lactic acid has been researched along with Tuberculosis, Meningeal in 18 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bacterial meningitis and tubercular meningitis are still neurological emergencies characterized by severe mortality and morbidity." | 2.48 | [Revival of old diagnostic markers in the cerebrospinal fluid for the detection of infectious meningitis]. ( Sakushima, K; Sasaki, H; Yabe, I, 2012) |
| "Scrub typhus is one of the most common causes of meningo-encephalitis in endemic areas of the Indian subcontinent." | 1.62 | Is cerebrospinal fluid lactate useful in differentiating scrub typhus meningitis from aseptic, bacterial and tuberculous meningitis? ( Abhilash, KPP; Arora, S; Gunasekharan, K; Hazra, D; Mitra, S; Yesudass, P, 2021) |
| "TBM causes hydrocephalus, cerebral edema, increased intracranial pressure, global ischemia, and neurologic deficits, which disturb cellular metabolism and increase lactate levels." | 1.48 | Correlation of Lactate Concentration in Peripheral Plasma and Cerebrospinal Fluid with Glasgow Outcome Scale for Patients with Tuberculous Meningitis Complicated by Acute Hydrocephalus Treated with Fluid Diversions. ( Arief, G; Arifin, MZ; Faried, A; Nataprawira, HM, 2018) |
| "Diagnosis of tubercular meningitis (TBM) continues to be a clinical challenge and available microbiological tests fail to attain the required accuracy standards." | 1.48 | Cerebrospinal Fluid Lactate in Tubercular Meningitis: Diagnostic or Prognostic Marker? ( Fatma, J; Gupta, M; Karoli, R; Siddiqi, MS; Siddiqi, Z; Singhal, V, 2018) |
| "However, distinction between untreated pyogenic meningitis and virus meningitis is rarely problematic in clinical practice, so routine use of the test as an emergency procedure offers no extra advantage." | 1.27 | How useful is cerebrospinal fluid lactate estimation in differential diagnosis of meningitis? ( Dunbar, EM; Hooper, J; Mandal, BK; Parker, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (50.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| de Almeida, SM | 2 |
| Kussen, GB | 2 |
| Cogo, LL | 2 |
| Nogueira, K | 2 |
| Arora, S | 1 |
| Abhilash, KPP | 1 |
| Mitra, S | 1 |
| Hazra, D | 1 |
| Gunasekharan, K | 1 |
| Yesudass, P | 1 |
| Faried, A | 1 |
| Arief, G | 1 |
| Arifin, MZ | 1 |
| Nataprawira, HM | 1 |
| Siddiqi, Z | 1 |
| Siddiqi, MS | 1 |
| Fatma, J | 1 |
| Karoli, R | 1 |
| Singhal, V | 1 |
| Gupta, M | 1 |
| Mason, S | 1 |
| Reinecke, CJ | 1 |
| Kulik, W | 1 |
| van Cruchten, A | 1 |
| Solomons, R | 1 |
| van Furth, AM | 1 |
| Sakushima, K | 1 |
| Yabe, I | 1 |
| Sasaki, H | 1 |
| Chen, Z | 1 |
| Wang, Y | 1 |
| Zeng, A | 1 |
| Chen, L | 1 |
| Wu, R | 1 |
| Chen, B | 1 |
| Chen, M | 1 |
| Bo, J | 1 |
| Zhang, H | 1 |
| Peng, Q | 1 |
| Lu, J | 1 |
| Meng, QH | 1 |
| Alam, SM | 1 |
| Mitra, SK | 1 |
| Vajpeyi, GN | 1 |
| Chandra, R | 1 |
| Srivastava, DR | 1 |
| Sikka, KK | 1 |
| Govil, MK | 1 |
| Ruf, B | 1 |
| Mandal, BK | 1 |
| Dunbar, EM | 1 |
| Hooper, J | 1 |
| Parker, L | 1 |
| Guindi, S | 1 |
| Mansour, MM | 1 |
| Girgis, NI | 1 |
| Carlini, SM | 1 |
| Beyers, N | 1 |
| Schoeman, JF | 3 |
| Nel, ED | 1 |
| Truter, EJ | 1 |
| Donald, PR | 4 |
| Elshof, JW | 1 |
| Laubscher, JA | 1 |
| Janse van Rensburg, A | 1 |
| Van Zyl, L | 1 |
| Tang, LM | 1 |
| Lin, EX | 1 |
| Malan, C | 1 |
| Hornig, CR | 1 |
| Dorndorf, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Diagnosis and Treatment Monitoring of Native and Device-associated Meningitis Using D-lactate, a Pathogen-specific Diagnostic Biomarker in Cerebrospinal Fluid[NCT05146570] | 842 participants (Anticipated) | Interventional | 2021-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Tuberculosis, Meningeal
| Article | Year |
|---|---|
[Revival of old diagnostic markers in the cerebrospinal fluid for the detection of infectious meningitis].
Topics: Adenosine Deaminase; Biomarkers; Humans; Lactic Acid; Meningitis, Bacterial; Practice Guidelines as | 2012 |
1 trial available for lactic acid and Tuberculosis, Meningeal
| Article | Year |
|---|---|
The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis.
Topics: Adenylate Kinase; Antitubercular Agents; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Drug | 2001 |
16 other studies available for lactic acid and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis.
Topics: Humans; Lactic Acid; Mycobacterium tuberculosis; Retrospective Studies; ROC Curve; Tuberculosis, Men | 2023 |
Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis.
Topics: Humans; Lactic Acid; Mycobacterium tuberculosis; Retrospective Studies; ROC Curve; Tuberculosis, Men | 2023 |
Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis.
Topics: Humans; Lactic Acid; Mycobacterium tuberculosis; Retrospective Studies; ROC Curve; Tuberculosis, Men | 2023 |
Cerebrospinal fluid lactate as a predictive biomarker for tuberculous meningitis diagnosis.
Topics: Humans; Lactic Acid; Mycobacterium tuberculosis; Retrospective Studies; ROC Curve; Tuberculosis, Men | 2023 |
Is cerebrospinal fluid lactate useful in differentiating scrub typhus meningitis from aseptic, bacterial and tuberculous meningitis?
Topics: Adult; Cross-Sectional Studies; Diagnosis, Differential; Female; Humans; Lactic Acid; Male; Meningit | 2021 |
Correlation of Lactate Concentration in Peripheral Plasma and Cerebrospinal Fluid with Glasgow Outcome Scale for Patients with Tuberculous Meningitis Complicated by Acute Hydrocephalus Treated with Fluid Diversions.
Topics: Adolescent; Adult; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Cohort Studies; Female; Glas | 2018 |
Cerebrospinal Fluid Lactate in Tubercular Meningitis: Diagnostic or Prognostic Marker?
Topics: Adenosine Deaminase; Adolescent; Cerebrospinal Fluid; Cross-Sectional Studies; Humans; Lactic Acid; | 2018 |
Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid.
Topics: Biomarkers; Cerebrospinal Fluid; Child; Child, Preschool; Chromatography, Liquid; Follow-Up Studies; | 2016 |
The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis.
Topics: Adolescent; Adult; Aged; Area Under Curve; Biomarkers; Child; Child, Preschool; Diagnosis, Different | 2012 |
Prognostic evaluation of CSF lactic acid in cases of meningitis.
Topics: Humans; Lactates; Lactic Acid; Meningitis; Meningitis, Aseptic; Prognosis; Tuberculosis, Meningeal | 1984 |
[Lactate determination in the cerebrospinal fluid. Differential diagnostic significance].
Topics: Diagnosis, Differential; Escherichia coli Infections; Female; Humans; Klebsiella Infections; Lactate | 1981 |
How useful is cerebrospinal fluid lactate estimation in differential diagnosis of meningitis?
Topics: Brain Diseases; Diagnosis, Differential; Humans; Lactates; Lactic Acid; Meningitis; Meningitis, Vira | 1983 |
Cerebrospinal fluid aldolase, lactate and creatine phosphokinase in the differential diagnosis of meningitis and meningo-encephalitis.
Topics: Adolescent; Adult; Child; Child, Preschool; Creatine Kinase; Diagnosis, Differential; Fructose-Bisph | 1982 |
Adenylate kinase activity in the cerebrospinal fluid of children with tuberculous meningitis and its relationship to neurological outcome.
Topics: Adenylate Kinase; Adolescent; Antitubercular Agents; Child; Child, Preschool; Drug Therapy, Combinat | 1997 |
Cerebrospinal fluid lactate and raised intracranial pressure in tuberculous meningitis.
Topics: Humans; Infant; Intracranial Pressure; Lactates; Lactic Acid; Tuberculosis, Meningeal | 1989 |
Serial lactate determinations in tuberculous meningitis.
Topics: Adolescent; Adult; Aged; Female; Humans; Lactates; Lactic Acid; Male; Middle Aged; Mycobacterium tub | 1988 |
[Implication of CSF lactic acid determination in the differential diagnosis of tuberculous meningitis].
Topics: Diagnosis, Differential; Humans; Lactates; Lactic Acid; Tuberculosis, Meningeal | 1987 |
Cerebrospinal fluid lactate and lactate dehydrogenase levels as diagnostic aids in tuberculous meningitis.
Topics: Child; Child, Preschool; Humans; Infant; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Tuberculosi | 1985 |
[Significance of lactate level, lysozyme concentration and phosphohexose isomerase activity in the cerebrospinal fluid in the differential diagnosis of meningitis].
Topics: Bacterial Infections; Cryptococcosis; Diagnosis, Differential; Glucose-6-Phosphate Isomerase; Humans | 1985 |