lactic acid has been researched along with Reperfusion Injury in 203 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Small-dose infusions of both propofol and NAC appear to provide similar protection against ischaemia-reperfusion injury in arthroscopic knee surgery." | 9.14 | Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia-reperfusion injury. ( Cekic, B; Coskun, I; Eroglu, A; Erturk, E; Geze, S; Karahan, C; Kerimoglu, S; Kosucu, M; Mentese, A; Ulusoy, H, 2009) |
| "The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified." | 9.09 | Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. ( Chang, K; Hanaoka, K; Hayashida, M; Makuuchi, M; Orii, R; Sugawara, Y; Takayama, T; Yamada, Y, 2000) |
| "To investigate the protective effects of ginkgo diterpene lactone meglumine injection (GDLMI) on cerebral focal ischemia reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats, and explore its possible mechanism." | 7.85 | [Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats]. ( Cao, L; Cao, ZY; Hu, HF; Luo, YP; Wang, ZZ; Xiao, W; Zhang, H; Zhang, XZ, 2017) |
| "To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline." | 7.80 | Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats. ( Belon, AR; Carvalho, JG; Felice Neto, R; Marques, GM; Montero, EF; Rasslan, R; Rasslan, S; Utiyama, EM, 2014) |
| "The general anesthetic propofol protects the adult heart against ischemia and reperfusion injury; however, its efficacy has not been investigated in the immature heart." | 7.80 | Propofol protects the immature rabbit heart against ischemia and reperfusion injury: impact on functional recovery and histopathological changes. ( Imura, H; Nitta, T; Shirakawa, M, 2014) |
| "It is well known that puerarin attenuates ischemia-reperfusion injury and promotes function recovery of ischemic region." | 7.79 | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. ( Du, D; Jiang, CL; Li, MH; Liu, MF; Meng, Q; Peng, HS; Sun, SL; Tao, HQ; Wang, YM; Yang, HC; Yang, LZ; Ye, W; Yu, H; Zhu, DL, 2013) |
| "To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG) in an ischemia-reperfusion rat model." | 7.77 | Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats. ( Garcia, JH; Gonçalves, ES; Guimarães, SB; Prado Neto, AX; Rabelo, CM; Vasconcelos, PR, 2011) |
| "To study the protective effects of lycopene (LP) on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia and oxidative stress in rats." | 7.76 | [The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats]. ( Mai, JY; Shen, H; Shen, XN; Wang, RZ; Wei, Y; Wu, M, 2010) |
| " Trimetazidine (TMZ) has been reported to exert a protective action against normothermic ischemia and reperfusion injury in several experimental and clinical studies." | 7.70 | Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution. ( Carretier, M; Eugene, M; Goujon, JM; Hauet, T; Tallineau, C; Tillement, JP, 1998) |
| "Methylene blue (MB) has been used as a vasopressor in sepsis and acute liver failure." | 6.70 | The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation. ( Baumann, J; Bellamy, MC; Gedney, JA; Koelzow, H; Snook, NJ, 2002) |
| "Global cerebral ischemia was established using the Pulsinelli four-vessel occlusion model and brain temperature was maintained at defined level for 60 min after 20-min ischemia." | 5.40 | Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures. ( Li, L; Mei, YW; Murong, SX; Sun, SG; Tong, ET; Xu, GY; Zhang, H; Zhang, JJ, 2014) |
| " In order to reduce rat proteins to elicit possible immune responses in humans, we determined the effect of human AM combined with human AMBP-1 after intestinal ischemia and reperfusion (I/R)." | 5.35 | Human adrenomedullin combined with human adrenomedullin binding protein-1 is protective in gut ischemia and reperfusion injury in the rat. ( Blau, SA; Wang, P; Wu, R; Zhang, F; Zhou, M, 2009) |
| "The focal cerebral ischemia was produced by the occlusion of the right common carotid artery and the right middle cerebral artery for 60 mins." | 5.31 | Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. ( Cheng, FC; Chung, SY; Lin, JY; Lin, MC, 2002) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 5.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "Phosphoenolpyruvate (PEP) is a high-energy metabolite in the final step of glycolysis." | 5.30 | Phosphoenolpyruvate prevents the decline in hepatic ATP and energy charge after ischemia and reperfusion injury in rats. ( Chijiiwa, K; Hamasaki, N; Saiki, S; Shimizu, S; Tanaka, M; Yamaguchi, K, 1997) |
| "Small-dose infusions of both propofol and NAC appear to provide similar protection against ischaemia-reperfusion injury in arthroscopic knee surgery." | 5.14 | Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia-reperfusion injury. ( Cekic, B; Coskun, I; Eroglu, A; Erturk, E; Geze, S; Karahan, C; Kerimoglu, S; Kosucu, M; Mentese, A; Ulusoy, H, 2009) |
| "The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified." | 5.09 | Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. ( Chang, K; Hanaoka, K; Hayashida, M; Makuuchi, M; Orii, R; Sugawara, Y; Takayama, T; Yamada, Y, 2000) |
| "To investigate the protective effects of ginkgo diterpene lactone meglumine injection (GDLMI) on cerebral focal ischemia reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats, and explore its possible mechanism." | 3.85 | [Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats]. ( Cao, L; Cao, ZY; Hu, HF; Luo, YP; Wang, ZZ; Xiao, W; Zhang, H; Zhang, XZ, 2017) |
| " In the CPIP acute phase, we observed mechanical and cold allodynia; increased levels of tumor necrosis factor-α (hind paw), ischemia-modified albumin (IMA) (serum), protein carbonyl (hind paw and spinal cord), lactate (serum), and 4-hydroxy-2-nonenal (4-HNE, hind paw and spinal cord); and higher myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAGase) activities (hind paw)." | 3.83 | Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms. ( Bochi, GV; da Silva, MA; de Prá, SD; Ferreira, J; Klafke, JZ; Moresco, RN; Rigo, FK; Rossato, MF; Trevisan, G; Walker, CI, 2016) |
| "In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury." | 3.81 | The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. ( Han, C; Hu, H; Hu, X; Pan, X; Shao, H; Xu, J; Yu, C; Zhi, L, 2015) |
| "To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline." | 3.80 | Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats. ( Belon, AR; Carvalho, JG; Felice Neto, R; Marques, GM; Montero, EF; Rasslan, R; Rasslan, S; Utiyama, EM, 2014) |
| "Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats." | 3.80 | [Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period]. ( Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa, 2014) |
| "The general anesthetic propofol protects the adult heart against ischemia and reperfusion injury; however, its efficacy has not been investigated in the immature heart." | 3.80 | Propofol protects the immature rabbit heart against ischemia and reperfusion injury: impact on functional recovery and histopathological changes. ( Imura, H; Nitta, T; Shirakawa, M, 2014) |
| "It is well known that puerarin attenuates ischemia-reperfusion injury and promotes function recovery of ischemic region." | 3.79 | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. ( Du, D; Jiang, CL; Li, MH; Liu, MF; Meng, Q; Peng, HS; Sun, SL; Tao, HQ; Wang, YM; Yang, HC; Yang, LZ; Ye, W; Yu, H; Zhu, DL, 2013) |
| "Flutamide failed to show any benefit to resuscitation in a model of severe injury and was associated with increased acidosis, hemodilution, and liver injury compared with standard crystalloid resuscitation." | 3.79 | Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model. ( Hempel, J; Hoffer, Z; Martin, M; Satterly, SA; Stallings, JD; Wingerd, M, 2013) |
| "To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG) in an ischemia-reperfusion rat model." | 3.77 | Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats. ( Garcia, JH; Gonçalves, ES; Guimarães, SB; Prado Neto, AX; Rabelo, CM; Vasconcelos, PR, 2011) |
| "To study the protective effects of lycopene (LP) on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia and oxidative stress in rats." | 3.76 | [The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats]. ( Mai, JY; Shen, H; Shen, XN; Wang, RZ; Wei, Y; Wu, M, 2010) |
| "Using the middle cerebral artery occlusion model (MCAO) in rats and cerebral ischemia-reperfusion models in gerbils and mice, we investigated the influence of pueraria compound on the brain water content and the infarct size, the cerebral apoplexy exponent, the contents of lactic acid (LA) and lipid peroxide (LPO), the activities of lactic dehydrogenase (LDH), glutathione peroxidase (GPx) and Na+ -K+ -ATPase." | 3.73 | [Experimental study of protective effect of pueraria compound on the cerebral ischemic injury]. ( Cao, CY; Cui, HF; Du, GY; Wang, XR; Zhang, CY; Zhao, Y, 2005) |
| " In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine." | 3.72 | The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers. ( Dunbar, JC; Levy, J; Zhu, Z, 2004) |
| " Trimetazidine (TMZ) has been reported to exert a protective action against normothermic ischemia and reperfusion injury in several experimental and clinical studies." | 3.70 | Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution. ( Carretier, M; Eugene, M; Goujon, JM; Hauet, T; Tallineau, C; Tillement, JP, 1998) |
| "The authors prepared an experimental animal model of ischemia and reperfusion of the limbs to evaluate in vivo the reactive oxygen species involvement and protective role of coenzyme Q10 in reperfusion injury." | 3.69 | Protective role in vivo of coenzyme Q10 during reperfusion of ischemic limbs. ( Destito, C; Iacocagni, A; Littarru, GP; Marin, AW; Oradei, A; Romagnoli, A, 1994) |
| " Thirty-three patients underwent ILP with rhTNF alpha and melphalan for melanoma or soft-tissue sarcoma." | 3.69 | [O2 utilization during hyperthermic extremity perfusion with rhTNF alpha and melphalan]. ( Beck, K; Haier, J; Hohenberger, P; Schlag, PM, 1997) |
| "The effects of dichloroacetate (DCA) on brain lactate, intracellular pH (pHi), phosphocreatine (PCr), and ATP during 60 min of complete cerebral ischemia and 2 h of reperfusion were investigated in rats by in vivo 1H and 31P magnetic resonance spectroscopy; brain lactate, water content, cations, and amino acids were measured in vitro after reperfusion." | 3.68 | Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. ( Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR, 1992) |
| "Methylene blue (MB) has been used as a vasopressor in sepsis and acute liver failure." | 2.70 | The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation. ( Baumann, J; Bellamy, MC; Gedney, JA; Koelzow, H; Snook, NJ, 2002) |
| "Twelve pigs were subjected to hemorrhagic shock and 45 min of REBOA." | 1.91 | Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock. ( Ewer, N; Ford, R; Hoareau, GL; Johnson, MA; Neff, LP; Patel, N; Van Brocklin, MW; Vapniarsky, N; Williams, TK; Youngquist, ST, 2023) |
| "In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death." | 1.48 | NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia. ( Baranovicova, E; Cierny, D; Grendar, M; Kalenska, D; Lehotsky, J; Tomascova, A, 2018) |
| " In the present study, neuroprotective properties of creatylglycine ethyl ester fumarate (CrGEt) in rats with focal cerebral ischemia were explored in a wide dosage range (30-280 mg/kg, intravenous and intragastric)." | 1.42 | Neuroprotective activity of creatylglycine ethyl ester fumarate. ( Barygin, OI; Isaeva, AV; Korzhevskii, DE; Morozov, VA; Portsel, MN; Tihonov, DB; Veselkina, OS; Vlasov, TD, 2015) |
| "Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE)." | 1.42 | Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats. ( Lou, H; Shi, H; Sun, D; Xue, A; Zhang, B; Zhang, X, 2015) |
| "Histological features of ischaemia and reperfusion injury were assessed." | 1.40 | Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion. ( Ahmed, N; Mirza, DF; Murphy, N; Neil, DA; Perera, MT; Richards, DA; Silva, MA, 2014) |
| "Global cerebral ischemia was established using the Pulsinelli four-vessel occlusion model and brain temperature was maintained at defined level for 60 min after 20-min ischemia." | 1.40 | Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures. ( Li, L; Mei, YW; Murong, SX; Sun, SG; Tong, ET; Xu, GY; Zhang, H; Zhang, JJ, 2014) |
| "The prolonged hemorrhagic shock model was established by keeping the arterial blood pressure from 31 to 40 mmHg for 3 h through the femoral artery bleeding, and performing the resuscitation for 2 h by conventional fluid resuscitation and ECMO resuscitation, respectively." | 1.40 | Utilization of extracorporeal membrane oxygenation alleviates intestinal ischemia-reperfusion injury in prolonged hemorrhagic shock animal model. ( Chen, J; Jia, W; Luo, L; Xiao, J; Xiao, Y; Zhao, L, 2014) |
| "Ischemic myalgia is a unique type of muscle pain in the patient population." | 1.40 | Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury. ( Hudgins, RC; Jankowski, MP; Queme, LF; Ross, JL; Shank, AT, 2014) |
| "Glycerol continued to increase during initial reperfusion." | 1.37 | Continuous assessment of intrahepatic metabolism by microdialysis during and after portal triad clamping. ( Björnstedt, M; D'souza, MA; Isaksson, B; Jersenius, U; Lundell, L; Nowak, G; Permert, J; Ungerstedt, J, 2011) |
| "Some mechanisms of reperfusion injury are now recognized; they include oxygen free radical (OFR), white blood cells activation, changes in calcium influx, alteration of microvascular blood flow, and sympathetic activation." | 1.36 | Oxidative stress implication after prolonged storage donor heart with blood versus crystalloid cardioplegia and reperfusion versus static storage. ( Albertini, JP; Artigou, JY; Bonnefont-Rousselot, D; Charniot, JC; DeLattre, J; Dever, S; Monsuez, JJ; Nataf, P; Pavie, A; Vignat, N, 2010) |
| "Thoracoabdominal aortic aneurysm open surgery is accompanied by a significant incidence of renal failure due to renal ischemia." | 1.35 | Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach. ( Charalambopoulos, A; Giamarellos-Bourboulis, EJ; Kakisis, JD; Karatzas, GM; Karkaletsis, KG; Lazaris, AM; Liakakos, TD; Maheras, AN; Martikos, G; Patapis, P; Vasdekis, SN, 2009) |
| " In order to reduce rat proteins to elicit possible immune responses in humans, we determined the effect of human AM combined with human AMBP-1 after intestinal ischemia and reperfusion (I/R)." | 1.35 | Human adrenomedullin combined with human adrenomedullin binding protein-1 is protective in gut ischemia and reperfusion injury in the rat. ( Blau, SA; Wang, P; Wu, R; Zhang, F; Zhou, M, 2009) |
| "Ischemia-reperfusion injury is a common pathological occurrence causing tissue damage in heart attack and stroke." | 1.35 | Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils. ( Arreola, J; Kaba, NK; Kim, M; Knauf, PA; Law, FY; Lefort, CT; Martel-Gallegos, G; Schultz, J; Waugh, RE, 2008) |
| "Propofol treatments, especially pre-treatment, significantly reduced Chiu's scores and levels of MDA, NO, ET-1 and LD, while restoring SOD activity." | 1.34 | Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat. ( He, W; Liu, KX; Rinne, T; Wang, F; Xia, Z, 2007) |
| "These data suggest that reperfusion injury following asphyxia in the immature brain is associated with marked free radical production." | 1.33 | White matter injury following prolonged free radical formation in the 0.65 gestation fetal sheep brain. ( Arvidsson, P; Kjellmer, I; Lindblom, A; Mallard, C; Nilsson, UA; Sandberg, M; Welin, AK, 2005) |
| "Treatment with SB 203580, a p38 MAPK inhibitor, reduced intestinal apoptosis (26." | 1.33 | Inhibition of p38 mitogen-activated protein kinase may decrease intestinal epithelial cell apoptosis and improve intestinal epithelial barrier function after ischemia- reperfusion injury. ( Chen, W; Fu, XB; Sun, TZ; Xu, JG; Zhao, JY; Zheng, SY, 2005) |
| "Transient (2 hours) middle cerebral artery occlusion (MCAO) was performed in eight macaque monkeys." | 1.33 | Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J, 2005) |
| "Incomplete cerebral ischemia induced was induced by ligating bilateral arteries carotis communis for 20 min followed by reperfusion 48 h in rats." | 1.33 | [Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils]. ( Liu, GQ; Lv, LL; Sun, R, 2006) |
| "This infarct-protective effect of remote IPC in LD muscle flaps was abolished by an intravenous bolus injection of the nonselective opioid receptor antagonist naloxone (3 mg/kg) 10 min before remote IPC and a continuous intravenous infusion (3 mg/kg) during remote IPC and by an intravenous bolus injection of the selective delta 1-opioid receptor antagonist 7-benzylidenealtrexone maleate (3 mg/kg)." | 1.32 | Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction. ( Addison, PD; Ashrafpour, H; Forrest, CR; Khan, A; Moses, M; Neligan, PC; Pang, CY; Zhong, A, 2003) |
| "Ischemia-reperfusion injury is a microvascular event documented in numerous in vivo animal models." | 1.32 | Human microvascular endothelial cell prostaglandin E1 synthesis during in vitro ischemia-reperfusion. ( Al-Badawi, H; Patton, GM; Peterson, B; Russo, AL; Soler, H; Watkins, MT, 2004) |
| "32 SD rats were randomly divided into four groups: normal group, model group, low dosage group, (treated with Astragalus membranaceus 10 g x kg(-1)); high dosage group (treated with Astragalus membranaceus 20 g x kg(-1))." | 1.32 | [Effects of Astragalus membranaceus injection on nitric oxide and endothelin concentration of intestinal mucosa after hemorrhage shock-reperfusion in rats]. ( Chen, BX; Hei, ZQ; Lin, SQ; Liu, KX; Zhang, JJ, 2004) |
| "Perhexiline is a potent prophylactic anti-anginal agent that has been shown to inhibit myocardial utilization of long-chain fatty acids and to inhibit the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1." | 1.31 | Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. ( Horowitz, JD; Kennedy, JA; Kiosoglous, AJ; Murphy, GA; Pelle, MA, 2000) |
| "Lactic acidosis has been implicated; however, increases in the excitotoxic amino acid glutamate, which correlate with increased neuronal damage, may be the cause for the increased damage seen in hyperglycemic stroke." | 1.31 | The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. ( Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D, 2001) |
| "Focal cerebral ischemia-reperfusion resulted in abnormal behavior which could be alleviated by Sal B 10 mg." | 1.31 | Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats. ( Chen, YH; Du, GH; Zhang, JT, 2000) |
| "Transorbital 2 hour middle cerebral artery occlusion (MCAO) was performed in eight monkeys, which were studied with continuous microdialysis for 24 hours." | 1.31 | Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J; Watanabe, Y, 2001) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 1.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| " This study addresses the essential role of dosage in studies using C1-INH." | 1.31 | Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects. ( Berg, O; Bhakdi, S; Bierbach, B; Darius, H; Götze, O; Hafner, G; Heimann, A; Horstick, G; Horstick, M; Kempski, O; Loos, M; Meyer, J; Petersen, S, 2001) |
| "The focal cerebral ischemia was produced by the occlusion of the right common carotid artery and the right middle cerebral artery for 60 mins." | 1.31 | Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. ( Cheng, FC; Chung, SY; Lin, JY; Lin, MC, 2002) |
| "Phosphoenolpyruvate (PEP) is a high-energy metabolite in the final step of glycolysis." | 1.30 | Phosphoenolpyruvate prevents the decline in hepatic ATP and energy charge after ischemia and reperfusion injury in rats. ( Chijiiwa, K; Hamasaki, N; Saiki, S; Shimizu, S; Tanaka, M; Yamaguchi, K, 1997) |
| "Cerebral ischemia was induced, using the bilateral carotid artery occlusion method, for 20 or 60 min, followed by reperfusion up to 120 min." | 1.30 | The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain. ( Fukuchi, T; Kamiya, T; Kashiwagi, F; Katayama, Y; McKee, A; Terashi, A, 1998) |
| "The clues of reperfusion injury do not become evident following detorsion of testicular torsion lasting more than 6 hours." | 1.29 | Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion. ( Akgür, FM; Büyükpamukçu, N; Hiçsönmez, A; Kilinç, K; Tanyel, FC, 1994) |
| "As unilateral testicular torsion and varicocele have been shown to affect contralateral testicular blood flow, reperfusion injury was studied in both testes." | 1.29 | Reperfusion injury after detorsion of unilateral testicular torsion. ( Akgür, FM; Aktuğ, T; Kilinç, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.99) | 18.7374 |
| 1990's | 39 (19.21) | 18.2507 |
| 2000's | 87 (42.86) | 29.6817 |
| 2010's | 66 (32.51) | 24.3611 |
| 2020's | 9 (4.43) | 2.80 |
| Authors | Studies |
|---|---|
| Schurink, IJ | 1 |
| de Haan, JE | 1 |
| Willemse, J | 1 |
| Mueller, M | 1 |
| Doukas, M | 1 |
| Roest, H | 1 |
| de Goeij, FHC | 1 |
| Polak, WG | 1 |
| Ijzermans, JNM | 1 |
| Dutkowski, P | 2 |
| van der Laan, LJW | 1 |
| de Jonge, J | 1 |
| Uzdenov, M | 1 |
| Kaisinova, A | 1 |
| Fedorov, A | 1 |
| Mairansaeva, S | 1 |
| Еmkuzhеv, К | 1 |
| Patel, N | 1 |
| Johnson, MA | 2 |
| Vapniarsky, N | 1 |
| Van Brocklin, MW | 1 |
| Williams, TK | 2 |
| Youngquist, ST | 1 |
| Ford, R | 1 |
| Ewer, N | 1 |
| Neff, LP | 2 |
| Hoareau, GL | 2 |
| Zhao, Y | 2 |
| Gao, J | 1 |
| Li, C | 3 |
| Song, G | 1 |
| Shan, Y | 1 |
| Takata, T | 1 |
| Nonaka, W | 1 |
| Iwama, H | 1 |
| Kobara, H | 1 |
| Deguchi, K | 1 |
| Masugata, H | 1 |
| Touge, T | 1 |
| Miyamoto, O | 1 |
| Nakamura, T | 2 |
| Itano, T | 1 |
| Masaki, T | 1 |
| Lonati, C | 1 |
| Battistin, M | 1 |
| Dondossola, DE | 1 |
| Bassani, GA | 1 |
| Brambilla, D | 1 |
| Merighi, R | 1 |
| Leonardi, P | 1 |
| Carlin, A | 1 |
| Meroni, M | 1 |
| Zanella, A | 1 |
| Catania, A | 1 |
| Gatti, S | 1 |
| Verhaar, N | 1 |
| de Buhr, N | 1 |
| von Köckritz-Blickwede, M | 1 |
| Hewicker-Trautwein, M | 1 |
| Pfarrer, C | 1 |
| Mazzuoli-Weber, G | 1 |
| Schulte, H | 1 |
| Kästner, S | 1 |
| Annoni, F | 1 |
| Peluso, L | 1 |
| Gouvêa Bogossian, E | 1 |
| Creteur, J | 1 |
| Zanier, ER | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial[NCT02548377] | 60 participants (Actual) | Interventional | 2015-09-29 | Completed | |||
| Evaluation of Microdialysis to Monitor Postoperative Outcomes After Proctectomy[NCT01999634] | Phase 3 | 21 participants (Actual) | Interventional | 2014-02-05 | Completed | ||
| Effects on Bleeding in Knee Arthroplasty After Ischemic Preconditioning With Sevoflurane[NCT03379103] | 30 participants (Actual) | Interventional | 2018-02-02 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lactic acid and Reperfusion Injury
| Article | Year |
|---|---|
Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?
Topics: Acidosis; Animals; Brain Injuries, Traumatic; Cell Death; Cerebrovascular Circulation; Energy Metabo | 2021 |
Diagnosis biomarkers in acute intestinal ischemic injury: so close, yet so far.
Topics: Acute Disease; Biomarkers; Citrulline; Fatty Acid-Binding Proteins; Humans; Intestines; Lactic Acid; | 2018 |
Concerning the importance of changes in hemorheological parameters caused by acid-base and blood gas alterations in experimental surgical models.
Topics: Acid-Base Equilibrium; Animals; Disease Models, Animal; Erythrocyte Deformability; Gases; Hemorheolo | 2012 |
Fatty acid oxidation in the heart.
Topics: Adenosine Triphosphate; Animals; Calcium; Fatty Acids; Fish Oils; Humans; Lactic Acid; Mitochondria, | 1996 |
10 trials available for lactic acid and Reperfusion Injury
| Article | Year |
|---|---|
Ischaemic postconditioning reduces apoptosis in experimental jejunal ischaemia in horses.
Topics: Animals; Apoptosis; Horses; HSP70 Heat-Shock Proteins; Intestinal Mucosa; Ischemic Postconditioning; | 2021 |
Remote ischaemic preconditioning down-regulates kinin receptor expression in neutrophils of patients undergoing heart surgery.
Topics: Aged; Biomarkers; Bradykinin; C-Reactive Protein; Cardiopulmonary Bypass; Coronary Artery Bypass; Cr | 2013 |
Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia-reperfusion injury.
Topics: Acetylcysteine; Adolescent; Adult; Aged; Anesthesia, Spinal; Anesthetics, Intravenous; Blood Gas Ana | 2009 |
Erythropoietin ameliorates early ischemia-reperfusion injury following the Pringle maneuver.
Topics: Aged; Animals; Digestive System Surgical Procedures; Erythropoietin; Female; Hematocrit; Hemoglobins | 2010 |
Transhepatic lactate gradient in relation to liver ischemia/reperfusion injury during major hepatectomies.
Topics: Aged; Aged, 80 and over; Biomarkers; Female; Hepatectomy; Humans; Lactic Acid; Liver; Liver Circulat | 2006 |
Sevoflurane but not propofol increases interstitial glycolysis metabolites availability during tourniquet-induced ischaemia-reperfusion.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Glucose; | 2008 |
The reflush effect--a prospective analysis of late perfusion.
Topics: Adolescent; Adult; Aged; Blood Coagulation; Calcium; Female; Follow-Up Studies; Humans; Hydrogen-Ion | 1993 |
Low-dose dopexamine in patients undergoing hemihepatectomy: an evaluation of effects on reduction of hepatic dysfunction and ischaemic liver injury.
Topics: Adult; Aged; Antithrombin III; Dopamine; Dopamine Agonists; Double-Blind Method; Female; Hemodynamic | 2000 |
Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1.
Topics: Aged; Alprostadil; Amrinone; Analysis of Variance; Female; Hepatectomy; Humans; Indocyanine Green; L | 2000 |
The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation.
Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Cyclic GMP; Enzyme Inhibitors; Female; Guan | 2002 |
189 other studies available for lactic acid and Reperfusion Injury
| Article | Year |
|---|---|
A proof of concept study on real-time LiMAx CYP1A2 liver function assessment of donor grafts during normothermic machine perfusion.
Topics: Adult; Aged; Cold Ischemia; Cytochrome P-450 CYP1A2; Graft Survival; Humans; Lactic Acid; Liver; Liv | 2021 |
[EVALUATION OF SYSTEMIC PRO-INFLAMMATORY REACTIONS IN SIMULATING REVERSIBLE OCCLUSION OF ANTERIOR MESENTERIC ARTERY TO JUSTIFY MEDICAL REHABILITATION].
Topics: Animals; Humans; Ischemia; Lactic Acid; Mesenteric Arteries; Rats; Reperfusion Injury; Tumor Necrosi | 2022 |
Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.
Topics: Animals; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Hemorrhage; Lactic Acid | 2023 |
MILD THERAPEUTIC HYPOTHERMIA REDUCES ISCHEMIA-REPERFUSION INJURY AFTER ZONE 1 REBOA IN A SWINE HEMORRHAGIC SHOCK MODEL.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Hypothermia; Hypothermia, Induced; Lactic | 2023 |
Light exercise without lactate elevation induces ischemic tolerance through the modulation of microRNA in the gerbil hippocampus.
Topics: Animals; Brain Ischemia; Gene Expression Regulation; Gerbillinae; Hippocampus; Lactic Acid; Male; Me | 2020 |
NDP-MSH treatment recovers marginal lungs during ex vivo lung perfusion (EVLP).
Topics: Adenosine Triphosphate; alpha-MSH; Animals; Death; Hyaluronic Acid; Inflammation Mediators; Lactic A | 2021 |
Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta using adenosine, lidocaine and magnesium: A pilot study.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Aorta; Balloon Occlusion; Disease Models, Animal; Drug | 2021 |
Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury.
Topics: Adenosine; Allopurinol; Animals; Biomarkers; Energy Metabolism; Extracellular Vesicles; Gene Express | 2017 |
Allowable warm ischemic time and morphological and biochemical changes in uterine ischemia/reperfusion injury in cynomolgus macaque: a basic study for uterus transplantation.
Topics: Acid-Base Equilibrium; Animals; Blood Gas Analysis; Female; Humans; Infertility, Female; Lactic Acid | 2017 |
[Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats].
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Creatine Kinase, BB Form; Ginkgo biloba; Glutamic A | 2017 |
NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia.
Topics: Acetic Acid; Animals; Biomarkers; Blood Glucose; Brain Ischemia; Cerebrovascular Disorders; Creatine | 2018 |
Synergistic effects of ischemic preconditioning and immediate post-conditioning in the protection against ischemia/reperfusion injury in rabbit submandibular glands.
Topics: Animals; Apoptosis; Blotting, Western; Enzyme-Linked Immunosorbent Assay; In Situ Nick-End Labeling; | 2018 |
Endovascular variable aortic control (EVAC) versus resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhage and ischemia reperfusion injury.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Female; Hemodyna | 2018 |
Aortic branch vessel flow during resuscitative endovascular balloon occlusion of the aorta.
Topics: Animals; Aorta; Arteries; Balloon Occlusion; Blood Flow Velocity; Disease Models, Animal; Endovascul | 2019 |
A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation.
Topics: Animals; Disease Models, Animal; Electrocardiography; Heart Transplantation; Hydrogen-Ion Concentrat | 2019 |
Early detection of gut ischemia-reperfusion injury during aortic abdominal aneurysmectomy: a pilot, observational study.
Topics: Aged; Aneurysm, Ruptured; Aortic Aneurysm, Abdominal; Carbon Dioxide; Colon; Constriction; Female; H | 2013 |
[The timing of infusion of hypertonic saline to exert protective effect on intestinal barrier function in the rabbit with intestinal ischemia/reperfusion injury].
Topics: Animals; Female; Interleukin-10; Intestinal Mucosa; Intestines; Lactic Acid; Male; Rabbits; Reperfus | 2013 |
Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model.
Topics: Acidosis; Androgen Antagonists; Animals; Crystalloid Solutions; Cyclodextrins; Disease Models, Anima | 2013 |
Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism.
Topics: Amine Oxidase (Copper-Containing); Animals; Biomarkers; Bone Marrow Transplantation; Cells, Cultured | 2013 |
Low-dose vasopressin improves cardiac function in newborn piglets with acute hypoxia-reoxygenation.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cardiac Output; Dobutamine; Glutathione; Heart Ventr | 2013 |
Effect of large colon ischemia and reperfusion on concentrations of calprotectin and other clinicopathologic variables in jugular and colonic venous blood in horses.
Topics: Acidosis; Animals; Blood Gas Analysis; Colon; Creatine Kinase; Enzyme-Linked Immunosorbent Assay; He | 2013 |
Detection of urinary metabolomics before and after Pringle maneuver-induced liver ischemia and reperfusion injury in rats using gas chromatography-mass spectrometry.
Topics: Alanine; Alanine Transaminase; Animals; Bilirubin; Gas Chromatography-Mass Spectrometry; Glycerophos | 2013 |
Microcirculatory perfusion shift in the gut wall layers induced by extracorporeal circulation.
Topics: Acidosis, Lactic; Animals; Aorta, Thoracic; Blood Flow Velocity; Constriction; Extracorporeal Circul | 2015 |
Renal cortical pyruvate depletion during AKI.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Gluconeogenesis; Glucose; Glycogen; Hydrogen P | 2014 |
Pyruvate-enriched resuscitation: metabolic support of post-ischemic hindlimb muscle in hypovolemic goats.
Topics: Animals; Antioxidants; Citric Acid; Dinoprost; Goats; Hypovolemia; Infusions, Intravenous; Lactic Ac | 2014 |
[The protective effect of asiatic acid against oxygen-glucose deprivation/reoxygenation injury of PC12 cells].
Topics: Animals; Apoptosis; Caspase 3; Cell Survival; Centella; Dose-Response Relationship, Drug; Glucose; L | 2013 |
Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion.
Topics: Adult; Aged; Brain Death; Cryopreservation; Energy Metabolism; Glycerol; Graft Survival; Heart Arres | 2014 |
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lacti | 2014 |
Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Cerebral Cortex; Hippocampus; Immunochemistry; Lac | 2014 |
Utilization of extracorporeal membrane oxygenation alleviates intestinal ischemia-reperfusion injury in prolonged hemorrhagic shock animal model.
Topics: Animals; Blood Pressure; Claudin-1; Disease Models, Animal; Extracorporeal Membrane Oxygenation; Int | 2014 |
Protection against intestinal injury from hemorrhagic shock by direct peritoneal resuscitation with pyruvate in rats.
Topics: Animals; Dialysis Solutions; Drug Evaluation, Preclinical; Fluid Therapy; Inflammation Mediators; In | 2014 |
Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Ischemia; Lactic Acid; Magnetic Fields; Magnetic | 2014 |
Propofol protects the immature rabbit heart against ischemia and reperfusion injury: impact on functional recovery and histopathological changes.
Topics: Animals; Cyclosporine; Heart; Hemodynamics; Lactic Acid; Myocardium; Propofol; Protective Agents; Ra | 2014 |
Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Disease Models, Animal; Forelimb; Ganglia, Spina | 2014 |
Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats.
Topics: Animals; Apoptosis; Caspase 3; Cyclooxygenase 2; Immunohistochemistry; Intestines; Ischemia; Lactic | 2014 |
The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns.
Topics: Adult; Burns; Case-Control Studies; Cohort Studies; Disease Progression; Hematocrit; Humans; Hypoxia | 2015 |
Neuroprotective activity of creatylglycine ethyl ester fumarate.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Behavior, Animal; Brain; Cell Survival; Creatine Kina | 2015 |
Metabolic shift in liver: correlation between perfusion temperature and hypoxia inducible factor-1α.
Topics: Animals; Cold Temperature; Energy Metabolism; Glycogen; Hypoxia-Inducible Factor 1, alpha Subunit; I | 2015 |
The influence of extracorporeal membrane oxygenation therapy on intestinal mucosal barrier in a porcine model for post-traumatic acute respiratory distress syndrome.
Topics: Animals; Disease Models, Animal; Extracorporeal Membrane Oxygenation; Fatty Acid-Binding Proteins; F | 2015 |
Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats.
Topics: Animals; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cerebrovascular Circulation; Cognition | 2015 |
Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.
Topics: Animals; Apoptosis; Area Under Curve; Biotransformation; Blood-Brain Barrier; Brain; Brain Injuries; | 2015 |
Acute and chronic nociceptive phases observed in a rat hind paw ischemia/reperfusion model depend on different mechanisms.
Topics: Acetylglucosaminidase; Acute Pain; Aldehydes; Animals; Chronic Pain; Cold Temperature; Hindlimb; Hyp | 2016 |
PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation/reperfusion and is regulated by Cdh1.
Topics: Animals; Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome; Astrocytes; Cadherins; Cell Hypoxia; Ce | 2015 |
Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner.
Topics: Animals; Antioxidants; Dinoprost; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fatty A | 2016 |
Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.
Topics: Administration, Intravenous; Animals; Biphenyl Compounds; Cardiotonic Agents; Disease Models, Animal | 2016 |
In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?
Topics: Acute Kidney Injury; Alanine; Animals; Bicarbonates; Biomarkers; Carbon Isotopes; Disease Models, An | 2017 |
Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils.
Topics: Amiloride; Ammonium Chloride; CD11b Antigen; CD18 Antigens; Cell Membrane; Guanidines; Humans; Hydro | 2008 |
Human adrenomedullin combined with human adrenomedullin binding protein-1 is protective in gut ischemia and reperfusion injury in the rat.
Topics: Adrenomedullin; Alanine Transaminase; Animals; Aspartate Aminotransferases; Complement Factor H; Cyt | 2009 |
Albumin resuscitation protects against traumatic/hemorrhagic shock-induced lung apoptosis in rats.
Topics: Albumins; Animals; Apoptosis; Enzyme Activation; Immunohistochemistry; In Situ Nick-End Labeling; La | 2008 |
Fructose-1,6-bisphosphate and fructose-2,6-bisphosphate do not influence brain carbohydrate or high-energy phosphate metabolism in a rat model of forebrain ischemia.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthe | 2009 |
Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Cerebral Infarction; Lactic Acid; Male; Nanopar | 2009 |
Physiologically relevant online electrochemical method for continuous and simultaneous monitoring of striatum glucose and lactate following global cerebral ischemia/reperfusion.
Topics: Animals; Biosensing Techniques; Brain Ischemia; Carbon; Corpus Striatum; Electrochemical Techniques; | 2009 |
Glutathione and amino acid concentrations in human liver during short warm ischaemia and reperfusion: a pilot study.
Topics: Adult; Aged; Amino Acids; Female; Glutathione; Hepatectomy; Humans; Intraoperative Care; Lactic Acid | 2009 |
Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Disease Models, An | 2009 |
Hematological responses of the grey carpet shark (Chiloscyllium punctatum) and the epaulette shark (Hemiscyllium ocellatum) to anoxia and re-oxygenation.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Disease Models, Animal; Erythrocyte Count; Hemato | 2009 |
Oxidative stress implication after prolonged storage donor heart with blood versus crystalloid cardioplegia and reperfusion versus static storage.
Topics: Animals; Arrhythmias, Cardiac; beta Carotene; Blood Transfusion, Autologous; Cryopreservation; Gluta | 2010 |
The protective effect of oxygenated perfluorocarbons (PFCs) on intestinal ischemia reperfusion injury (I/R) in rabbits.
Topics: Animals; Cell Survival; Cytoprotection; Disease Models, Animal; Fluorocarbons; Infusions, Parenteral | 2010 |
[Ishemic-reperfusion syndrome prophylaxis in general hypothermia in experiment].
Topics: Animals; Antioxidants; Body Temperature; Catalase; Female; Glucose; Glutathione; Homeostasis; Hypoth | 2009 |
Exogenous modulation of intrinsic optic nerve neuroprotective activity.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Ciliary Neurotrophic Factor; Disease Mode | 2010 |
Continuous assessment of intrahepatic metabolism by microdialysis during and after portal triad clamping.
Topics: Adult; Aged; Biomarkers; Constriction; Feasibility Studies; Female; Glucose; Glycerol; Hepatectomy; | 2011 |
[The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats].
Topics: Animals; Antioxidants; Brain Ischemia; Carotenoids; Hippocampus; Infarction, Middle Cerebral Artery; | 2010 |
Partial liver ischemia is followed by metabolic changes in the normally perfused part of the liver during reperfusion.
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Glucose; Glycerol; Humans; Ischemia; | 2010 |
[Effects of lactate on cell injury in primary cultures of rat cortical neurons during hypoxia/reoxygenation].
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Lactic Acid; Neurons; Neu | 2008 |
The impact of deep and moderate body temperatures on end-organ function during hypothermic circulatory arrest.
Topics: Animals; Biomarkers; Body Temperature; Carbon Dioxide; Cardiopulmonary Bypass; Cerebrovascular Circu | 2011 |
Hemoglobin vesicle improves recovery of cardiac function after ischemia-reperfusion by attenuating oxidative stress in isolated rat hearts.
Topics: Animals; Blood Substitutes; Catalase; Coronary Circulation; Glutathione; Glutathione Disulfide; Glut | 2011 |
Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats.
Topics: Animals; Calcium Carbonate; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Ischemia; | 2011 |
Preconditioning with L-alanyl-L-glutamine in a Mongolian gerbil model of acute cerebral ischemia/reperfusion injury.
Topics: Animals; Blood Glucose; Brain Ischemia; Dipeptides; Disease Models, Animal; Gerbillinae; Ischemic Pr | 2011 |
N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs.
Topics: Acetylcysteine; Adenosine Triphosphate; Analysis of Variance; Animals; Apoptosis; Aspartate Aminotra | 2012 |
Single injection of ONO-1301-loaded PLGA microspheres directly after ischaemia reduces ischaemic damage in rats subjected to middle cerebral artery occlusion.
Topics: Animals; Biocompatible Materials; Epoprostenol; Infarction, Middle Cerebral Artery; Injections, Subc | 2012 |
[The protective effects of bifidobacterial adhesin on ischemic reperfusion injury of intestine in rats].
Topics: Adhesins, Bacterial; Animals; Bifidobacterium; D-Amino-Acid Oxidase; Interleukin-10; Interleukin-6; | 2011 |
Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats.
Topics: Adrenergic alpha-Agonists; Amine Oxidase (Copper-Containing); Animals; Apoptosis; Blood Gas Analysis | 2012 |
Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.
Topics: Amine Oxidase (Copper-Containing); Animals; Apoptosis; Caspase 3; Dinoprost; Endothelin-1; Enzyme Ac | 2012 |
Dynamic alteration of the colonic microbiota in intestinal ischemia-reperfusion injury.
Topics: Animals; Biodiversity; Colon; Intestinal Mucosa; Lactic Acid; Male; Metagenome; Rats; Rats, Sprague- | 2012 |
Cuff width increases the serum biochemical markers of tourniquet-induced skeletal muscle ischemia in rabbits.
Topics: Animals; Biomarkers; Creatine Kinase, MM Form; Ischemia; L-Lactate Dehydrogenase; Lactic Acid; Muscl | 2012 |
[Diagnostics and treatment of the ischemic and reperfusion disorders by the intraabdominal ischemic syndrome].
Topics: Abdominal Cavity; Adult; Algorithms; Animals; Combined Modality Therapy; Decompression, Surgical; Fe | 2012 |
HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Biological Availability; Blood-Brain | 2013 |
Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase.
Topics: Aldehyde Reductase; Amine Oxidase (Copper-Containing); Animals; Apoptosis; Enzyme Inhibitors; Ileum; | 2013 |
Methylene blue protects liver oxidative capacity after gut ischaemia-reperfusion in the rat.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Biomarkers; Cytoprotection; D | 2013 |
Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway.
Topics: Animals; Brain Edema; Brain Infarction; Chromones; Energy Metabolism; Enzyme Inhibitors; L-Lactate D | 2013 |
Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: in vitro and in vivo evaluation.
Topics: Abietanes; Animals; Benzofurans; Brain; Carotid Arteries; Drug Administration Routes; Drug Carriers; | 2013 |
The influence of apoptosis of mucosal epithelial cells on intestinal barrier integrity after scald in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Apoptosis; Burns; DNA Fragmentation; Electrophoresis, Ag | 2002 |
Kinetics of endotoxin concentration and tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 activities in the systemic and portal circulation during small intestinal ischemia and reperfusion in dogs.
Topics: Animals; Biological Assay; Cytotoxicity Tests, Immunologic; Dog Diseases; Dogs; Endotoxins; Female; | 2002 |
Calcium prevents loss of glutathione and reduces oxidative stress upon reperfusion in the perfused liver.
Topics: Animals; Calcium; Energy Metabolism; Glutathione; Hypothermia, Induced; In Vitro Techniques; L-Lacta | 2000 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction.
Topics: Abdomen; Adenosine Triphosphate; Animals; Ganglionic Blockers; Hexamethonium; Hindlimb; Infarction; | 2003 |
Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium.
Topics: Animals; Area Under Curve; Blood Glucose; Cardiovascular System; Glucagon; Glucagon-Like Peptide 1; | 2003 |
Aspartate transporter expression and activity in hypertrophic rat heart and ischaemia-reperfusion injury.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, | 2004 |
Gut barrier dysfunction as detected by intestinal luminal microdialysis.
Topics: Analysis of Variance; Animals; Biomarkers; Glucose; Glycerol; Intestinal Absorption; Intestinal Muco | 2004 |
The effect of hyperglycemia on experimental retinal ischemia.
Topics: Animals; Blood Glucose; Cyclophilins; Deoxyglucose; Diabetes Mellitus, Experimental; Electroretinogr | 2004 |
Human microvascular endothelial cell prostaglandin E1 synthesis during in vitro ischemia-reperfusion.
Topics: Alprostadil; Cell Line; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelium | 2004 |
Splanchnic metabolism during gut ischemia and short-term endotoxin and hemorrhagic shock as evaluated by intravasal microdialysis.
Topics: Abdomen; Animals; Endotoxemia; Endotoxins; Glucose; Glycerol; Hemodynamics; Ileum; Ischemia; Lactic | 2004 |
Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion.
Topics: Animals; Benzylamines; Brain Chemistry; Brain Injuries; Brain Ischemia; Cerebral Cortex; Coloring Ag | 2004 |
[Effects of acidic fibroblast growth factor on intestinal mucosal damage due to ischemia/reperfusion].
Topics: Animals; Disease Models, Animal; Fibroblast Growth Factor 1; Intestinal Mucosa; Lactic Acid; Random | 2004 |
Glutamine supplemented parenteral nutrition prevents intestinal ischemia- reperfusion injury in rats.
Topics: Animals; Atrophy; Bacterial Translocation; Glutamine; Intestinal Mucosa; Intestines; Lactic Acid; Ma | 2004 |
Limb ischemia and reperfusion during abdominal aortic aneurysm surgery.
Topics: Aged; Aortic Aneurysm, Abdominal; Female; Humans; Hydrogen-Ion Concentration; Iliac Artery; Ischemia | 2004 |
[Protective effects of modified recombinant human acidic fibroblast growth factor on small intestine after ischemia/reperfusion injury in rats].
Topics: Animals; Apoptosis; Disease Models, Animal; Epithelial Cells; Fibroblast Growth Factor 1; Humans; In | 2005 |
Inhibition of p38 mitogen-activated protein kinase may decrease intestinal epithelial cell apoptosis and improve intestinal epithelial barrier function after ischemia- reperfusion injury.
Topics: Animals; Apoptosis; Biological Transport; Enzyme Inhibitors; Imidazoles; Intestinal Mucosa; Lactic A | 2005 |
Hypoxia/reoxygenation reduces microvascular endothelial cell coupling by a tyrosine and MAP kinase dependent pathway.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Connexin 43; Electric Conductivity; Endothelial Ce | 2005 |
[Protective effects of acidic fibroblast growth factor on intestinal ischemia/reperfusion in rats].
Topics: Animals; Disease Models, Animal; Fibroblast Growth Factor 1; Humans; Intestines; Lactic Acid; Male; | 2005 |
[Effects of Astragalus membranaceus injection on nitric oxide and endothelin concentration of intestinal mucosa after hemorrhage shock-reperfusion in rats].
Topics: Animals; Astragalus propinquus; Drugs, Chinese Herbal; Endothelins; Ileum; Injections, Intravenous; | 2004 |
The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Calcium; Calcium Channel Blockers; | 2004 |
White matter injury following prolonged free radical formation in the 0.65 gestation fetal sheep brain.
Topics: Animals; Antioxidants; Ascorbic Acid; Asphyxia; Brain; Dehydroascorbic Acid; Electron Spin Resonance | 2005 |
Pyruvate but not lactate prevents NADH-induced myoglobin oxidation.
Topics: Animals; Antioxidants; Catalase; Dose-Response Relationship, Drug; Free Radicals; Horses; Hydrogen P | 2005 |
Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and glutathione-associated oxidative stress.
Topics: Aged; Coronary Artery Bypass; Female; Glutathione; Heart; Heart Arrest, Induced; Humans; Lactic Acid | 2005 |
[Experimental study of protective effect of pueraria compound on the cerebral ischemic injury].
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Drug Combinations; Gerbillinae; Glutathione Peroxidase | 2005 |
Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates.
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Extracellular Space; Glucose; Infarcti | 2005 |
Gut luminal microdialysis of glycerol as a marker of intestinal ischemic injury and recovery.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Endothelium, Vascular; Glycerol; Intestinal Mucosa; Int | 2005 |
Effect of nutritional status on oxidative stress in an ex vivo perfused rat liver.
Topics: Animals; Bilirubin; Biomarkers; Blood Glucose; Cytochromes c; Enzyme-Linked Immunosorbent Assay; Enz | 2005 |
Effect of Polygala tenuifolia root extract on cerebral ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Brain; Brain Ischemia; Gerbillinae; Lactic Acid; Lipid P | 2006 |
Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping.
Topics: Animals; Aorta, Abdominal; Blood Pressure; Carbon Dioxide; Celiac Artery; Dopamine; Lactic Acid; Mal | 2006 |
D-lactate is not a reliable marker of gut ischemia-reperfusion in a rat model of supraceliac aortic clamping.
Topics: Animals; Aortic Aneurysm; Inflammation; Intestinal Mucosa; Lactic Acid; Male; Models, Biological; Ra | 2006 |
A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors.
Topics: Adamantane; Adenosine Triphosphate; Animals; Anisoles; Glucose; Lactic Acid; Male; Propylamines; Rat | 2006 |
Diagnostic and scientific dilemma: the ischemic bowel.
Topics: Animals; Aorta; Lactic Acid; Models, Biological; Reperfusion Injury; Splanchnic Circulation; Stereoi | 2006 |
Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts.
Topics: Amiloride; Animals; Carnitine O-Palmitoyltransferase; Cell Survival; Enzyme Inhibitors; Fasting; Fat | 2006 |
A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres.
Topics: Animals; Cell Death; Delayed-Action Preparations; Drug Administration Schedule; Drug Evaluation, Pre | 2006 |
[Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils].
Topics: Animals; Benzoates; Brain; Brain Ischemia; Bridged-Ring Compounds; Ca(2+) Mg(2+)-ATPase; Calcium-Tra | 2006 |
Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat.
Topics: Animals; Endothelin-1; Free Radical Scavengers; Intestinal Mucosa; Intestine, Small; Lactic Acid; Ma | 2007 |
Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillaries; Cells, Cultured; Cerebrovascular Circulat | 2008 |
[Testicular perfusion injury. Cytokines and cell adhesion molecules in humans].
Topics: Anastomosis, Surgical; Cell Adhesion Molecules; Cryptorchidism; Cytokines; Epigastric Arteries; Huma | 2007 |
Lactate and glycerol released to the intestinal lumen reflect mucosal injury and permeability changes caused by strangulation obstruction.
Topics: Animals; Cell Membrane Permeability; Disease Models, Animal; Glycerol; Intestinal Mucosa; Intestinal | 2007 |
Gut luminal lactate measured by microdialysis mirrors permeability of the intestinal mucosa after ischemia.
Topics: Animals; Glycerol; Hemodynamics; Intestinal Mucosa; Intestines; Ischemia; Lactic Acid; Male; Microdi | 2008 |
Impact of female sex hormones on liver tissue lactic acidosis during ischemia.
Topics: Acidosis, Lactic; Animals; Estradiol; Female; Gonadal Steroid Hormones; Hydrogen; Lactic Acid; Liver | 2007 |
Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats.
Topics: Animals; Cytokines; Disease Models, Animal; Lactic Acid; Lipid Peroxidation; Male; Membrane Glycopro | 2008 |
Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion.
Topics: Animals; Ghrelin; Inflammation; Injections, Intraventricular; Interleukin-6; Intestinal Mucosa; Inte | 2008 |
Intermittent ischemia but not ischemic preconditioning is effective in restoring bile flow after ischemia reperfusion injury in the livers of aged rats.
Topics: Aging; Animals; Bile; Bilirubin; Hepatocytes; Ischemic Preconditioning; Lactic Acid; Liver; Liver Fu | 2009 |
Bradykinin accounts for improved postischemic function and decreased glutathione release of guinea pig heart treated with the angiotensin-converting enzyme inhibitor ramiprilat.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Angiotensin Receptor Antagonists; Angiotensin-Convert | 1994 |
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; C | 1994 |
Effects of sepsis on recovery of the heart from 50 min ischemia.
Topics: Adenosine Triphosphate; Alcoholism; Animals; Catalase; Escherichia coli; Lactates; Lactic Acid; Male | 1994 |
Protective role in vivo of coenzyme Q10 during reperfusion of ischemic limbs.
Topics: Animals; Aorta, Abdominal; Coenzymes; Constriction; Creatine Kinase; Extremities; Ischemia; Isoenzym | 1994 |
Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation.
Topics: Analysis of Variance; Animals; Cell Death; Glutamic Acid; Hippocampus; Imidazoles; Injections, Intra | 1994 |
Spinal cord ischemia and reperfusion metabolism: the effect of hypothermia.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Body Temperature; Combined Modality Therapy; Energy | 1994 |
Ipsilateral and contralateral testicular biochemical acute changes after unilateral testicular torsion and detorsion.
Topics: Animals; Hypoxanthine; Hypoxanthines; Hypoxia; Lactates; Lactic Acid; Lipid Peroxidation; Male; Rats | 1994 |
Reperfusion injury after detorsion of unilateral testicular torsion.
Topics: Animals; Hypoxanthine; Hypoxanthines; Lactates; Lactic Acid; Male; Rats; Reperfusion Injury; Spermat | 1993 |
Experimental evaluation of oxygen free radical scavengers in the prevention of reperfusion injury in skeletal muscle.
Topics: Animals; Body Water; Female; Free Radical Scavengers; Free Radicals; Lactates; Lactic Acid; Male; Mu | 1994 |
Substrate-induced changes in the lipid content of ischemic and reperfused myocardium. Its relation to hemodynamic recovery.
Topics: Animals; Disease Models, Animal; Fatty Acids; Glucose; Glycerol; Heart; Lactates; Lactic Acid; Male; | 1993 |
[Reperfusion shock after occlusion of the superior mesenteric artery and accumulation of leukocytes within the wall of the small intestine].
Topics: Animals; Blood Pressure; Intestine, Small; Ischemia; Lactates; Lactic Acid; Leukocyte Count; Leukocy | 1996 |
[Behavior of the lactate level in occlusion and reperfusion of the right superior mesenteric artery. An animal experiment study].
Topics: Animals; Blood Pressure; Hydrogen-Ion Concentration; Intestinal Mucosa; Ischemia; Lactic Acid; Mesen | 1996 |
Mapping of lactate and N-acetyl-L-aspartate predicts infarction during acute focal ischemia: in vivo 1H magnetic resonance spectroscopy in rats.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Ischemia; Cerebral Infarction; Lactates; Lactic Acid; Magn | 1996 |
Effects of platelet-activating factor antagonist E5880 on intrahepatic and systemic metabolic responses to transient hepatic inflow occlusion and reperfusion in the rabbit.
Topics: 6-Ketoprostaglandin F1 alpha; Adenine Nucleotides; Ammonia; Analysis of Variance; Animals; Blood Gas | 1996 |
High energy phosphates and direct calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia.
Topics: Adenine Nucleotides; Animals; Bile; Calorimetry; Energy Metabolism; In Vitro Techniques; Ischemia; L | 1996 |
Ischemia/reperfusion injury in the rat colon.
Topics: 6-Ketoprostaglandin F1 alpha; Aerobiosis; Aminosalicylic Acids; Anaerobiosis; Animals; Antioxidants; | 1997 |
[The protective effects of dichloroacetate on cerebral ischemia after reperfusion of fed rats].
Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Lactic Acid; Male; Neuroprotective Agents; Random Allo | 1996 |
[O2 utilization during hyperthermic extremity perfusion with rhTNF alpha and melphalan].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Carbon Dioxide; Chemotherapy, Cancer, Re | 1997 |
Phosphoenolpyruvate prevents the decline in hepatic ATP and energy charge after ischemia and reperfusion injury in rats.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arteries; Energy Metabolism; Infusions, In | 1997 |
Lipid peroxidation products and antioxidant capacity in portal venous and systemic arterial plasma during gradual intestinal ischemia and reperfusion in pigs.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Hemodynamics; Hydrogen-Ion Concentration; Int | 1998 |
The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Energ | 1998 |
Forearm semi-ischemic exercise test in pediatric patients.
Topics: Adolescent; Ammonia; Child; Exercise Test; Forearm; Humans; Lactic Acid; Metabolic Diseases; Reperfu | 1998 |
Evidence that S-adenosyl-L-methionine diastereoisomers may reduce ischaemia-reperfusion injury by interacting with purinoceptors in isolated rat liver.
Topics: Animals; Bile; Blood Flow Velocity; Enzyme Inhibitors; Glucose; Lactic Acid; Liver; Male; omega-N-Me | 1998 |
Efficiency of trimetazidine in renal dysfunction secondary to cold ischemia-reperfusion injury: a proposed addition to University of Wisconsin solution.
Topics: Adenosine; Allopurinol; Animals; Citric Acid; Cold Temperature; Glomerular Filtration Rate; Glutathi | 1998 |
Serum D-lactate levels as a predictor of intestinal ischemia-reperfusion injury.
Topics: Animals; Biomarkers; Diuretics, Osmotic; Intestines; Lactic Acid; Mannitol; Rabbits; Reperfusion Inj | 1998 |
Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats.
Topics: Acidosis, Lactic; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brain Injuries; Br | 1999 |
Investigation of metabolism and perfusion in arterialized venous replantation: experimental study in rabbits.
Topics: Animals; Arteries; Blood Flow Velocity; Blood Glucose; Carbon Dioxide; Ear, External; Energy Metabol | 1999 |
Influence of deflated and anaerobic conditions during cold storage on rat lungs.
Topics: Air; Anaerobiosis; Animals; Bronchoalveolar Lavage Fluid; Cryopreservation; Lactic Acid; Lung; Male; | 1999 |
Lactate reduces amino acid release and fuels recovery of function in the ischemic brain.
Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Electroencephalography; Injections; Lactic Ac | 1999 |
Intestinal luminal microdialysis: a new approach to assess gut mucosal ischemia.
Topics: Animals; Carbon Dioxide; Female; Intestinal Mucosa; Ischemia; Lactic Acid; Microdialysis; Regional B | 1999 |
Implementation of the microdialysis method in the hamster dorsal skinfold chamber.
Topics: Animals; Brain Chemistry; Cricetinae; Diffusion Chambers, Culture; Lactic Acid; Male; Mesocricetus; | 1999 |
[Parameters of energy metabolism in patients after vascular reconstructive surgical procedures].
Topics: Acid-Base Equilibrium; Adult; Antioxidants; Energy Metabolism; Female; Humans; Ischemia; Lactic Acid | 1999 |
[Relationship between plasma D(-)-lactate levels and acute intestinal injury in rats following ischemia-reperfusion].
Topics: Animals; Biomarkers; Intestinal Mucosa; Intestines; Lactic Acid; Male; Random Allocation; Rats; Rats | 1998 |
A new method of long-term preventive cardioprotection using Lactobacillus.
Topics: Adenosine Triphosphate; Animals; Body Temperature; Cardiovascular Agents; Catalase; Coronary Circula | 2000 |
Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain I | 2000 |
Effects of naloxone on lactate, pyruvate metabolism and antioxidant enzyme activity in rat cerebral ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain; Catalase; Energy Metabolism; Free Radicals; Glutathione Peroxidase; Is | 2000 |
The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Energy Metabolism; gamma-Aminobutyric Acid | 2000 |
Hypertonic/hyperoncotic resuscitation after intestinal superior mesenteric artery occlusion: early effects on circulation and intestinal reperfusion.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Cardiac Output; Constriction; Fluid Therapy; H | 2000 |
Posthypoxic reoxygenation-induced neurotoxicity prevented by free radical scavenger and NMDA/non-NMDA antagonist in tandem as revealed by dynamic changes in glucose metabolism with positron autoradiography.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Autoradiography; Cell Hypoxia; Cell Survival; Colorin | 2000 |
Cardioplegic strategies for calcium control: low Ca(2+), high Mg(2+), citrate, or Na(+)/H(+) exchange inhibitor HOE-642.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cardioplegic Solutions; Citric Acid | 2000 |
Inhibition of Na(+)/H(+) exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex.
Topics: Acidosis; Amiloride; Animals; Brain Ischemia; Cardiovascular Physiological Phenomena; Cerebral Corte | 2000 |
Reduced production of lactate during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Astrocytes; Carrier Proteins; Cell Death; Cells, Cultured; Fetus; Hypoxia, Brain; L-Lactate | 2000 |
Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart.
Topics: Animals; Calcium Channel Blockers; Carnitine O-Palmitoyltransferase; Coronary Circulation; Enzyme In | 2000 |
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease | 2001 |
Noninvasive monitoring of citrate, acetate, lactate, and renal medullary osmolyte excretion in urine as biomarkers of exposure to ischemic reperfusion injury.
Topics: Acetic Acid; Acetylglucosaminidase; Acute Kidney Injury; Adenosine; Allopurinol; Animals; Biomarkers | 2000 |
Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Benzofurans; Brain; Brain Ischemia; Lactic Acid; Male | 2000 |
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Animal | 2001 |
Further studies on the effects of topical lactate on amino acid efflux from the ischemic rat cortex.
Topics: Administration, Topical; Amino Acids; Animals; Brain Ischemia; Cardiovascular Physiological Phenomen | 2001 |
Effects of hyperglycemia or hypoglycemia on brain cell membrane function and energy metabolism during the immediate reoxygenation-reperfusion period after acute transient global hypoxia-ischemia in the newborn piglet.
Topics: Adenosine Triphosphatases; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Gas Analysis; Blood | 2001 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction | 2001 |
Mesenteric and renal oxygen transport during hemorrhage and reperfusion: evaluation of optimal goals for resuscitation.
Topics: Acid-Base Equilibrium; Animals; Female; Fluid Therapy; Gastric Acidity Determination; Hemodynamics; | 2001 |
Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model.
Topics: Animals; Brain Damage, Chronic; Extracellular Space; Glutamic Acid; Glycerol; Infarction, Middle Cer | 2001 |
Effects of ovariectomy and estrogen on ischemia-reperfusion injury in hindlimbs of female rats.
Topics: Animals; Antigens, CD; Calpain; Creatine Kinase; Estrogens; Female; Glycogen; Hindlimb; Insulin-Like | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic | 2001 |
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero | 2001 |
Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects.
Topics: Anaphylatoxins; Animals; Blood Gas Analysis; Cardiac Output; Complement C1 Inactivator Proteins; Cor | 2001 |
Changes in the contents of glycogen and lactate in the brain and blood during hypoxic preconditioning.
Topics: Animals; Brain; Diencephalon; Female; Glycogen; Hypoxia, Brain; Ischemic Preconditioning; Lactic Aci | 2001 |
Intestinal energy metabolism after ischemia-reperfusion: Effects of moderate hypothermia and perfluorocarbons.
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Fluorocarbons; Hypothermia, Induced; Ileum; Inte | 2002 |
Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Energy Metabolism; Gerbillinae; Gluco | 2002 |
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Anima | 1992 |
Hypothermia relieves oxidative stress in reperfused skeletal muscle following partial ischemia.
Topics: Adenosine Triphosphate; Animals; Free Radicals; Hypothermia, Induced; Lactates; Lactic Acid; Lipid P | 1992 |
Prolonged adenine nucleotide resynthesis and reperfusion injury in postischemic skeletal muscle.
Topics: Adenine Nucleotides; Animals; Creatine Kinase; Dogs; Ischemia; Lactates; Lactic Acid; Muscles; Necro | 1992 |
Effects of acute lower limb ischemia on femoral venous efflux.
Topics: Animals; Creatine Kinase; Femoral Vein; Humans; Hydrogen-Ion Concentration; Ischemia; L-Lactate Dehy | 1990 |
Intraischemic metabolic effects of different disaccharides on protected canine kidneys.
Topics: Adenosine Triphosphate; Animals; Dogs; Energy Metabolism; Glucose; Hypertonic Solutions; Kidney; Lac | 1989 |
Hyperoxia during reperfusion is a factor in reperfusion injury.
Topics: Free Radicals; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Oxygen; Reperfusion Injury; Supero | 1989 |