lactic acid has been researched along with Squamous Cell Carcinoma of Head and Neck in 18 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Squamous Cell Carcinoma of Head and Neck: The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 5.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
| "Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive." | 1.91 | F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. ( Chen, G; Chen, L; Huang, X; Lei, H; Sun, J; Tang, Q; Wan, Q; Wo, K; Xie, M; Yin, Y; Yu, S; Zhang, J; Zheng, W, 2023) |
| "However, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear." | 1.91 | A novel tyrosine tRNA-derived fragment, tRF ( Cao, J; Chen, X; Guo, Y; Li, W; Liu, M; Liu, Y; Sun, Y; Tian, L; Wang, J; Xu, L; Yang, Z; Zhang, J; Zhao, B; Zhao, R, 2023) |
| "Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial malignancies, characterized by a low five-year survival rate primarily caused by invasion and metastasis." | 1.91 | Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. ( Huang, W; Jiang, M; Li, B; Lin, Y; Qi, Y, 2023) |
| "The glucose metabolism of oral squamous cell carcinoma (HSC-2 and HSC-3) and normal epithelial (HaCaT) cells cultured under normoxic (21% oxygen) or hypoxic (1% oxygen) conditions was measured using a pH-stat system under normoxic or hypoxic conditions." | 1.62 | Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions. ( Abiko, Y; Kobayashi, Y; Sasaki, K; Shinohara, Y; Takahashi, N; Washio, J, 2021) |
| "Furthermore, LDHA/PDHA1 changes in HNSCC cells resulted in a broad metabolic reprogramming while intracellular molecules including polyunsaturated fatty acids and nitrogen metabolism related metabolites underlie the malignant changes." | 1.51 | Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis. ( Chang, CW; Chen, HM; Chen, TY; Chen, YF; Chia, HY; Chou, CY; Chuang, LT; Hsieh, YT; Huang, JM; Huang, PC; Kuo, TY; Li, WC; Liu, CJ; Lo, JF, 2019) |
| "Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis." | 1.46 | Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. ( Chen, G; Jia, J; Li, HM; Liu, ZJ; Ren, JG; Wang, WM; Yang, JG; Yu, ZL; Zhang, W, 2017) |
| "Monitoring surgical removal of oral squamous cell carcinomas (OSCC) is being routinely performed through clinical and imaging follow-up." | 1.43 | Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase. ( Biegner, T; Calgéer, B; Grimm, M; Hoefert, S; Kraut, W; Krimmel, M; Munz, A; Reinert, S; Teriete, P, 2016) |
| "In head and neck squamous cell carcinoma (HNSCC) aerobic glycolysis is the key feature for energy supply of the tumor." | 1.39 | Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. ( Himpe, B; Nitsch, S; Pries, R; Schroeder, U; Vonthein, R; Wollenberg, B, 2013) |
| "A high lactate content in malignant head and neck cancer (Head and neck squamous cell carcinomas, HNSCC) is associated with a higher risk of metastatic spread and lower overall patient survival." | 1.37 | Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue. ( Kunkel, M; Mueller-Klieser, W; Reichert, TE; Wagner, W; Walenta, S; Ziebart, T, 2011) |
| "A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 1.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| Authors | Studies |
|---|---|
| Shinohara, Y | 1 |
| Washio, J | 1 |
| Kobayashi, Y | 1 |
| Abiko, Y | 1 |
| Sasaki, K | 1 |
| Takahashi, N | 1 |
| Nakashima, C | 1 |
| Fujiwara-Tani, R | 1 |
| Mori, S | 1 |
| Kishi, S | 1 |
| Ohmori, H | 1 |
| Fujii, K | 1 |
| Mori, T | 1 |
| Miyagawa, Y | 1 |
| Yamamoto, K | 1 |
| Kirita, T | 1 |
| Luo, Y | 1 |
| Kuniyasu, H | 1 |
| Sun, J | 1 |
| Tang, Q | 1 |
| Yu, S | 1 |
| Xie, M | 1 |
| Zheng, W | 1 |
| Chen, G | 2 |
| Yin, Y | 1 |
| Huang, X | 1 |
| Wo, K | 1 |
| Lei, H | 1 |
| Zhang, J | 2 |
| Wan, Q | 1 |
| Chen, L | 1 |
| Zhao, R | 1 |
| Yang, Z | 1 |
| Zhao, B | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Chen, X | 1 |
| Cao, J | 1 |
| Guo, Y | 1 |
| Xu, L | 1 |
| Wang, J | 1 |
| Sun, Y | 1 |
| Liu, M | 1 |
| Tian, L | 1 |
| Lin, Y | 1 |
| Qi, Y | 1 |
| Jiang, M | 1 |
| Huang, W | 1 |
| Li, B | 1 |
| Ohashi, T | 2 |
| Terasawa, K | 1 |
| Aoki, M | 2 |
| Akazawa, T | 2 |
| Shibata, H | 1 |
| Kuze, B | 2 |
| Asano, T | 1 |
| Kato, H | 1 |
| Miyazaki, T | 1 |
| Matsuo, M | 1 |
| Inoue, N | 2 |
| Ito, Y | 2 |
| Chang, H | 1 |
| Xu, Q | 2 |
| Li, J | 2 |
| Li, M | 1 |
| Zhang, Z | 1 |
| Ma, H | 1 |
| Yang, X | 1 |
| Tomita, H | 1 |
| Sato, K | 1 |
| Mizuta, K | 1 |
| Hara, A | 1 |
| Nagaoka, H | 1 |
| Chen, TY | 1 |
| Hsieh, YT | 1 |
| Huang, JM | 1 |
| Liu, CJ | 1 |
| Chuang, LT | 1 |
| Huang, PC | 1 |
| Kuo, TY | 1 |
| Chia, HY | 1 |
| Chou, CY | 1 |
| Chang, CW | 1 |
| Chen, YF | 1 |
| Chen, HM | 1 |
| Lo, JF | 1 |
| Li, WC | 1 |
| Schroeder, U | 1 |
| Himpe, B | 1 |
| Pries, R | 1 |
| Vonthein, R | 1 |
| Nitsch, S | 1 |
| Wollenberg, B | 1 |
| Sandulache, VC | 3 |
| Chen, Y | 2 |
| Skinner, HD | 2 |
| Lu, T | 1 |
| Feng, L | 2 |
| Court, LE | 1 |
| Myers, JN | 3 |
| Meyn, RE | 2 |
| Fuller, CD | 2 |
| Bankson, JA | 2 |
| Lai, SY | 2 |
| Grimm, M | 1 |
| Krimmel, M | 1 |
| Hoefert, S | 1 |
| Kraut, W | 1 |
| Calgéer, B | 1 |
| Biegner, T | 1 |
| Teriete, P | 1 |
| Munz, A | 1 |
| Reinert, S | 1 |
| Masloub, SM | 1 |
| Elmalahy, MH | 1 |
| Sabry, D | 1 |
| Mohamed, WS | 1 |
| Ahmed, SH | 1 |
| Zhang, Q | 1 |
| Ishida, Y | 1 |
| Hajjar, S | 1 |
| Tang, X | 1 |
| Shi, H | 1 |
| Dang, CV | 1 |
| Le, AD | 1 |
| Li, HM | 1 |
| Yang, JG | 1 |
| Liu, ZJ | 1 |
| Wang, WM | 1 |
| Yu, ZL | 1 |
| Ren, JG | 1 |
| Zhang, W | 1 |
| Jia, J | 1 |
| William, WN | 1 |
| Mijiti, A | 1 |
| Konopleva, MY | 1 |
| Ziebart, T | 1 |
| Walenta, S | 1 |
| Kunkel, M | 1 |
| Reichert, TE | 1 |
| Wagner, W | 1 |
| Mueller-Klieser, W | 1 |
| Ow, TJ | 1 |
| Pickering, CR | 1 |
| Frederick, MJ | 1 |
| Zhou, G | 1 |
| Fokt, I | 1 |
| Davis-Malesevich, M | 1 |
| Priebe, W | 1 |
18 other studies available for lactic acid and Squamous Cell Carcinoma of Head and Neck
| Article | Year |
|---|---|
Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions.
Topics: Adenosine Triphosphate; Cell Hypoxia; Cell Line, Tumor; Glucose; Humans; Lactic Acid; Mouth Neoplasm | 2021 |
An Axis between the Long Non-Coding RNA
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Flavin-Adenine Dinucleotide | 2022 |
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.
Topics: Carcinoma, Squamous Cell; Glucose Transporter Type 1; GTPase-Activating Proteins; Head and Neck Neop | 2023 |
A novel tyrosine tRNA-derived fragment, tRF
Topics: Carcinogenesis; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Lactate Deh | 2023 |
Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplas | 2023 |
The importance of FDG-PET/CT parameters for the assessment of the immune status in advanced HNSCC.
Topics: Aged; Aged, 80 and over; Antigens, CD; Antigens, Differentiation, Myelomonocytic; C-Reactive Protein | 2020 |
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Topics: Base Sequence; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Galectins; Gen | 2021 |
M2-like macrophage polarization in high lactic acid-producing head and neck cancer.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers, Tumor; Carcinoma, Squamous Cell | 2017 |
Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Heterografts; Humans; L-L | 2019 |
Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer.
Topics: Aged; Carcinoma, Squamous Cell; Circadian Rhythm; Diet, Ketogenic; Female; Glucose; Head and Neck Ne | 2013 |
Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model.
Topics: Animals; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Line, Tu | 2015 |
Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase.
Topics: Biomarkers, Tumor; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Immuno | 2016 |
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug | 2016 |
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Anti | 2017 |
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2017 |
Metabolic interrogation as a tool to optimize chemotherapeutic regimens.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug | 2017 |
Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Carcin | 2011 |
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol | 2011 |