lactic acid has been researched along with Spinal Cord Injuries in 111 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate the absorption curve and acute effects of caffeine at rest in individuals with no spinal cord injury (SCI), paraplegia (PARA), and tetraplegia (TETRA)." | 3.85 | Spinal Cord Injury Level Influences Acute Plasma Caffeine Responses. ( Cordery, P; Goosey-Tolfrey, VL; Graham-Paulson, TS; Paulson, TA; Perret, C; Tolfrey, K, 2017) |
| "Detecting spinal cord ischemia early during replacement of the thoracoabdominal aorta remains a challenge." | 2.73 | The role of cerebrospinal fluid S100 and lactate to predict clinically evident spinal cord ischaemia in thoraco-abdominal aortic surgery. ( Hagl, C; Haverich, A; Hoy, L; Khaladj, N; Lichtinghagen, R; Pichlmaier, M; Teebken, OE; Tschan, C; Weissenborn, K; Wilhelmi, MH, 2008) |
| "In order to examine the influence of autonomic dysreflexia on plasma catecholamines, cardiocirculatory and metabolic parameters, 6 spinal cord injured wheelchair athletes with high-level lesions underwent wheelchair ergometry without (ST1) and with (ST2) autonomic dysreflexia." | 2.70 | Catecholamines response of high performance wheelchair athletes at rest and during exercise with autonomic dysreflexia. ( Brunner, C; Eisenbarth, I; Huonker, M; Keul, J; König, D; Lehmann, M; Sauerwein, H; Schmid, A; Schmidt-Trucksäss, A; Storch, MJ, 2001) |
| " We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination with biomaterials." | 1.42 | A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material. ( Feng, L; Guo, W; Jiang, Z; Li, L; Li, X; Tian, W; Xie, L; Xiong, J; Yang, B; Yang, C; Yu, M, 2015) |
| " Importantly, we demonstrate that this new hydrogel is both biocompatible in the intrathecal space based on immunohistochemistry of the host tissue response and safe based on behavioral analysis of locomotor function." | 1.42 | Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord. ( Führmann, T; Obermeyer, J; Shoichet, MS; Tator, CH, 2015) |
| "Animals with a lateral demyelination lesion showed a reduction in CD68+ macrophages when treated with hirudin-loaded PLGA/F-127 gels compared to control and heparin-treated animals." | 1.40 | Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion. ( Horner, PJ; Kim, TH; Mount, CW; Pun, SH; Sellers, DL, 2014) |
| " Thus, long-term administration of Shh is a potential valuable therapeutic intervention for SCI." | 1.38 | The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice. ( Banerjee, A; Charniga, C; Goderie, SK; Gooch, MR; Gracey, KD; Kane, RS; Lederman, P; Lowry, N; Punyani, S; Silver, J; Stern, JH; Temple, S, 2012) |
| " With the ability to control the release of drug dosage locally within the spinal cord, drug-eluting microfibrous patches demonstrate the importance of appropriate local release-kinetics of rolipram, proving their usefulness as a therapeutic platform for the study and repair of SCI." | 1.38 | Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. ( Beattie, MS; Bresnahan, JC; Downing, TL; Farmer, DL; Lee, AL; Li, S; Nout, Y; Wang, A; Yan, ZQ, 2012) |
| "Using a complete spinal cord transection model, the present study employed a combinatorial strategy comprising rat bone marrow stem cells (rBMSCs) and polymer scaffolds to regenerate neurological function after spinal cord injury (SCI) of different lengths." | 1.37 | Regeneration of completely transected spinal cord using scaffold of poly(D,L-lactide-co-glycolide)/small intestinal submucosa seeded with rat bone marrow stem cells. ( Ahn, HH; Kang, KN; Khang, G; Kim, DY; Kim, JH; Kim, MS; Lee, B; Lee, BN; Lee, HB; Lee, JY; Min, BH; Park, SR, 2011) |
| " Our results showed that the preservation of PLGA-FBSA was observed in the injured spinal cord at 24h, and PLGA-FBSA nanoparticles were well absorbed by neurons and glia, indicating that PLGA as a considerable nanovehicle for the delivery of neuroprotective polypeptide into injured spinal cord." | 1.35 | Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. ( Huang, HY; Lin, HI; Lo, LW; Tzeng, SF; Wang, YC; Wu, YT; Yang, CS, 2008) |
| "Similarly, a trend for less kyphosis was evident in the fixed group (7." | 1.35 | Rigid fixation of the spinal column improves scaffold alignment and prevents scoliosis in the transected rat spinal cord. ( Ameenuddin, S; Chen, B; Currier, BL; Knight, A; Macura, SI; Mishra, PK; Rooney, GE; Schiefer, TK; Spinner, RJ; Vaishya, S; Windebank, AJ; Yaszemski, MJ, 2008) |
| "Before spinal cord trauma, there were not any significant differences in glucose, lactate and magnesium levels between group I and II whereas, after spinal cord trauma in group II, the significant suppression in elevation of lactate and glucose depletion (p<0." | 1.35 | The efficacy of intratechal administration of a very low dose potirelin after acute spinal cord injury. ( Ahmet, AK; Cengiz, SL; Topcu, C; Ustun, ME, 2008) |
| "To investigate the glucose uptake in spastic paralysed SCI legs compared to able-bodied." | 1.35 | Higher glucose uptake in paralysed spastic leg. ( Bennegard, GM; Karlsson, AK, 2008) |
| "A group of people with incomplete spinal cord injuries (SCI) were evaluated and compared with able-bodied individuals during several walking conditions." | 1.31 | Functional community ambulation requirements in incomplete spinal cord injured subjects. ( Barbeau, H; Lajoie, Y; Lapointe, R; Serresse, O, 2001) |
| "In patients with tetraplegia and high paraplegia, arm cranking revealed deficient sympathetic regulation of cardiovascular functions resulting in hypotension." | 1.27 | Cardiorespiratory capacity in tetra- and paraplegia shortly after injury. ( Hjeltnes, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.90) | 18.7374 |
| 1990's | 9 (8.11) | 18.2507 |
| 2000's | 33 (29.73) | 29.6817 |
| 2010's | 64 (57.66) | 24.3611 |
| 2020's | 4 (3.60) | 2.80 |
| Authors | Studies |
|---|---|
| Hutchinson, MJ | 1 |
| Goosey-Tolfrey, VL | 5 |
| Laliwala, A | 1 |
| Daverey, A | 1 |
| Agrawal, SK | 1 |
| Dash, AK | 1 |
| Antunes, D | 1 |
| Borszcz, FK | 1 |
| Nascimento, EMF | 1 |
| Cavalheiro, GP | 1 |
| Fischer, G | 1 |
| Brickley, G | 1 |
| de Lucas, RD | 1 |
| Gallagher, MJ | 1 |
| López, DM | 1 |
| Sheen, HV | 1 |
| Hogg, FRA | 1 |
| Zoumprouli, A | 1 |
| Papadopoulos, MC | 1 |
| Saadoun, S | 1 |
| Nawrotek, K | 1 |
| Marqueste, T | 2 |
| Modrzejewska, Z | 1 |
| Zarzycki, R | 1 |
| Rusak, A | 1 |
| Decherchi, P | 2 |
| Yang, EZ | 1 |
| Zhang, GW | 1 |
| Xu, JG | 1 |
| Chen, S | 1 |
| Wang, H | 4 |
| Cao, LL | 1 |
| Liang, B | 1 |
| Lian, XF | 1 |
| Lundgaard, E | 1 |
| Wouda, MF | 1 |
| Strøm, V | 1 |
| Santhosh, KT | 1 |
| Alizadeh, A | 1 |
| Karimi-Abdolrezaee, S | 1 |
| Sun, F | 1 |
| Shi, T | 1 |
| Zhou, T | 1 |
| Dong, D | 1 |
| Xie, J | 1 |
| Wang, R | 1 |
| An, X | 1 |
| Chen, M | 1 |
| Cai, J | 2 |
| Xia, L | 2 |
| Wan, H | 3 |
| Hao, SY | 1 |
| Li, DZ | 2 |
| Chen, G | 2 |
| Gao, CC | 1 |
| Li, JH | 3 |
| Yang, F | 3 |
| Wang, SG | 3 |
| Liu, S | 1 |
| Zamani, F | 1 |
| Amani-Tehran, M | 1 |
| Latifi, M | 1 |
| Shokrgozar, MA | 1 |
| Zaminy, A | 1 |
| Okon, EB | 1 |
| Streijger, F | 1 |
| Lee, JH | 1 |
| Anderson, LM | 1 |
| Russell, AK | 1 |
| Kwon, BK | 1 |
| Du, BL | 2 |
| Zeng, CG | 2 |
| Zhang, W | 2 |
| Quan, DP | 2 |
| Ling, EA | 1 |
| Zeng, YS | 2 |
| Thomas, AM | 1 |
| Shea, LD | 2 |
| West, CR | 2 |
| Campbell, IG | 3 |
| Mason, BS | 1 |
| Romer, LM | 2 |
| Ansorena, E | 1 |
| De Berdt, P | 1 |
| Ucakar, B | 1 |
| Simón-Yarza, T | 1 |
| Jacobs, D | 1 |
| Schakman, O | 1 |
| Jankovski, A | 1 |
| Deumens, R | 1 |
| Blanco-Prieto, MJ | 1 |
| Préat, V | 1 |
| des Rieux, A | 1 |
| Binan, L | 1 |
| Tendey, C | 1 |
| De Crescenzo, G | 1 |
| El Ayoubi, R | 1 |
| Ajji, A | 1 |
| Jolicoeur, M | 1 |
| Zhang, Y | 2 |
| Gu, Z | 1 |
| Qiu, G | 1 |
| Song, Y | 1 |
| Grahn, PJ | 1 |
| Vaishya, S | 2 |
| Knight, AM | 4 |
| Chen, BK | 2 |
| Schmeichel, AM | 1 |
| Currier, BL | 4 |
| Spinner, RJ | 4 |
| Yaszemski, MJ | 6 |
| Windebank, AJ | 6 |
| Zangrillo, A | 2 |
| Buratti, L | 2 |
| Carozzo, A | 2 |
| Casiraghi, G | 2 |
| Landoni, G | 2 |
| Lembo, R | 1 |
| Pasin, L | 1 |
| Marone, EM | 1 |
| Melissano, G | 1 |
| Chiesa, R | 1 |
| Ren, H | 1 |
| Han, M | 1 |
| Zhou, J | 1 |
| Zheng, ZF | 1 |
| Lu, P | 1 |
| Wang, JJ | 1 |
| Wang, JQ | 1 |
| Mao, QJ | 1 |
| Gao, JQ | 1 |
| Ouyang, HW | 1 |
| Pertici, V | 1 |
| Trimaille, T | 1 |
| Laurin, J | 1 |
| Felix, MS | 1 |
| Pettmann, B | 1 |
| Chauvin, JP | 1 |
| Gigmes, D | 1 |
| Kim, M | 1 |
| Park, SR | 2 |
| Choi, BH | 1 |
| Sellers, DL | 1 |
| Kim, TH | 1 |
| Mount, CW | 1 |
| Pun, SH | 1 |
| Horner, PJ | 1 |
| Li, X | 1 |
| Yang, C | 1 |
| Li, L | 1 |
| Xiong, J | 1 |
| Xie, L | 1 |
| Yang, B | 1 |
| Yu, M | 1 |
| Feng, L | 1 |
| Jiang, Z | 1 |
| Guo, W | 1 |
| Tian, W | 1 |
| Führmann, T | 1 |
| Obermeyer, J | 1 |
| Tator, CH | 3 |
| Shoichet, MS | 4 |
| Zeller, S | 1 |
| Abel, T | 2 |
| Rojas-Vega, S | 1 |
| Foitschik, T | 1 |
| Strueder, HK | 1 |
| Wilems, TS | 1 |
| Sakiyama-Elbert, SE | 1 |
| Sánchez-Pay, A | 1 |
| Torres-Luque, G | 1 |
| Sanz-Rivas, D | 1 |
| Wen, Y | 2 |
| Yu, S | 2 |
| Wu, Y | 1 |
| Ju, R | 1 |
| Liu, Y | 2 |
| Wang, Y | 4 |
| Xu, Q | 2 |
| McCreedy, DA | 1 |
| Margul, DJ | 1 |
| Seidlits, SK | 1 |
| Antane, JT | 1 |
| Thomas, RJ | 1 |
| Sissman, GM | 1 |
| Boehler, RM | 1 |
| Smith, DR | 1 |
| Goldsmith, SW | 1 |
| Kukushliev, TV | 1 |
| Lamano, JB | 1 |
| Vedia, BH | 1 |
| He, T | 1 |
| Gwak, SJ | 1 |
| Yun, Y | 1 |
| Yoon, DH | 1 |
| Kim, KN | 1 |
| Ha, Y | 1 |
| Hesari, Z | 1 |
| Soleimani, M | 1 |
| Atyabi, F | 1 |
| Sharifdini, M | 1 |
| Nadri, S | 1 |
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| Dinarvand, R | 1 |
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| Chang, J | 1 |
| Feng, SQ | 1 |
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| Kim, YH | 2 |
| Kim, JW | 1 |
| Ha, KY | 1 |
| Yao, S | 1 |
| Graham-Paulson, TS | 1 |
| Paulson, TA | 1 |
| Perret, C | 3 |
| Tolfrey, K | 1 |
| Cordery, P | 1 |
| Astorino, TA | 1 |
| Thum, JS | 1 |
| Ropper, AE | 1 |
| Thakor, DK | 1 |
| Han, I | 1 |
| Yu, D | 2 |
| Zeng, X | 1 |
| Anderson, JE | 1 |
| Aljuboori, Z | 1 |
| Kim, SW | 1 |
| Sidman, RL | 1 |
| Zafonte, RD | 1 |
| Teng, YD | 2 |
| Bin, S | 1 |
| Zhou, N | 1 |
| Pan, J | 1 |
| Pan, F | 1 |
| Wu, XF | 1 |
| Zhou, ZH | 1 |
| Platen, P | 1 |
| Rojas Vega, S | 1 |
| Schneider, S | 1 |
| Strüder, HK | 1 |
| Wang, YC | 1 |
| Wu, YT | 1 |
| Huang, HY | 1 |
| Lin, HI | 1 |
| Lo, LW | 1 |
| Tzeng, SF | 1 |
| Yang, CS | 1 |
| Rooney, GE | 3 |
| Ameenuddin, S | 2 |
| Schiefer, TK | 1 |
| Knight, A | 2 |
| Chen, B | 4 |
| Mishra, PK | 1 |
| Macura, SI | 1 |
| Jung, W | 1 |
| Yamasaki, M | 1 |
| Cengiz, SL | 2 |
| Ustun, ME | 2 |
| Topcu, C | 1 |
| Ahmet, AK | 1 |
| Rauch, MF | 1 |
| Hynes, SR | 1 |
| Bertram, J | 1 |
| Redmond, A | 1 |
| Robinson, R | 1 |
| Williams, C | 2 |
| Xu, H | 1 |
| Madri, JA | 1 |
| Lavik, EB | 1 |
| Olson, HE | 1 |
| Gross, L | 2 |
| Nesbitt, JJ | 2 |
| Galvin, KE | 1 |
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| Fukuoka, Y | 2 |
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| de Ruiter, GC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Potential Adverse Effect of Pressure After Spinal Cord Injury[NCT02721615] | 100 participants (Anticipated) | Interventional | 2010-09-30 | Recruiting | |||
| Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery[NCT03280849] | 1 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Sprint Interval Training During Rehabilitation After Spinal Cord Injury[NCT03709095] | 20 participants (Actual) | Interventional | 2017-06-01 | Completed | |||
| Effect of the Combined (Aerobic/Resisted) and Interval Physical Training on Oxygen Uptake and Heart Rate On-kinetics Responses in Patients With Moderate to Very Severe COPD: Double-blind, Randomized, Controlled Trial[NCT01529489] | 40 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| Effects of Stepping Training With External Feedback on Walking and Functional Ability in Ambulatory Patients With Spinal Cord Injury[NCT03254797] | 44 participants (Actual) | Interventional | 2017-08-20 | Completed | |||
| Immediate Effects of Stepping Training With or Without External Feedback on Walking and Functional Ability in Ambulatory Patients With Spinal Cord Injury[NCT03875066] | 30 participants (Actual) | Interventional | 2017-04-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Spinal Cord Injuries
| Article | Year |
|---|---|
Biomaterial scaffolds used for the regeneration of spinal cord injury (SCI).
Topics: Alginates; Animals; Apoptosis; Axons; Biocompatible Materials; Chitosan; Collagen; Disease Models, A | 2014 |
11 trials available for lactic acid and Spinal Cord Injuries
| Article | Year |
|---|---|
Effect of pre-exercise carbohydrate ingestion on substrate consumption in persons with spinal cord injury.
Topics: Activities of Daily Living; Adult; Analysis of Variance; Energy Metabolism; Exercise; Fatty Acids, N | 2009 |
Comparison of peak cardiopulmonary performance parameters during robotics-assisted treadmill exercise and arm crank ergometry in incomplete spinal cord injury.
Topics: Adult; Exercise Test; Female; Heart Rate; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; Oxyg | 2010 |
The metabolic cost of passive walking during robotics-assisted treadmill exercise.
Topics: Adult; Energy Metabolism; Exercise Test; Female; Heart Rate; Hemodynamics; Humans; Lactic Acid; Male | 2011 |
Can the efficacy of electrically stimulated pedaling using a commercially available ergometer BE improved by minimizing the muscle stress-time integral?
Topics: Adolescent; Adult; Analysis of Variance; Bicycling; Electric Stimulation Therapy; Ergometry; Female; | 2012 |
Relation between muscular strength and cardiorespiratory fitness in people with thoracic-level paraplegia.
Topics: Adult; Cardiovascular Physiological Phenomena; Ergometry; Humans; Lactic Acid; Male; Middle Aged; Mu | 2005 |
Influence of creatine supplementation on 800 m wheelchair performance: a pilot study.
Topics: Adult; Analysis of Variance; Body Weight; Creatine; Cross-Over Studies; Dietary Supplements; Double- | 2006 |
Effects of graduated compression stockings on cardiovascular and metabolic responses to exercise and exercise recovery in persons with spinal cord injury.
Topics: Adult; Blood Pressure; Cross-Over Studies; Exercise; Heart Rate; Humans; Lactic Acid; Male; Middle A | 2007 |
The role of cerebrospinal fluid S100 and lactate to predict clinically evident spinal cord ischaemia in thoraco-abdominal aortic surgery.
Topics: Adult; Aged; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Biomarkers; Blood Vessel Prosthesis | 2008 |
Physiologic responses during functional electrical stimulation leg cycling and hybrid exercise in spinal cord injured subjects.
Topics: Adult; Arm; Combined Modality Therapy; Electric Stimulation Therapy; Exercise Test; Exercise Therapy | 1997 |
Catecholamines response of high performance wheelchair athletes at rest and during exercise with autonomic dysreflexia.
Topics: Adult; Autonomic Dysreflexia; Catecholamines; Disabled Persons; Exercise; Heart Rate; Humans; Hypert | 2001 |
Physiological responses to two wheelchair-racing exercise protocols.
Topics: Adult; Anaerobic Threshold; Blood Pressure; Blood Volume; Exercise; Exercise Therapy; Humans; Lactic | 2001 |
99 other studies available for lactic acid and Spinal Cord Injuries
| Article | Year |
|---|---|
Rethinking aerobic exercise intensity prescription in adults with spinal cord injury: time to end the use of "moderate to vigorous" intensity?
Topics: Adult; Cohort Studies; Exercise; Exercise Test; Heart Rate; Humans; Lactic Acid; Oxygen Consumption; | 2022 |
Alpha Tocopherol Loaded Polymeric Nanoparticles: Preparation, Characterizations, and In Vitro Assessments Against Oxidative Stress in Spinal Cord Injury Treatment.
Topics: alpha-Tocopherol; Drug Carriers; Humans; Hydrogen Peroxide; Lactic Acid; Nanoparticles; Oxidative St | 2022 |
Physiological and Perceptual Responses in Spinal Cord Injury Handcyclists During an Endurance Interval Training: The Role of Critical Speed.
Topics: Exercise; Exercise Test; Humans; Lactic Acid; Oxygen; Spinal Cord Injuries | 2022 |
Heterogeneous effect of increasing spinal cord perfusion pressure on sensory evoked potentials recorded from acutely injured human spinal cord.
Topics: Adult; Blood Pressure; Catheterization; Cerebrospinal Fluid Pressure; Electric Stimulation Therapy; | 2020 |
Thermogelling chitosan lactate hydrogel improves functional recovery after a C2 spinal cord hemisection in rat.
Topics: Animals; Cell Line; Chitosan; Hydrogels; Lactic Acid; Male; Mice; Rats; Rats, Sprague-Dawley; Spinal | 2017 |
Multichannel polymer scaffold seeded with activated Schwann cells and bone mesenchymal stem cells improves axonal regeneration and functional recovery after rat spinal cord injury.
Topics: Animals; Axons; Cell Differentiation; Female; Lactic Acid; Mesenchymal Stem Cell Transplantation; Ne | 2017 |
A comparative study of two protocols for treadmill walking exercise testing in ambulating subjects with incomplete spinal cord injury.
Topics: Adolescent; Adult; Aged; Blood Pressure; Chronic Disease; Exercise Test; Female; Heart Rate; Humans; | 2017 |
Design and optimization of PLGA microparticles for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury.
Topics: Animals; Cell Differentiation; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; D | 2017 |
3D Poly(Lactic-co-glycolic acid) Scaffolds for Treating Spinal Cord Injury.
Topics: Animals; Equipment Design; Equipment Failure Analysis; Female; Guided Tissue Regeneration; Lactic Ac | 2017 |
Co-transplantation of neural stem cells and Schwann cells within poly (L-lactic-co-glycolic acid) scaffolds facilitates axonal regeneration in hemisected rat spinal cord.
Topics: Animals; Axons; Cells, Cultured; Electrophysiology; Female; Fluorescent Antibody Technique; Lactic A | 2013 |
Promotion of spinal cord axon regeneration by 3D nanofibrous core-sheath scaffolds.
Topics: Animals; Axons; Lactic Acid; Male; Nanofibers; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid | 2014 |
Intraparenchymal microdialysis after acute spinal cord injury reveals differential metabolic responses to contusive versus compressive mechanisms of injury.
Topics: Animals; Blood Pressure; Energy Metabolism; Female; Glucose; Heart Rate; Ischemia; Lactic Acid; Micr | 2013 |
A comparative study of gelatin sponge scaffolds and PLGA scaffolds transplanted to completely transected spinal cord of rat.
Topics: Acid Sensing Ion Channels; Animals; Cell Survival; Female; Gelatin; Lactic Acid; Neurons; Polyglycol | 2014 |
Polysaccharide-modified scaffolds for controlled lentivirus delivery in vitro and after spinal cord injury.
Topics: Animals; Chitosan; Female; Gene Transfer Techniques; Genetic Therapy; HEK293 Cells; Heparin; Humans; | 2013 |
Effects of abdominal binding on field-based exercise responses in Paralympic athletes with cervical spinal cord injury.
Topics: Abdomen; Acceleration; Adult; Cervical Vertebrae; Compression Bandages; Exercise; Exercise Test; Fem | 2014 |
Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury.
Topics: Alginates; Animals; Disease Models, Animal; Female; Gait; Glial Cell Line-Derived Neurotrophic Facto | 2013 |
Differentiation of neuronal stem cells into motor neurons using electrospun poly-L-lactic acid/gelatin scaffold.
Topics: Cell Differentiation; Cell Survival; Cells, Cultured; Gelatin; Humans; Lactic Acid; Microscopy, Elec | 2014 |
Combination of chondroitinase ABC, glial cell line-derived neurotrophic factor and Nogo A antibody delayed-release microspheres promotes the functional recovery of spinal cord injury.
Topics: Animals; Antibodies; Chondroitin ABC Lyase; Delayed-Action Preparations; Disease Models, Animal; Dru | 2013 |
Implantation of cauda equina nerve roots through a biodegradable scaffold at the conus medullaris in rat.
Topics: Animals; Biocompatible Materials; Cauda Equina; Lactic Acid; Nerve Regeneration; Pilot Projects; Pol | 2014 |
Intrathecal lactate as a predictor of early- but not late-onset spinal cord injury in thoracoabdominal aneurysmectomy.
Topics: Aged; Aortic Aneurysm, Thoracic; Critical Care; Fatal Outcome; Female; Humans; Lactic Acid; Male; Mi | 2014 |
Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles.
Topics: Animals; Astrocytes; Behavior, Animal; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Dru | 2014 |
Repair of the injured spinal cord by implantation of a synthetic degradable block copolymer in rat.
Topics: Animals; Lactic Acid; Male; Motor Activity; Neurites; Polyesters; Polyhydroxyethyl Methacrylate; Pol | 2014 |
Effect of abdominal binding on respiratory mechanics during exercise in athletes with cervical spinal cord injury.
Topics: Abdomen; Adult; Athletes; Cervical Cord; Exercise; Exercise Test; Exercise Tolerance; Functional Res | 2014 |
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.
Topics: Animals; Antithrombins; Delayed-Action Preparations; Demyelinating Diseases; Fibrinolytic Agents; He | 2014 |
A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material.
Topics: Adolescent; Adult; Animals; Biocompatible Materials; Cells, Cultured; Dental Sac; Female; Humans; La | 2015 |
Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord.
Topics: Animals; Biocompatible Materials; Brain-Derived Neurotrophic Factor; Click Chemistry; Cross-Linking | 2015 |
Brain-derived neurotrophic factor concentrations in tetraplegic athletes.
Topics: Adult; Brain-Derived Neurotrophic Factor; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Exercis | 2015 |
Sustained dual drug delivery of anti-inhibitory molecules for treatment of spinal cord injury.
Topics: Animals; Chickens; Chondroitin ABC Lyase; Delayed-Action Preparations; Drug Delivery Systems; Female | 2015 |
Match activity and physiological load in wheelchair tennis players: a pilot study.
Topics: Adult; Athletic Performance; Disabled Persons; Heart Rate; Humans; Lactic Acid; Male; Middle Aged; P | 2016 |
Spinal cord injury repair by implantation of structured hyaluronic acid scaffold with PLGA microspheres in the rat.
Topics: Animals; Female; Hyaluronic Acid; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Poly | 2016 |
Semi-automated counting of axon regeneration in poly(lactide co-glycolide) spinal cord bridges.
Topics: Analysis of Variance; Animals; Axons; Biocompatible Materials; Electronic Data Processing; Female; L | 2016 |
Therapeutic Use of 3β-[N-(N',N'-Dimethylaminoethane) Carbamoyl] Cholesterol-Modified PLGA Nanospheres as Gene Delivery Vehicles for Spinal Cord Injury.
Topics: Animals; Biological Transport; Cholesterol; Gene Expression; Gene Transfer Techniques; Genetic Thera | 2016 |
A hybrid microfluidic system for regulation of neural differentiation in induced pluripotent stem cells.
Topics: Animals; Behavior, Animal; Cell Differentiation; Cell Survival; Female; Gene Expression Regulation; | 2016 |
The effect from maximal bench press strength training on work economy during wheelchair propulsion in men with spinal cord injury.
Topics: Adult; Case-Control Studies; Exercise Therapy; Humans; Lactic Acid; Male; Middle Aged; Oxygen Consum | 2016 |
New approach to treating spinal cord injury using PEG-TAT-modified, cyclosporine-A-loaded PLGA/polymeric liposomes.
Topics: Animals; Cyclosporine; Drug Carriers; Drug Liberation; Female; GAP-43 Protein; Gene Expression; Gene | 2017 |
Transplantation of Mesenchymal Stem Cells for Acute Spinal Cord Injury in Rats: Comparative Study between Intralesional Injection and Scaffold Based Transplantation.
Topics: Animals; Bone Marrow Cells; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cells, Cultured | 2016 |
Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats.
Topics: Animals; Anisotropy; Axons; Ephrin-A3; Female; Lactic Acid; Magnetic Resonance Imaging; MicroRNAs; M | 2016 |
Spinal Cord Injury Level Influences Acute Plasma Caffeine Responses.
Topics: Absorption, Physiological; Blood Glucose; Caffeine; Epinephrine; Fatty Acids, Nonesterified; Humans; | 2017 |
Within-session responses to high-intensity interval training in spinal cord injury.
Topics: Adult; Exercise; Female; Heart Rate; High-Intensity Interval Training; Humans; Lactic Acid; Male; Mi | 2018 |
Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantation.
Topics: Adult; Animals; Coculture Techniques; Female; Ganglia, Spinal; Hindlimb; Humans; Lactic Acid; Lipopo | 2017 |
Nano-carrier mediated co-delivery of methyl prednisolone and minocycline for improved post-traumatic spinal cord injury conditions in rats.
Topics: Albumins; Animals; Anti-Inflammatory Agents; Astrocytes; Behavior, Animal; Cell Survival; Chitosan; | 2017 |
Energy expenditure in ball games for wheelchair users.
Topics: Adult; Athletic Performance; Basal Metabolism; Breathing Exercises; Cardiovascular Diseases; Energy | 2008 |
Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury.
Topics: Absorbable Implants; Animals; Astrocytes; Cells, Cultured; Contusions; Drug Administration Routes; F | 2008 |
Rigid fixation of the spinal column improves scaffold alignment and prevents scoliosis in the transected rat spinal cord.
Topics: Animals; Barium Sulfate; Contrast Media; Disease Models, Animal; Female; Glycolates; Imaging, Three- | 2008 |
The efficacy of intratechal administration of a very low dose potirelin after acute spinal cord injury.
Topics: Animals; Blood Pressure; Glucose; Heart Rate; Injections, Spinal; Lactic Acid; Magnesium; Male; Rabb | 2008 |
Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood-spinal cord barrier.
Topics: Absorbable Implants; Animals; Blood Vessels; Blood-Brain Barrier; Cells, Cultured; Coculture Techniq | 2009 |
Neural stem cell- and Schwann cell-loaded biodegradable polymer scaffolds support axonal regeneration in the transected spinal cord.
Topics: Animals; Animals, Newborn; Axons; Biocompatible Materials; Cell Shape; Cell Survival; Cells, Culture | 2009 |
Manufacture of PLGA multiple-channel conduits with precise hierarchical pore architectures and in vitro/vivo evaluation for spinal cord injury.
Topics: Animals; Biocompatible Materials; Cell Proliferation; Cell Shape; Lactic Acid; Mechanical Phenomena; | 2009 |
Effects of wheelchair training on VO2 kinetics in the participants with spinal-cord injury.
Topics: Disabled Persons; Exercise Test; Exercise Therapy; Female; Heart Rate; Humans; Lactic Acid; Male; Mi | 2006 |
Axon regeneration through scaffold into distal spinal cord after transection.
Topics: Absorbable Implants; Amidines; Animals; Axonal Transport; Biocompatible Materials; Brain Mapping; Ce | 2009 |
Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer.
Topics: Acute Disease; Animals; Annexin A5; Blotting, Western; Caspases; Cell Death; Cell Line; Cytoprotecti | 2009 |
Interaction of olfactory ensheathing cells with nerve repairing scaffolds.
Topics: Animals; Animals, Newborn; Biocompatible Materials; Cells, Cultured; Lactic Acid; Nerve Regeneration | 2009 |
Early metabolic reactivation versus antioxidant therapy after a traumatic spinal cord injury in adult rats.
Topics: Acute Disease; Aging; Animals; Antioxidants; Catalase; Creatine Kinase; Female; Lactic Acid; Lipid P | 2010 |
Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles.
Topics: Action Potentials; Animals; Axons; Lactic Acid; Male; Micelles; Motor Activity; Polyesters; Polyethy | 2010 |
The effects of stimulating lower leg muscles on the mechanical work and metabolic response in functional electrically stimulated pedaling.
Topics: Adolescent; Adult; Bicycling; Electric Stimulation Therapy; Energy Metabolism; Female; Humans; Lacti | 2010 |
Intrathecal lactate concentration and spinal cord injury in thoracoabdominal aortic surgery.
Topics: Adult; Anesthesia, General; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Biomarkers | 2011 |
Implantation of polymer scaffolds seeded with neural stem cells in a canine spinal cord injury model.
Topics: Animals; Biocompatible Materials; Cell Movement; Disease Models, Animal; Dogs; Feasibility Studies; | 2010 |
Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury.
Topics: Animals; Behavior, Animal; Biocompatible Materials; Drug Administration Routes; Drug Carriers; Femal | 2010 |
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells and Schwann cells.
Topics: Animals; Cell Differentiation; Cell Movement; Evoked Potentials, Motor; Evoked Potentials, Somatosen | 2010 |
Development of complete thoracic spinal cord transection model in rats for delayed transplantation of stem cells.
Topics: Animals; Disease Models, Animal; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid C | 2011 |
Transplantation of nanostructured composite scaffolds results in the regeneration of chronically injured spinal cords.
Topics: Amino Acid Sequence; Animals; Chronic Disease; Electrophysiological Phenomena; Female; Guided Tissue | 2011 |
Sustained delivery of dibutyryl cyclic adenosine monophosphate to the transected spinal cord via oligo [(polyethylene glycol) fumarate] hydrogels.
Topics: Animals; Axons; Biocompatible Materials; Bucladesine; Delayed-Action Preparations; Fumarates; Guided | 2011 |
Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transection.
Topics: Animals; Hindlimb; Humans; Lactic Acid; Locomotion; Neurotrophin 3; Polyglycolic Acid; Polylactic Ac | 2011 |
Regeneration of completely transected spinal cord using scaffold of poly(D,L-lactide-co-glycolide)/small intestinal submucosa seeded with rat bone marrow stem cells.
Topics: Animals; Bone Marrow Cells; Electrophysiology; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyg | 2011 |
Submaximal exercise responses in tetraplegic, paraplegic and non spinal cord injured elite wheelchair athletes.
Topics: Adolescent; Adult; Analysis of Variance; Exercise; Exercise Test; Heart Rate; Humans; Lactic Acid; M | 2012 |
Robust CNS regeneration after complete spinal cord transection using aligned poly-L-lactic acid microfibers.
Topics: Animals; Astrocytes; Cells, Cultured; Central Nervous System; Female; Ganglia, Spinal; Immunohistoch | 2011 |
Biodegradable nanoparticles for protein delivery: analysis of preparation conditions on particle morphology and protein loading, activity and sustained release properties.
Topics: Acetates; Acetone; Animals; Cattle; Delayed-Action Preparations; Lactic Acid; Methylene Chloride; Mu | 2012 |
Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection.
Topics: Animals; Animals, Newborn; Biotin; Cell Count; Cells, Cultured; Dextrans; Disease Models, Animal; Di | 2011 |
Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep.
Topics: Absorbable Implants; Animals; Female; Fetal Therapies; Fibrosis; Foreign-Body Reaction; Implants, Ex | 2011 |
The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice.
Topics: Animals; Astrocytes; Biodegradation, Environmental; Cell Proliferation; Delayed-Action Preparations; | 2012 |
In vitro sustained release of bioactive anti-NogoA, a molecule in clinical development for treatment of spinal cord injury.
Topics: Antibodies, Monoclonal; Calcium Carbonate; Chemistry, Pharmaceutical; Delayed-Action Preparations; D | 2012 |
Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells.
Topics: Animals; Cells, Cultured; Electrophysiology; Female; Humans; Lactic Acid; Mesenchymal Stem Cells; Po | 2012 |
Energetics of paraplegic cycling: adaptations to 12 months of high volume training.
Topics: Adult; Bicycling; Electric Stimulation Therapy; Female; Humans; Lactic Acid; Male; Middle Aged; Oxyg | 2012 |
Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Drug Delivery Systems; Excipients; Female; Glucuronic | 2012 |
Localized and sustained delivery of fibroblast growth factor-2 from a nanoparticle-hydrogel composite for treatment of spinal cord injury.
Topics: Animals; Female; Fibroblast Growth Factor 2; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; I | 2013 |
Kinetics and steady-state of VO2 responses to arm exercise in trained spinal cord injury humans.
Topics: Adult; Arm; Carbon Dioxide; Cardiac Output; Cross-Sectional Studies; Exercise; Female; Heart Rate; H | 2002 |
Physiological adaptations to exercise in people with spinal cord injury.
Topics: Adaptation, Physiological; Blood Glucose; Blood Pressure; Body Temperature; Cardiovascular Physiolog | 2003 |
Effects of gamma-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma.
Topics: Adjuvants, Anesthesia; Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Glucos | 2004 |
Functional magnetic ventilation in dogs.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Carbon Dioxide; Cervical Vertebrae; Disease Model | 2004 |
Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord.
Topics: Animals; Axons; Blood Vessels; Cell Enlargement; Cell Survival; Chondroitin Sulfates; Culture Media, | 2006 |
Multiple-channel scaffolds to promote spinal cord axon regeneration.
Topics: Absorbable Implants; Animals; Animals, Genetically Modified; Axons; Delayed-Action Preparations; Dex | 2006 |
Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma.
Topics: Animals; Blood Pressure; Carbon Dioxide; Heart Rate; Lactic Acid; Magnesium Sulfate; Malondialdehyde | 2005 |
Evaluation of cellular organization and axonal regeneration through linear PLA foam implants in acute and chronic spinal cord injury.
Topics: Acute Disease; Animals; Axons; Biocompatible Materials; Calcitonin Gene-Related Peptide; Chronic Dis | 2007 |
Higher glucose uptake in paralysed spastic leg.
Topics: Adult; Arm; Glucose; Humans; Insulin; Lactic Acid; Leg; Muscle Spasticity; Paraplegia; Plethysmograp | 2008 |
[Research about schwann cells and PLGA implanted to rat transected spinal cord].
Topics: Animals; Cells, Cultured; Disease Models, Animal; Evoked Potentials, Motor; Female; Immunohistochemi | 2007 |
Influence of the sympathetic nervous system on insulin sensitivity and adipose tissue metabolism: a study in spinal cord-injured subjects.
Topics: Adipose Tissue; Administration, Oral; Adult; Female; Glucose Tolerance Test; Glycerol; Humans; Insul | 1995 |
Increased hypoxic ventilatory sensitivity during exercise in man: are neural afferents necessary?
Topics: Adult; Blood Pressure; Carbon Dioxide; Electric Stimulation; Electrocardiography; Exercise Test; Fem | 1994 |
Plasma catecholamine and lactate relationship during graded exercise in men with spinal cord injury.
Topics: Adrenal Cortex; Adult; Epinephrine; Exercise; Exercise Test; Humans; Lactic Acid; Male; Norepinephri | 1997 |
Physiological responses of wheelchair athletes at percentages of top speed.
Topics: Exercise Test; Heart Rate; Humans; Lactic Acid; Male; Oxygen Consumption; Physical Endurance; Spinal | 1997 |
Poly(alpha-hydroxyacids) for application in the spinal cord: resorbability and biocompatibility with adult rat Schwann cells and spinal cord.
Topics: Animals; Biocompatible Materials; Biotransformation; Cells, Cultured; Female; Humans; Inflammation; | 1998 |
An intact central nervous system is not necessary for insulin-mediated increases in leg blood flow in humans.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Epinephrine; Fatty Acids, Nonesterified; | 2000 |
[Effect of regional hypothermia on cerebrospinal fluid parameters during thoracoabdominal aorta clamping in dogs].
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Carbon Dioxide; Cerebrospinal Fluid; Dogs; Glucose; Hemo | 2000 |
Axonal regeneration into Schwann cell grafts within resorbable poly(alpha-hydroxyacid) guidance channels in the adult rat spinal cord.
Topics: Animals; Axons; Biocompatible Materials; Female; Lactic Acid; Materials Testing; Myelin Sheath; Neov | 2001 |
Functional community ambulation requirements in incomplete spinal cord injured subjects.
Topics: Activities of Daily Living; Adult; Analysis of Variance; Energy Metabolism; Female; Heart Rate; Huma | 2001 |
Functional community ambulation requirements in incomplete spinal cord injured subjects.
Topics: Activities of Daily Living; Adult; Analysis of Variance; Energy Metabolism; Female; Heart Rate; Huma | 2001 |
Functional community ambulation requirements in incomplete spinal cord injured subjects.
Topics: Activities of Daily Living; Adult; Analysis of Variance; Energy Metabolism; Female; Heart Rate; Huma | 2001 |
Functional community ambulation requirements in incomplete spinal cord injured subjects.
Topics: Activities of Daily Living; Adult; Analysis of Variance; Energy Metabolism; Female; Heart Rate; Huma | 2001 |
Fatty acid kinetics and carbohydrate metabolism during electrical exercise in spinal cord-injured humans.
Topics: Adult; Animals; Blood Glucose; Carbohydrate Metabolism; Electric Stimulation; Exercise; Fatty Acids, | 2001 |
Alcohol exacerbates behavioral and neurochemical effects of rat spinal cord trauma.
Topics: Amino Acids; Animals; Behavior, Animal; Body Water; Cations; Cholesterol; Ethanol; Fatty Acids, None | 1992 |
Does aluminum lactate cause spinal cord infarction in rabbits?
Topics: Animals; Artifacts; Infarction; Lactates; Lactic Acid; Organometallic Compounds; Paraplegia; Pentano | 1991 |
Physiologic responses of elite paraplegic road racers to prolonged exercise.
Topics: Adult; Blood Volume; Energy Metabolism; Exercise Test; Fatty Acids, Nonesterified; Female; Heart Rat | 1990 |
Cardiorespiratory capacity in tetra- and paraplegia shortly after injury.
Topics: Adult; Female; Heart Rate; Humans; Lactates; Lactic Acid; Male; Oxygen; Paraplegia; Physical Exertio | 1986 |