Bai, L | 1 |
| Wu, H | 1 |
| Song, W | 1 |
| Guo, G | 1 |
| Dou, K | 1 |
| Mendoza-Juez, B | 1 |
| Martínez-González, A | 1 |
| Calvo, GF | 1 |
| Pérez-García, VM | 1 |
| Wang, H | 1 |
| Wang, S | 1 |
| Liao, Z | 1 |
| Zhao, P | 1 |
| Su, W | 1 |
| Niu, R | 1 |
| Chang, J | 1 |
| Dauchy, RT | 1 |
| Dauchy, EM | 1 |
| Mao, L | 1 |
| Belancio, VP | 1 |
| Hill, SM | 1 |
| Blask, DE | 1 |
| Ampasavate, C | 1 |
| Vaupel, PW | 1 |
| Kelleher, DK | 1 |
| Ditto, AJ | 1 |
| Shah, KN | 1 |
| Robishaw, NK | 1 |
| Panzner, MJ | 1 |
| Youngs, WJ | 1 |
| Yun, YH | 1 |
| Kim, H | 1 |
| Jeong, D | 1 |
| Kang, HE | 1 |
| Lee, KC | 1 |
| Na, K | 1 |
| Walenta, S | 4 |
| Schroeder, T | 1 |
| Mueller-Klieser, W | 4 |
| PREISLER, O | 2 |
| Schwickert, G | 2 |
| Sundfør, K | 2 |
| Rofstad, EK | 2 |
| Wetterling, M | 1 |
| Lehrke, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Phase II Clinical Trial of Oral Turmeric Supplementation in Patients With Advanced Cervical Cancer[NCT04294836] | Phase 2 | 0 participants (Actual) | Interventional | 2021-12-01 | Withdrawn (stopped due to Issues with local regulatory authority) | ||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Uterine Cervical Neoplasms
| Article | Year |
|---|---|
Blood flow and associated pathophysiology of uterine cervix cancers: characterisation and relevance for localised hyperthermia.
Topics: Animals; Cervix Uteri; Female; Glucose; Humans; Hyperthermia, Induced; Hypoxia; Lactic Acid; Uterine | 2012 |
36 other studies available for lactic acid and Uterine Cervical Neoplasms
| Article | Year |
|---|---|
Comparative measurement of D- and L-lactic acid isomers in vaginal secretions: association with high-grade cervical squamous intraepithelial lesions.
Topics: Colposcopy; Female; Humans; Lactic Acid; Pregnancy; Squamous Intraepithelial Lesions; Squamous Intra | 2022 |
Lactate Suppresses Retroviral Transduction in Cervical Epithelial Cells through DNA-PKcs Modulation.
Topics: Benzoates; Butyric Acid; Cell Line, Tumor; Cell Nucleus; Chromones; DNA-Activated Protein Kinase; Fe | 2021 |
Lactate-mediated Fascin protrusions promote cell adhesion and migration in cervical cancer.
Topics: Animals; beta Catenin; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; H | 2023 |
PSME3 induces radioresistance and enhances aerobic glycolysis in cervical cancer by regulating PARP1.
Topics: Cell Line, Tumor; Cell Proliferation; Female; Glucose; Glycolysis; HeLa Cells; Humans; Lactic Acid; | 2023 |
NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer.
Topics: B7-H1 Antigen; Female; Forkhead Transcription Factors; Glycolysis; Humans; Immunosuppression Therapy | 2023 |
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring.
Topics: Female; Humans; Lactic Acid; Lactobacillus; Microbiota; Tumor Microenvironment; Uterine Cervical Neo | 2023 |
Tanshinone IIA inhibits glucose metabolism leading to apoptosis in cervical cancer.
Topics: Abietanes; Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cel | 2019 |
Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical Cancer Cells Through the FRA1/MDM2/p53 Pathway.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cervix Uteri; Female; Gene Expression Regulati | 2021 |
The lactate receptor (HCAR1/GPR81) contributes to doxorubicin chemoresistance via ABCB1 transporter up-regulation in human cervical cancer HeLa cells.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cel | 2017 |
Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism.
Topics: Animals; Auranofin; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Citric Acid Cycle; Deoxygl | 2018 |
Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells.
Topics: Carrier Proteins; Cell Proliferation; Cytosol; Female; Glucose; Glucose Transporter Type 1; Glycolys | 2018 |
Lactic acid induced microRNA-744 enhances motility of SiHa cervical cancer cells through targeting ARHGAP5.
Topics: Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Gene Expression Reg | 2019 |
Lactate secreted by cervical cancer cells modulates macrophage phenotype.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocultur | 2019 |
Normal and tumour cervical cells respond differently to vaginal lactobacilli, independent of pH and lactate.
Topics: Apoptosis; Caspase 3; Chorionic Gonadotropin, beta Subunit, Human; Female; Gene Expression Regulatio | 2013 |
Cholic acid-functionalized nanoparticles of star-shaped PLGA-vitamin E TPGS copolymer for docetaxel delivery to cervical cancer.
Topics: Animals; Antineoplastic Agents; Cholic Acid; Docetaxel; Female; HeLa Cells; Humans; Lactic Acid; Mic | 2013 |
Curcumin-loaded PLGA nanoparticles conjugated with anti- P-glycoprotein antibody to overcome multidrug resistance.
Topics: Animals; Antibodies; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette | 2014 |
Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.
Topics: Brain Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Cell Hypoxia; Choline; Female; Humans; Lactic | 2015 |
L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation.
Topics: Acetylation; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cervix Uteri; Cisplatin; DNA Br | 2015 |
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cervix Uteri; Female; Forkhe | 2016 |
Curcumin Nanoformulation for Cervical Cancer Treatment.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Curcumin; Female; | 2016 |
Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer.
Topics: Cell Line; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Delivery Systems; Female; HeLa Cells | 2016 |
Robust aptamer-polydopamine-functionalized M-PLGA-TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy.
Topics: Animals; Antineoplastic Agents; Aptamers, Nucleotide; Docetaxel; Drug Carriers; Drug Delivery System | 2016 |
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squam | 2016 |
Paclitaxel-loaded microparticles for intratumoral administration via the TMT technique: preparation, characterization, and preliminary antitumoral evaluation.
Topics: Antineoplastic Agents, Phytogenic; Calorimetry, Differential Scanning; Delayed-Action Preparations; | 2008 |
Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma; Cell Hypoxia; Cell Survival | 2009 |
A mathematical model for the glucose-lactate metabolism of in vitro cancer cells.
Topics: Cell Line, Tumor; Colonic Neoplasms; Energy Metabolism; Female; Glioma; Glucose; Humans; Lactic Acid | 2012 |
Folate-targeting magnetic core-shell nanocarriers for selective drug release and imaging.
Topics: Antibiotics, Antineoplastic; Chemistry, Pharmaceutical; Contrast Media; Delayed-Action Preparations; | 2012 |
A new apparatus and surgical technique for the dual perfusion of human tumor xenografts in situ in nude rats.
Topics: Adenocarcinoma; Animals; Artificial Organs; Blood Glucose; Carbon Dioxide; Cell Proliferation; Colon | 2012 |
Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells.
Topics: Animals; Antibodies; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2012 |
The Interactions between L-tyrosine based nanoparticles decorated with folic acid and cervical cancer cells under physiological flow.
Topics: Cells, Cultured; Dermis; Drug Carriers; Female; Fibroblasts; Fluorescent Antibody Technique; Folate | 2012 |
A sulfate polysaccharide/TNF-related apoptosis-inducing ligand (TRAIL) complex for the long-term delivery of TRAIL in poly(lactic-co-glycolic acid) (PLGA) microspheres.
Topics: Animals; Antineoplastic Agents; Apoptosis; Chondroitin Sulfates; Delayed-Action Preparations; Drug C | 2013 |
In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Hydrogen; Lactic Acid; Luminescen | 2002 |
[Intestinal flora of women with cancer treated with radiations and their management with products of microbic metabolism].
Topics: Bacteria; Female; Humans; Lactic Acid; Milk; Neoplasms; Radiation; Radiation Injuries; Radiotherapy; | 1956 |
[Intestinal flora of women with cancer treated with radiations and their management with products of microbic metabolism].
Topics: Bacteria; Female; Humans; Lactic Acid; Milk; Neoplasms; Radiation; Radiation Injuries; Radiotherapy; | 1956 |
[Intestinal flora of women with cancer treated with radiations and their management with products of microbic metabolism].
Topics: Bacteria; Female; Humans; Lactic Acid; Milk; Neoplasms; Radiation; Radiation Injuries; Radiotherapy; | 1956 |
[Intestinal flora of women with cancer treated with radiations and their management with products of microbic metabolism].
Topics: Bacteria; Female; Humans; Lactic Acid; Milk; Neoplasms; Radiation; Radiation Injuries; Radiotherapy; | 1956 |
Correlation of high lactate levels in human cervical cancer with incidence of metastasis.
Topics: Adenosine Triphosphate; Biopsy; Female; Glucose; Humans; Lactates; Lactic Acid; Luminescent Measurem | 1995 |
Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Female; Frozen Sections; Glucose; H | 1993 |
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.
Topics: Adenosine Triphosphate; Female; Humans; Lactic Acid; Neoplasm Metastasis; Neoplasm Recurrence, Local | 2000 |