lactic acid has been researched along with Tetralogy of Fallot in 7 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Tetralogy of Fallot: A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Romolo, H | 1 |
| Hernisa, L | 1 |
| Fakhri, D | 1 |
| Rachmat, J | 1 |
| Dwi Mulia, D | 1 |
| Rahmat, B | 1 |
| Li, B | 1 |
| Chen, R | 2 |
| Huang, R | 1 |
| Luo, W | 1 |
| Luo, WJ | 1 |
| Jiang, HH | 1 |
| Long, L | 1 |
| Huang, RM | 1 |
| Luo, FY | 1 |
| Amirnovin, R | 1 |
| Keller, RL | 1 |
| Herrera, C | 1 |
| Hsu, JH | 1 |
| Datar, S | 1 |
| Karl, TR | 1 |
| Adatia, I | 1 |
| Oishi, P | 1 |
| Fineman, JR | 1 |
| CASTELLO, D | 1 |
| MADON, E | 1 |
| Van Arsdell, GS | 1 |
| Maharaj, GS | 1 |
| Tom, J | 1 |
| Rao, VK | 1 |
| Coles, JG | 1 |
| Freedom, RM | 1 |
| Williams, WG | 1 |
| McCrindle, BW | 1 |
| Pisarenko, OI | 1 |
| Portnoy, VF | 1 |
| Studneva, IM | 1 |
| Arapov, AD | 1 |
| Korostylev, AN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827] | Phase 3 | 865 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 147 |
| Saline Infusion | 152 |
ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay
| Intervention | hours (Median) |
|---|---|
| Intravenous Glutamate | 21 |
| Saline Infusion | 21 |
(NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 31 |
| Saline Infusion | 25 |
Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 4 |
| Saline Infusion | 6 |
Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 1 |
| Saline Infusion | 5 |
maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days
| Intervention | µmol/L (Mean) |
|---|---|
| Intravenous Glutamate | 106 |
| Saline Infusion | 106 |
Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Intravenous Glutamate | 3 |
| Saline Infusion | 16 |
p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative
| Intervention | µg/L (Median) | |
|---|---|---|
| CK-MB day 1 | Troponin-T day 3 | |
| Intravenous Glutamate | 14 | 0.27 |
| Saline Infusion | 14 | 0.24 |
Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU
| Intervention | percentage of saturated hemoglobin (Mean) | |
|---|---|---|
| SvO2 at weaning from CPB | SvO2 on arrival to ICU | |
| Intravenous Glutamate | 72.0 | 65.0 |
| Saline Infusion | 72.2 | 64.9 |
3 trials available for lactic acid and Tetralogy of Fallot
| Article | Year |
|---|---|
Comparison between blood and non-blood cardioplegia in tetralogy of Fallot.
Topics: Adolescent; Adult; Biomarkers; Cardiac Surgical Procedures; Cardioplegic Solutions; Cardiopulmonary | 2019 |
Clinical benefit of cardiac ischemic postconditioning in corrections of tetralogy of Fallot.
Topics: Adolescent; Aorta; Cardiac Surgical Procedures; Cardiotonic Agents; Child; Child, Preschool; Constri | 2009 |
[Cardiopulmonary protection of ischemic postconditioning in cardiac surgery in children with tetralogy of Fallot].
Topics: Adolescent; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschool; Female; He | 2009 |
4 other studies available for lactic acid and Tetralogy of Fallot
| Article | Year |
|---|---|
B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion.
Topics: Biomarkers; Cardiac Surgical Procedures; Female; Heart Defects, Congenital; Heart Ventricles; Hemody | 2013 |
[BEHAVIOR OF BLOOD LACTIC ACID IN CHILDREN WITH HEART DISEASE. II. CONGENITAL HEART DISEASE].
Topics: Aortic Coarctation; Blood Chemical Analysis; Child; Ductus Arteriosus; Ductus Arteriosus, Patent; He | 1963 |
What is the optimal age for repair of tetralogy of Fallot?
Topics: Age Distribution; Age Factors; Blood Pressure; Canada; Cardiac Surgical Procedures; Child; Child, Pr | 2000 |
Glutamate-blood cardioplegia improves ATP preservation in human myocardium.
Topics: Adenosine Triphosphate; Blood; Cardioplegic Solutions; Coronary Circulation; Glutamates; Glutamic Ac | 1987 |