lactic acid has been researched along with Pruritus in 13 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Due to the actives urea, lactate, polidocanol, and the anti-inflammatory licochalcone A, the new scalp tonic exhibited excellent performance in alleviating scalp dryness, itching, microinflammation, and in normalizing disturbances of scalp lipids." | 5.17 | Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp. ( Baufeld, C; Drescher, P; Filbry, A; Höpfner, S; Lüttke, J; Max, H; Mess, A; Oltrogge, B; Rippke, F; Schweiger, D, 2013) |
| "To determine the degree of satisfaction reported by a group of Mexican patients used the combination lactoserum lactic acid and to the relief of vulvovaginal symptoms (odor, itching and burning) or not associated with infection and the safety of that combination when used for external genital hygiene daily." | 5.14 | [Lactic acid and lactoserum in vulvovaginal infections]. ( Bravo, Mde L; Hernández-López, LA, 2010) |
| "We analyzed the relationship between the frequency of response at each sensation (stinging, burning, and itching) during a lactic acid sting test and the current perception threshold (CPT) value of each frequency." | 3.83 | Itching sensation and neuronal sensitivity of the skin. ( An, SM; Ham, H; Kim, HO; Koh, JS; Lee, E; Lee, EJ, 2016) |
| "Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function." | 2.87 | Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. ( Barysch, M; Borelli, S; Gasser, UE; Hasan-Ali, O; Kunz, M; Nägeli, M; Nobbe, S; Simon, D; Wildi, E, 2018) |
| "Atopic dermatitis (synonym atopic eczema, AD) is a chronic inflammatory skin disorder essentially characterised by a red "itchy" skin rash." | 2.58 | pH in Atopic Dermatitis. ( Cork, MJ; Danby, SG, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yatagai, T | 1 |
| Shimauchi, T | 1 |
| Yamaguchi, H | 1 |
| Sakabe, JI | 1 |
| Aoshima, M | 1 |
| Ikeya, S | 1 |
| Tatsuno, K | 1 |
| Fujiyama, T | 1 |
| Ito, T | 1 |
| Ojima, T | 1 |
| Tokura, Y | 1 |
| Danby, SG | 1 |
| Cork, MJ | 1 |
| Simon, D | 1 |
| Nobbe, S | 1 |
| Nägeli, M | 1 |
| Barysch, M | 1 |
| Kunz, M | 1 |
| Borelli, S | 1 |
| Hasan-Ali, O | 1 |
| Wildi, E | 1 |
| Gasser, UE | 1 |
| Hasan, MZ | 1 |
| Kitamura, M | 1 |
| Kawai, M | 1 |
| Ohira, M | 1 |
| Mori, K | 1 |
| Shoju, S | 1 |
| Takagi, K | 1 |
| Tsukamoto, K | 1 |
| Kawai, Y | 1 |
| Inoue, A | 1 |
| Schweiger, D | 1 |
| Baufeld, C | 1 |
| Drescher, P | 1 |
| Oltrogge, B | 1 |
| Höpfner, S | 1 |
| Mess, A | 1 |
| Lüttke, J | 1 |
| Rippke, F | 1 |
| Filbry, A | 1 |
| Max, H | 1 |
| Matsumoto, M | 1 |
| Ebata, T | 1 |
| Hirooka, J | 1 |
| Hosoya, R | 1 |
| Inoue, N | 1 |
| Itami, S | 1 |
| Tsuji, K | 1 |
| Yaginuma, T | 1 |
| Muramatsu, K | 1 |
| Nakamura, A | 1 |
| Fujita, A | 1 |
| Nagakura, T | 1 |
| Ham, H | 1 |
| An, SM | 1 |
| Lee, EJ | 1 |
| Lee, E | 1 |
| Kim, HO | 1 |
| Koh, JS | 1 |
| Bravo, Mde L | 1 |
| Hernández-López, LA | 1 |
| Marriott, M | 1 |
| Whittle, E | 1 |
| Basketter, DA | 1 |
| Grove, G | 1 |
| Zerweck, C | 1 |
| Lee, SH | 1 |
| Shin, YW | 1 |
| Bae, EA | 1 |
| Lee, B | 1 |
| Min, S | 1 |
| Baek, NI | 1 |
| Chung, HG | 1 |
| Kim, NJ | 1 |
| Kim, DH | 1 |
| Muizzuddin, N | 1 |
| Marenus, KD | 1 |
| Maes, DH | 1 |
| Jennings, MB | 1 |
| Logan, L | 1 |
| Alfieri, DM | 1 |
| Ross, CF | 1 |
| Goodwin, S | 1 |
| Lesczczynski, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Center Clinical Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris[NCT03128723] | 45 participants (Actual) | Interventional | 2017-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 14. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.02 |
Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 28. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 14. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.11 |
Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 28. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.14 |
Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 14. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 28. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 14. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.09 |
Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 28. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.07 |
Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 14. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.04 |
Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 28. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 14. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.02 |
Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 28. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.05 |
1 review available for lactic acid and Pruritus
| Article | Year |
|---|---|
pH in Atopic Dermatitis.
Topics: Amino Acids; Antimicrobial Cationic Peptides; Dermatitis, Atopic; Humans; Hydrogen-Ion Concentration | 2018 |
6 trials available for lactic acid and Pruritus
| Article | Year |
|---|---|
Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Double-Blind Method; Drug Administration Schedul | 2018 |
Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp.
Topics: Chalcones; Cytokines; Glycyrrhiza; Humans; Lactic Acid; Lipid Metabolism; Plant Extracts; Plant Root | 2013 |
Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis.
Topics: Adult; Analgesics; Animals; Antipruritics; Bifidobacterium; Dermatitis, Atopic; Feces; Female; Human | 2014 |
[Lactic acid and lactoserum in vulvovaginal infections].
Topics: Adolescent; Adult; Asymptomatic Diseases; Combined Modality Therapy; Female; Feminine Hygiene Produc | 2010 |
An evaluation of the moisturizing and anti-itch effects of a lactic acid and pramoxine hydrochloride cream.
Topics: Administration, Topical; Adolescent; Adult; Antipruritics; Drug Combinations; Female; Galvanic Skin | 2004 |
A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.
Topics: Adult; Aged; Aged, 80 and over; Dermatologic Agents; Double-Blind Method; Erythema; Female; Foot Der | 2002 |
6 other studies available for lactic acid and Pruritus
| Article | Year |
|---|---|
Sensitive skin is highly frequent in extrinsic atopic dermatitis and correlates with disease severity markers but not necessarily with skin barrier impairment.
Topics: Adult; Aged; Biomarkers; Cytokines; Dermatitis, Atopic; Female; Filaggrin Proteins; Humans; Immunogl | 2018 |
Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch.
Topics: Epidermis; Filaggrin Proteins; Humans; Irritants; Lactic Acid; Pruritus; Transcriptome | 2019 |
Itching sensation and neuronal sensitivity of the skin.
Topics: Adult; Differential Threshold; Electric Stimulation; Electrodiagnosis; Female; Humans; Hyperalgesia; | 2016 |
Facial variations in sensory responses.
Topics: Administration, Topical; Adolescent; Adult; Dermatitis, Allergic Contact; Facial Dermatoses; Female; | 2003 |
Lactic acid bacteria increase antiallergic effect of Artemisia princeps pampanini SS-1.
Topics: Animals; Anti-Allergic Agents; Artemisia; Bacteria; beta-N-Acetylhexosaminidases; Cell Line; Feces; | 2006 |
Factors defining sensitive skin and its treatment.
Topics: Adult; Balsams; Cosmetics; Dermatitis, Contact; Dermatologic Agents; Epidermis; Erythema; Exanthema; | 1998 |