lactic acid has been researched along with Status Epilepticus in 25 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 7.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "To evaluate the efficacy and tolerability of intravenous (IV) levetiracetam in refractory status epilepticus of migrating partial seizures in infancy (MPSI)." | 7.75 | Intravenous levetiracetam terminates refractory status epilepticus in two patients with migrating partial seizures in infancy. ( Balestri, M; Bianchi, R; Cilio, MR; Di Capua, M; Giovannini, S; Onofri, A; Vigevano, F, 2009) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 7.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 7.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| "The brain uptake of phenobarbital during prolonged status epilepticus (3 h) was studied in paralyzed, ventilated sheep." | 7.67 | Brain phenobarbital uptake during prolonged status epilepticus. ( Benowitz, NL; Bronstein, J; Copeland, JR; Jacob, P; Simon, RP, 1987) |
| " Furthermore, real-time measurement of lactate and oxygen concentration dynamics concurrently with network electrical activity during status epilepticus induced by 4-aminopyridine (4-AP) demonstrated phasic changes in lactate levels that correlated with bursts of electrical activity, while tonic levels of lactate remained stable during seizures." | 4.84 | Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus. ( Barbosa, RM; Fernandes, E; Gerhardt, GA; Ledo, A, 2024) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 3.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "To evaluate the efficacy and tolerability of intravenous (IV) levetiracetam in refractory status epilepticus of migrating partial seizures in infancy (MPSI)." | 3.75 | Intravenous levetiracetam terminates refractory status epilepticus in two patients with migrating partial seizures in infancy. ( Balestri, M; Bianchi, R; Cilio, MR; Di Capua, M; Giovannini, S; Onofri, A; Vigevano, F, 2009) |
| " Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus." | 3.75 | In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009) |
| "The correlation between seizure-induced hypermetabolism and subsequent neuronal damage was studied in 10-day-old (P10), 21-day-old (P21), and adult rats subjected to lithium-pilocarpine status epilepticus (SE)." | 3.70 | Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats. ( Boyet, S; Dubé, C; Fernandes, MJ; Marescaux, C; Nehlig, A, 1999) |
| " Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus." | 3.68 | Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. ( Bellander, BM; Ingvar, M; Meller, D; Schmidt-Kastner, R, 1993) |
| "The purpose of these experiments was to determine whether flurothyl-induced status epilepticus causes progressive decline of brain high-energy phosphates and progressive increase in brain lactate in neonatal dogs who are paralyzed and oxygenated." | 3.68 | Brain energy state and lactate metabolism during status epilepticus in the neonatal dog: in vivo 31P and 1H nuclear magnetic resonance study. ( Aquila, WJ; Chen, B; Gore, JC; Petroff, OA; Young, RS, 1991) |
| "The brain uptake of phenobarbital during prolonged status epilepticus (3 h) was studied in paralyzed, ventilated sheep." | 3.67 | Brain phenobarbital uptake during prolonged status epilepticus. ( Benowitz, NL; Bronstein, J; Copeland, JR; Jacob, P; Simon, RP, 1987) |
| "Video-EEG recordings evaluated seizure duration, severity, and immunohistochemistry was used to determine neuronal loss." | 1.91 | Glycolytic lactate production supports status epilepticus in experimental animals. ( Kapur, J; Kasprzak, I; Sharma, S; Skwarzynska, D; Sun, H; Williamson, J, 2023) |
| "The effect of seizure activity on CSF lactate concentration in dogs is unknown." | 1.56 | Cerebrospinal fluid lactate concentrations in dogs with seizure disorders. ( Early, PJ; Green, L; Guevar, J; Lau, J; Lee, CS; Mariani, CL; Muñana, KR; Nye, CJ; Olby, NJ; Ruterbories, L; Tokarz, DA; Zidan, N, 2020) |
| "Status epilepticus was evoked in half of the sedentary and trained rats by a repetitive intraperitoneal injection of KA in low subconvulsive doses." | 1.46 | Effect of Training at Lactate Threshold Intensity on Maximal Time to Exhaustion, Depression and Anxiety Behaviour of Spontaneously Hypertensive Rats after Kainate-Induced Status Epilepticus. ( Andreev, GG; Georgiev, NG; Georgieva, KN; Hadjieva, MS; Shishmanova-Doseva, MS; Tchekalarova, JD; Terzieva, DD, 2017) |
| "Findings were correlated with seizure types, seizure etiology (symptomatic, cryptogenic, occasional seizure), and seizure duration." | 1.42 | Effect of epileptic seizures on the cerebrospinal fluid--A systematic retrospective analysis. ( Brettschneider, J; Fauser, S; Hoppner, AC; Jobs, C; Kerling, F; Tumani, H, 2015) |
| "Alpers syndrome is a progressive encephalopathy of early onset, characterized by rapid and severe developmental delay, intractable seizures and liver involvement in a previously healthy child." | 1.31 | Respiratory chain deficiency in Alpers syndrome. ( Chrétien, D; Cormier-Daire, V; de Lonlay, P; Gauthier-Villars, M; Jacquemin, E; Landrieu, P; Munnich, A; Rötig, A; Rustin, P, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 6 (24.00) | 2.80 |
| Authors | Studies |
|---|---|
| Süße, M | 1 |
| Gag, K | 1 |
| Hamann, L | 1 |
| Hannich, MJ | 1 |
| von Podewils, F | 1 |
| Skwarzynska, D | 1 |
| Sun, H | 1 |
| Kasprzak, I | 1 |
| Sharma, S | 1 |
| Williamson, J | 1 |
| Kapur, J | 1 |
| Tan, THL | 1 |
| Sanfilippo, P | 1 |
| Colman, B | 1 |
| Perucca, P | 1 |
| Kwan, P | 1 |
| O'Brien, TJ | 1 |
| Monif, M | 1 |
| Fernandes, E | 1 |
| Ledo, A | 1 |
| Gerhardt, GA | 1 |
| Barbosa, RM | 1 |
| Hurth, H | 1 |
| Schlak, D | 1 |
| Ebner, FH | 1 |
| Mariani, CL | 1 |
| Nye, CJ | 1 |
| Ruterbories, L | 1 |
| Tokarz, DA | 1 |
| Green, L | 1 |
| Lau, J | 1 |
| Zidan, N | 1 |
| Early, PJ | 1 |
| Muñana, KR | 1 |
| Olby, NJ | 1 |
| Lee, CS | 1 |
| Guevar, J | 1 |
| Georgieva, KN | 1 |
| Hadjieva, MS | 1 |
| Shishmanova-Doseva, MS | 1 |
| Terzieva, DD | 1 |
| Georgiev, NG | 1 |
| Andreev, GG | 1 |
| Tchekalarova, JD | 1 |
| Tumani, H | 1 |
| Jobs, C | 1 |
| Brettschneider, J | 1 |
| Hoppner, AC | 1 |
| Kerling, F | 1 |
| Fauser, S | 1 |
| Imran, I | 1 |
| Hillert, MH | 1 |
| Klein, J | 1 |
| Cilio, MR | 1 |
| Bianchi, R | 1 |
| Balestri, M | 1 |
| Onofri, A | 1 |
| Giovannini, S | 1 |
| Di Capua, M | 1 |
| Vigevano, F | 1 |
| Zahr, NM | 1 |
| Crawford, EL | 1 |
| Hsu, O | 1 |
| Vinco, S | 1 |
| Mayer, D | 1 |
| Rohlfing, T | 1 |
| Sullivan, EV | 1 |
| Pfefferbaum, A | 1 |
| Slais, K | 1 |
| Vorisek, I | 1 |
| Zoremba, N | 1 |
| Homola, A | 1 |
| Dmytrenko, L | 1 |
| Sykova, E | 1 |
| Vespa, PM | 1 |
| Miller, C | 1 |
| McArthur, D | 1 |
| Eliseo, M | 1 |
| Etchepare, M | 1 |
| Hirt, D | 1 |
| Glenn, TC | 1 |
| Martin, N | 1 |
| Hovda, D | 1 |
| Meller, D | 1 |
| Bellander, BM | 1 |
| Schmidt-Kastner, R | 1 |
| Ingvar, M | 2 |
| Ebisu, T | 1 |
| Rooney, WD | 1 |
| Graham, SH | 1 |
| Mancuso, A | 1 |
| Weiner, MW | 1 |
| Maudsley, AA | 1 |
| Fernandes, MJ | 1 |
| Dubé, C | 1 |
| Boyet, S | 1 |
| Marescaux, C | 1 |
| Nehlig, A | 1 |
| Fornai, F | 1 |
| Bassi, L | 1 |
| Gesi, M | 1 |
| Giorgi, FS | 1 |
| Guerrini, R | 1 |
| Bonaccorsi, I | 1 |
| Alessandrì, MG | 1 |
| Gauthier-Villars, M | 1 |
| Landrieu, P | 1 |
| Cormier-Daire, V | 1 |
| Jacquemin, E | 1 |
| Chrétien, D | 1 |
| Rötig, A | 1 |
| Rustin, P | 1 |
| Munnich, A | 1 |
| de Lonlay, P | 1 |
| Young, RS | 2 |
| Petroff, OA | 2 |
| Chen, B | 1 |
| Gore, JC | 1 |
| Aquila, WJ | 1 |
| Simon, RP | 2 |
| Copeland, JR | 1 |
| Benowitz, NL | 1 |
| Jacob, P | 1 |
| Bronstein, J | 1 |
| Prichard, JW | 1 |
| Ogino, T | 1 |
| Avison, M | 1 |
| Alger, JR | 1 |
| Shulman, RG | 1 |
| Swan, JH | 1 |
| Meldrum, BS | 1 |
| Folbegrova, J | 1 |
| Siesjö, BK | 1 |
| Fripp, RR | 1 |
| Yagel, SK | 1 |
| Werner, JC | 1 |
| McGrath, G | 1 |
| Schuler, HG | 1 |
| Johansson, BB | 1 |
| Fredriksson, K | 1 |
25 other studies available for lactic acid and Status Epilepticus
| Article | Year |
|---|---|
Time dependency of CSF cell count, lactate and blood-CSF barrier dysfunction after epileptic seizures and status epilepticus.
Topics: Cell Count; Epilepsy; Humans; Lactic Acid; Seizures; Status Epilepticus | 2022 |
Glycolytic lactate production supports status epilepticus in experimental animals.
Topics: Animals; Glucose; Glycolysis; Humans; Lactic Acid; Mice; Pyruvates; Seizures; Status Epilepticus | 2023 |
Development and validation of a peripheral cell ratio and lactate score for differentiating status epilepticus from prolonged psychogenic nonepileptic seizures.
Topics: Humans; Lactic Acid; Leukocyte Count; Psychogenic Nonepileptic Seizures; Retrospective Studies; Stat | 2023 |
Amperometric bio-sensing of lactate and oxygen concurrently with local field potentials during status epilepticus.
Topics: 4-Aminopyridine; Animals; Biosensing Techniques; Brain; Epilepsy; Humans; Lactic Acid; Oxygen; Rats; | 2024 |
Microdialysis Findings in a Patient with New Onset Refractory Non-convulsive Status Epilepticus.
Topics: Anticonvulsants; Electroencephalography; Female; Frontal Lobe; Glucose; Glutamic Acid; Humans; Immun | 2020 |
Cerebrospinal fluid lactate concentrations in dogs with seizure disorders.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Humans; Lactic Acid; Seizures; Status Epilepticus | 2020 |
Effect of Training at Lactate Threshold Intensity on Maximal Time to Exhaustion, Depression and Anxiety Behaviour of Spontaneously Hypertensive Rats after Kainate-Induced Status Epilepticus.
Topics: Animals; Anxiety; Behavior, Animal; Comorbidity; Depression; Disease Models, Animal; Essential Hyper | 2017 |
Effect of epileptic seizures on the cerebrospinal fluid--A systematic retrospective analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Cell Count; Cerebrospinal Fluid; Epilepsy; Fem | 2015 |
Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.
Topics: Animals; Brain; Choline; Convulsants; Disease Models, Animal; Electrochemistry; Electron Transport C | 2015 |
Intravenous levetiracetam terminates refractory status epilepticus in two patients with migrating partial seizures in infancy.
Topics: Ammonia; Anticonvulsants; Blood Cell Count; Creatine; Drug Administration Schedule; Electroencephalo | 2009 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image | 2009 |
Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus.
Topics: Animals; Body Water; Brain Chemistry; Cerebral Cortex; Diffusion Magnetic Resonance Imaging; Electro | 2008 |
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis.
Topics: Case-Control Studies; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2007 |
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat.
Topics: Animals; Axons; Biomarkers; Brain Injuries; Cerebral Infarction; Immunoenzyme Techniques; Lactates; | 1993 |
MR spectroscopic imaging and diffusion-weighted MRI for early detection of kainate-induced status epilepticus in the rat.
Topics: Animals; Aspartic Acid; Blood Gas Analysis; Brain; Excitatory Amino Acid Agonists; Hydrogen-Ion Conc | 1996 |
Correlation between hypermetabolism and neuronal damage during status epilepticus induced by lithium and pilocarpine in immature and adult rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Glucose; Lactic Acid; Lithium; Male; Nerv | 1999 |
Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Denervation; Dose-Response Relationship, Drug; Ep | 2000 |
Respiratory chain deficiency in Alpers syndrome.
Topics: Atrophy; Biopsy, Needle; Cerebral Cortex; Child, Preschool; Consanguinity; Diagnosis, Differential; | 2001 |
Brain energy state and lactate metabolism during status epilepticus in the neonatal dog: in vivo 31P and 1H nuclear magnetic resonance study.
Topics: Adenine Nucleotides; Amino Acids; Animals; Animals, Newborn; Brain; Dogs; Energy Metabolism; Fluroth | 1991 |
Brain phenobarbital uptake during prolonged status epilepticus.
Topics: Animals; Bicuculline; Blood; Blood Pressure; Blood-Brain Barrier; Brain; Cerebrovascular Circulation | 1987 |
Combined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline-induced seizures in vivo.
Topics: Animals; Bicuculline; Blood Pressure; Electroencephalography; Female; Heart Rate; Hydrogen; Hydrogen | 1986 |
Hyperglycemia does not augment neuronal damage in experimental status epilepticus.
Topics: Animals; Brain; Glucose; Hyperglycemia; Lactates; Lactic Acid; Male; Neurons; Rats; Rats, Inbred Str | 1986 |
Metabolic alterations underlying the development of hypermetabolic necrosis in the substantia nigra in status epilepticus.
Topics: Adenosine Triphosphate; Animals; Glucose; Glycogen; Lactates; Lactic Acid; Necrosis; Periaqueductal | 1987 |
Cardiac dysfunction during status epilepticus in the neonatal pig.
Topics: Acid-Base Equilibrium; Animals; Animals, Newborn; Bicuculline; Blood Glucose; Blood Pressure; Cardia | 1985 |
Cerebral energy metabolism during bicuculline-induced status epilepticus in spontaneously hypertensive rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bicuculline; Brain; Cerebrovascular Circulat | 1985 |