lactic acid has been researched along with Renal Insufficiency in 27 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed a retrospective cohort study using propensity score-matched analyses comparing the incidence of lactic acidosis between LZD and VAN therapy." | 7.88 | Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors. ( Aoki, Y; Bito, S; Hirose, S; Kamimura, Y; Kimura, Y; Mori, N, 2018) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 7.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "The crude incidence of lactic acidosis or elevated lactate concentrations in current metformin users was 7." | 7.80 | Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. ( De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M, 2014) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 7.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| "Critically ill patients who suffer from hepatic failure have elevated plasma arginine concentrations." | 7.72 | High plasma arginine concentrations in critically ill patients suffering from hepatic failure. ( Girbes, AR; Nijveldt, RJ; Prins, HA; Siroen, MP; Teerlink, T; van der Hoven, B; van Leeuwen, PA, 2004) |
| "Metformin has been associated with lactic acidosis." | 4.95 | Lactate Levels with Chronic Metformin Use: A Narrative Review. ( Castelino, RL; Huang, W; Peterson, GM, 2017) |
| "We evaluated the ability of four biomarkers (C-Reactive protein (CRP), lactate, mid-regional proadrenomedullin (MR-proADM) and procalcitonin (PCT)) to detect each kind of organ failure considered in the SOFA in 213 patients with infection, sepsis or septic shock, by using multivariate regression analysis and calculation of the area under the receiver operating curve (AUROC)." | 3.96 | MR- proADM to detect specific types of organ failure in infection. ( Aldecoa, C; Almansa, R; Andaluz-Ojeda, D; Andrés, C; Bermejo-Martin, JF; Calvo, D; Cicuendez, R; Esteban-Velasco, MC; Martín, S; Martin-Fernandez, M; Muñoz-Bellvís, L; Nogales, L; Ríos-Llorente, A; Sanchez-Barrado, E; Vaquero-Roncero, LM, 2020) |
| "We performed a retrospective cohort study using propensity score-matched analyses comparing the incidence of lactic acidosis between LZD and VAN therapy." | 3.88 | Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors. ( Aoki, Y; Bito, S; Hirose, S; Kamimura, Y; Kimura, Y; Mori, N, 2018) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 3.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock." | 3.81 | Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock. ( Dong, Z; Huang, T; Li, Q, 2015) |
| "The crude incidence of lactic acidosis or elevated lactate concentrations in current metformin users was 7." | 3.80 | Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. ( De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M, 2014) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 3.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| " This is largely due to the historical experience of lactic acidosis with phenformin, despite the fact that metformin does not predispose to this when compared with other therapies." | 3.73 | Contraindications can damage your health--is metformin a case in point? ( Holstein, A; Stumvoll, M, 2005) |
| "Critically ill patients who suffer from hepatic failure have elevated plasma arginine concentrations." | 3.72 | High plasma arginine concentrations in critically ill patients suffering from hepatic failure. ( Girbes, AR; Nijveldt, RJ; Prins, HA; Siroen, MP; Teerlink, T; van der Hoven, B; van Leeuwen, PA, 2004) |
| "Metformin is a biguanaide antidiabetic drug used worldwide, and its effectiveness and benefits have already been established." | 1.43 | Investigation of Risk Factors Affecting Lactate Levels in Japanese Patients Treated with Metformin. ( Hiraoka, S; Nishihara, M; Tsuji, H; Yokoyama, S, 2016) |
| "Thoracoabdominal aortic aneurysm open surgery is accompanied by a significant incidence of renal failure due to renal ischemia." | 1.35 | Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach. ( Charalambopoulos, A; Giamarellos-Bourboulis, EJ; Kakisis, JD; Karatzas, GM; Karkaletsis, KG; Lazaris, AM; Liakakos, TD; Maheras, AN; Martikos, G; Patapis, P; Vasdekis, SN, 2009) |
| "To highlight selected adverse effects of continuous renal replacement therapy and to suggest measures for reducing harm." | 1.34 | Primum non nocere, safety of continuous renal replacement therapy. ( Oudemans-van Straaten, HM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 12 (44.44) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Theurey, P | 1 |
| Vial, G | 1 |
| Fontaine, E | 1 |
| Monternier, PA | 1 |
| Fouqueray, P | 1 |
| Bolze, S | 1 |
| Moller, DE | 1 |
| Hallakou-Bozec, S | 1 |
| Sood, N | 1 |
| Sangari, A | 1 |
| Goyal, A | 1 |
| Conway, JAS | 1 |
| Azushima, K | 1 |
| Kovalik, JP | 1 |
| Yamaji, T | 1 |
| Ching, J | 1 |
| Chng, TW | 1 |
| Guo, J | 1 |
| Liu, JJ | 1 |
| Nguyen, M | 1 |
| Sakban, RB | 1 |
| George, SE | 1 |
| Tan, PH | 1 |
| Lim, SC | 1 |
| Gurley, SB | 1 |
| Coffman, TM | 1 |
| Fischer, MO | 1 |
| Lemoine, S | 1 |
| Tavernier, B | 1 |
| Bouchakour, CE | 1 |
| Colas, V | 1 |
| Houard, M | 1 |
| Greub, W | 1 |
| Daccache, G | 1 |
| Hulet, C | 1 |
| Compère, V | 1 |
| Taing, D | 1 |
| Lorne, E | 1 |
| Parienti, JJ | 1 |
| Hanouz, JL | 1 |
| Andrés, C | 1 |
| Andaluz-Ojeda, D | 1 |
| Cicuendez, R | 1 |
| Nogales, L | 1 |
| Martín, S | 1 |
| Martin-Fernandez, M | 1 |
| Almansa, R | 1 |
| Calvo, D | 1 |
| Esteban-Velasco, MC | 1 |
| Vaquero-Roncero, LM | 1 |
| Ríos-Llorente, A | 1 |
| Sanchez-Barrado, E | 1 |
| Muñoz-Bellvís, L | 1 |
| Aldecoa, C | 1 |
| Bermejo-Martin, JF | 1 |
| Posma, RA | 1 |
| Hulman, A | 1 |
| Thomsen, RW | 1 |
| Jespersen, B | 1 |
| Nijsten, MW | 2 |
| Christiansen, CF | 1 |
| Freire Jorge, P | 1 |
| Wieringa, N | 1 |
| de Felice, E | 1 |
| van der Horst, ICC | 1 |
| Oude Lansink, A | 1 |
| Huang, W | 1 |
| Castelino, RL | 1 |
| Peterson, GM | 1 |
| Yang, C | 1 |
| Vu-Quang, H | 1 |
| Husum, DMU | 1 |
| Tingskov, SJ | 1 |
| Vinding, MS | 1 |
| Nielsen, T | 1 |
| Song, P | 1 |
| Nielsen, NC | 1 |
| Nørregaard, R | 1 |
| Kjems, J | 1 |
| Mori, N | 1 |
| Kamimura, Y | 1 |
| Kimura, Y | 1 |
| Hirose, S | 1 |
| Aoki, Y | 1 |
| Bito, S | 1 |
| Eppenga, WL | 1 |
| Lalmohamed, A | 1 |
| Geerts, AF | 1 |
| Derijks, HJ | 1 |
| Wensing, M | 1 |
| Egberts, A | 1 |
| De Smet, PA | 1 |
| de Vries, F | 1 |
| Li, Q | 1 |
| Huang, T | 1 |
| Dong, Z | 1 |
| Nagai, T | 1 |
| Nishimura, K | 1 |
| Honma, T | 1 |
| Higashiyama, A | 1 |
| Sugano, Y | 1 |
| Nakai, M | 1 |
| Honda, S | 1 |
| Iwakami, N | 1 |
| Okada, A | 1 |
| Kawakami, S | 1 |
| Kanaya, T | 1 |
| Asaumi, Y | 1 |
| Aiba, T | 1 |
| Nishida, Y | 1 |
| Kubota, Y | 1 |
| Sugiyama, D | 1 |
| Okamura, T | 1 |
| Noguchi, T | 1 |
| Kusano, K | 1 |
| Ogawa, H | 1 |
| Yasuda, S | 1 |
| Anzai, T | 1 |
| Yokoyama, S | 1 |
| Tsuji, H | 1 |
| Hiraoka, S | 1 |
| Nishihara, M | 1 |
| Lee, EY | 1 |
| Hwang, S | 1 |
| Lee, YH | 1 |
| Lee, SH | 1 |
| Lee, YM | 1 |
| Kang, HP | 1 |
| Han, E | 1 |
| Lee, W | 1 |
| Lee, BW | 1 |
| Kang, ES | 1 |
| Cha, BS | 1 |
| Lee, HC | 1 |
| Lazaris, AM | 1 |
| Maheras, AN | 1 |
| Vasdekis, SN | 1 |
| Karkaletsis, KG | 1 |
| Charalambopoulos, A | 1 |
| Kakisis, JD | 1 |
| Martikos, G | 1 |
| Patapis, P | 1 |
| Giamarellos-Bourboulis, EJ | 1 |
| Karatzas, GM | 1 |
| Liakakos, TD | 1 |
| Titov, VN | 1 |
| Dmitriev, LF | 1 |
| Krylin, VA | 1 |
| Dmitriev, VA | 1 |
| van Berlo-van de Laar, IR | 1 |
| Vermeij, CG | 1 |
| Doorenbos, CJ | 1 |
| Zouaoui, K | 1 |
| Dulaurent, S | 1 |
| Gaulier, JM | 1 |
| Moesch, C | 1 |
| Lachâtre, G | 1 |
| Stemmler, J | 1 |
| Wittmann, GW | 1 |
| Hacker, U | 1 |
| Heinemann, V | 1 |
| Nijveldt, RJ | 1 |
| Siroen, MP | 1 |
| van der Hoven, B | 1 |
| Teerlink, T | 1 |
| Prins, HA | 1 |
| Girbes, AR | 1 |
| van Leeuwen, PA | 1 |
| Holstein, A | 1 |
| Stumvoll, M | 1 |
| Baslaim, G | 1 |
| Bashore, J | 1 |
| Al-Malki, F | 1 |
| Jamjoom, A | 1 |
| Oudemans-van Straaten, HM | 1 |
| Lewis, NP | 1 |
| Macdougall, IC | 1 |
| Willis, N | 1 |
| Coles, GA | 1 |
| Williams, JD | 1 |
| Henderson, AH | 1 |
| Guiserix, J | 1 |
| Finielz, P | 1 |
| Feng, J | 1 |
| Li, X | 1 |
| Pei, F | 1 |
| Chen, X | 1 |
| Li, S | 1 |
| Nie, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In Severe Traumatic Brain Injury Patients Scheduled for Emergency Craniotomies: A Randomised Control Trial[NCT04664699] | 64 participants (Actual) | Interventional | 2019-05-29 | Completed | |||
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and Renal Insufficiency
| Article | Year |
|---|---|
Predictors of survival for pediatric extracorporeal cardiopulmonary resuscitation: A systematic review and meta-analysis.
Topics: Cardiopulmonary Resuscitation; Child; Creatinine; Humans; Lactic Acid; Nervous System Diseases; Oxyg | 2022 |
Lactate Levels with Chronic Metformin Use: A Narrative Review.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Metformin; Renal Insufficienc | 2017 |
1 trial available for lactic acid and Renal Insufficiency
| Article | Year |
|---|---|
Individualized Fluid Management Using the Pleth Variability Index: A Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Algorithms; Anesthesia, General; Arterial Pressure; Arthroplasty; Female; F | 2020 |
24 other studies available for lactic acid and Renal Insufficiency
| Article | Year |
|---|---|
Reduced lactic acidosis risk with Imeglimin: Comparison with Metformin.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Dogs; Humans; Hypoglycemic Agents; Lactic Acid | 2022 |
Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Di | 2023 |
MR- proADM to detect specific types of organ failure in infection.
Topics: Adrenomedullin; Aged; Aged, 80 and over; Area Under Curve; Blood Coagulation Disorders; C-Reactive P | 2020 |
Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment.
Topics: Aged; Critical Illness; Denmark; Female; Humans; Hypoglycemic Agents; Lactic Acid; Male; Metformin; | 2020 |
The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients.
Topics: Adult; Aged; APACHE; Critical Illness; Female; Glucose; Hospital Mortality; Hospitalization; Humans; | 2017 |
Theranostic poly(lactic-co-glycolic acid) nanoparticle for magnetic resonance/infrared fluorescence bimodal imaging and efficient siRNA delivery to macrophages and its evaluation in a kidney injury model.
Topics: Animals; Cyclooxygenase 2; Drug Carriers; Lactic Acid; Macrophages; Magnetic Resonance Imaging; Male | 2017 |
Comparative analysis of lactic acidosis induced by linezolid and vancomycin therapy using cohort and case-control studies of incidence and associated risk factors.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biomarkers; | 2018 |
Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Comorbidity; Diabetes Mellitus, Type 2; Female; Human | 2014 |
Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock.
Topics: Animals; Biomarkers; Disease Models, Animal; Fluid Therapy; Hemodynamics; Inflammation Mediators; In | 2015 |
Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure.
Topics: Acute Disease; Aged; Aged, 80 and over; Anemia; Cause of Death; Cohort Studies; Disease Progression; | 2016 |
Investigation of Risk Factors Affecting Lactate Levels in Japanese Patients Treated with Metformin.
Topics: Adult; Aged; Asian People; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Type 2; Female; Glyca | 2016 |
Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; H | 2017 |
Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Disease Models, An | 2009 |
[Methylglyoxal--a test for impaired biological functions of exotrophy and endoecology, low glucose level in the cytosol and gluconeogenesis from fatty acids (a lecture)].
Topics: Animals; Cytosol; Diabetes Mellitus; Diabetic Ketoacidosis; Energy Metabolism; Fatty Acids; Gluconeo | 2010 |
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Early | 2011 |
Determination of glyphosate and AMPA in blood and urine from humans: about 13 cases of acute intoxication.
Topics: Accidents; Acidosis; Adult; Aged; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chro | 2013 |
Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure.
Topics: Aged; Biomarkers; Female; Humans; Lactic Acid; Leukapheresis; Leukemia, Myelomonocytic, Chronic; Leu | 2002 |
High plasma arginine concentrations in critically ill patients suffering from hepatic failure.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Critical Illness; Cross-Sectional Studies; Fem | 2004 |
Contraindications can damage your health--is metformin a case in point?
Topics: Acidosis, Lactic; Aging; Contraindications; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypog | 2005 |
Can the outcome of pediatric extracorporeal membrane oxygenation after cardiac surgery be predicted?
Topics: Cardiac Surgical Procedures; Cardiotonic Agents; Child; Child, Preschool; Disseminated Intravascular | 2006 |
Primum non nocere, safety of continuous renal replacement therapy.
Topics: Anticoagulants; Blood Coagulation; Citric Acid; Hot Temperature; Humans; Inflammation; Lactic Acid; | 2007 |
Effects of the correction of renal anaemia by erythropoietin on physiological changes during exercise.
Topics: Adolescent; Adult; Aged; Anemia; Bicarbonates; Erythropoietin; Exercise Tolerance; Female; Humans; K | 1993 |
Emergency hemodialysis using lactate-buffered dialysate.
Topics: Emergency Medical Services; Hemodialysis Solutions; Humans; Lactic Acid; Renal Dialysis; Renal Insuf | 1997 |
1H NMR analysis for metabolites in serum and urine from rats administrated chronically with La(NO3)3.
Topics: Amino Acids; Animals; Citric Acid; Ethylamines; Ketone Bodies; Lactic Acid; Lanthanum; Liver Failure | 2002 |