lactic acid has been researched along with Renal Insufficiency, Chronic in 19 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 9.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| "Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient." | 8.31 | Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report. ( Wu, C; Xia, Y; Zhu, X, 2023) |
| "To study the incidence of lactic acidosis due to metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5." | 7.91 | Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D, 2019) |
| "Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4." | 7.91 | Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019) |
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 5.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| "Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient." | 4.31 | Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report. ( Wu, C; Xia, Y; Zhu, X, 2023) |
| "To study the incidence of lactic acidosis due to metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5." | 3.91 | Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D, 2019) |
| "Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4." | 3.91 | Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019) |
| "Metformin therapy is limited in patients with chronic kidney disease (CKD) due to the potential risk of lactic acidosis." | 3.78 | Metformin therapy in patients with chronic kidney disease. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Kirkpatrick, CM; Kumar, SS; Roberts, DM; Williams, KM, 2012) |
| "First, in the dose-finding study, the appropriate daily dosing schedules were 1,500 mg (0." | 1.48 | Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4. ( Belpaire, F; Bennis, Y; De Broe, ME; Hurtel-Lemaire, AS; Kajbaf, F; Lalau, JD, 2018) |
| "Urea was extracted iontophoretically over a 2-h period across the skin of adult volunteers and patients with chronic kidney disease." | 1.34 | Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo. ( Caspers, P; de Sterke, J; Guy, RH; Jadoul, M; Préat, V; Wascotte, V, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 9 (47.37) | 2.80 |
| Authors | Studies |
|---|---|
| Sheng, Y | 1 |
| Zheng, WL | 1 |
| Shi, QF | 1 |
| Zhang, BY | 1 |
| Yang, GY | 1 |
| Sumbal, R | 1 |
| Ali Baig, MM | 1 |
| Sumbal, A | 1 |
| Rahman, F | 1 |
| Tuba, S | 1 |
| Xia, Y | 1 |
| Zhu, X | 1 |
| Wu, C | 1 |
| Gosmanova, EO | 1 |
| Shahzad, SR | 1 |
| Sumida, K | 1 |
| Kovesdy, CP | 1 |
| Gosmanov, AR | 1 |
| He, LX | 1 |
| Abdolmaleky, HM | 1 |
| Yin, S | 1 |
| Wang, Y | 1 |
| Zhou, JR | 1 |
| Jia, L | 1 |
| Sheng, X | 1 |
| Zamperetti, A | 1 |
| Xie, Y | 1 |
| Corradi, V | 1 |
| Chandel, S | 1 |
| De Cal, M | 1 |
| Montin, DP | 1 |
| Caprara, C | 1 |
| Ronco, C | 1 |
| Han, C | 1 |
| Jiang, YH | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Gewin, LS | 1 |
| Lin, YF | 2 |
| Lee, YH | 1 |
| Hsu, YH | 1 |
| Chen, YJ | 1 |
| Cheng, FY | 1 |
| Chiu, HW | 1 |
| Lalau, JD | 1 |
| Kajbaf, F | 1 |
| Bennis, Y | 1 |
| Hurtel-Lemaire, AS | 1 |
| Belpaire, F | 1 |
| De Broe, ME | 1 |
| Weigand, KM | 1 |
| Schirris, TJJ | 1 |
| Houweling, M | 1 |
| van den Heuvel, JJMW | 1 |
| Koenderink, JB | 1 |
| Dankers, ACA | 1 |
| Russel, FGM | 1 |
| Greupink, R | 1 |
| Prabhu, RA | 1 |
| Mareddy, AS | 1 |
| Nagaraju, SP | 1 |
| Rangaswamy, D | 1 |
| Guddattu, V | 1 |
| Tanemoto, M | 1 |
| Watson, EL | 1 |
| Kosmadakis, GC | 1 |
| Smith, AC | 1 |
| Viana, JL | 1 |
| Brown, JR | 1 |
| Molyneux, K | 1 |
| Pawluczyk, IZ | 1 |
| Mulheran, M | 1 |
| Bishop, NC | 1 |
| Shirreffs, S | 1 |
| Maughan, RJ | 1 |
| Owen, PJ | 1 |
| John, SG | 1 |
| McIntyre, CW | 1 |
| Feehally, J | 1 |
| Bevington, A | 1 |
| Kalantar-Zadeh, K | 1 |
| Uppot, RN | 1 |
| Lewandrowski, KB | 1 |
| Ficek, J | 1 |
| Wyskida, K | 1 |
| Ficek, R | 1 |
| Wajda, J | 1 |
| Klein, D | 1 |
| Witkowicz, J | 1 |
| Rotkegel, S | 1 |
| Spiechowicz-Zatoń, U | 1 |
| Kocemba-Dyczek, J | 1 |
| Ciepał, J | 1 |
| Więcek, A | 1 |
| Olszanecka-Glinianowicz, M | 1 |
| Chudek, J | 1 |
| Duong, JK | 1 |
| Roberts, DM | 1 |
| Furlong, TJ | 1 |
| Kumar, SS | 1 |
| Greenfield, JR | 1 |
| Kirkpatrick, CM | 1 |
| Graham, GG | 1 |
| Williams, KM | 1 |
| Day, RO | 1 |
| Wascotte, V | 1 |
| Caspers, P | 1 |
| de Sterke, J | 1 |
| Jadoul, M | 1 |
| Guy, RH | 1 |
| Préat, V | 1 |
3 reviews available for lactic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Predictors of Mortality in Acute Mesenteric Ischemia: A Systematic Review and Meta-Analysis.
Topics: Arrhythmias, Cardiac; Creatinine; Female; Humans; Hypotension; Ischemia; Lactic Acid; Male; Mesenter | 2022 |
Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; La | 2022 |
Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease.
Topics: Acute Kidney Injury; Dietary Sugars; Disease Progression; Fatty Acids; Humans; Kidney Tubules; Kidne | 2021 |
1 trial available for lactic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Combined walking exercise and alkali therapy in patients with CKD4-5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Bicarbonates; Combined Modality Therapy; Exercise Thera | 2013 |
15 other studies available for lactic acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Clinical characteristics and prognosis in patients with urosepsis from intensive care unit in Shanghai, China: a retrospective bi-centre study.
Topics: Age Distribution; Aged; China; Critical Illness; Female; Humans; Intensive Care Units; Lactic Acid; | 2021 |
Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report.
Topics: Acidosis, Lactic; Aeromonas veronii; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2023 |
Metformin is associated with increase in lactate level in elderly patients with type 2 diabetes and CKD stage 3: A case-control study.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Neph | 2020 |
Dietary Fermented Soy Extract and Oligo-Lactic Acid Alleviate Chronic Kidney Disease in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota.
Topics: Adenine; Animals; Biomarkers; Cecum; Clostridium; Cystatin C; Cytokines; Dietary Supplements; Diseas | 2020 |
Combination of biomarker with clinical risk factors for prediction of severe acute kidney injury in critically ill patients.
Topics: Acute Kidney Injury; Age Factors; Aged; Aged, 80 and over; Biomarkers; Clinical Decision Rules; Cont | 2020 |
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
Topics: Animals; Astragalus propinquus; Butyric Acid; Colon; Cyclosporine; Drugs, Chinese Herbal; Endoplasmi | 2021 |
Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease.
Topics: Animals; Antibodies; Autophagy; Cell Line; Cell Survival; Creatinine; Drug Carriers; Drug Liberation | 2017 |
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4.
Topics: Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin | 2018 |
Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity.
Topics: Adenosine Triphosphate; HEK293 Cells; Hepatocytes; Humans; Lactic Acid; Membrane Transport Proteins; | 2019 |
Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Moni | 2019 |
Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Aged; Aged, 80 and over; Biomarkers; Disease Prog | 2019 |
Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion.
Topics: Abdominal Pain; Acidosis, Lactic; Confusion; Diabetes Mellitus, Type 2; Diagnosis, Differential; Fem | 2013 |
Relationship between plasma levels of zonulin, bacterial lipopolysaccharides, D-lactate and markers of inflammation in haemodialysis patients.
Topics: Biomarkers; C-Reactive Protein; Cholera Toxin; Female; Haptoglobins; Humans; Inflammation; Interleuk | 2017 |
Metformin therapy in patients with chronic kidney disease.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Response Relationship, Dr | 2012 |
Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo.
Topics: Adult; Humans; Iontophoresis; Lactic Acid; Microscopy, Confocal; Renal Insufficiency, Chronic; Sever | 2007 |