lactic acid has been researched along with Retinoblastoma in 5 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To specifically deliver paclitaxel (PTX) to retinoblastoma (RB) cells, the anionic surface-charged poly(lactic-co-glycolic acid) (PLGA) NPs loaded with paclitaxel were conjugated with epithelial cell adhesion molecule (EpCAM) antibody for enhancing site-specific intracellular delivery of paclitaxel against EpCAM overexpressing RB cells." | 7.77 | Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells. ( Harilal, A; Krishnakumar, S; Misra, R; Mitra, M; Sahoo, SK, 2011) |
| "To specifically deliver paclitaxel (PTX) to retinoblastoma (RB) cells, the anionic surface-charged poly(lactic-co-glycolic acid) (PLGA) NPs loaded with paclitaxel were conjugated with epithelial cell adhesion molecule (EpCAM) antibody for enhancing site-specific intracellular delivery of paclitaxel against EpCAM overexpressing RB cells." | 3.77 | Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells. ( Harilal, A; Krishnakumar, S; Misra, R; Mitra, M; Sahoo, SK, 2011) |
| "Retinoblastoma is the most common intraocular tumor in children." | 1.38 | Folate decorated dual drug loaded nanoparticle: role of curcumin in enhancing therapeutic potential of nutlin-3a by reversing multidrug resistance. ( Das, M; Sahoo, SK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sradhanjali, S | 1 |
| Tripathy, D | 1 |
| Rath, S | 1 |
| Mittal, R | 1 |
| Reddy, MM | 1 |
| Boddu, SH | 1 |
| Jwala, J | 1 |
| Chowdhury, MR | 1 |
| Mitra, AK | 1 |
| Mitra, M | 2 |
| Misra, R | 1 |
| Harilal, A | 2 |
| Sahoo, SK | 3 |
| Krishnakumar, S | 2 |
| Das, M | 1 |
| Mohanty, C | 1 |
| Maheswari, UK | 1 |
5 other studies available for lactic acid and Retinoblastoma
| Article | Year |
|---|---|
Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dichloroaceti | 2017 |
In vitro evaluation of a targeted and sustained release system for retinoblastoma cells using Doxorubicin as a model drug.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Doxorubic | 2010 |
Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells.
Topics: Antibodies; Antigens, Neoplasm; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Adhesi | 2011 |
Folate decorated dual drug loaded nanoparticle: role of curcumin in enhancing therapeutic potential of nutlin-3a by reversing multidrug resistance.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Curcumin; Drug Carriers; Drug Resistance, Neopl | 2012 |
A novel in vitro three-dimensional retinoblastoma model for evaluating chemotherapeutic drugs.
Topics: Antineoplastic Agents; Biocompatible Materials; Carboplatin; Cell Culture Techniques; Cell Prolifera | 2012 |